We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Improves | -1.19 |
| Age: 60-70 | Improves | -1.7 |
| Asymptomatic: No Health Issues | Worsen | 2.72 |
| Blood Type: A Positive | Worsen | 1.86 |
| Blood Type: O Positive | Worsen | 1.86 |
| Comorbid-Mouth: Dry Mouth | Improves | -2.8 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -1.62 |
| Comorbid: Histamine or Mast Cell issues | Improves | -1.7 |
| Comorbid: Migraine | Worsen | 1.86 |
| Comorbid: Multiple Chemical Sensitivity | Improves | -2.9 |
| DePaul University Fatigue Questionnaire : Allergies | Improves | -2.72 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Improves | -2.72 |
| DePaul University Fatigue Questionnaire : Difficulty falling asleep | Improves | -2.72 |
| DePaul University Fatigue Questionnaire : Difficulty finding the right word | Improves | -2.72 |
| DePaul University Fatigue Questionnaire : Fatigue | Improves | -2.28 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Improves | -2.28 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Improves | -2.94 |
| General: Fatigue | Improves | -2.9 |
| General: Headaches | Improves | -1.62 |
| Immune Manifestations: Alcohol Intolerant | Improves | -1.62 |
| Joint: Stiffness and swelling | Improves | -1.7 |
| Neurocognitive: Can only focus on one thing at a time | Improves | -1.7 |
| Neuroendocrine Manifestations: Excessive adrenaline | Improves | -1.68 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Improves | -2.9 |
| Neuroendocrine Manifestations: Muscle weakness | Improves | -3.51 |
| Neuroendocrine: Alcohol intolerance | Improves | -1.7 |
| Neuroendocrine: Lost or gained weight without trying | Improves | -3.51 |
| Neurological-Audio: Tinnitus (ringing in ear) | Improves | -1.7 |
| Neurological: Slowed speech | Improves | -1.61 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -1.7 |
| Onset: Gradual | Improves | -2.65 |
| Pain: Joint pain | Improves | -1.56 |
| Sleep: Problems staying asleep | Improves | -1.7 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Improves | -1.7 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Worsen | 0 |
| ADHD | Improves | -2.72 |
| Allergies | Improves | -1.94 |
| Alzheimer's disease | Worsen | 4.03 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.72 |
| Ankylosing spondylitis | Worsen | 3.73 |
| Asthma | Improves | -2.9 |
| Atherosclerosis | Worsen | 3.96 |
| Autism | Worsen | 1.52 |
| Barrett esophagus cancer | Improves | -3.16 |
| Bipolar Disorder | Worsen | 1.9 |
| Brain Trauma | Improves | -1.45 |
| Celiac Disease | Improves | -4.34 |
| Cerebral Palsy | Worsen | 2.9 |
| Chronic Fatigue Syndrome | Improves | -3.38 |
| Chronic Kidney Disease | Improves | -2.28 |
| Colorectal Cancer | Improves | -1.93 |
| Coronary artery disease | Improves | -1.44 |
| COVID-19 | Worsen | 1.04 |
| Crohn's Disease | Worsen | 2.62 |
| Depression | Worsen | 2.64 |
| Epilepsy | Improves | -3.48 |
| Fibromyalgia | Improves | -2.72 |
| Functional constipation / chronic idiopathic constipation | Worsen | 2.72 |
| gallstone disease (gsd) | Worsen | 2.72 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -1.46 |
| High Blood Pressure | Improves | -2.72 |
| Histamine Issues | Worsen | 1.84 |
| Histamine Issues From Ubiome | Improves | -2.96 |
| Hyperlipidemia (High Blood Fats) | Worsen | 2.96 |
| IgA nephropathy (IgAN) | Improves | -3.38 |
| Inflammatory Bowel Disease | Worsen | 1.98 |
| Irritable Bowel Syndrome | Improves | -3.52 |
| Liver Cirrhosis | Worsen | 3.42 |
| ME/CFS with IBS | Worsen | 0 |
| ME/CFS without IBS | Worsen | 1.7 |
| Metabolic Syndrome | Improves | -2.9 |
| Multiple Sclerosis | Worsen | 4.16 |
| Multiple system atrophy (MSA) | Worsen | 3.48 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -2.58 |
| Obesity | Improves | -4.31 |
| Osteoporosis | Worsen | 3.71 |
| Parkinson's Disease | Worsen | 5.5 |
| Psoriasis | Worsen | 3.72 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -3.06 |
| Rosacea | Improves | -2.72 |
| Schizophrenia | Worsen | 4.12 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -2.48 |
| Stress / posttraumatic stress disorder | Improves | -3.31 |
| Systemic Lupus Erythematosus | Improves | -2.58 |
| Type 1 Diabetes | Improves | -3.08 |
| Type 2 Diabetes | Improves | -3.51 |
| Ulcerative colitis | Improves | -2.88 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.