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Neurotransmitter Function: Acetylcholine is a neurotransmitter involved in various physiological processes, including muscle contraction, cognition, memory, and autonomic nervous system function. Inhibition of choline uptake by HC-3 reduces the synthesis and release of acetylcholine, leading to disruptions in cholinergic neurotransmission.
Effects on Muscles: Acetylcholine is essential for neuromuscular transmission, the process by which nerve impulses are transmitted to muscles, leading to muscle contraction. Inhibition of acetylcholine synthesis by HC-3 may result in muscle weakness, paralysis, or other neuromuscular impairments.
Cognitive Function: Acetylcholine plays a crucial role in cognitive processes such as learning, memory, and attention. Disruption of cholinergic neurotransmission by HC-3 may impair cognitive function and lead to deficits in memory formation and retention.
Autonomic Nervous System: Acetylcholine is involved in the regulation of the autonomic nervous system, which controls involuntary bodily functions such as heart rate, digestion, and respiratory rate. Alterations in cholinergic neurotransmission by HC-3 may affect autonomic functions, leading to changes in heart rate, blood pressure, and gastrointestinal motility.
Research and Therapeutic Applications: While hemicholinium bromide is primarily used as a research tool to investigate the role of cholinergic neurotransmission in various physiological and pathological conditions, its potential therapeutic applications are limited due to its non-selective inhibition of choline uptake and the widespread effects on cholinergic signaling throughout the body.
Rank | Probiotic | Impact |
---|---|---|
species | Lacticaseibacillus paracasei | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
Abdominal Aortic Aneurysm | 0.1 | 0.1 | |
ADHD | 0.7 | 0.7 | |
Age-Related Macular Degeneration and Glaucoma | 0 | 0.2 | 0 |
Allergic Rhinitis (Hay Fever) | 0.5 | 0.5 | |
Allergies | 0.1 | 0 | 0 |
Allergy to milk products | 0.1 | 0.2 | -1 |
Alopecia (Hair Loss) | 0.5 | 0.5 | |
Alzheimer's disease | 0.2 | 1.2 | -5 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.7 | 0.7 | |
Ankylosing spondylitis | 0.5 | 0.6 | -0.2 |
Anorexia Nervosa | 0.2 | 0.6 | -2 |
Antiphospholipid syndrome (APS) | 0 | 0.1 | 0 |
Asthma | 0.1 | -0.1 | |
Atherosclerosis | 0 | 0 | |
Atrial fibrillation | 0.9 | 0.3 | 2 |
Autism | 0.6 | 1.8 | -2 |
Barrett esophagus cancer | 0 | 0 | 0 |
Bipolar Disorder | 0.3 | 0.3 | |
Brain Trauma | 0.1 | -0.1 | |
Carcinoma | 0.4 | 0.3 | 0.33 |
Celiac Disease | 0.1 | 0.7 | -6 |
Cerebral Palsy | 0 | 0.1 | 0 |
Chronic Fatigue Syndrome | 0.8 | 0.7 | 0.14 |
Chronic Kidney Disease | 0.5 | 0.8 | -0.6 |
Chronic Lyme | 0.1 | -0.1 | |
Chronic Obstructive Pulmonary Disease (COPD) | 0.1 | 0.3 | -2 |
