🍽️ propylthiouracil,(prescription)

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  1. Treatment of Hyperthyroidism: Propylthiouracil works by inhibiting the production of thyroid hormones thyroxine (T4) and triiodothyronine (T3) by the thyroid gland. It blocks the activity of an enzyme called thyroperoxidase, which is necessary for the synthesis of thyroid hormones. By reducing thyroid hormone levels, propylthiouracil helps to normalize thyroid function and alleviate symptoms of hyperthyroidism, such as rapid heart rate, tremors, weight loss, and heat intolerance.

  2. Management of Thyroid Storm: In severe cases of hyperthyroidism, such as thyroid storm, propylthiouracil may be used to rapidly lower thyroid hormone levels and mitigate life-threatening symptoms, including severe agitation, delirium, fever, and cardiovascular complications.

  3. Preparation for Thyroidectomy or Radioactive Iodine Therapy: Propylthiouracil may be prescribed as a preoperative treatment to prepare patients with hyperthyroidism for thyroidectomy (surgical removal of the thyroid gland) or radioactive iodine therapy. By reducing thyroid hormone levels, it can help to minimize the risk of complications during these procedures and improve surgical outcomes.

  4. Side Effects: Common side effects of propylthiouracil may include gastrointestinal disturbances (such as nausea, vomiting, and abdominal pain), rash, itching, and altered taste sensation. Rare but serious side effects may include liver toxicity, agranulocytosis (a severe decrease in white blood cell count), and vasculitis (inflammation of blood vessels).

  5. Hepatotoxicity: Propylthiouracil has been associated with an increased risk of liver toxicity, including hepatitis and fulminant hepatic failure. Patients taking propylthiouracil should be monitored closely for signs of liver dysfunction, such as jaundice, abdominal pain, and elevated liver enzymes.

  6. Agranulocytosis: Agranulocytosis is a rare but potentially life-threatening side effect of propylthiouracil characterized by a severe decrease in neutrophil count, which increases the risk of serious infections. Patients should be advised to seek immediate medical attention if they develop symptoms of infection, such as fever, sore throat, or mouth ulcers.

  7. Drug Interactions: Propylthiouracil may interact with other medications, including anticoagulants (such as warfarin), leading to alterations in their effects and potentially increasing the risk of bleeding. Concurrent use of propylthiouracil with certain drugs that affect liver function or bone marrow function may also increase the risk of adverse reactions.

  8. Pregnancy and Breastfeeding: Propylthiouracil is considered safe for use during pregnancy, particularly in the first trimester, when radioactive iodine therapy is contraindicated due to the risk of harming the developing fetus. However, it may be associated with an increased risk of congenital anomalies, and close monitoring of thyroid function is recommended during pregnancy. Propylthiouracil is also excreted in breast milk and should be used with caution in breastfeeding women.

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Impacted of propylthiouracil,(prescription) On Probiotics

