We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Age: 20-30 | Worsen | 3.22 |
Age: 50-60 | Worsen | 2.14 |
Age: 60-70 | Improves | -0.44 |
Asymptomatic: Minor Health Issues (a few symptoms only) | Improves | -2.21 |
Asymptomatic: No Health Issues | Worsen | 2.63 |
Autism: Official Diagnosis | Worsen | 3.7 |
Autonomic Manifestations: irritable bowel syndrome | Worsen | 0.92 |
Autonomic Manifestations: light-headedness | Worsen | 2.56 |
Autonomic Manifestations: Orthostatic intolerance | Improves | -3.89 |
Autonomic Manifestations: palpitations | Improves | -3.89 |
Autonomic: Dizziness or fainting | Improves | -1.56 |
Autonomic: Graying or blacking out after standing | Worsen | 2.93 |
Autonomic: Heart rate increase after standing | Improves | -1.56 |
Autonomic: Inability to tolerate an upright position | Worsen | 2.12 |
Autonomic: Irregular heartbeats | Worsen | 3.46 |
Autonomic: Ocassional Tachycardia (Rapid heart beat) | Improves | -2.05 |
Autonomic: Shortness of breath | Worsen | 1.67 |
Blood Type: A Positive | Worsen | 1.08 |
Blood Type: O Positive | Worsen | 2.31 |
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Worsen | 2.96 |
Comorbid-Mouth: Dry Mouth | Improves | -3.05 |
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 4.03 |
Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 3.86 |
Comorbid: Fibromyalgia | Improves | -3.29 |
Comorbid: High Anxiety | Worsen | 3.41 |
Comorbid: Histamine or Mast Cell issues | Worsen | 3.53 |
Comorbid: Hypothyroidism | Worsen | 3.63 |
Comorbid: Inflammatory bowel disease | Improves | -3.43 |
Comorbid: Methylation issues (MTHFR) | Worsen | 3.01 |
Comorbid: Migraine | Worsen | 2.54 |
Comorbid: Multiple Chemical Sensitivity | Improves | -3.49 |
Comorbid: Restless Leg | Worsen | 2.89 |
Comorbid: Snoring (NOT Sleep Apnea | Worsen | 3.36 |
Condition: ME/CFS with IBS | Worsen | 2.8 |
DePaul University Fatigue Questionnaire : Allergies | Worsen | 4.24 |
DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 3.83 |
DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 3.74 |
DePaul University Fatigue Questionnaire : Fatigue | Worsen | 4.34 |
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 4.1 |
DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 4.15 |
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 1.79 |
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 3.91 |
Gender: Female | Worsen | 2.83 |
General: Depression | Improves | -1.71 |
General: Fatigue | Improves | -0.41 |
General: Headaches | Improves | -1.62 |
General: Myalgia (pain) | Worsen | 1.85 |
General: Sinus issues with headaches | Worsen | 2.5 |
Immune Manifestations: Abdominal Pain | Worsen | 3.05 |
Immune Manifestations: Alcohol Intolerant | Worsen | 2.72 |
Immune Manifestations: Bloating | Worsen | 2.7 |
Immune Manifestations: Constipation | Worsen | 2.87 |
Immune Manifestations: Diarrhea | Improves | -1.67 |
Immune Manifestations: general malaise | Worsen | 3.14 |
Immune Manifestations: Inflammation (General) | Worsen | 3.39 |
Immune Manifestations: Mucus in the stool | Worsen | 2.83 |
Immune Manifestations: tender lymph nodes | Improves | -3.7 |
Immune: Sensitivity to smell/food/medication/chemicals | Worsen | 1.97 |
Immune: Viral infections with prolonged recovery periods | Worsen | 1.67 |
Infection: Epstein-Barr virus | Improves | -1.21 |
Infection: Human Herpesvirus 6 (HHV6) | Worsen | 3.85 |
Infection: Mycoplasma | Worsen | 2.34 |
