We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 60-70 | Worsen | 1.88 |
| Autism: Official Diagnosis | Worsen | 3.21 |
| Autonomic Manifestations: light-headedness | Improves | -1.67 |
| Autonomic Manifestations: Orthostatic intolerance | Improves | -1.79 |
| Blood Type: O Positive | Worsen | 1.88 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Worsen | 1.88 |
| Comorbid-Mouth: Dry Mouth | Improves | -2.8 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 1.88 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 1.88 |
| Comorbid: High Anxiety | Worsen | 1.88 |
| Comorbid: Histamine or Mast Cell issues | Worsen | 1.88 |
| Comorbid: Hypothyroidism | Worsen | 1.88 |
| Comorbid: Multiple Chemical Sensitivity | Improves | -2.9 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 1.88 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 1.78 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 1.78 |
| General: Fatigue | Improves | -2.9 |
| General: Headaches | Worsen | 1.88 |
| General: Sinus issues with headaches | Worsen | 1.88 |
| Immune Manifestations: Abdominal Pain | Worsen | 1.88 |
| Immune Manifestations: Alcohol Intolerant | Worsen | 1.88 |
| Immune Manifestations: Constipation | Worsen | 1.88 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 1.88 |
| Joint: Stiffness and swelling | Worsen | 1.88 |
| Neurocognitive: Difficulty paying attention for a long period of time | Worsen | 1.88 |
| Neurocognitive: Unable to focus vision and/or attention | Worsen | 1.88 |
| Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Improves | -1.86 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Improves | -2.9 |
| Neuroendocrine Manifestations: Muscle weakness | Improves | -3.51 |
| Neuroendocrine Manifestations: subnormal body temperature | Worsen | 1.88 |
| Neuroendocrine Manifestations: sweating episodes | Worsen | 2.96 |
| Neuroendocrine: Alcohol intolerance | Worsen | 1.88 |
| Neuroendocrine: Feeling like you have a low temperature | Improves | -3.11 |
| Neuroendocrine: Lost or gained weight without trying | Improves | -3.65 |
| Neurological-Sleep: Sleep Apnea | Improves | -1.86 |
| Neurological-Vision: inability to focus eye/vision | Worsen | 1.88 |
| Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 1.88 |
| Neurological: Difficulty reading | Worsen | 1.88 |
| Neurological: Word-finding problems | Improves | -1.79 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 1.88 |
| Official Diagnosis: Mast Cell Dysfunction | Worsen | 1.88 |
| Onset: 2010-2020 | Worsen | 1.88 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -2.17 |
| ADHD | Improves | -3.18 |
| Allergic Rhinitis (Hay Fever) | Improves | -1.86 |
| Allergies | Worsen | 3.53 |
| Alzheimer's disease | Worsen | 4.43 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.55 |
| Ankylosing spondylitis | Improves | -4.29 |
| Asthma | Improves | -3.16 |
| Atherosclerosis | Improves | -3.59 |
| Autism | Improves | -3.45 |
| Barrett esophagus cancer | Improves | -3.07 |
| Brain Trauma | Improves | -2.86 |
| Carcinoma | Worsen | 1.58 |
| Celiac Disease | Improves | -4.29 |
| Cerebral Palsy | Worsen | 2.9 |
| Chronic Fatigue Syndrome | Worsen | 1.58 |
| Chronic Kidney Disease | Worsen | 2.63 |
| Chronic Urticaria (Hives) | Worsen | 2.92 |
| Colorectal Cancer | Worsen | 2.84 |
| Coronary artery disease | Worsen | 1.67 |
| Crohn's Disease | Improves | -3.53 |
| Depression | Improves | -3.43 |
| Epilepsy | Improves | -2.54 |
| Functional constipation / chronic idiopathic constipation | Worsen | 2.91 |
| Gout | Worsen | 3.18 |
| Graves' disease | Worsen | 2.86 |
| High Blood Pressure | Worsen | 3.29 |
| Hyperlipidemia (High Blood Fats) | Worsen | 2.73 |
| IgA nephropathy (IgAN) | Worsen | 2.71 |
| Inflammatory Bowel Disease | Worsen | 2.92 |
| Irritable Bowel Syndrome | Worsen | 3.69 |
| Liver Cirrhosis | Worsen | 4.28 |
| ME/CFS without IBS | Worsen | 1.58 |
| Metabolic Syndrome | Improves | -2.9 |
| Multiple Sclerosis | Worsen | 4.59 |
| Multiple system atrophy (MSA) | Worsen | 2.9 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -2.91 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Worsen | 2.42 |
| Obesity | Improves | -3.22 |
| Osteoporosis | Improves | -1.74 |
| Parkinson's Disease | Worsen | 5.22 |
| Psoriasis | Worsen | 4.06 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 1.85 |
| Schizophrenia | Worsen | 0.13 |
| Stress / posttraumatic stress disorder | Worsen | 4.05 |
| Systemic Lupus Erythematosus | Improves | -1.79 |
| Type 1 Diabetes | Worsen | 2.86 |
| Type 2 Diabetes | Improves | -3.68 |
| Ulcerative colitis | Improves | -3.9 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.