Eubacteriales Family XIII. Incertae Sedis Details: NCBI 543314, gram-negative or unknown [family]

| Clostridiales Family XIII. Incertae Sedis

1. Mucosal Surfaces:

   • Verrucomicrobia bacteria are often found in mucosal surfaces, including the gastrointestinal tract. Their presence in the mucosal environment suggests potential interactions with the host's immune system and other microorganisms in these regions.

2. Akkermansia muciniphila:

   • One of the well-studied genera within Verrucomicrobia is Akkermansia. Akkermansia muciniphila is a species known to inhabit the mucus layer of the intestinal lining. Research has suggested that A. muciniphila may have positive effects on metabolic health, including its potential role in maintaining mucosal integrity and modulating metabolic pathways.

3. Mucus Degradation:

   • Some members of Verrucomicrobia, including Akkermansia species, are specialized in utilizing mucin, a component of the protective mucus layer in the gut. This ability to degrade mucin may influence the gut environment and the interactions between the microbiota and the host.

4. Metabolic Health:

   • Akkermansia muciniphila has been associated with metabolic health benefits in preclinical studies. It has been linked to improvements in glucose metabolism, insulin sensitivity, and lipid metabolism. However, the translation of these findings to human health is an area of ongoing investigation.

5. Immunomodulation:

   • Verrucomicrobia bacteria may play a role in immunomodulation, influencing the host's immune response. The interactions between Verrucomicrobia and the immune system are complex and context-dependent.

6. Associations with Disease:

   • Altered abundances of Verrucomicrobia have been observed in studies of the gut microbiota in various health conditions. Changes in the relative abundance of Verrucomicrobia, including increases or decreases, have been reported in conditions such as inflammatory bowel disease (IBD), obesity, and diabetes. However, the specific contributions of Verrucomicrobia to these conditions are still being explored.

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Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

More Information

Statistics

NCBI

Data Punk

End Products Produced

Lab Reporting

Different labs use different software to read the sample. See this post for more details.
One lab may say you have none, another may say you have a lot! - This may be solely due to the software they are using to estimate.
We deem lab specific values using values from the KM method for each specific lab to be the most reliable.

Desired Levels Suggestions for Eubacteriales Family XIII. Incertae Sedis

• Frequency - how often do samples show this bacteria
• UD - An alternative statistical algorithm (which factors in the frequency)
• Kaltoft-Moldrup Heuristic Using uploaded data
• Lab Low and High are calculated using the formula that most labs use: Mean - 2 Standard Deviation to Mean + 2 Standard Deviation

These are values that are computed from lab specific samples (Patent Pending)

Lab	Frequency	UD-Low	UD-High	KM Low	KM High	Lab Low	Lab High	Mean	Median	Standard Deviation	Box Plot Low	Box Plot High	KM Percentile Low	KM Percentile High
Other Labs	4.24	0	0	10	1358	0	2489	773	429	875.6	0	1865	0 %ile	92 %ile
biomesight	78.46	0	270	10	530	0	2914	459.9	160	1252.2	0	600	0 %ile	90.9 %ile
thorne	100			63	724	0	510	205.6	158	155.2	58	266	0 %ile	100 %ile
thryve	93.59	11	1027	51	1145	0	6229	1004.7	283	2665.6	0	1321	11.5 %ile	90.7 %ile
ubiome	83.02	0	1132	18	1827	0	5683	1320.1	621	2226.1	0	2085	0 %ile	91.4 %ile

External Reference Ranges for Eubacteriales Family XIII. Incertae Sedis

Eubacteriales Family XIII. Incertae Sedis (NCBI 543314) per million

Source of Ranges	Low Boundary	High Boundary	Low Boundary %age	High Boundary %age

Statistic by Lab Source for Eubacteriales Family XIII. Incertae Sedis

These desired values are reported from the lab reports

Lab	Frequency Seen	Average	Standard Deviation	Sample Count	Lab Samples
AmericanGut	66.667 %	0.048 %	0.033 %	10.0	15
Biomesight	83.469 %	0.046 %	0.121 %	2454.0	2940
BiomeSightRdp	90.625 %	0.059 %	0.083 %	29.0	32
bugspeak	100 %	0.026 %	%	1.0	1
CerbaLab	100 %	0.057 %	0.016 %	3.0	3
CosmosId	56.25 %	0.018 %	0.033 %	18.0	32
custom	13.115 %	0.011 %	0.026 %	8.0	61
es-xenogene	24.138 %	0.037 %	0.021 %	7.0	29
Medivere	100 %	0.024 %	0.015 %	7.0	7
Microba	10.714 %	0.125 %	0.135 %	3.0	28
Microba1	100 %	0.14 %	%	1.0	1
SequentiaBiotech	86.111 %	0.135 %	0.099 %	31.0	36
Thorne	86.022 %	0.013 %	0.012 %	80.0	93
Thryve	94.296 %	0.103 %	0.351 %	1306.0	1385
Tiny	100 %	0.003 %	%	1.0	1
uBiome	82.702 %	0.132 %	0.223 %	655.0	792

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Data Contradictions — Limits of Certainity

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General Substance	Specific Substance	Effect
Common Supplements	Exercise	1 Studies recorded. The consensus is Decreases👪, Click for details.
Common Supplements	sodium butyrate	1 Studies recorded. The consensus is Decreases👪, Click for details.
Common Supplements	Tributyrin	1 Studies recorded. The consensus is Decreases👪, Click for details.
Diet Style	dietary fiber	2 Studies recorded. The consensus is Increases👶👪, Click for details.
Diet Style	high fiber diet	2 Studies recorded. The consensus is Increases👶👪, Click for details.
Diet Style	high sugar diet	1 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	high-fat diets	1 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	low protein diet	2 Studies recorded. The consensus is Increases👶👪, Click for details.
Food (excluding seasonings)	brown rice	2 Studies recorded. The consensus is Increases👶👪, Click for details.
Food (excluding seasonings)	whey	1 Studies recorded. The consensus is Decreases👪, Click for details.
Herb or Spice	triphala	1 Studies recorded. The consensus is Increases👪, Click for details.
Prebiotics and similar	Psyllium (Plantago Ovata Husk)	1 Studies recorded. The consensus is Decreases👪, Click for details.
Prebiotics and similar	resistant starch	2 Studies recorded. The consensus is Increases👶👪, Click for details.
Probiotics	Pediococcus pentosaceus	1 Studies recorded. The consensus is Decreases👪, Click for details.
Sugar and similar	saccharin	1 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	iron	1 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	vitamin d	1 Studies recorded. The consensus is Increases👪, Click for details.

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