Rank Probiotic Impact
species Bifidobacterium longum Reduces
species Lacticaseibacillus paracasei Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by propylthiouracil,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Ruminococcus genus Decreases 👪 Source Study
Lachnospira genus Decreases 👪 Source Study
Coprococcus genus Decreases 👪 Source Study
Enterocloster genus Decreases 👪 Source Study
Agathobacter genus Decreases 👪 Source Study
Lacticaseibacillus genus Decreases 👪 Source Study
Mediterraneibacter genus Decreases 👪 Source Study
Bifidobacterium genus Decreases 👪 Source Study
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
Eggerthellales order Decreases ⚗️ Source Study
Ruminococcus bromii species Decreases 📓 Source Study
Lachnospira eligens species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Coprococcus comes species Decreases 📓 Source Study
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Enterocloster bolteae species Decreases 📓 Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Agathobacter rectalis species Decreases 📓 Source Study
Lacticaseibacillus paracasei species Decreases 📓 Source Study
[Ruminococcus] gnavus species Decreases 📓 Source Study
Bifidobacterium longum species Decreases 📓 Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. infantis subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. longum subspecies Decreases 👶 Source Study
Bifidobacterium longum subsp. suillum subspecies Decreases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of propylthiouracil,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 0 0
ADHD 0.6 0.1 5
Allergic Rhinitis (Hay Fever) 0.1 0.1 0
Allergies 0 1 0
Allergy to milk products 0.5 0 0
Alzheimer's disease 0.5 1 -1
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.6 0.5 0.2
Ankylosing spondylitis 0 0.8 0
Anorexia Nervosa 0.8 -0.8
Asthma 0 0
Atherosclerosis 0.5 0.5
Atrial fibrillation 0.9 0 0
Autism 0.8 1.4 -0.75
Bipolar Disorder 0.5 0.6 -0.2
Brain Trauma 0 0
Carcinoma 0.5 0.5 0
Celiac Disease 0.8 -0.8
Cerebral Palsy 0 0.5 0
Chronic Fatigue Syndrome 0.9 0.3 2
Chronic Kidney Disease 0.1 0.4 -3
Chronic Obstructive Pulmonary Disease (COPD) 0.3 -0.3
Coagulation / Micro clot triggering bacteria 0.5 -0.5
Colorectal Cancer 0.5 0.1 4
Constipation 0.2 0.2
Coronary artery disease 0.6 0.1 5
COVID-19 0.6 2.2 -2.67
Crohn's Disease 0.7 1.4 -1
cystic fibrosis 0 0
deep vein thrombosis 0.5 -0.5
Depression 0.9 1 -0.11
Dermatomyositis 0 0
Eczema 0.1 0 0
Endometriosis 0.1 0.7 -6
Epilepsy 0 0 0
Fibromyalgia 0.2 -0.2
Functional constipation / chronic idiopathic constipation 0.8 0.1 7
gallstone disease (gsd) 0.5 0 0
Generalized anxiety disorder 0.1 0.2 -1
Gout 0.1 -0.1
Graves' disease 0 0
Hashimoto's thyroiditis 0 0 0
Histamine Issues,Mast Cell Issue, DAO Insufficiency 0.3 0.1 2
hyperglycemia 0 0
Hyperlipidemia (High Blood Fats) 0 0
hypertension (High Blood Pressure 0.5 0.1 4
Hypothyroidism 0.1 -0.1
IgA nephropathy (IgAN) 0.5 -0.5
Inflammatory Bowel Disease 0.1 2 -19
Insomnia 0.2 -0.2
Intelligence 0.1 0.1
Intracranial aneurysms 0.5 0.5
Irritable Bowel Syndrome 0.5 0.3 0.67
Liver Cirrhosis 0.6 0.6 0
Long COVID 0.7 2.3 -2.29
Low bone mineral density 0.3 -0.3
Lung Cancer 0.5 -0.5
ME/CFS with IBS 0.2 0.2 0
ME/CFS without IBS 0.2 0 0
Menopause 0 0
Metabolic Syndrome 0.7 0.7 0
Mood Disorders 1.4 1 0.4
Multiple Sclerosis 0.6 1 -0.67
Multiple system atrophy (MSA) 0.5 -0.5
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 1 -1
NonCeliac Gluten Sensitivity 0 0
Obesity 0.7 0.7 0
obsessive-compulsive disorder 1.2 0.2 5
Osteoarthritis 0.1 0.5 -4
Osteoporosis 0.5 0.5
Parkinson's Disease 0.1 0.8 -7
Polycystic ovary syndrome 0.5 1 -1
Postural orthostatic tachycardia syndrome 0.1 -0.1
Premenstrual dysphoric disorder 0 0
Psoriasis 0.5 0.1 4
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.9 0.1 8
Rosacea 0.5 0.5
Schizophrenia 0.9 0.6 0.5
scoliosis 0.1 0.9 -8
Sjögren syndrome 0.1 -0.1
Sleep Apnea 0.6 0.1 5
Small Intestinal Bacterial Overgrowth (SIBO) 0 0
Stress / posttraumatic stress disorder 0 0.1 0
Systemic Lupus Erythematosus 0.1 0.7 -6
Tic Disorder 0.5 0 0
Type 1 Diabetes 0.6 0.2 2
Type 2 Diabetes 0.7 0.6 0.17
Ulcerative colitis 0.1 0.1 0
Unhealthy Ageing 0.3 0.2 0.5

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