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We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Improves | -6.64 |
| Age: 30-40 | Improves | -4.29 |
| Age: 40-50 | Improves | -3.55 |
| Age: 50-60 | Improves | -5.37 |
| Age: 60-70 | Worsen | 6.72 |
| Asymptomatic: Live in house with person with probable microbiome dysfunction | Improves | -4.02 |
| Asymptomatic: Minor Health Issues (a few symptoms only) | Improves | -6.53 |
| Asymptomatic: No Health Issues | Worsen | 6.18 |
| Autism: Official Diagnosis | Improves | -8.79 |
| Autonomic Manifestations: cardiac arrhythmias | Worsen | 8.72 |
| Autonomic Manifestations: Cortisol disorders or irregularity | Worsen | 6.4 |
| Autonomic Manifestations: irritable bowel syndrome | Worsen | 5.51 |
| Autonomic Manifestations: light-headedness | Improves | -2.56 |
| Autonomic Manifestations: Orthostatic intolerance | Worsen | 7.66 |
| Autonomic Manifestations: palpitations | Worsen | 7.91 |
| Autonomic Manifestations: urinary frequency dysfunction | Worsen | 8.38 |
| Autonomic: Heart rate increase after standing | Worsen | 6.6 |
| Autonomic: Inability to tolerate an upright position | Improves | -8.41 |
| Autonomic: Irregular heartbeats | Improves | -6.77 |
| Autonomic: Ocassional Tachycardia (Rapid heart beat) | Worsen | 6.87 |
| Autonomic: Shortness of breath | Worsen | 5.79 |
| Blood Type: A Positive | Worsen | 6.5 |
| Blood Type: O Positive | Improves | -8.96 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Worsen | 5.67 |
| Comorbid-Mouth: Dry Mouth | Worsen | 7.68 |
| Comorbid-Mouth: Mouth Sores | Improves | -6.51 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -8.04 |
| Comorbid: Constipation and Explosions (not diarrohea) | Improves | -8.62 |
| Comorbid: Fibromyalgia | Worsen | 6.82 |
| Comorbid: High Anxiety | Improves | -9.07 |
| Comorbid: Histamine or Mast Cell issues | Improves | -8.2 |
| Comorbid: Hypothyroidism | Improves | -6.69 |
| Comorbid: Inflammatory bowel disease | Improves | -8.69 |
| Comorbid: Migraine | Improves | -8.37 |
| Comorbid: Mold Sensitivity / Exposure | Worsen | 6.87 |
| Comorbid: Multiple Chemical Sensitivity | Worsen | 6.25 |
| Comorbid: Restless Leg | Improves | -6.91 |
| Comorbid: Snoring (NOT Sleep Apnea | Improves | -8.63 |
| DePaul University Fatigue Questionnaire : Fatigue | Improves | -9.29 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -9.44 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Improves | -9.09 |
| Gender: Female | Improves | -6.61 |
| Gender: Male | Improves | -4.41 |
| General: Depression | Improves | -7.16 |
| General: Fatigue | Worsen | 7.66 |
| General: Headaches | Worsen | 6.06 |
| General: Myalgia (pain) | Worsen | 6.43 |
| General: Sinus issues with headaches | Improves | -7.64 |
| Immune Manifestations: Abdominal Pain | Improves | -7.4 |
| Immune Manifestations: Alcohol Intolerant | Improves | -7.08 |
| Immune Manifestations: Bloating | Worsen | 5.61 |
| Immune Manifestations: Constipation | Worsen | 7.11 |
| Immune Manifestations: Diarrhea | Worsen | 7.01 |
| Immune Manifestations: general malaise | Worsen | 6.05 |
| Immune Manifestations: Hair loss | Improves | -3.47 |
| Immune Manifestations: Inflammation (General) | Improves | -9.01 |
| Immune Manifestations: Inflammation of skin, eyes or joints | Worsen | 4.01 |
| Immune Manifestations: medication sensitivities. | Worsen | 3.79 |
| Immune Manifestations: Mucus in the stool | Improves | -8.81 |
| Immune Manifestations: new food sensitivities | Worsen | 7.58 |
| Immune Manifestations: tender lymph nodes | Worsen | 7.8 |
| Immune: Chronic Sinusitis | Worsen | 5.21 |
| Immune: Recurrent Sore throat | Worsen | 5.22 |
| Immune: Sensitivity to smell/food/medication/chemicals | Worsen | 5.32 |
| Immune: Tender / sore lymph nodes | Improves | -3.83 |
| Infection: Epstein-Barr virus | Improves | -7.57 |
| Infection: Human Herpesvirus 6 (HHV6) | Improves | -5.4 |
| Infection: Mycoplasma | Improves | -8.12 |
| Infection: Parasite - Other | Improves | -4.17 |
| Joint: Redness | Improves | -4.4 |
| Joint: Stiffness and swelling | Improves | -6.61 |
| Joint: Sudden and severe episodes of pain | Worsen | 6.28 |
| Joint: Tenderness | Improves | -8.03 |
