Megasphaera Details: NCBI 906, gram-negative or unknown [genus]

| Megasphaera| Megasphaera Rogosa 1971 (Approved Lists 1980) emend. Marchandin et al. 2003

1. Anaerobic Fermentation:

   • Megasphaera species are generally anaerobic bacteria, and they are capable of fermenting a variety of substrates. In the gut, they participate in the fermentation of dietary fibers and complex carbohydrates.

2. Short-Chain Fatty Acid Production:

   • As part of their metabolic activities, Megasphaera bacteria can produce short-chain fatty acids (SCFAs) during the fermentation process. SCFAs, such as acetate, propionate, and butyrate, have been associated with various health benefits, including providing an energy source for colonic cells and influencing immune function.

3. Role in the Rumen of Ruminant Animals:

   • Some Megasphaera species are found in the rumen of ruminant animals, where they contribute to the digestion of fibrous plant materials through fermentation. The breakdown of complex carbohydrates in the rumen is important for the nutrition of ruminants.

4. Metabolism of Lactate:

   • Certain Megasphaera species are known for their ability to metabolize lactate. This characteristic is of interest in various environments, including the human gut, where the balance of lactate-producing and lactate-utilizing bacteria can influence gut health.

5. Influence on Gut Microbiota Composition:

   • The presence and abundance of Megasphaera species can contribute to the overall composition and diversity of the gut microbiota. Changes in the relative abundance of Megasphaera may be associated with specific dietary patterns or health conditions.

6. Associations with Gastrointestinal Disorders:

   • Some studies have investigated the association between Megasphaera and gastrointestinal disorders. For example, shifts in the abundance of Megasphaera have been observed in conditions such as irritable bowel syndrome (IBS).

A lot more information is available when you are logged in and raise the display level

Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

More Information

Statistics

NCBI

Data Punk

End Products Produced

Lab Reporting

Different labs use different software to read the sample. See this post for more details.
One lab may say you have none, another may say you have a lot! - This may be solely due to the software they are using to estimate.
We deem lab specific values using values from the KM method for each specific lab to be the most reliable.

Desired Levels Suggestions for Megasphaera

• Frequency - how often do samples show this bacteria
• UD - An alternative statistical algorithm (which factors in the frequency)
• Kaltoft-Moldrup Heuristic Using uploaded data
• Lab Low and High are calculated using the formula that most labs use: Mean - 2 Standard Deviation to Mean + 2 Standard Deviation

These are values that are computed from lab specific samples (Patent Pending)

Lab	Frequency	UD-Low	UD-High	KM Low	KM High	Lab Low	Lab High	Mean	Median	Standard Deviation	Box Plot Low	Box Plot High	KM Percentile Low	KM Percentile High
Other Labs	1.77			10	34000	0	11562	1047.5	102	5364.3	15	295	0 %ile	100 %ile
biomesight	84.74	0	310	40	460	0	15945	1224.2	160	7510.6	0	520	10.4 %ile	89.1 %ile
thorne	100			29	950	0	436	105.9	63	168.2	23	149	0 %ile	100 %ile
thryve	67.15	0	47	16	124	0	22202	1400.4	43	10613	7	135	8.5 %ile	92 %ile
ubiome	65.53	0	257	19	1626	0	31162	3543.5	229	14090.9	0	1495	0 %ile	90.9 %ile

External Reference Ranges for Megasphaera

Megasphaera (NCBI 906) per million

Source of Ranges	Low Boundary	High Boundary	Low Boundary %age	High Boundary %age
Metagenomics	0	0	0	0
Thorne (20/80%ile)	46.46	105.02	0.0046	0.0105

Statistic by Lab Source for Megasphaera

These desired values are reported from the lab reports

Lab	Frequency Seen	Average	Standard Deviation	Sample Count	Lab Samples
AmericanGut	13.333 %	0.032 %	0.02 %	2.0	15
BiomeSight	91.323 %	0.127 %	0.812 %	2705.0	2962
BiomeSightRdp	25.806 %	0.008 %	0.012 %	8.0	31
bugspeak	100 %	0.011 %	%	1.0	1
CerbaLab	100 %	0.02 %	0.004 %	3.0	3
CosmosId	3.125 %	0.019 %	%	1.0	32
custom	18.033 %	0.318 %	1.022 %	11.0	61
es-xenogene	93.103 %	0.009 %	0.008 %	27.0	29
Medivere	100 %	0.053 %	0.11 %	7.0	7
Thorne	85.577 %	0.008 %	0.015 %	89.0	104
Thryve	68.345 %	0.115 %	0.679 %	950.0	1390
Tiny	50 %	0.027 %	%	1.0	2
uBiome	65.404 %	0.354 %	1.408 %	518.0	792

To see medical conditions associated you may be logged in

And display level must be raised above public.

I would like to know what can change the quality that I have

• If I want to know that a substance also changes, then I just click on it
• If I want to know which study this information comes from, then I just clink in increases or decreases

Data Contradictions — Limits of Certainity

To get the list of studies, you must be logged in and raise your display level.