Infection: Parasite - Other | Worsen | 3.7 |
Joint: Redness | Improves | -2.82 |
Joint: Stiffness and swelling | Improves | -1.49 |
Joint: Tenderness | Worsen | 3.5 |
Neurocognitive: Difficulty paying attention for a long period of time | Worsen | 2.39 |
Neurocognitive: Slowness of thought | Worsen | 2.39 |
Neurocognitive: Unable to focus vision and/or attention | Worsen | 3.53 |
Neuroendocrine Manifestations: Excessive adrenaline | Worsen | 0.87 |
Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Improves | -3.43 |
Neuroendocrine Manifestations: Muscle weakness | Improves | -3.95 |
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Worsen | 3.18 |
Neuroendocrine Manifestations: subnormal body temperature | Worsen | 3.71 |
Neuroendocrine Manifestations: sweating episodes | Worsen | 2.9 |
Neuroendocrine Manifestations: worsening of symptoms with stress. | Improves | -2.04 |
Neuroendocrine: Alcohol intolerance | Worsen | 2.88 |
Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Improves | -2.79 |
Neuroendocrine: Feeling like you have a high temperature | Worsen | 3.34 |
Neuroendocrine: Feeling like you have a low temperature | Worsen | 3.61 |
Neuroendocrine: Lack of appetite | Worsen | 3.05 |
Neuroendocrine: Lost or gained weight without trying | Improves | -3.26 |
Neuroendocrine: Sweating hands | Improves | -1.3 |
Neurological-Audio: hypersensitivity to noise | Worsen | 3.64 |
Neurological-Audio: Tinnitus (ringing in ear) | Improves | -1.71 |
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -3.34 |
Neurological-Sleep: Insomnia | Improves | -2.92 |
Neurological-Sleep: Night Sweats | Improves | -1.71 |
Neurological-Sleep: Sleep Apnea | Improves | -2.51 |
Neurological-Sleep: Vivid Dreams/Nightmares | Worsen | 2.83 |
Neurological-Vision: Blurred Vision | Improves | -3.17 |
Neurological-Vision: inability to focus eye/vision | Worsen | 3.58 |
Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 3.25 |
Neurological: Difficulty processing information (Understanding) | Worsen | 1.67 |
Neurological: Difficulty reading | Improves | -2.32 |
Neurological: Disorientation | Improves | -2.96 |
Neurological: emotional overload | Worsen | 2.53 |
Neurological: Executive Decision Making (Difficulty making) | Improves | -1.71 |
Neurological: fasciculations | Improves | -2.64 |
Neurological: High degree of Empathy before onset | Worsen | 2.74 |
Neurological: Impairment of concentration | Improves | -2.62 |
Neurological: Joint hypermobility | Worsen | 1.7 |
Neurological: Neuropathy | Improves | -2.96 |
Neurological: Seasonal Affective Disorder (SAD) | Worsen | 2.41 |
Neurological: Short-term memory issues | Improves | -2.58 |
Neurological: Slowed speech | Improves | -1.61 |
Neurological: Spatial instability and disorientation | Improves | -1.52 |
Neurological: Word-finding problems | Worsen | 1.79 |
Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 3.41 |
Official Diagnosis: Autoimmune Disease | Improves | -2.05 |
Official Diagnosis: Chronic Fatigue Syndrome | Improves | -2.51 |
Official Diagnosis: Irritable Bowel Syndrome | Worsen | 1.87 |
Official Diagnosis: Mast Cell Dysfunction | Worsen | 2.94 |
Onset: 2010-2020 | Worsen | 3.58 |
Onset: Gradual | Improves | -3.18 |
Onset: less than 02 years since onset | Worsen | 2.74 |
Other: Sensitivity to mold | Improves | -2.24 |
Pain: Aching of the eyes or behind the eyes | Improves | -1.63 |
Pain: Joint pain | Worsen | 2.83 |
Pain: Myofascial pain | Improves | -1.63 |
