We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Age: 0-10 | Improves | -2.75 |
Age: 20-30 | Worsen | 2.48 |
Age: 60-70 | Improves | -2.7 |
Asymptomatic: Minor Health Issues (a few symptoms only) | Worsen | 2.96 |
Asymptomatic: No Health Issues | Improves | -1.9 |
Autism: Official Diagnosis | Worsen | 0.73 |
Autonomic Manifestations: cardiac arrhythmias | Worsen | 3.5 |
Autonomic Manifestations: Orthostatic intolerance | Worsen | 1.76 |
Autonomic Manifestations: palpitations | Improves | -1.75 |
Autonomic: Inability to tolerate an upright position | Improves | -3.05 |
Autonomic: Irregular heartbeats | Improves | -3.68 |
Autonomic: Shortness of breath | Improves | -1.72 |
Blood Type: A Positive | Improves | -3.21 |
Blood Type: O Positive | Improves | -1.67 |
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Improves | -2.96 |
Comorbid-Mouth: Mouth Sores | Worsen | 1.84 |
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -3.08 |
Comorbid: Constipation and Explosions (not diarrohea) | Improves | -3 |
Comorbid: Fibromyalgia | Worsen | 1.64 |
Comorbid: High Anxiety | Improves | -3 |
Comorbid: Histamine or Mast Cell issues | Improves | -2.7 |
Comorbid: Hypothyroidism | Improves | -3.68 |
Comorbid: Inflammatory bowel disease | Improves | -3.66 |
Comorbid: Methylation issues (MTHFR) | Worsen | 3.01 |
Comorbid: Migraine | Improves | -1.86 |
Comorbid: Snoring (NOT Sleep Apnea | Improves | -3.68 |
Condition: ME/CFS with IBS | Worsen | 2.8 |
DePaul University Fatigue Questionnaire : Abdomen pain | Improves | -1.29 |
DePaul University Fatigue Questionnaire : Allergies | Worsen | 2.25 |
DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 3.03 |
DePaul University Fatigue Questionnaire : Depression | Improves | -1.33 |
DePaul University Fatigue Questionnaire : Difficulty falling asleep | Improves | -3.08 |
DePaul University Fatigue Questionnaire : Difficulty finding the right word | Improves | -3.78 |
DePaul University Fatigue Questionnaire : Difficulty staying asleep | Improves | -2.96 |
DePaul University Fatigue Questionnaire : Fatigue | Improves | -3.42 |
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 3.07 |
DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -3.55 |
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Improves | -3.21 |
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 2.66 |
General: Depression | Worsen | 1.71 |
General: Headaches | Worsen | 1.62 |
Immune Manifestations: Abdominal Pain | Improves | -3.05 |
Immune Manifestations: Alcohol Intolerant | Improves | -2.72 |
Immune Manifestations: Constipation | Improves | -2.96 |
Immune Manifestations: Diarrhea | Worsen | 1.67 |
Immune Manifestations: Hair loss | Improves | -1.9 |
Immune Manifestations: Inflammation (General) | Improves | -3.24 |
Immune Manifestations: Mucus in the stool | Improves | -2.83 |
Infection: Human Herpesvirus 6 (HHV6) | Improves | -3.81 |
Infection: Mycoplasma | Improves | -3.05 |
Infection: Parasite - Other | Improves | -0.6 |
Joint: Stiffness and swelling | Improves | -2.7 |
Joint: Tenderness | Improves | -3.21 |
Neurocognitive: Brain Fog | Improves | -2.96 |
Neurocognitive: Can only focus on one thing at a time | Worsen | 1.7 |
Neurocognitive: Difficulty understanding things | Improves | -1.68 |
Neurocognitive: Unable to focus vision and/or attention | Worsen | 0.73 |
Neuroendocrine Manifestations: cold extremities | Improves | -3.05 |
Neuroendocrine Manifestations: Excessive adrenaline | Improves | -2.63 |
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Improves | -3.05 |
Neuroendocrine Manifestations: subnormal body temperature | Improves | -3.68 |
Neuroendocrine: Alcohol intolerance | Improves | -3.56 |
Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Worsen | 1.71 |
Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
Neurological-Audio: Tinnitus (ringing in ear) | Worsen | 1.7 |
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Worsen | 1.84 |
Neurological-Sleep: Sleep Apnea | Worsen | 3.41 |
Neurological-Sleep: Vivid Dreams/Nightmares | Improves | -1.73 |
Neurological-Vision: inability to focus eye/vision | Improves | -3.68 |
Neurological-Vision: photophobia (Light Sensitivity) | Improves | -2.96 |
Neurological: Confusion | Worsen | 2.97 |
Neurological: Difficulty processing information (Understanding) | Improves | -2.17 |
Neurological: Disorientation | Worsen | 2.96 |
