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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
Age: 0-10	Improves	-3.12
Age: 20-30	Worsen	2.85
Age: 30-40	Improves	-3.2
Age: 40-50	Improves	-2.81
Age: 50-60	Improves	-1.78
Age: 60-70	Improves	-3.07
Asymptomatic: Live in house with person with probable microbiome dysfunction	Worsen	2.53
Asymptomatic: Minor Health Issues (a few symptoms only)	Worsen	1.52
Asymptomatic: No Health Issues	Improves	-2.78
Autism: Official Diagnosis	Worsen	3.76
Autonomic Manifestations: cardiac arrhythmias	Improves	-2.03
Autonomic Manifestations: Cortisol disorders or irregularity	Improves	-2.93
Autonomic Manifestations: irritable bowel syndrome	Improves	-3.86
Autonomic Manifestations: light-headedness	Improves	-2.74
Autonomic Manifestations: Orthostatic intolerance	Improves	-3.84
Autonomic Manifestations: palpitations	Worsen	0.29
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS)	Worsen	2.03
Autonomic Manifestations: urinary frequency dysfunction	Improves	-0.95
Autonomic: Blurred or tunnel vision after standing	Improves	-2.03
Autonomic: Dizziness or fainting	Improves	-2.76
Autonomic: Heart rate increase after standing	Improves	-2.89
Autonomic: Inability to tolerate an upright position	Worsen	1.85
Autonomic: Irregular heartbeats	Worsen	2.61
Autonomic: Nausea	Improves	-2.03
Autonomic: Ocassional Tachycardia (Rapid heart beat)	Improves	-3.88
Autonomic: Shortness of breath	Improves	-2.95
Blood Type: A Positive	Improves	-3.26
Blood Type: O Positive	Worsen	3.38
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding	Improves	-3.53
Comorbid-Mouth: Dry Mouth	Improves	-3.76
Comorbid-Mouth: Gingivits / Gum Disease	Worsen	3.01
Comorbid-Mouth: Mouth Sores	Improves	-1.71
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome	Worsen	3.46
Comorbid: Constipation and Diarrohea (not explosions)	Worsen	0.59
Comorbid: Constipation and Explosions (not diarrohea)	Worsen	4.22
Comorbid: Fibromyalgia	Improves	-3.65
Comorbid: High Anxiety	Worsen	3.49
Comorbid: Histamine or Mast Cell issues	Improves	-2.59
Comorbid: Hypothyroidism	Improves	-2.02
Comorbid: Inflammatory bowel disease	Improves	-3.85
Comorbid: Methylation issues (MTHFR)	Improves	-2.03
Comorbid: Migraine	Worsen	3.67
Comorbid: Mold Sensitivity / Exposure	Improves	-0.99
Comorbid: Multiple Chemical Sensitivity	Improves	-4.07
Comorbid: Restless Leg	Worsen	2.96
Comorbid: Small intestinal bacterial overgrowth (SIBO)	Improves	-3.54
Comorbid: Snoring (NOT Sleep Apnea	Worsen	3.42
Condition: ME/CFS with IBS	Worsen	2.14
DePaul University Fatigue Questionnaire : Abdomen pain	Improves	-3.07
DePaul University Fatigue Questionnaire : Allergies	Worsen	4
DePaul University Fatigue Questionnaire : Anxiety/tension	Worsen	3.81
DePaul University Fatigue Questionnaire : Chemical sensitivity	Worsen	0.59
DePaul University Fatigue Questionnaire : Depression	Worsen	2.33
DePaul University Fatigue Questionnaire : Difficulty comprehending Information	Worsen	3.85
DePaul University Fatigue Questionnaire : Difficulty falling asleep	Worsen	2.66
DePaul University Fatigue Questionnaire : Difficulty finding the right word	Worsen	4.34
DePaul University Fatigue Questionnaire : Difficulty staying asleep	Improves	-0.76
DePaul University Fatigue Questionnaire : Dizziness	Worsen	4.19
DePaul University Fatigue Questionnaire : Fatigue	Worsen	4.18
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say	Worsen	3
