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Hormone Replacement Therapy (HRT): Estrone is often included in hormone replacement therapy formulations along with other estrogens such as estradiol. HRT is commonly prescribed to alleviate symptoms associated with menopause, such as hot flashes, vaginal dryness, and mood swings. By replenishing estrogen levels in the body, HRT can improve quality of life for menopausal individuals.
Osteoporosis Prevention and Treatment: Estrogen, including estrone, plays a crucial role in maintaining bone density and strength. Hormone replacement therapy with estrone and other estrogens may help prevent or slow down the progression of osteoporosis, a condition characterized by weak and brittle bones that are more prone to fractures. It is especially beneficial for postmenopausal women who are at an increased risk of developing osteoporosis due to estrogen deficiency.
Urogenital Health: Estrogen is essential for maintaining the health of the urogenital tract, including the vagina, urethra, and surrounding tissues. Estrone-containing hormone replacement therapy can alleviate symptoms of vaginal atrophy, such as vaginal dryness, itching, burning, and painful intercourse, by restoring moisture and elasticity to the vaginal tissues.
Cardiovascular Health: There is evidence to suggest that estrogen therapy, including estrone-containing HRT, may have a protective effect on cardiovascular health, particularly in younger menopausal women. Estrogen may help improve lipid profiles, decrease the risk of atherosclerosis, and reduce the incidence of cardiovascular events. However, the use of estrogen therapy for cardiovascular protection is still a topic of debate and requires careful consideration of individual risk factors.
Breast Cancer Risk: Estrogen replacement therapy, including estrone-containing formulations, has been associated with an increased risk of breast cancer, particularly when used for prolonged periods or in combination with certain progestins. Therefore, healthcare providers carefully weigh the potential benefits of estrogen therapy against the risks, especially in women with a personal or family history of breast cancer.
Endometrial Hyperplasia and Cancer: Unopposed estrogen therapy, meaning estrogen without a progestin component, can increase the risk of endometrial hyperplasia (overgrowth of the uterine lining) and endometrial cancer in women who have not undergone a hysterectomy. To mitigate this risk, estrogen therapy is often combined with a progestin in women with an intact uterus to prevent endometrial hyperplasia.
Other Considerations: Estrogen therapy, including estrone-containing formulations, may also have other effects on the body, including changes in mood, libido, and menstrual bleeding patterns. It is important for individuals considering estrogen therapy to discuss the potential risks and benefits with their healthcare provider, as well as any personal or family medical history that may influence treatment decisions.
Rank | Probiotic | Impact |
---|---|---|
species | Akkermansia muciniphila | Reduces |
species | Bifidobacterium adolescentis | Reduces |
species | Bifidobacterium longum | Reduces |
species | Escherichia coli | Reduces |
subspecies | Bifidobacterium longum subsp. infantis | Reduces |
subspecies | Bifidobacterium longum subsp. longum | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
Acne | 0.4 | -0.4 | |
ADHD | 4.1 | 0.5 | 7.2 |
Age-Related Macular Degeneration and Glaucoma | 0.6 | 0.1 | 5 |
Allergic Rhinitis (Hay Fever) | 0.6 | 2 | -2.33 |
Allergies | 3.9 | 1.7 | 1.29 |
Allergy to milk products | 0.5 | 0.6 | -0.2 |
Alopecia (Hair Loss) | 1.2 | 1.2 | |
Alzheimer's disease | 2 | 2.9 | -0.45 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | 2.7 | 1 | 1.7 |
Ankylosing spondylitis | 2.4 | 0.6 | 3 |
Anorexia Nervosa | 0.1 | 1 | -9 |
Antiphospholipid syndrome (APS) | 0.9 | 0.9 | |
Asthma | 1.2 | 1.6 | -0.33 |
Atherosclerosis | 1 | 1.6 | -0.6 |