Neurological: emotional overload | Worsen | 2.74 |
Neurological: Executive Decision Making (Difficulty making) | Worsen | 2.42 |
Neurological: fasciculations | Worsen | 2.74 |
Neurological: High degree of Empathy before onset | Worsen | 2.74 |
Neurological: Impairment of concentration | Worsen | 3.38 |
Neurological: Joint hypermobility | Improves | -3.68 |
Neurological: Neuropathy | Worsen | 2.96 |
Neurological: Seasonal Affective Disorder (SAD) | Worsen | 0.86 |
Neurological: Short-term memory issues | Worsen | 2.74 |
Neurological: Slowed speech | Worsen | 1.61 |
Neurological: Spatial instability and disorientation | Worsen | 3.52 |
Official Diagnosis: Allergic Rhinitis (Hay Fever) | Improves | -3 |
Official Diagnosis: Autoimmune Disease | Improves | -2.97 |
Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.96 |
Official Diagnosis: Mast Cell Dysfunction | Improves | -2.34 |
Onset: 2010-2020 | Improves | -2.96 |
Onset: Gradual | Worsen | 1.67 |
Onset: less than 02 years since onset | Worsen | 2.74 |
Other: Sensitivity to mold | Improves | -0.47 |
Pain: Sensitivity to pain | Improves | -3.68 |
Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 3.01 |
Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.56 |
Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
Sleep: Daytime drowsiness | Improves | -2.96 |
Sleep: Problems staying asleep | Worsen | 2.38 |
Sleep: Waking up early in the morning (e.g. 3 AM) | Improves | -2.7 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Acne | Improves | -3.15 |
ADHD | Worsen | 4.19 |
Allergic Rhinitis (Hay Fever) | Improves | -4.23 |
Allergies | Improves | -3.62 |
Alzheimer's disease | Worsen | 3.85 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.68 |
Ankylosing spondylitis | Worsen | 2.4 |
Asthma | Improves | -4.25 |
Atherosclerosis | Improves | -4.78 |
Autism | Improves | -2.89 |
Barrett esophagus cancer | Worsen | 3.68 |
Bipolar Disorder | Improves | -4.12 |
Brain Trauma | Improves | -3.04 |
Carcinoma | Improves | -3.3 |
Celiac Disease | Worsen | 3.68 |
Cerebral Palsy | Worsen | 3.04 |
Chronic Fatigue Syndrome | Improves | -5.23 |
Chronic Kidney Disease | Improves | -3.99 |
Chronic Lyme | Improves | -3.55 |
Chronic Urticaria (Hives) | Improves | -3.56 |
Colorectal Cancer | Improves | -4.98 |
Coronary artery disease | Improves | -2.39 |
COVID-19 | Improves | -3.21 |
Crohn's Disease | Improves | -3.46 |
Depression | Improves | -4.05 |
Eczema | Improves | -4.88 |
Epilepsy | Improves | -2.99 |
Fibromyalgia | Worsen | 1.49 |
Functional constipation / chronic idiopathic constipation | Improves | -4.88 |
gallstone disease (gsd) | Improves | -4.55 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 4.2 |
Generalized anxiety disorder | Improves | -2.48 |
Gout | Improves | -2.84 |
Graves' disease | Worsen | 2.74 |
Hashimoto's thyroiditis | Improves | -3.53 |
High Blood Pressure | Worsen | 1.11 |
Histamine Issues | Improves | -2.38 |
Histamine Issues From Ubiome | Improves | -2.42 |
Hyperlipidemia (High Blood Fats) | Worsen | 2 |
hypertension (High Blood Pressure | Improves | -3.09 |
IgA nephropathy (IgAN) | Improves | -3.52 |
Inflammatory Bowel Disease | Improves | -3.76 |
Insomnia | Improves | -3.7 |
Irritable Bowel Syndrome | Improves | -5.24 |
Liver Cirrhosis | Improves | -5.22 |
ME/CFS with IBS | Improves | -4.26 |
ME/CFS without IBS | Improves | -4.72 |
Metabolic Syndrome | Worsen | 3.01 |
Mood Disorders | Improves | -2.74 |
Multiple Sclerosis | Worsen | 4.3 |
Multiple system atrophy (MSA) | Worsen | 3.58 |
neuropsychiatric disorders (PANDAS, PANS) | Improves | -2.42 |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -4.98 |
NonCeliac Gluten Sensitivity | Improves | -2.88 |
Obesity | Worsen | 4.52 |
Osteoarthritis | Improves | -3.79 |
Osteoporosis | Improves | -1.2 |
Parkinson's Disease | Worsen | 5.26 |
Psoriasis | Improves | -4.32 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -5.48 |
Rosacea | Improves | -3.76 |
Schizophrenia | Worsen | 4.03 |
Sjögren syndrome | Improves | -4.93 |
Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -3.88 |
Stress / posttraumatic stress disorder | Improves | -5.01 |
Systemic Lupus Erythematosus | Improves | -4.39 |
Type 1 Diabetes | Improves | -4.72 |
Type 2 Diabetes | Worsen | 3.89 |
Ulcerative colitis | Improves | -4.71 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.