We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Worsen | 3.22 |
| Age: 50-60 | Worsen | 2.14 |
| Age: 60-70 | Improves | -0.44 |
| Asymptomatic: Minor Health Issues (a few symptoms only) | Improves | -2.21 |
| Asymptomatic: No Health Issues | Worsen | 2.63 |
| Autism: Official Diagnosis | Worsen | 3.7 |
| Autonomic Manifestations: irritable bowel syndrome | Worsen | 0.92 |
| Autonomic Manifestations: light-headedness | Worsen | 2.56 |
| Autonomic Manifestations: Orthostatic intolerance | Improves | -3.89 |
| Autonomic Manifestations: palpitations | Improves | -3.89 |
| Autonomic: Dizziness or fainting | Improves | -1.56 |
| Autonomic: Graying or blacking out after standing | Worsen | 2.93 |
| Autonomic: Heart rate increase after standing | Improves | -1.56 |
| Autonomic: Inability to tolerate an upright position | Worsen | 2.12 |
| Autonomic: Irregular heartbeats | Worsen | 3.46 |
| Autonomic: Ocassional Tachycardia (Rapid heart beat) | Improves | -2.05 |
| Autonomic: Shortness of breath | Worsen | 1.67 |
| Blood Type: A Positive | Worsen | 1.08 |
| Blood Type: O Positive | Worsen | 2.31 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Worsen | 2.96 |
| Comorbid-Mouth: Dry Mouth | Improves | -3.05 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 4.03 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 3.86 |
| Comorbid: Fibromyalgia | Improves | -3.29 |
| Comorbid: High Anxiety | Worsen | 3.41 |
| Comorbid: Histamine or Mast Cell issues | Worsen | 3.53 |
| Comorbid: Hypothyroidism | Worsen | 3.63 |
| Comorbid: Inflammatory bowel disease | Improves | -3.43 |
| Comorbid: Methylation issues (MTHFR) | Worsen | 3.01 |
| Comorbid: Migraine | Worsen | 2.54 |
| Comorbid: Multiple Chemical Sensitivity | Improves | -3.49 |
| Comorbid: Restless Leg | Worsen | 2.89 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 3.36 |
| Condition: ME/CFS with IBS | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 4.24 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 3.83 |
| DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 3.74 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 4.34 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 4.1 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 4.15 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 1.79 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 3.91 |
| Gender: Female | Worsen | 2.83 |
| General: Depression | Improves | -1.71 |
| General: Fatigue | Improves | -0.41 |
| General: Headaches | Improves | -1.62 |
| General: Myalgia (pain) | Worsen | 1.85 |
| General: Sinus issues with headaches | Worsen | 2.5 |
| Immune Manifestations: Abdominal Pain | Worsen | 3.05 |
| Immune Manifestations: Alcohol Intolerant | Worsen | 2.72 |
| Immune Manifestations: Bloating | Worsen | 2.7 |
| Immune Manifestations: Constipation | Worsen | 2.87 |
| Immune Manifestations: Diarrhea | Improves | -1.67 |
| Immune Manifestations: general malaise | Worsen | 3.14 |
| Immune Manifestations: Inflammation (General) | Worsen | 3.39 |
| Immune Manifestations: Mucus in the stool | Worsen | 2.83 |
| Immune Manifestations: tender lymph nodes | Improves | -3.7 |
| Immune: Sensitivity to smell/food/medication/chemicals | Worsen | 1.97 |
| Immune: Viral infections with prolonged recovery periods | Worsen | 1.67 |
| Infection: Epstein-Barr virus | Improves | -1.21 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 3.85 |
| Infection: Mycoplasma | Worsen | 2.34 |
| Infection: Parasite - Other | Worsen | 3.7 |
