We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Worsen | 2.76 |
| Age: 30-40 | Worsen | 1.79 |
| Autonomic Manifestations: Orthostatic intolerance | Worsen | 1.79 |
| Neurological: Word-finding problems | Worsen | 1.79 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Cerebral Palsy | Improves | -2.76 |
| ADHD | Worsen | 2.86 |
| Ankylosing spondylitis | Improves | -2.59 |
| Atherosclerosis | Worsen | 3.21 |
| Autism | Worsen | 4.34 |
| Brain Trauma | Worsen | 3.48 |
| Carcinoma | Improves | -2.76 |
| Celiac Disease | Worsen | 2.76 |
| Chronic Fatigue Syndrome | Worsen | 1.21 |
| Chronic Kidney Disease | Improves | -2.76 |
| Chronic urticaria (Hives) | Worsen | 2.76 |
| Colorectal Cancer | Improves | -3.57 |
| Coronary artery disease | Improves | -2.76 |
| Crohn's Disease | Worsen | 3.42 |
| Depression | Improves | -1.45 |
| Epilepsy | Worsen | 2.76 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 0 |
| Graves' disease | Improves | -3.48 |
| Hashimoto's thyroiditis | Worsen | 2.76 |
| High Blood Pressure | Worsen | 2.38 |
| hypercholesterolemia (High Cholesterol) | Improves | -2.76 |
| IgA nephropathy (IgAN) | Worsen | 2.76 |
| Inflammatory Bowel Disease | Improves | -3.42 |
| Insomnia | Worsen | 2.76 |
| Irritable Bowel Syndrome | Improves | -4.32 |
| Liver Cirrhosis | Improves | -3.83 |
| Multiple Sclerosis | Worsen | 3.82 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -2.98 |
| Obesity | Improves | -2.76 |
| Osteoporosis | Improves | -3.06 |
| Parkinson's Disease | Worsen | 4.18 |
| Psoriasis | Improves | -2.76 |
| Rheumatoid arthritis | Improves | -2.6 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -3.82 |
| Schizophrenia | Worsen | 2.76 |
| Sclerosis | Improves | -2.76 |
| Sjögren syndrome | Worsen | 2.76 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -2.76 |
| Systemic Lupus Erythematosus | Improves | -3.48 |
| Type 1 Diabetes | Improves | -2.86 |
| Type 2 Diabetes | Worsen | 2.23 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.