🧙? Search Hints:

General Substance	Specific Substance	Effect
Amino Acid and similar	l-glutamine	1 Studies recorded. The consensus is Decreases📓, Click for details.
Amino Acid and similar	l-proline	1 Studies recorded. The consensus is Decreases📓, Click for details.
Antibiotics, Antivirals etc	rifaximin (antibiotic)s	2 Studies recorded. The consensus is Decreases📓, Click for details.
Antibiotics, Antivirals etc	trimethoprim (antibiotic)s	1 Studies recorded. The consensus is Decreases📓, Click for details.
Antibiotics, Antivirals etc	vancomycin (antibiotic)[CFS]	1 Studies recorded. The consensus is Increases👶, Click for details.
Diet Style	gluten-free diet	1 Studies recorded. The consensus is Decreases📓, Click for details.
Diet Style	low protein diet	1 Studies recorded. The consensus is Increases👶, Click for details.
Diet Style	moderate-protein moderate-carbohydrate	1 Studies recorded. The consensus is Increases👶, Click for details.
Diet Style	Olive Oil	1 Studies recorded. The consensus is Increases📓, Click for details.
Diet Style	vegetable/fruit juice-based diets	1 Studies recorded. The consensus is Decreases📓, Click for details.
Drug or "Non-drug"	chlorhexidine	1 Studies recorded. The consensus is Decreases📓, Click for details.
Food (excluding seasonings)	almonds/ almond skins	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	barley	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	carbohydrates	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	fish oil	2 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	Konjaku flour	1 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	ku ding cha tea	1 Studies recorded. The consensus is Decreases👶, Click for details.
Food (excluding seasonings)	mulberry fruit polysaccharide	1 Studies recorded. The consensus is Decreases👶, Click for details.
Food (excluding seasonings)	Pumpkin	2 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	rice bran	1 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	vegetable	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	wheat bran	1 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	whey	1 Studies recorded. The consensus is Increases👶, Click for details.
Herb or Spice	berberine	1 Studies recorded. The consensus is Increases📓, Click for details.
Herb or Spice	camelina seed	1 Studies recorded. The consensus is Increases👶, Click for details.
Herb or Spice	Dangshen	1 Studies recorded. The consensus is Decreases👶, Click for details.
Herb or Spice	ginko	1 Studies recorded. The consensus is Increases👶, Click for details.
Herb or Spice	Shen Ling Bai Zhu San	1 Studies recorded. The consensus is Decreases📓, Click for details.
Prebiotics and similar	galacto-oligosaccharides (prebiotic)	1 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	inulin (prebiotic)	2 Studies recorded. The consensus is Increases📓, Click for details.
Prebiotics and similar	partially hydrolyzed guar gum	1 Studies recorded. The consensus is Increases👶, Click for details.
Prebiotics and similar	ß-glucan	1 Studies recorded. The consensus is Increases📓, Click for details.
Prescription - Other	chemotherapy (prescription)	1 Studies recorded. The consensus is Decreases📓, Click for details.
Prescription - Other	metformin (prescription)	1 Studies recorded. The consensus is Increases👶, Click for details.
Prescription - Other	Morphine	1 Studies recorded. The consensus is Increases👶, Click for details.
Prescription - Other	proton-pump inhibitors (prescription)	1 Studies recorded. The consensus is Increases📓, Click for details.
Prescription - Other	Streptococcus faecalis (Enterococcus faecalis)	1 Studies recorded. The consensus is Decreases👶, Click for details.
Probiotics	bacillus amyloliquefaciens (probiotic)	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	bacillus licheniformis,(probiotics)	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	bacillus subtilis (probiotics)	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	bifidobacterium animalis lactis (probiotics)	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	bifidobacterium longum (probiotics)	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	candida albicans (prescription)	1 Studies recorded. The consensus is Increases📓, Click for details.
Probiotics	clostridium butyricum (probiotics),Miya,Miyarisan	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	enterococcus faecium (probiotic)	2 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	lactobacillus acidophilus (probiotics)	2 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	lactobacillus kefiri (NOT KEFIR)	1 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	lactobacillus paracasei (probiotics)	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	lactobacillus reuteri (probiotics)	2 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	saccharomyces boulardii (probiotics)	1 Studies recorded. The consensus is Decreases👶, Click for details.
Sugar and similar	lactulose	1 Studies recorded. The consensus is Increases📓, Click for details.
Sugar and similar	saccharin	1 Studies recorded. The consensus is Decreases📓, Click for details.
Vitamins, Minerals and similar	iron	1 Studies recorded. The consensus is Decreases📓, Click for details.
Vitamins, Minerals and similar	vitamin a	2 Studies recorded. The consensus is Decreases📓, Click for details.
Vitamins, Minerals and similar	Vitamin B9,folic acid	1 Studies recorded. The consensus is Increases📓, Click for details.
Vitamins, Minerals and similar	vitamin d	2 Studies recorded. The consensus is Decreases📓, Click for details.
Vitamins, Minerals and similar	zinc	1 Studies recorded. The consensus is Increases📓, Click for details.

Foods Containing the Megasphaera bacteria

Data comes from FoodMicrobionet. For the meaning of weight, see that site. The bacteria does not need to be alive to have an effect.

Robiola di Roccaverano Cheese (Italy) Weight: 0.4187 Trentingrana Cheese (Italy) Weight: 0.2168 Nunu, Ghana Weight: 0.05382 Malaysian fermented fish sauce Weight: 0.02306 Butter cheese, cow milk Weight: 0.006204 Sausage, Cyprus: Limassol Weight: 0.003483

---