| Joint: Redness | Improves | -2.82 |
| Joint: Stiffness and swelling | Improves | -1.49 |
| Joint: Tenderness | Worsen | 3.5 |
| Neurocognitive: Difficulty paying attention for a long period of time | Worsen | 2.39 |
| Neurocognitive: Slowness of thought | Worsen | 2.39 |
| Neurocognitive: Unable to focus vision and/or attention | Worsen | 3.53 |
| Neuroendocrine Manifestations: Excessive adrenaline | Worsen | 0.87 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Improves | -3.43 |
| Neuroendocrine Manifestations: Muscle weakness | Improves | -3.95 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Worsen | 3.18 |
| Neuroendocrine Manifestations: subnormal body temperature | Worsen | 3.71 |
| Neuroendocrine Manifestations: sweating episodes | Worsen | 2.9 |
| Neuroendocrine Manifestations: worsening of symptoms with stress. | Improves | -2.04 |
| Neuroendocrine: Alcohol intolerance | Worsen | 2.88 |
| Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Improves | -2.79 |
| Neuroendocrine: Feeling like you have a high temperature | Worsen | 3.34 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 3.61 |
| Neuroendocrine: Lack of appetite | Worsen | 3.05 |
| Neuroendocrine: Lost or gained weight without trying | Improves | -3.26 |
| Neuroendocrine: Sweating hands | Improves | -1.3 |
| Neurological-Audio: hypersensitivity to noise | Worsen | 3.64 |
| Neurological-Audio: Tinnitus (ringing in ear) | Improves | -1.71 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -3.34 |
| Neurological-Sleep: Insomnia | Improves | -2.92 |
| Neurological-Sleep: Night Sweats | Improves | -1.71 |
| Neurological-Sleep: Sleep Apnea | Improves | -2.51 |
| Neurological-Sleep: Vivid Dreams/Nightmares | Worsen | 2.83 |
| Neurological-Vision: Blurred Vision | Improves | -3.17 |
| Neurological-Vision: inability to focus eye/vision | Worsen | 3.58 |
| Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 3.25 |
| Neurological: Difficulty processing information (Understanding) | Worsen | 1.67 |
| Neurological: Difficulty reading | Improves | -2.32 |
| Neurological: Disorientation | Improves | -2.96 |
| Neurological: emotional overload | Worsen | 2.53 |
| Neurological: Executive Decision Making (Difficulty making) | Improves | -1.71 |
| Neurological: fasciculations | Improves | -2.64 |
| Neurological: High degree of Empathy before onset | Worsen | 2.74 |
| Neurological: Impairment of concentration | Improves | -2.62 |
| Neurological: Joint hypermobility | Worsen | 1.7 |
| Neurological: Neuropathy | Improves | -2.96 |
| Neurological: Seasonal Affective Disorder (SAD) | Worsen | 2.41 |
| Neurological: Short-term memory issues | Improves | -2.58 |
| Neurological: Slowed speech | Improves | -1.61 |
| Neurological: Spatial instability and disorientation | Improves | -1.52 |
| Neurological: Word-finding problems | Worsen | 1.79 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 3.41 |
| Official Diagnosis: Autoimmune Disease | Improves | -2.05 |
| Official Diagnosis: Chronic Fatigue Syndrome | Improves | -2.51 |
| Official Diagnosis: Irritable Bowel Syndrome | Worsen | 1.87 |
| Official Diagnosis: Mast Cell Dysfunction | Worsen | 2.94 |
| Onset: 2010-2020 | Worsen | 3.58 |
| Onset: Gradual | Improves | -3.18 |
| Onset: less than 02 years since onset | Worsen | 2.74 |
| Other: Sensitivity to mold | Improves | -2.24 |
| Pain: Aching of the eyes or behind the eyes | Improves | -1.63 |
| Pain: Joint pain | Worsen | 2.83 |
| Pain: Myofascial pain | Improves | -1.63 |
