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Peptic Ulcers: Pirenzepine dihydrochloride is used to treat peptic ulcers, which are sores that develop on the lining of the stomach, small intestine, or esophagus. It works by blocking the action of acetylcholine at muscarinic receptors in the stomach, leading to a reduction in gastric acid secretion. By decreasing acid production, pirenzepine dihydrochloride helps to promote ulcer healing and alleviate symptoms such as abdominal pain, bloating, and heartburn.
Gastroesophageal Reflux Disease (GERD): Pirenzepine dihydrochloride may also be prescribed for the management of GERD, a condition characterized by the backward flow of stomach acid into the esophagus, causing symptoms such as heartburn, regurgitation, and chest pain. By reducing gastric acid secretion, pirenzepine dihydrochloride helps to alleviate symptoms and prevent esophageal irritation and damage.
Symptomatic Relief: Pirenzepine dihydrochloride therapy can lead to symptomatic improvement in patients with peptic ulcers and GERD, including reduced abdominal discomfort, heartburn, and regurgitation. It helps to enhance the quality of life by alleviating symptoms and promoting healing of the gastrointestinal mucosa.
Gastric Acid Secretion: Pirenzepine dihydrochloride selectively inhibits the secretion of gastric acid by blocking muscarinic receptors in the stomach. By reducing acid production, it helps to maintain the pH balance in the stomach and prevent excessive acidity, which can contribute to the development and exacerbation of peptic ulcers and GERD.
Mucosal Protection: Pirenzepine dihydrochloride may have additional benefits beyond its acid-suppressing effects. It may help to enhance the protective mechanisms of the gastric mucosa, including increasing mucus secretion and improving blood flow to the stomach lining, thereby promoting mucosal integrity and reducing the risk of ulcer formation.
Minimal Side Effects: Pirenzepine dihydrochloride is generally well-tolerated, with minimal systemic side effects compared to other medications used for the treatment of peptic ulcers and GERD. However, like any medication, it may cause adverse effects such as dry mouth, blurred vision, constipation, and urinary retention in some individuals.
Dosage Adjustment: The dosage of pirenzepine dihydrochloride may vary depending on the severity of the condition being treated and individual patient factors such as age, renal function, and concomitant medications. Healthcare providers should titrate the dosage carefully to achieve optimal therapeutic outcomes while minimizing the risk of side effects.
Rank | Probiotic | Impact |
---|---|---|
species | Akkermansia muciniphila | Reduces |
species | Bifidobacterium adolescentis | Reduces |
species | Escherichia coli | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
Acne | 0.1 | -0.1 | |
ADHD | 1.3 | 0.3 | 3.33 |
Age-Related Macular Degeneration and Glaucoma | 0.7 | 0.4 | 0.75 |
Allergic Rhinitis (Hay Fever) | 0.8 | 0.4 | 1 |
Allergies | 1.5 | 0.9 | 0.67 |
Allergy to milk products | 0.4 | 0.6 | -0.5 |
Alopecia (Hair Loss) | 1 | 1 | |
Alzheimer's disease | 1.3 | 2.1 | -0.62 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1.7 | 0.8 | 1.13 |
Ankylosing spondylitis | 2 | 0.3 | 5.67 |
Anorexia Nervosa | 0.4 | 0.5 | -0.25 |
Antiphospholipid syndrome (APS) | 1.7 | 1.7 | |
Asthma | 0.5 | 1.3 | -1.6 |
Atherosclerosis | 0.2 | 1.3 | -5.5 |
Atrial fibrillation | 1.6 | 0.8 | 1 |
Autism | 4.8 | 3.8 | 0.26 |
Barrett esophagus cancer | 0.1 | 0.3 | -2 |
benign prostatic hyperplasia | 0.1 | 0.1 | |
Bipolar Disorder | 0.6 | 0.7 | -0.17 |
Brain Trauma | 0.2 | 0.5 | -1.5 |
Carcinoma | 1.7 | 1 | 0.7 |
