We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 0-10 | Improves | -1.81 |
| Age: 50-60 | Worsen | 1.6 |
| Autism: Official Diagnosis | Worsen | 3.63 |
| Autonomic Manifestations: Orthostatic intolerance | Worsen | 1.79 |
| Autonomic Manifestations: palpitations | Improves | -2.93 |
| Blood Type: A Positive | Improves | -2.85 |
| Blood Type: O Positive | Improves | -2.85 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 2.96 |
| Comorbid: Hypothyroidism | Worsen | 2.96 |
| Comorbid: Migraine | Improves | -2.85 |
| Comorbid: Mold Sensitivity / Exposure | Improves | -1.82 |
| Comorbid: Restless Leg | Worsen | 2.89 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 2.96 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 2.56 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 2.93 |
| DePaul University Fatigue Questionnaire : Depression | Worsen | 2.93 |
| DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 2.93 |
| DePaul University Fatigue Questionnaire : Fatigue | Improves | -1.66 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 2.93 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 2.93 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 0.96 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 2.56 |
| Immune Manifestations: Inflammation (General) | Improves | -3.24 |
| Infection: Human Herpesvirus 6 (HHV6) | Improves | -1.75 |
| Joint: Stiffness and swelling | Worsen | 2.96 |
| Joint: Tenderness | Improves | -2.97 |
| Neuroendocrine Manifestations: subnormal body temperature | Worsen | 2.96 |
| Neuroendocrine Manifestations: sweating episodes | Worsen | 3.63 |
| Neuroendocrine: Feeling hot or cold for no reason | Worsen | 1.81 |
| Neuroendocrine: Feeling like you have a high temperature | Worsen | 3.14 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 3.11 |
| Neuroendocrine: Lack of appetite | Worsen | 1.81 |
| Neuroendocrine: Lost or gained weight without trying | Worsen | 1.79 |
| Neurological-Vision: Blurred Vision | Improves | -2.93 |
| Neurological: Confusion | Worsen | 2.97 |
| Neurological: Difficulty reading | Worsen | 2.96 |
| Neurological: fasciculations | Improves | -3.16 |
| Neurological: Joint hypermobility | Worsen | 2.96 |
| Neurological: Word-finding problems | Worsen | 1.79 |
| Official Diagnosis: Autoimmune Disease | Improves | -2.97 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Worsen | 3.22 |
| ADHD | Worsen | 3.53 |
| Allergies | Improves | -2.97 |
| Alzheimer's disease | Worsen | 4.75 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -3.65 |
| Ankylosing spondylitis | Worsen | 2.93 |
| Asthma | Improves | -2.97 |
| Atherosclerosis | Worsen | 2.55 |
| Autism | Worsen | 4.49 |
| Barrett esophagus cancer | Worsen | 2.93 |
| Bipolar Disorder | Improves | -3.9 |
| Brain Trauma | Worsen | 2.86 |
| Carcinoma | Worsen | 0 |
| Celiac Disease | Improves | -2.87 |
| Cerebral Palsy | Improves | -2.82 |
| Chronic Fatigue Syndrome | Improves | -2.97 |
| Chronic Kidney Disease | Improves | -1.66 |
| Colorectal Cancer | Improves | -3.18 |
| COVID-19 | Improves | -2.93 |
| Crohn's Disease | Worsen | 2.56 |
| Depression | Improves | -3.02 |
| Fibromyalgia | Improves | -3.13 |
| Functional constipation / chronic idiopathic constipation | Improves | -1.46 |
| Graves' disease | Improves | -2.86 |
| High Blood Pressure | Improves | -3.46 |
| Hyperlipidemia (High Blood Fats) | Improves | -3.98 |
| IgA nephropathy (IgAN) | Worsen | 2.96 |
| Inflammatory Bowel Disease | Worsen | 3.14 |
| Irritable Bowel Syndrome | Worsen | 1.25 |
| Liver Cirrhosis | Worsen | 1.16 |
| ME/CFS without IBS | Improves | -2.97 |
| Multiple Sclerosis | Worsen | 2.56 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Worsen | 3.06 |
| Obesity | Worsen | 2.81 |
| Osteoporosis | Improves | -2.62 |
| Parkinson's Disease | Worsen | 4.49 |
| Psoriasis | Worsen | 1.79 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 2.72 |
| Rosacea | Improves | -1.93 |
| Schizophrenia | Improves | -3.72 |
| Stress / posttraumatic stress disorder | Worsen | 2.82 |
| Systemic Lupus Erythematosus | Improves | -3.43 |
| Type 1 Diabetes | Improves | -3.34 |
| Type 2 Diabetes | Improves | -2.94 |
| Ulcerative colitis | Worsen | 3.38 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.