| Neurocognitive: Absent-mindedness or forgetfulness | Improves | -3.7 |
| Neurocognitive: Brain Fog | Worsen | 5.29 |
| Neurocognitive: Can only focus on one thing at a time | Improves | -6.71 |
| Neurocognitive: Difficulty expressing thoughts | Worsen | 5.26 |
| Neurocognitive: Difficulty paying attention for a long period of time | Improves | -6.55 |
| Neurocognitive: Difficulty understanding things | Worsen | 3.79 |
| Neurocognitive: Problems remembering things | Improves | -7.72 |
| Neurocognitive: Slowness of thought | Improves | -6.5 |
| Neurocognitive: Unable to focus vision and/or attention | Improves | -6.95 |
| Neuroendocrine Manifestations: abnormal appetite | Improves | -2.87 |
| Neuroendocrine Manifestations: Air Hunger | Worsen | 6.87 |
| Neuroendocrine Manifestations: cold extremities | Worsen | 7.59 |
| Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Improves | -2.86 |
| Neuroendocrine Manifestations: Excessive adrenaline | Improves | -7.52 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 6.41 |
| Neuroendocrine Manifestations: marked weight change | Improves | -3.48 |
| Neuroendocrine Manifestations: Muscle weakness | Worsen | 7.9 |
| Neuroendocrine Manifestations: Neuralgia | Improves | -3.52 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Improves | -8.31 |
| Neuroendocrine Manifestations: Rapid muscular fatiguability | Worsen | 6.73 |
| Neuroendocrine Manifestations: recurrent feelings of feverishness | Improves | -3.88 |
| Neuroendocrine Manifestations: subnormal body temperature | Worsen | 6.29 |
| Neuroendocrine Manifestations: sweating episodes | Worsen | 6.27 |
| Neuroendocrine Manifestations: worsening of symptoms with stress. | Worsen | 7.65 |
| Neuroendocrine: Alcohol intolerance | Worsen | 6.06 |
| Neuroendocrine: Chills or shivers | Worsen | 6.76 |
| Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Improves | -3.97 |
| Neuroendocrine: Feeling hot or cold for no reason | Worsen | 7.95 |
| Neuroendocrine: Feeling like you have a high temperature | Worsen | 6.94 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 7.5 |
| Neuroendocrine: Lack of appetite | Worsen | 6.84 |
| Neuroendocrine: Lost or gained weight without trying | Worsen | 8.08 |
| Neuroendocrine: Sweating hands | Worsen | 2.75 |
| Neurological-Audio: hypersensitivity to noise | Worsen | 7.29 |
| Neurological-Audio: Tinnitus (ringing in ear) | Improves | -6.27 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Irratic Sleep) | Worsen | 6.79 |
| Neurological-Sleep: Insomnia | Improves | -7.21 |
| Neurological-Sleep: Night Sweats | Worsen | 3.25 |
| Neurological-Sleep: Sleep Apnea | Worsen | 5.54 |
| Neurological-Sleep: Vivid Dreams/Nightmares | Worsen | 7.55 |
| Neurological-Vision: Blurred Vision | Worsen | 7.56 |
| Neurological-Vision: inability to focus eye/vision | Improves | -7.73 |
| Neurological-Vision: photophobia (Light Sensitibity) | Improves | -7 |
| Neurological: Cognitive Overload | Worsen | 6.85 |
| Neurological: Difficulty processing information (Understanding) | Worsen | 7.77 |
| Neurological: Difficulty reading | Improves | -5.65 |
| Neurological: Dysautonomia | Improves | -3.83 |
| Neurological: emotional overload | Worsen | 7.77 |
| Neurological: Executive Decision Making (Difficulty making) | Improves | -7.37 |
| Neurological: fasciculations | Worsen | 7.89 |
| Neurological: High degree of Empathy before onset | Worsen | 7.49 |
| Neurological: Impairment of concentration | Worsen | 7.73 |
| Neurological: Joint hypermobility | Improves | -7.5 |
| Neurological: Seasonal Affective Disorder (SAD) | Improves | -6.92 |
| Neurological: Short-term memory issues | Worsen | 7.76 |
| Neurological: Spatial instability and disorientation | Worsen | 7.5 |
| Neurological: Word-finding problems | Worsen | 5.16 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Improves | -8.64 |
| Official Diagnosis: Autoimmune Disease | Improves | -4.58 |
| Official Diagnosis: Chronic Fatigue Syndrome | Worsen | 6.74 |
| Official Diagnosis: Irritable Bowel Syndrome | Improves | -8.1 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -8.08 |
| Onset: 2000-2010 | Worsen | 5.03 |
| Onset: 2010-2020 | Worsen | 7.18 |