| Pain: Sensitivity to pain | Worsen | 2.39 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 3.13 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 2.74 |
| Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 2.39 |
| Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 3.24 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
| Post-exertional malaise: Worsening of symptoms after mild physical activity | Improves | -1.63 |
| Sleep: Daytime drowsiness | Worsen | 3.45 |
| Sleep: Problems staying asleep | Improves | -3.16 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 2.7 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Cerebral Palsy | Improves | -3.52 |
| Acne | Improves | -3.47 |
| ADHD | Worsen | 4.46 |
| Allergic Rhinitis (Hay Fever) | Improves | -2.22 |
| Allergies | Worsen | 2.88 |
| Alzheimer's disease | Improves | -4.29 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 2.61 |
| Ankylosing spondylitis | Improves | -3.43 |
| Asthma | Worsen | 3.04 |
| Atherosclerosis | Worsen | 2.3 |
| Autism | Improves | -5.15 |
| Barrett esophagus cancer | Improves | -2.24 |
| bipolar disorder | Worsen | 2.39 |
| Brain Trauma | Improves | -3.38 |
| Carcinoma | Improves | -3.73 |
| Celiac Disease | Improves | -3.07 |
| Chronic Fatigue Syndrome | Improves | -4.52 |
| Chronic Kidney Disease | Improves | -3.97 |
| Chronic urticaria (Hives) | Improves | -3.44 |
| Colorectal Cancer | Improves | -4.76 |
| Coronary artery disease | Improves | -3.85 |
| COVID-19 | Improves | -3.84 |
| Crohn's Disease | Improves | -4.32 |
| Depression | Worsen | 4.46 |
| Epilepsy | Improves | -3.96 |
| Fibromyalgia | Improves | -4.25 |
| Functional constipation / chronic idiopathic constipation | Worsen | 2.38 |
| gallstone disease (gsd) | Worsen | 1.92 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -1.46 |
| Generalized anxiety disorder | Improves | -3.58 |
| Gout | Improves | -2.84 |
| Graves' disease | Improves | -3.54 |
| Hashimoto's thyroiditis | Worsen | 2.54 |
| High Blood Pressure | Improves | -4.56 |
| Histamine Issues | Worsen | 3.89 |
| Histamine Issues From Ubiome | Improves | -2.96 |
| hypercholesterolemia (High Cholesterol) | Improves | -3.48 |
| Hyperlipidemia (High Blood Fats) | Worsen | 3.63 |
| IgA nephropathy (IgAN) | Improves | -4.36 |
| Inflammatory Bowel Disease | Improves | -5.88 |
| Insomnia | Worsen | 2.81 |
| Irritable Bowel Syndrome | Improves | -5.59 |
| Liver Cirrhosis | Improves | -4.26 |
| ME/CFS with IBS | Improves | -3.17 |
| ME/CFS without IBS | Worsen | 3.11 |
| Metabolic Syndrome | Improves | -3.62 |
| Mood Disorders | Improves | -2.74 |
| Multiple Sclerosis | Improves | -2.73 |
| Multiple system atrophy (MSA) | Improves | -3.12 |
| neuropsychiatric disorders (PANDAS, PANS) | Worsen | 1.35 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -4.77 |
| Obesity | Improves | -5.29 |
| Osteoporosis | Worsen | 1.24 |
| Parkinson's Disease | Worsen | 5.41 |
| Psoriasis | Improves | -3.83 |
| Rheumatoid arthritis | Improves | -4.84 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -4.44 |
| Rosacea | Improves | -2.39 |
| Schizophrenia | Worsen | 4 |
| Sclerosis | Improves | -3.61 |
| Sjögren syndrome | Improves | -1.09 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.42 |
| Stress / posttraumatic stress disorder | Worsen | 2.4 |
| Systemic Lupus Erythematosus | Improves | -4.14 |
| Type 1 Diabetes | Improves | -3.85 |
| Type 2 Diabetes | Improves | -4.31 |
| Ulcerative colitis | Improves | -4.82 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.