Chronic Urticaria (Hives) | 0 | 0 | 0 |
Coagulation / Micro clot triggering bacteria | 0.2 | 0 | 0 |
Colorectal Cancer | 0.4 | 0.2 | 1 |
Constipation | 0.4 | 0.4 | |
Coronary artery disease | 0.4 | 0.4 | |
COVID-19 | 0.7 | 1.9 | -1.71 |
Crohn's Disease | 0.9 | 1.7 | -0.89 |
cystic fibrosis | 0.1 | -0.1 | |
deep vein thrombosis | 0 | 0 | |
Depression | 1.9 | 1.2 | 0.58 |
Dermatomyositis | 0 | 0 | |
Eczema | 0.2 | 0.1 | 1 |
Endometriosis | 0.3 | 0.3 | 0 |
Eosinophilic Esophagitis | 0 | 0 | |
Epilepsy | 0.1 | 0.3 | -2 |
Fibromyalgia | 0.3 | 0.3 | 0 |
Functional constipation / chronic idiopathic constipation | 0.6 | 0.1 | 5 |
gallstone disease (gsd) | 0.3 | 0 | 0 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.1 | 0 | 0 |
Generalized anxiety disorder | 0.2 | 0.1 | 1 |
Glioblastoma | 0 | 0 | |
Graves' disease | 0.3 | 0 | 0 |
Halitosis | 0.1 | 0 | 0 |
Hashimoto's thyroiditis | 0.1 | 0.1 | 0 |
Hidradenitis Suppurativa | 0.1 | 0.1 | |
Histamine Issues,Mast Cell Issue, DAO Insufficiency | 0.6 | 0.3 | 1 |
hyperglycemia | 0.3 | -0.3 | |
hypersomnia | 0.1 | -0.1 | |
hypertension (High Blood Pressure | 0.3 | 0.2 | 0.5 |
Hypoxia | 0.3 | 0.3 | |
IgA nephropathy (IgAN) | 1.1 | -1.1 | |
Inflammatory Bowel Disease | 0.4 | 1.5 | -2.75 |
Insomnia | 0.1 | 0.4 | -3 |
Intelligence | 0.2 | 0 | 0 |
Intracranial aneurysms | 0.3 | 0.3 | |
Irritable Bowel Syndrome | 0.1 | 0.8 | -7 |
Liver Cirrhosis | 0.4 | 0.2 | 1 |
Long COVID | 1.2 | 1.5 | -0.25 |
Low bone mineral density | 0.3 | -0.3 | |
Lung Cancer | 0 | 0 | |
ME/CFS with IBS | 0 | 0.2 | 0 |
ME/CFS without IBS | 0.3 | 0.6 | -1 |
Metabolic Syndrome | 0.6 | 0.7 | -0.17 |
Mood Disorders | 1.9 | 1.2 | 0.58 |
multiple chemical sensitivity [MCS] | 0.1 | 0.1 | |
Multiple Sclerosis | 0.4 | 1.8 | -3.5 |
Neuropathy (all types) | 0 | 0 | |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.1 | 0.8 | -7 |
Obesity | 0.7 | 0.6 | 0.17 |
obsessive-compulsive disorder | 0.9 | 0.5 | 0.8 |
Osteoarthritis | 0.4 | 0.4 | |
Osteoporosis | 0.1 | 0.1 | 0 |
pancreatic cancer | 0 | 0 | |
Parkinson's Disease | 0.3 | 0.6 | -1 |
Polycystic ovary syndrome | 0.3 | 0.3 | |
Premenstrual dysphoric disorder | 0.2 | -0.2 | |
primary biliary cholangitis | 0 | 0.2 | 0 |
Psoriasis | 0.1 | 0.7 | -6 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 0.9 | 0.2 | 3.5 |
Schizophrenia | 0.9 | 0.9 | |
scoliosis | 0.7 | -0.7 | |
Sjögren syndrome | 0.2 | 0.8 | -3 |
Sleep Apnea | 0 | 0.1 | 0 |
Small Intestinal Bacterial Overgrowth (SIBO) | 0 | 0 | |
Stress / posttraumatic stress disorder | 0.3 | 0.1 | 2 |
Systemic Lupus Erythematosus | 0.6 | 0.3 | 1 |
Tic Disorder | 0 | 0.1 | 0 |
Tourette syndrome | 0.1 | -0.1 | |
Type 1 Diabetes | 0.2 | 0.4 | -1 |
Type 2 Diabetes | 0.7 | 0.6 | 0.17 |
Ulcerative colitis | 0.2 | 0.6 | -2 |
Unhealthy Ageing | 0.5 | 0.4 | 0.25 |
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