We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 0-10 | Improves | -3.56 |
| Age: 50-60 | Worsen | 1.51 |
| Age: 60-70 | Improves | -2.75 |
| Asymptomatic: Minor Health Issues (a few symptoms only) | Worsen | 2.82 |
| Asymptomatic: No Health Issues | Worsen | 1.36 |
| Autism: Official Diagnosis | Worsen | 1.36 |
| Autonomic Manifestations: cardiac arrhythmias | Improves | -2.92 |
| Autonomic Manifestations: Orthostatic intolerance | Improves | -3.45 |
| Autonomic Manifestations: palpitations | Improves | -3.59 |
| Autonomic: Graying or blacking out after standing | Improves | -2.92 |
| Autonomic: Inability to tolerate an upright position | Improves | -3.45 |
| Autonomic: Irregular heartbeats | Improves | -2.92 |
| Blood Type: A Positive | Improves | -2.82 |
| Blood Type: O Positive | Improves | -3.45 |
| Comorbid: Constipation and Diarrohea (not explosions) | Worsen | 2.93 |
| Comorbid: Constipation and Explosions (not diarrohea) | Improves | -3.53 |
| Comorbid: Fibromyalgia | Improves | -3.53 |
| Comorbid: High Anxiety | Improves | -3.53 |
| Comorbid: Inflammatory bowel disease | Improves | -3.45 |
| Comorbid: Methylation issues (MTHFR) | Improves | -2.83 |
| Comorbid: Snoring (NOT Sleep Apnea | Improves | -3.45 |
| Condition: ME/CFS with IBS | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Abdomen pain | Worsen | 3.95 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 3.58 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 3.95 |
| DePaul University Fatigue Questionnaire : Depression | Worsen | 3.95 |
| DePaul University Fatigue Questionnaire : Difficulty falling asleep | Worsen | 3.59 |
| DePaul University Fatigue Questionnaire : Difficulty finding the right word | Worsen | 3.95 |
| DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 3.59 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 2.92 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 3.95 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 1.78 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 3.02 |
| DePaul University Fatigue Questionnaire : Upset stomach | Worsen | 3.59 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 3.95 |
| Gender: Female | Worsen | 2.92 |
| General: Sinus issues with headaches | Worsen | 1.36 |
| Immune Manifestations: Inflammation (General) | Improves | -2.92 |
| Immune Manifestations: Mucus in the stool | Improves | -2.92 |
| Infection: Human Herpesvirus 6 (HHV6) | Improves | -1.04 |
| Infection: Mycoplasma | Improves | -2.92 |
| Joint: Redness | Improves | -2.82 |
| Joint: Stiffness and swelling | Improves | -2.92 |
| Joint: Tenderness | Improves | -3.45 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Improves | -2.75 |
| Neuroendocrine Manifestations: worsening of symptoms with stress. | Improves | -1.59 |
| Neuroendocrine: Alcohol intolerance | Improves | -2.92 |
| Neuroendocrine: Lack of appetite | Worsen | 2.88 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -2.92 |
| Neurological-Sleep: Insomnia | Improves | -2.92 |
| Neurological-Vision: Blurred Vision | Improves | -3.59 |
| Neurological-Vision: inability to focus eye/vision | Improves | -2.92 |
| Neurological-Vision: photophobia (Light Sensitivity) | Improves | -2.92 |
| Neurological: Difficulty reading | Improves | -2.92 |
| Neurological: Executive Decision Making (Difficulty making) | Improves | -1.59 |
| Neurological: fasciculations | Improves | -3.71 |
| Neurological: Impairment of concentration | Improves | -1.59 |
| Neurological: Joint hypermobility | Improves | -2.82 |
| Neurological: Seasonal Affective Disorder (SAD) | Worsen | 1.36 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Improves | -2.82 |
| Official Diagnosis: Autoimmune Disease | Improves | -2.75 |
| Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.92 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -3.45 |
| Pain: Sensitivity to pain | Improves | -2.82 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.56 |
| Sleep: Problems staying asleep | Improves | -3.12 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Improves | -2.92 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -3.94 |
| ADHD | Worsen | 4.47 |
| Allergic Rhinitis (Hay Fever) | Improves | -2.93 |
| Allergies | Improves | -3.87 |
| Alzheimer's disease | Worsen | 4.42 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.59 |
| Ankylosing spondylitis | Worsen | 4.76 |
| Asthma | Improves | -2.82 |
| Atherosclerosis | Worsen | 4.45 |
| Autism | Worsen | 4 |
| Barrett esophagus cancer | Worsen | 3.66 |
| Bipolar Disorder | Improves | -2.83 |
| Brain Trauma | Worsen | 1.39 |
| Carcinoma | Worsen | 0 |
| Celiac Disease | Improves | -3.81 |
| Cerebral Palsy | Worsen | 2.88 |
| Chronic Fatigue Syndrome | Improves | -4.57 |
| Chronic Kidney Disease | Improves | -2.68 |
| Colorectal Cancer | Improves | -1.77 |
| COVID-19 | Improves | -2.93 |
| Crohn's Disease | Improves | -1.35 |
| Depression | Worsen | 4.62 |
| Eczema | Improves | -4.43 |
| Epilepsy | Improves | -3.47 |
| Fibromyalgia | Improves | -4.43 |
| Functional constipation / chronic idiopathic constipation | Worsen | 2.88 |
| gallstone disease (gsd) | Improves | -2.99 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -1.46 |
| Graves' disease | Worsen | 2.88 |
| Hashimoto's thyroiditis | Improves | -3.51 |
| High Blood Pressure | Improves | -3.93 |
| Histamine Issues | Worsen | 1.84 |
| Histamine Issues From Ubiome | Improves | -2.72 |
| Hyperlipidemia (High Blood Fats) | Improves | -2.63 |
| hypertension (High Blood Pressure | Worsen | 2.92 |
| IgA nephropathy (IgAN) | Improves | -2.26 |
| Inflammatory Bowel Disease | Worsen | 3.38 |
| Irritable Bowel Syndrome | Improves | -4.44 |
| Liver Cirrhosis | Improves | -4.58 |
| ME/CFS with IBS | Improves | -2.88 |
| ME/CFS without IBS | Improves | -2.88 |
| Multiple Sclerosis | Worsen | 3.4 |
| Multiple system atrophy (MSA) | Improves | -1.3 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -4.27 |
| NonCeliac Gluten Sensitivity | Improves | -2.88 |
| Obesity | Worsen | 3.28 |
| Osteoporosis | Improves | -0.98 |
| Parkinson's Disease | Worsen | 5.51 |
| Psoriasis | Worsen | 3.87 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -4.36 |
| Rosacea | Worsen | 1.3 |
| Schizophrenia | Worsen | 4.6 |
| Sjögren syndrome | Improves | -3.89 |
| Stress / posttraumatic stress disorder | Worsen | 2.61 |
| Systemic Lupus Erythematosus | Worsen | 1.29 |
| Type 1 Diabetes | Improves | -2.54 |
| Type 2 Diabetes | Worsen | 4.96 |
| Ulcerative colitis | Worsen | 2.09 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.