Celiac Disease | 1.2 | 1.4 | -0.17 |
Cerebral Palsy | 0.9 | 0.5 | 0.8 |
Chronic Fatigue Syndrome | 2.2 | 4 | -0.82 |
Chronic Kidney Disease | 1.2 | 0.5 | 1.4 |
Chronic Lyme | 0.5 | -0.5 | |
Chronic Obstructive Pulmonary Disease (COPD) | 1.2 | 0.5 | 1.4 |
Chronic Urticaria (Hives) | 0.8 | 0.7 | 0.14 |
Coagulation / Micro clot triggering bacteria | 1.1 | 0.7 | 0.57 |
Colorectal Cancer | 1.6 | 0.2 | 7 |
Constipation | 0.7 | 0.4 | 0.75 |
Coronary artery disease | 0.2 | 0.2 | 0 |
COVID-19 | 5.2 | 5.5 | -0.06 |
Crohn's Disease | 3 | 2 | 0.5 |
cystic fibrosis | 0.4 | 0.6 | -0.5 |
deep vein thrombosis | 0.4 | 0.7 | -0.75 |
Depression | 5.2 | 3.7 | 0.41 |
Dermatomyositis | 0.3 | 0.1 | 2 |
Eczema | 0.4 | 0.7 | -0.75 |
Endometriosis | 1.8 | 0.1 | 17 |
Eosinophilic Esophagitis | 0 | 0.1 | 0 |
Epilepsy | 1.2 | 2.3 | -0.92 |
Fibromyalgia | 2.1 | 0.7 | 2 |
Functional constipation / chronic idiopathic constipation | 2.2 | 1.4 | 0.57 |
gallstone disease (gsd) | 1 | 0.5 | 1 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.7 | 0.4 | 0.75 |
Generalized anxiety disorder | 0.6 | 0.4 | 0.5 |
giant cell arteritis | 0 | 0 | |
Glioblastoma | 0.3 | -0.3 | |
Gout | 0.1 | -0.1 | |
Graves' disease | 0.6 | 0.8 | -0.33 |
Halitosis | 0.2 | 0.3 | -0.5 |
Hashimoto's thyroiditis | 1.5 | 0.2 | 6.5 |
Hidradenitis Suppurativa | 0.4 | 0.1 | 3 |
Histamine Issues,Mast Cell Issue, DAO Insufficiency | 1.2 | 0.1 | 11 |
hypercholesterolemia (High Cholesterol) | 0 | 0.5 | 0 |
hyperglycemia | 0.1 | 1.4 | -13 |
Hyperlipidemia (High Blood Fats) | 0.4 | 0 | 0 |
hypersomnia | 0 | 0 | |
hypertension (High Blood Pressure | 1.4 | 2.5 | -0.79 |
Hypothyroidism | 0.4 | -0.4 | |
Hypoxia | 0.7 | 0.7 | |
IgA nephropathy (IgAN) | 1 | -1 | |
Inflammatory Bowel Disease | 1.5 | 3 | -1 |
Insomnia | 0.5 | 0.5 | 0 |
Intelligence | 0.3 | 0 | 0 |
Intracranial aneurysms | 0.5 | 0 | 0 |
Irritable Bowel Syndrome | 2.3 | 2.2 | 0.05 |
Liver Cirrhosis | 2.3 | 1.8 | 0.28 |
Long COVID | 3.8 | 2.4 | 0.58 |
Low bone mineral density | 0.5 | -0.5 | |
Lung Cancer | 0.4 | 0.9 | -1.25 |
ME/CFS with IBS | 0.9 | 1.2 | -0.33 |
ME/CFS without IBS | 1.1 | 1.9 | -0.73 |
Menopause | 0.3 | 0.3 | |
Metabolic Syndrome | 3.3 | 4.5 | -0.36 |
Mood Disorders | 6.1 | 3.9 | 0.56 |
multiple chemical sensitivity [MCS] | 0.7 | 0 | 0 |
Multiple Sclerosis | 3.2 | 2 | 0.6 |
Multiple system atrophy (MSA) | 2.3 | 0.2 | 10.5 |
Neuropathy (all types) | 0.6 | 0.1 | 5 |
neuropsychiatric disorders (PANDAS, PANS) | 0.3 | 0.3 | |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.9 | 1.3 | -0.44 |
NonCeliac Gluten Sensitivity | 0.1 | -0.1 | |
Obesity | 4.4 | 1.9 | 1.32 |
obsessive-compulsive disorder | 2.3 | 1.7 | 0.35 |
Osteoarthritis | 0.8 | 0.8 | |
Osteoporosis | 0.5 | 0.7 | -0.4 |
pancreatic cancer | 0.3 | 0.3 | |
Parkinson's Disease | 2.2 | 1.9 | 0.16 |
Polycystic ovary syndrome | 1.1 | 0.8 | 0.38 |
Postural orthostatic tachycardia syndrome | 0 | 0.3 | 0 |
Premenstrual dysphoric disorder | 0.2 | 0.4 | -1 |
primary biliary cholangitis | 0.3 | 0.2 | 0.5 |
Psoriasis | 2 | 2.1 | -0.05 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2.7 | 1.4 | 0.93 |
Rosacea | 0.4 | 0.4 | 0 |
Schizophrenia | 2.1 | 0.7 | 2 |
scoliosis | 0.1 | 0.1 | |
Sjögren syndrome | 1.2 | 1.4 | -0.17 |
Sleep Apnea | 0.3 | 0.8 | -1.67 |
Small Intestinal Bacterial Overgrowth (SIBO) | 0.6 | 0.6 | |
Stress / posttraumatic stress disorder | 1.9 | 1.6 | 0.19 |
Systemic Lupus Erythematosus | 1.7 | 0.5 | 2.4 |
Tic Disorder | 0.4 | 0.6 | -0.5 |
Tourette syndrome | 0.3 | 0.1 | 2 |
Type 1 Diabetes | 1.1 | 1.4 | -0.27 |
Type 2 Diabetes | 3.7 | 4.1 | -0.11 |
Ulcerative colitis | 1.4 | 2.5 | -0.79 |
Unhealthy Ageing | 2.6 | 0.9 | 1.89 |
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