DePaul University Fatigue Questionnaire : Impaired Memory & concentration	Worsen	3.47
DePaul University Fatigue Questionnaire : Racing heart	Worsen	3.64
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired	Worsen	3.11
DePaul University Fatigue Questionnaire : Upset stomach	Worsen	3.48
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM)	Worsen	2.19
Gender: Female	Worsen	1.94
Gender: Male	Improves	-2.62
General: Depression	Improves	-3.38
General: Fatigue	Worsen	1.75
General: Headaches	Improves	-3.36
General: Heavy feeling in arms and legs	Improves	-2.86
General: Myalgia (pain)	Improves	-3.15
General: Sinus issues with headaches	Improves	-2.73
Immune Manifestations: Abdominal Pain	Improves	-3.62
Immune Manifestations: Alcohol Intolerant	Improves	-2.14
Immune Manifestations: Bloating	Improves	-3.34
Immune Manifestations: Constipation	Improves	-2.6
Immune Manifestations: Diarrhea	Improves	-2.38
Immune Manifestations: general malaise	Worsen	1.6
Immune Manifestations: Hair loss	Improves	-3.29
Immune Manifestations: Inflammation (General)	Improves	-3.54
Immune Manifestations: Inflammation of skin, eyes or joints	Improves	-2.83
Immune Manifestations: medication sensitivities.	Worsen	1.66
Immune Manifestations: Mucus in the stool	Improves	-3.04
Immune Manifestations: new food sensitivities	Improves	-3.51
Immune Manifestations: tender lymph nodes	Worsen	2.03
Immune: Chronic Sinusitis	Worsen	2.83
Immune: Recurrent Sore throat	Worsen	2.03
Immune: Sensitivity to smell/food/medication/chemicals	Worsen	0.67
Immune: Viral infections with prolonged recovery periods	Worsen	2.03
Infection: Epstein-Barr virus	Improves	-3.58
Infection: Human Herpesvirus 6 (HHV6)	Worsen	3.84
Infection: Mycoplasma	Improves	-3.11
Infection: Parasite - Other	Worsen	3.44
Joint: Redness	Improves	-3.56
Joint: Stiffness and swelling	Improves	-3.08
Joint: Sudden and severe episodes of pain	Improves	-2.03
Joint: Tenderness	Improves	-3.6
Neurocognitive: Absent-mindedness or forgetfulness	Improves	-3.75
Neurocognitive: Brain Fog	Improves	-3.09
Neurocognitive: Can only focus on one thing at a time	Improves	-3.92
Neurocognitive: Difficulty expressing thoughts	Worsen	1.11
Neurocognitive: Difficulty paying attention for a long period of time	Improves	-3.75
Neurocognitive: Difficulty understanding things	Worsen	1.28
Neurocognitive: Problems remembering things	Improves	-4.21
Neurocognitive: Slowness of thought	Improves	-2.84
Neurocognitive: Unable to focus vision and/or attention	Improves	-3.74
Neuroendocrine Manifestations: abnormal appetite	Improves	-3.21
Neuroendocrine Manifestations: Air Hunger	Worsen	2.03
Neuroendocrine Manifestations: cold extremities	Improves	-2.11
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome)	Improves	-2.98
Neuroendocrine Manifestations: Excessive adrenaline	Improves	-2.61
Neuroendocrine Manifestations: intolerance of extremes of heat and cold	Worsen	1.94
Neuroendocrine Manifestations: marked weight change	Improves	-2.6
Neuroendocrine Manifestations: Muscle weakness	Improves	-2.85
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin)	Improves	-1.23
Neuroendocrine Manifestations: Rapid muscular fatiguability	Worsen	0.57
Neuroendocrine Manifestations: recurrent feelings of feverishness	Improves	-0.81
Neuroendocrine Manifestations: subnormal body temperature	Improves	-2.11
Neuroendocrine Manifestations: sweating episodes	Worsen	1.74