Pain: Sensitivity to pain | Worsen | 2.39 |
Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 3.13 |
Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 2.74 |
Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 2.39 |
Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 3.24 |
Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
Post-exertional malaise: Worsening of symptoms after mild physical activity | Improves | -1.63 |
Sleep: Daytime drowsiness | Worsen | 3.45 |
Sleep: Problems staying asleep | Improves | -3.16 |
Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 2.7 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Cerebral Palsy | Improves | -3.52 |
Acne | Improves | -3.47 |
ADHD | Worsen | 4.46 |
Allergic Rhinitis (Hay Fever) | Improves | -2.22 |
Allergies | Worsen | 2.88 |
Alzheimer's disease | Improves | -4.29 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 2.61 |
Ankylosing spondylitis | Improves | -3.43 |
Asthma | Worsen | 3.04 |
Atherosclerosis | Worsen | 2.3 |
Autism | Improves | -5.15 |
Barrett esophagus cancer | Improves | -2.24 |
bipolar disorder | Worsen | 2.39 |
Brain Trauma | Improves | -3.38 |
Carcinoma | Improves | -3.73 |
Celiac Disease | Improves | -3.07 |
Chronic Fatigue Syndrome | Improves | -4.52 |
Chronic Kidney Disease | Improves | -3.97 |
Chronic urticaria (Hives) | Improves | -3.44 |
Colorectal Cancer | Improves | -4.76 |
Coronary artery disease | Improves | -3.85 |
COVID-19 | Improves | -3.84 |
Crohn's Disease | Improves | -4.32 |
Depression | Worsen | 4.46 |
Epilepsy | Improves | -3.96 |
Fibromyalgia | Improves | -4.25 |
Functional constipation / chronic idiopathic constipation | Worsen | 2.38 |
gallstone disease (gsd) | Worsen | 1.92 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -1.46 |
Generalized anxiety disorder | Improves | -3.58 |
Gout | Improves | -2.84 |
Graves' disease | Improves | -3.54 |
Hashimoto's thyroiditis | Worsen | 2.54 |
High Blood Pressure | Improves | -4.56 |
Histamine Issues | Worsen | 3.89 |
Histamine Issues From Ubiome | Improves | -2.96 |
hypercholesterolemia (High Cholesterol) | Improves | -3.48 |
Hyperlipidemia (High Blood Fats) | Worsen | 3.63 |
IgA nephropathy (IgAN) | Improves | -4.36 |
Inflammatory Bowel Disease | Improves | -5.88 |
Insomnia | Worsen | 2.81 |
Irritable Bowel Syndrome | Improves | -5.59 |
Liver Cirrhosis | Improves | -4.26 |
ME/CFS with IBS | Improves | -3.17 |
ME/CFS without IBS | Worsen | 3.11 |
Metabolic Syndrome | Improves | -3.62 |
Mood Disorders | Improves | -2.74 |
Multiple Sclerosis | Improves | -2.73 |
Multiple system atrophy (MSA) | Improves | -3.12 |
neuropsychiatric disorders (PANDAS, PANS) | Worsen | 1.35 |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -4.77 |
Obesity | Improves | -5.29 |
Osteoporosis | Worsen | 1.24 |
Parkinson's Disease | Worsen | 5.41 |
Psoriasis | Improves | -3.83 |
Rheumatoid arthritis | Improves | -4.84 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -4.44 |
Rosacea | Improves | -2.39 |
Schizophrenia | Worsen | 4 |
Sclerosis | Improves | -3.61 |
Sjögren syndrome | Improves | -1.09 |
Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.42 |
Stress / posttraumatic stress disorder | Worsen | 2.4 |
Systemic Lupus Erythematosus | Improves | -4.14 |
Type 1 Diabetes | Improves | -3.85 |
Type 2 Diabetes | Improves | -4.31 |
Ulcerative colitis | Improves | -4.82 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.