Atrial fibrillation | 2.3 | 0.8 | 1.87 |
Autism | 6.1 | 5.5 | 0.11 |
Barrett esophagus cancer | 0.6 | 0.1 | 5 |
benign prostatic hyperplasia | 0.1 | 0.1 | |
Bipolar Disorder | 0.5 | 1.3 | -1.6 |
Brain Trauma | 0.8 | 0.4 | 1 |
Carcinoma | 2.8 | 2.3 | 0.22 |
Celiac Disease | 1.4 | 3.7 | -1.64 |
Cerebral Palsy | 1.4 | 0.8 | 0.75 |
Chronic Fatigue Syndrome | 4 | 4.7 | -0.18 |
Chronic Kidney Disease | 0.9 | 0.9 | 0 |
Chronic Lyme | 0.4 | -0.4 | |
Chronic Obstructive Pulmonary Disease (COPD) | 1 | 0.5 | 1 |
Chronic Urticaria (Hives) | 0.8 | 0.7 | 0.14 |
Coagulation / Micro clot triggering bacteria | 0.5 | 0.7 | -0.4 |
Colorectal Cancer | 2.2 | 0.8 | 1.75 |
Constipation | 0.4 | 0.5 | -0.25 |
Coronary artery disease | 0.6 | 0.9 | -0.5 |
COVID-19 | 10.3 | 9.7 | 0.06 |
Crohn's Disease | 4.8 | 3.4 | 0.41 |
cystic fibrosis | 0.2 | 0.8 | -3 |
deep vein thrombosis | 0.2 | 0.4 | -1 |
Depression | 6.7 | 6 | 0.12 |
Dermatomyositis | 0.1 | 0.4 | -3 |
Eczema | 0.7 | 0.8 | -0.14 |
Endometriosis | 1.8 | 1.1 | 0.64 |
Eosinophilic Esophagitis | 0.1 | 0.5 | -4 |
Epilepsy | 1.9 | 2.4 | -0.26 |
Fibromyalgia | 1.8 | 1.2 | 0.5 |
Functional constipation / chronic idiopathic constipation | 3 | 1.4 | 1.14 |
gallstone disease (gsd) | 1.4 | 0.7 | 1 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.6 | 0.7 | -0.17 |
Generalized anxiety disorder | 0.7 | 1.7 | -1.43 |
giant cell arteritis | 0 | 0 | |
Glioblastoma | 0.1 | -0.1 | |
Gout | 0.2 | -0.2 | |
Graves' disease | 1.1 | 1.2 | -0.09 |
Halitosis | 0.8 | 0.1 | 7 |
Hashimoto's thyroiditis | 1.8 | 0.6 | 2 |
Hidradenitis Suppurativa | 0.2 | 0.5 | -1.5 |
Histamine Issues,Mast Cell Issue, DAO Insufficiency | 2.3 | 0.4 | 4.75 |
hypercholesterolemia (High Cholesterol) | 0.5 | 0.7 | -0.4 |
hyperglycemia | 0.1 | 2.1 | -20 |
Hyperlipidemia (High Blood Fats) | 1.1 | 0.4 | 1.75 |
hypersomnia | 0.3 | -0.3 | |
hypertension (High Blood Pressure | 1.7 | 4.3 | -1.53 |
Hypothyroidism | 1.2 | -1.2 | |
Hypoxia | 0.7 | 0.7 | |
IgA nephropathy (IgAN) | 2.4 | -2.4 | |
Inflammatory Bowel Disease | 2.5 | 4.8 | -0.92 |
Insomnia | 0.6 | 0.5 | 0.2 |
Intelligence | 0.4 | 0.4 | |
Intracranial aneurysms | 0.7 | 0.4 | 0.75 |
Irritable Bowel Syndrome | 3.3 | 3.3 | 0 |
Liver Cirrhosis | 3.4 | 2.4 | 0.42 |
Long COVID | 5.6 | 6.8 | -0.21 |
Low bone mineral density | 0.5 | -0.5 | |
Lung Cancer | 0.4 | 1.4 | -2.5 |
ME/CFS with IBS | 0.5 | 2.2 | -3.4 |
ME/CFS without IBS | 1.5 | 1.8 | -0.2 |
Menopause | 2.4 | 2.4 | |
Metabolic Syndrome | 5.1 | 6.6 | -0.29 |
Mood Disorders | 9.1 | 6.4 | 0.42 |
multiple chemical sensitivity [MCS] | 1.2 | 0.3 | 3 |
Multiple Sclerosis | 4.8 | 1.3 | 2.69 |
Multiple system atrophy (MSA) | 2.1 | 0.8 | 1.63 |
Neuropathy (all types) | 0.7 | 0.1 | 6 |
neuropsychiatric disorders (PANDAS, PANS) | 0.6 | 0.6 | |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 1.2 | 4.6 | -2.83 |
NonCeliac Gluten Sensitivity | 0.4 | -0.4 | |
Obesity | 6.5 | 3.9 | 0.67 |
obsessive-compulsive disorder | 3.6 | 2.7 | 0.33 |
Osteoarthritis | 1 | 0.1 | 9 |
Osteoporosis | 1.2 | 1.2 | 0 |
pancreatic cancer | 0.5 | 0.5 | |
Parkinson's Disease | 2.8 | 1.7 | 0.65 |
Polycystic ovary syndrome | 0.8 | 1.7 | -1.13 |
Postural orthostatic tachycardia syndrome | 0 | 0.6 | 0 |
Premenstrual dysphoric disorder | 1.1 | 0.1 | 10 |
primary biliary cholangitis | 0.3 | 0.6 | -1 |
Psoriasis | 3.3 | 1.7 | 0.94 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 4.3 | 2.8 | 0.54 |
Rosacea | 0.5 | 0.3 | 0.67 |
Schizophrenia | 5.9 | 1.2 | 3.92 |
scoliosis | 0.2 | 0.3 | -0.5 |
Sjögren syndrome | 2.4 | 2.3 | 0.04 |
Sleep Apnea | 1 | 1.3 | -0.3 |
Small Intestinal Bacterial Overgrowth (SIBO) | 0.3 | 0.9 | -2 |
Stress / posttraumatic stress disorder | 2 | 2.9 | -0.45 |
Systemic Lupus Erythematosus | 2.5 | 1.6 | 0.56 |
Tic Disorder | 0.5 | 1.1 | -1.2 |
Tourette syndrome | 0.4 | 0.2 | 1 |
Type 1 Diabetes | 2.1 | 1.2 | 0.75 |
Type 2 Diabetes | 5 | 4.4 | 0.14 |
Ulcerative colitis | 1.6 | 3.8 | -1.37 |
Unhealthy Ageing | 2.6 | 1.7 | 0.53 |
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