| Onset: Gradual | Worsen | 6.8 |
| Onset: less than 16 years since onset | Worsen | 3.47 |
| Other: Sensitivity to mold | Worsen | 6.85 |
| Pain: Chest pain | Improves | -7.16 |
| Pain: Eye pain | Improves | -6.54 |
| Pain: Joint pain | Worsen | 7.06 |
| Pain: Myofascial pain | Improves | -4.87 |
| Pain: Pain or aching in muscles | Worsen | 8.16 |
| Pain: Sensitivity to pain | Improves | -8.18 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 5.39 |
| Post-exertional malaise: General | Worsen | 7.5 |
| Post-exertional malaise: Inappropriate loss of physical and mental stamina, | Worsen | 6.53 |
| Post-exertional malaise: Mentally tired after the slightest effort | Improves | -5.22 |
| Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 7.28 |
| Post-exertional malaise: Post-exertional malaise | Worsen | 6.43 |
| Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 8.16 |
| Post-exertional malaise: Rapid muscular fatigability, | Worsen | 6.43 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 7.47 |
| Post-exertional malaise: Worsening of symptoms after mild physical activity | Worsen | 6.62 |
| Sleep: Daytime drowsiness | Worsen | 6.62 |
| Sleep: Need to nap daily | Improves | -6.36 |
| Sleep: Problems falling asleep | Worsen | 8.38 |
| Sleep: Problems staying asleep | Worsen | 5.96 |
| Sleep: Unrefreshed sleep | Worsen | 7.52 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 5.12 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Worsen | 5.97 |
| ADHD | Improves | -8.22 |
| Allergic Rhinitis (Hay Fever) | Improves | -3.24 |
| Allergies | Worsen | 7.73 |
| Alzheimer's disease | Worsen | 8.83 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 7.76 |
| Ankylosing spondylitis | Worsen | 9.22 |
| Asthma | Worsen | 5.67 |
| Atherosclerosis | Improves | -9.6 |
| Autism | Worsen | 9.73 |
| Autoimmune Disease | Improves | -3.29 |
| Barrett esophagus cancer | Improves | -6.03 |
| Brain Trauma | Improves | -6.89 |
| Carcinoma | Improves | -9.03 |
| Celiac Disease | Improves | -5.4 |
| Chronic Fatigue Syndrome | Improves | -7.4 |
| Chronic Kidney Disease | Improves | -7.56 |
| Chronic urticaria (Hives) | Improves | -8.55 |
| Colorectal Cancer | Improves | -10.61 |
| Crohn's Disease | Improves | -9.75 |
| cystic fibrosis | Improves | -7.49 |
| Depression | Improves | -9.13 |
| Epilepsy | Worsen | 8.25 |
| Fibromyalgia | Worsen | 7.49 |
| Functional constipation / chronic idiopathic constipation | Improves | -8.21 |
| Gastro-esophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 7.3 |
| Generalized anxiety disorder | Improves | -8.69 |
| Gout | Improves | -6.12 |
| Graves' disease | Worsen | 6.97 |
| Hashimoto's thyroiditis | Improves | -7.8 |
| High Blood Pressure | Worsen | 8.63 |
| Histamine Issues | Improves | -8.9 |
| Histamine Issues From Ubiome | Worsen | 6.01 |
| hypercholesterolemia (High Cholesterol) | Improves | -7.01 |
| IgA nephropathy (IgAN) | Worsen | 8.52 |
| Inflammatory Bowel Disease | Improves | -9.07 |
| Irritable Bowel Syndrome | Improves | -9.4 |
| Juvenile idiopathic arthritis | Worsen | 5.45 |
| Liver Cirrhosis | Improves | -9.14 |
| ME/CFS with IBS | Improves | -8.5 |
| ME/CFS without IBS | Improves | -9.27 |
| Metabolic Syndrome | Worsen | 7.16 |
| Mood Disorders | Improves | -7.57 |
| Multiple Sclerosis | Improves | -8.86 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -8.02 |
| Non-alcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -6.8 |
| Non-Celiac Gluten Sensitivity | Worsen | 1.35 |
| Obesity | Improves | -9.07 |
| Parkinson's Disease | Improves | -8.14 |
| Psoriasis | Improves | -9.34 |
| Rheumatoid arthritis | Worsen | 8.15 |
| rheumatoid arthritis (RA) and Spondyloarthritis (SpA) | Improves | -8.43 |
| Schizophrenia | Worsen | 7.86 |
| Sclerosis | Worsen | 6.54 |
| Sjögren syndrome | Improves | -8.4 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -9.08 |
| Stress / post-traumatic stress disorder | Improves | -9.85 |
| Systemic Lupus Erythematosus | Improves | -8.95 |
| Type 1 Diabetes | Improves | -7.25 |
| Type 2 Diabetes | Improves | -8.21 |
| Ulcerative colitis | Worsen | 8.38 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.