We have automatic error reporting on most pages. Our goal is fix breaks due to refactor and cleanup resolved in 24hrs. If a problem persists longer than that, please email us.

low energy diet/ calorie restriction ** full range

Check for interactions on Supp.AI



Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

SymptomImpactPredictor of Bacteria Shift
Age: 20-30Improves-6.64
Age: 30-40Improves-4.29
Age: 40-50Improves-3.55
Age: 50-60Improves-5.37
Age: 60-70Worsen6.79
Asymptomatic: Live in house with person with probable microbiome dysfunctionImproves-4.02
Asymptomatic: Minor Health Issues (a few symptoms only)Improves-6.53
Asymptomatic: No Health IssuesWorsen6.18
Autism: Official DiagnosisImproves-8.67
Autonomic Manifestations: cardiac arrhythmiasWorsen8.72
Autonomic Manifestations: Cortisol disorders or irregularity Worsen6.4
Autonomic Manifestations: irritable bowel syndromeWorsen5.68
Autonomic Manifestations: light-headednessImproves-2.56
Autonomic Manifestations: Orthostatic intoleranceWorsen7.66
Autonomic Manifestations: palpitationsWorsen7.91
Autonomic Manifestations: urinary frequency dysfunctionWorsen8.38
Autonomic: Dizziness or faintingImproves-6.85
Autonomic: Heart rate increase after standingWorsen6.6
Autonomic: Inability to tolerate an upright positionImproves-8.41
Autonomic: Irregular heartbeatsImproves-6.98
Autonomic: Ocassional Tachycardia (Rapid heart beat)Worsen6.87
Autonomic: Shortness of breathWorsen5.79
Blood Type: A PositiveWorsen6.35
Blood Type: O PositiveImproves-8.95
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grindingWorsen5.67
Comorbid-Mouth: Dry MouthWorsen7.68
Comorbid-Mouth: Mouth SoresImproves-5.97
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndromeImproves-7.82
Comorbid: Constipation and Explosions (not diarrohea)Improves-8.82
Comorbid: FibromyalgiaWorsen6.82
Comorbid: High AnxietyImproves-9.07
Comorbid: Histamine or Mast Cell issuesImproves-7.97
Comorbid: HypothyroidismImproves-5.19
Comorbid: Inflammatory bowel disease Improves-8.69
Comorbid: MigraineImproves-8.37
Comorbid: Mold Sensitivity / ExposureWorsen6.87
Comorbid: Multiple Chemical SensitivityWorsen6.25
Comorbid: Restless LegImproves-6.91
Comorbid: Snoring (NOT Sleep ApneaImproves-8.84
Condition: ME/CFS with IBSImproves-6.57
DePaul University Fatigue Questionnaire : FatigueImproves-9.28
DePaul University Fatigue Questionnaire : Impaired Memory & concentrationImproves-9.44
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired Improves-9.09
Gender: FemaleImproves-6.61
Gender: MaleImproves-3.62
General: DepressionImproves-7.16
General: FatigueWorsen7.66
General: HeadachesWorsen6.06
General: Myalgia (pain)Worsen6.44
General: Sinus issues with headachesImproves-7.64
Immune Manifestations: Abdominal PainImproves-7.4
Immune Manifestations: Alcohol IntolerantImproves-6.95
Immune Manifestations: BloatingWorsen5.71
Immune Manifestations: ConstipationWorsen7.14
Immune Manifestations: DiarrheaWorsen7.01
Immune Manifestations: general malaiseWorsen6.05
Immune Manifestations: Hair lossImproves-3.47
Immune Manifestations: Inflammation (General)Improves-9.01
Immune Manifestations: Inflammation of skin, eyes or jointsWorsen4.01
Immune Manifestations: medication sensitivities.Worsen3.79
Immune Manifestations: Mucus in the stoolImproves-8.81
Immune Manifestations: new food sensitivitiesWorsen7.58
Immune Manifestations: tender lymph nodesWorsen7.8
Immune: Chronic SinusitisWorsen5.21
Immune: Recurrent Sore throatWorsen5.22
Immune: Sensitivity to smell/food/medication/chemicalsWorsen5.32
Immune: Tender / sore lymph nodesImproves-3.83
Infection: Epstein-Barr virusWorsen4.33
Infection: Human Herpesvirus 6 (HHV6)Improves-5.78
Infection: MycoplasmaImproves-8.12
Infection: Parasite - OtherImproves-4.17
Joint: RednessImproves-4.4
Joint: Stiffness and swellingImproves-6.61
Joint: Sudden and severe episodes of painWorsen6.28
Joint: TendernessImproves-8.03
Neurocognitive: Absent-mindedness or forgetfulnessImproves-3.7
Neurocognitive: Brain FogWorsen5.29
Neurocognitive: Can only focus on one thing at a timeImproves-6.71
