We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Worsen | 2.48 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Allergies | Worsen | 2.23 |
| Ankylosing spondylitis | Worsen | 3.29 |
| Asthma | Worsen | 0 |
| Atherosclerosis | Improves | -1.96 |
| Autism | Improves | -2.48 |
| Celiac Disease | Improves | -2.48 |
| Colorectal Cancer | Improves | -1.74 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 2.01 |
| High Blood Pressure | Worsen | 0 |
| Hyperlipidemia (High Blood Fats) | Improves | -2.01 |
| Inflammatory Bowel Disease | Improves | -2.48 |
| Liver Cirrhosis | Worsen | 1.7 |
| Obesity | Worsen | 0 |
| Osteoporosis | Improves | -2.01 |
| Psoriasis | Improves | -2.23 |
| Rheumatoid arthritis | Improves | -2.48 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -2.48 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -2.48 |
| Stress / posttraumatic stress disorder | Improves | -3.8 |
| Type 1 Diabetes | Worsen | 2.48 |
| Type 2 Diabetes | Worsen | 0 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.