Neuroendocrine Manifestations: worsening of symptoms with stress.	Improves	-3.42
Neuroendocrine: Alcohol intolerance	Improves	-2.56
Neuroendocrine: Chills or shivers	Improves	-2.03
Neuroendocrine: Cold limbs (e.g. arms, legs hands)	Improves	-2.07
Neuroendocrine: Feeling hot or cold for no reason	Improves	-2.04
Neuroendocrine: Feeling like you have a high temperature	Worsen	2.42
Neuroendocrine: Lack of appetite	Worsen	2.96
Neuroendocrine: Lost or gained weight without trying	Improves	-3.61
Neuroendocrine: Sweating hands	Improves	-2.03
Neuroendocrine: Temperature fluctuations throughout the day	Improves	-2.03
Neurological-Audio: hypersensitivity to noise	Worsen	1.6
Neurological-Audio: Tinnitus (ringing in ear)	Improves	-2.75
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep)	Improves	-2.69
Neurological-Sleep: Insomnia	Improves	-3.85
Neurological-Sleep: Night Sweats	Improves	-2.62
Neurological-Sleep: Sleep Apnea	Improves	-1.74
Neurological-Sleep: Vivid Dreams/Nightmares	Improves	-3.06
Neurological-Vision: Blurred Vision	Improves	-2.85
Neurological-Vision: inability to focus eye/vision	Worsen	2.75
Neurological-Vision: photophobia (Light Sensitivity)	Improves	-0.48
Neurological: Cognitive/Sensory Overload	Improves	-1.9
Neurological: Confusion	Improves	-2.56
Neurological: Difficulty processing information (Understanding)	Improves	-2.92
Neurological: Difficulty reading	Improves	-3.39
Neurological: Disorientation	Improves	-3.56
Neurological: Dysautonomia	Improves	-3.61
Neurological: emotional overload	Improves	-3.17
Neurological: Executive Decision Making (Difficulty making)	Improves	-3.85
Neurological: fasciculations	Improves	-2.01
Neurological: High degree of Empathy before onset	Worsen	2.74
Neurological: Impairment of concentration	Improves	-3.57
Neurological: Joint hypermobility	Improves	-3.5
Neurological: Myoclonic jerks or seizures	Improves	-2.82
Neurological: Neuropathy	Worsen	2.03
Neurological: Seasonal Affective Disorder (SAD)	Improves	-2.9
Neurological: Short-term memory issues	Improves	-1.9
Neurological: Slowed speech	Improves	-1.86
Neurological: Spatial instability and disorientation	Improves	-2.41
Neurological: Word-finding problems	Improves	-2.99
Official Diagnosis: Allergic Rhinitis (Hay Fever)	Worsen	3.42
Official Diagnosis: Autoimmune Disease	Improves	-2.47
Official Diagnosis: Chronic Fatigue Syndrome	Improves	-3.58
Official Diagnosis: Irritable Bowel Syndrome	Improves	-2.68
Official Diagnosis: Mast Cell Dysfunction	Improves	-2.26
Onset: 2000-2010	Improves	-2.55
Onset: 2010-2020	Improves	-3.51
Onset: Gradual	Improves	-3.28
Other: Sensitivity to mold	Worsen	1.4
Other: Sensitivity to vibrations	Improves	-2.84
Pain: Aching of the eyes or behind the eyes	Worsen	2.03
Pain: Chest pain	Improves	-2.03
Pain: Eye pain	Worsen	3.22
Pain: Joint pain	Improves	-2.04
Pain: Myofascial pain	Improves	-0.81
Pain: Pain or aching in muscles	Improves	-2.81
Pain: Sensitivity to pain	Improves	-3.16
Post-exertional malaise: Difficulty reading after mild physical or mental activity	Worsen	3.51
Post-exertional malaise: General	Worsen	1.64
Post-exertional malaise: Mentally tired after the slightest effort	Worsen	3.25
Post-exertional malaise: Muscle fatigue after mild physical activity	Improves	-2.62
Post-exertional malaise: Physically drained or sick after mild activity	Worsen	2.23
Post-exertional malaise: Physically tired after minimum exercise	Improves	-3.06
