We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 0-10 | Improves | -2.75 |
| Age: 20-30 | Worsen | 2.48 |
| Age: 60-70 | Improves | -1.7 |
| Autism: Official Diagnosis | Worsen | 1.93 |
| Autonomic Manifestations: Cortisol disorders or irregularity | Improves | -1.7 |
| Autonomic: Shortness of breath | Improves | -0.24 |
| Blood Type: A Positive | Worsen | 2.42 |
| Blood Type: O Positive | Worsen | 3.42 |
| Comorbid-Mouth: Dry Mouth | Improves | -1.76 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 2.79 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 3.23 |
| Comorbid: High Anxiety | Worsen | 3.23 |
| Comorbid: Histamine or Mast Cell issues | Improves | -1.7 |
| Comorbid: Inflammatory bowel disease | Worsen | 1.64 |
| Comorbid: Methylation issues (MTHFR) | Worsen | 3.01 |
| Comorbid: Migraine | Worsen | 1.86 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 0.02 |
| Condition: ME/CFS with IBS | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Abdomen pain | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 2.86 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 3.07 |
| DePaul University Fatigue Questionnaire : Depression | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Difficulty finding the right word | Worsen | 3.11 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 3.61 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 1.76 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 1.84 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 2.93 |
| General: Headaches | Improves | -1.62 |
| Immune Manifestations: Alcohol Intolerant | Improves | -1.62 |
| Immune Manifestations: Inflammation (General) | Worsen | 1.93 |
| Infection: Parasite - Other | Worsen | 1.96 |
| Joint: Stiffness and swelling | Improves | -1.7 |
| Joint: Tenderness | Worsen | 3.01 |
| Neurocognitive: Can only focus on one thing at a time | Improves | -1.7 |
| Neurocognitive: Unable to focus vision and/or attention | Worsen | 3.01 |
| Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Worsen | 2.48 |
| Neuroendocrine Manifestations: Excessive adrenaline | Improves | -1.68 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 1.58 |
| Neuroendocrine Manifestations: sweating episodes | Improves | -2.96 |
| Neuroendocrine: Alcohol intolerance | Improves | -1.7 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
| Neuroendocrine: Lack of appetite | Improves | -2.88 |
| Neurological-Audio: Tinnitus (ringing in ear) | Improves | -1.7 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -1.64 |
| Neurological-Sleep: Sleep Apnea | Worsen | 2.48 |
| Neurological-Sleep: Vivid Dreams/Nightmares | Improves | -1.73 |
| Neurological: Confusion | Worsen | 0 |
| Neurological: emotional overload | Worsen | 2.74 |
| Neurological: Executive Decision Making (Difficulty making) | Worsen | 2.42 |
| Neurological: fasciculations | Improves | -0.91 |
| Neurological: High degree of Empathy before onset | Worsen | 2.74 |
| Neurological: Impairment of concentration | Worsen | 2.42 |
| Neurological: Short-term memory issues | Worsen | 2.47 |
| Neurological: Slowed speech | Improves | -1.61 |
| Neurological: Spatial instability and disorientation | Worsen | 2.74 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 3.23 |
| Official Diagnosis: Autoimmune Disease | Worsen | 0 |
| Official Diagnosis: Mast Cell Dysfunction | Worsen | 2.77 |
| Onset: less than 02 years since onset | Worsen | 2.74 |
| Other: Sensitivity to mold | Improves | -1.76 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 3.01 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.56 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
| Sleep: Problems staying asleep | Improves | -1.7 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Improves | -1.7 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -4.12 |
| ADHD | Worsen | 3.34 |
| Allergic Rhinitis (Hay Fever) | Improves | -3.24 |
| Allergies | Improves | -3.42 |
| Alzheimer's disease | Improves | -3.87 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -2.52 |
| Ankylosing spondylitis | Worsen | 1.43 |
| Asthma | Improves | -3.23 |
| Atherosclerosis | Worsen | 2.51 |
| Autism | Improves | -5.53 |
| Barrett esophagus cancer | Improves | -0.12 |
| Bipolar Disorder | Improves | -3.71 |
| Brain Trauma | Improves | -3.04 |
| Carcinoma | Improves | -2.41 |
| Celiac Disease | Improves | -4.83 |
| Cerebral Palsy | Improves | -2.01 |
| Chronic Fatigue Syndrome | Improves | -4.87 |
| Chronic Kidney Disease | Improves | -4.06 |
| Chronic Lyme | Improves | -3.55 |
| Chronic Urticaria (Hives) | Improves | -3.39 |
| Colorectal Cancer | Improves | -2.12 |
| Coronary artery disease | Improves | -3.94 |
| COVID-19 | Improves | -3.38 |
| Crohn's Disease | Improves | -4.23 |
| Depression | Worsen | 3.41 |
| Eczema | Improves | -5.06 |
| Epilepsy | Improves | -3.47 |
| Fibromyalgia | Improves | -2.33 |
| Functional constipation / chronic idiopathic constipation | Improves | -3.97 |
| gallstone disease (gsd) | Worsen | 2.38 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 2.4 |
| Generalized anxiety disorder | Improves | -3.45 |
| Gout | Improves | -2.84 |
| Graves' disease | Improves | -1.16 |
| Hashimoto's thyroiditis | Improves | -2.08 |
| High Blood Pressure | Improves | -3.7 |
| Histamine Issues | Improves | -2.18 |
| Histamine Issues From Ubiome | Improves | -2.96 |
| Hyperlipidemia (High Blood Fats) | Worsen | 3.11 |
| hypertension (High Blood Pressure | Worsen | 3.09 |
| IgA nephropathy (IgAN) | Improves | -4.3 |
| Inflammatory Bowel Disease | Improves | -5.41 |
| Insomnia | Improves | -3.01 |
| Irritable Bowel Syndrome | Improves | -4.9 |
| Liver Cirrhosis | Improves | -4.85 |
| ME/CFS with IBS | Improves | -3.11 |
| ME/CFS without IBS | Improves | -2.89 |
| Mood Disorders | Improves | -2.74 |
| Multiple Sclerosis | Worsen | 3.35 |
| Multiple system atrophy (MSA) | Improves | -3.04 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -2.42 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -5.19 |
| NonCeliac Gluten Sensitivity | Improves | -2.88 |
| Obesity | Improves | -2.79 |
| Osteoarthritis | Improves | -2.41 |
| Osteoporosis | Worsen | 2.91 |
| Parkinson's Disease | Worsen | 2.47 |
| Psoriasis | Worsen | 4.02 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -4.51 |
| Rosacea | Worsen | 2.89 |
| Schizophrenia | Worsen | 3.91 |
| Sjögren syndrome | Improves | -3.37 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.77 |
| Stress / posttraumatic stress disorder | Improves | -4.38 |
| Systemic Lupus Erythematosus | Improves | -3.76 |
| Type 1 Diabetes | Improves | -3.51 |
| Type 2 Diabetes | Improves | -2.59 |
| Ulcerative colitis | Improves | -4.41 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.