Post-exertional malaise: Post-exertional malaise	Improves	-2.69
Post-exertional malaise: Rapid cognitive fatigability,	Worsen	2.81
Post-exertional malaise: Rapid muscular fatigability,	Improves	-2.31
Post-exertional malaise: Worsening of symptoms after mild mental activity	Worsen	1.99
Post-exertional malaise: Worsening of symptoms after mild physical activity	Improves	-1.4
Sleep: Daytime drowsiness	Worsen	1.97
Sleep: Need to nap daily	Improves	-3.73
Sleep: Problems falling asleep	Improves	-2.29
Sleep: Problems staying asleep	Improves	-3.86
Sleep: Unrefreshed sleep	Improves	-2.61
Sleep: Waking up early in the morning (e.g. 3 AM)	Improves	-3.5

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
Acne	Improves	-4.22
ADHD	Worsen	5.49
Allergic Rhinitis (Hay Fever)	Improves	-4.57
Allergies	Worsen	1.84
Alzheimer's disease	Improves	-3.81
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Worsen	3.57
Ankylosing spondylitis	Improves	-4.36
Anorexia Nervosa	Improves	-4.39
Asthma	Improves	-3.15
Atherosclerosis	Improves	-2.53
Autism	Improves	-5.51
Barrett esophagus cancer	Improves	-2.24
Bipolar Disorder	Improves	-3.89
Brain Trauma	Improves	-3.77
Carcinoma	Improves	-3.73
Celiac Disease	Improves	-5.44
Cerebral Palsy	Improves	-2.94
Chronic Fatigue Syndrome	Improves	-4.32
Chronic Kidney Disease	Improves	-3.97
Chronic Lyme	Improves	-3.55
Chronic Urticaria (Hives)	Improves	-3.44
Colorectal Cancer	Improves	-4.76
Coronary artery disease	Improves	-3.85
COVID-19	Improves	-3.84
Crohn's Disease	Improves	-4.69
Depression	Worsen	3.78
Eczema	Improves	-5
Epilepsy	Worsen	3.02
Fibromyalgia	Improves	-4.2
Functional constipation / chronic idiopathic constipation	Improves	-2.93
gallstone disease (gsd)	Improves	-2.42
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	Improves	-1.46
Generalized anxiety disorder	Improves	-3.58
Gout	Improves	-2.84
Graves' disease	Improves	-3.79
Hashimoto's thyroiditis	Improves	-1.82
Histamine Issues	Worsen	3.89
Histamine Issues From Ubiome	Improves	-2.96
hypercholesterolemia (High Cholesterol)	Improves	-3.48
Hyperlipidemia (High Blood Fats)	Worsen	3.63
hypertension (High Blood Pressure	Improves	-5.24
IgA nephropathy (IgAN)	Improves	-4.36
Inflammatory Bowel Disease	Improves	-5.88
Insomnia	Worsen	2.81
Irritable Bowel Syndrome	Improves	-5.44
Liver Cirrhosis	Improves	-4.26
Long COVID	Worsen	3.81
ME/CFS with IBS	Improves	-3.17
ME/CFS without IBS	Worsen	3.11
Metabolic Syndrome	Improves	-3.59
Mood Disorders	Improves	-2.74
Multiple Sclerosis	Worsen	2.66
Multiple system atrophy (MSA)	Improves	-3.12
neuropsychiatric disorders (PANDAS, PANS)	Worsen	1.35
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	Improves	-5.51
NonCeliac Gluten Sensitivity	Improves	-2.26
Obesity	Improves	-5.9
obsessive-compulsive disorder	Improves	-4.36
Osteoarthritis	Improves	-3.42
Osteoporosis	Improves	-2.72
Parkinson's Disease	Worsen	5.95
Psoriasis	Worsen	3.96
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Improves	-5.4
Rosacea	Improves	-2.39
Schizophrenia	Worsen	4.39
Sjögren syndrome	Improves	-4.77
Sleep Apnea	Worsen	3.81
Small Intestinal Bacterial Overgrowth (SIBO)	Improves	-3.42
Stress / posttraumatic stress disorder	Improves	-3.55
Systemic Lupus Erythematosus	Improves	-4.42
Type 1 Diabetes	Improves	-4.87
Type 2 Diabetes	Improves	-5.34
Ulcerative colitis	Improves	-5.49

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.