Neurocognitive: Difficulty expressing thoughtsWorsen5.26
Neurocognitive: Difficulty paying attention for a long period of timeImproves-6.55
Neurocognitive: Difficulty understanding thingsWorsen3.79
Neurocognitive: Problems remembering thingsImproves-7.72
Neurocognitive: Slowness of thoughtImproves-6.53
Neurocognitive: Unable to focus vision and/or attentionImproves-6.99
Neuroendocrine Manifestations: abnormal appetiteImproves-2.87
Neuroendocrine Manifestations: Air HungerWorsen6.87
Neuroendocrine Manifestations: cold extremitiesWorsen7.59
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome)Improves-2.86
Neuroendocrine Manifestations: Excessive adrenalineImproves-7.52
Neuroendocrine Manifestations: intolerance of extremes of heat and coldWorsen6.41
Neuroendocrine Manifestations: marked weight change Improves-3.48
Neuroendocrine Manifestations: Muscle weakness Worsen7.9
Neuroendocrine Manifestations: NeuralgiaImproves-3.52
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin)Improves-8.31
Neuroendocrine Manifestations: Rapid muscular fatiguabilityWorsen6.73
Neuroendocrine Manifestations: recurrent feelings of feverishnessImproves-3.88
Neuroendocrine Manifestations: subnormal body temperatureWorsen6.14
Neuroendocrine Manifestations: sweating episodesWorsen6.27
Neuroendocrine Manifestations: worsening of symptoms with stress.Worsen7.31
Neuroendocrine: Alcohol intoleranceWorsen6.06
Neuroendocrine: Chills or shiversWorsen6.76
Neuroendocrine: Cold limbs (e.g. arms, legs hands)Improves-3.97
Neuroendocrine: Feeling hot or cold for no reasonWorsen7.95
Neuroendocrine: Feeling like you have a high temperatureWorsen6.92
Neuroendocrine: Feeling like you have a low temperatureWorsen7.5
Neuroendocrine: Lack of appetiteWorsen6.84
Neuroendocrine: Lost or gained weight without tryingWorsen8.07
Neuroendocrine: Sweating handsWorsen2.75
Neurological-Audio: hypersensitivity to noiseWorsen7.28
Neurological-Audio: Tinnitus (ringing in ear)Improves-6.49
Neurological-Sleep: Chaotic diurnal sleep rhythms (Irratic Sleep)Worsen6.79
Neurological-Sleep: InsomniaImproves-7.21
Neurological-Sleep: Night SweatsWorsen3.25
Neurological-Sleep: Sleep ApneaWorsen5.54
Neurological-Sleep: Vivid Dreams/NightmaresWorsen7.55
Neurological-Vision: Blurred VisionWorsen7.56
Neurological-Vision: inability to focus eye/visionImproves-7.32
Neurological-Vision: photophobia (Light Sensitibity)Improves-7.03
Neurological: Cognitive OverloadWorsen6.8
Neurological: Difficulty processing information (Understanding)Worsen7.77
Neurological: Difficulty readingImproves-5.65
Neurological: DysautonomiaImproves-3.83
Neurological: emotional overloadWorsen7.77
Neurological: Executive Decision Making (Difficulty making)Improves-7.37
Neurological: fasciculations Worsen7.89
Neurological: High degree of Empathy before onsetWorsen7.49
Neurological: Impairment of concentrationWorsen7.39
Neurological: Joint hypermobilityImproves-7.51
Neurological: Seasonal Affective Disorder (SAD)Improves-6.92
Neurological: Short-term memory issuesWorsen7.76
Neurological: Spatial instability and disorientationWorsen7.5
Neurological: Word-finding problemsWorsen5.16
Official Diagnosis: Allergic Rhinitis (Hay Fever)Improves-8.76
Official Diagnosis: Autoimmune DiseaseImproves-4.58
Official Diagnosis: Chronic Fatigue SyndromeWorsen6.74
Official Diagnosis: Irritable Bowel SyndromeImproves-8.1
Official Diagnosis: Mast Cell DysfunctionImproves-8.41
Onset: 2000-2010Worsen5.03
Onset: 2010-2020Worsen7.18
Onset: GradualWorsen6.75
Onset: less than 16 years since onsetWorsen3.47
Other: Sensitivity to moldWorsen6.85
Pain: Chest painImproves-7.16
Pain: Eye painImproves-6.54
Pain: Joint painWorsen7.06
Pain: Myofascial painImproves-4.87
Pain: Pain or aching in musclesWorsen7.86
Pain: Sensitivity to painImproves-8.18
Post-exertional malaise: Difficulty reading after mild physical or mental activityWorsen5.39
Post-exertional malaise: GeneralWorsen7.48
Post-exertional malaise: Inappropriate loss of physical and mental stamina,Worsen6.53
Post-exertional malaise: Mentally tired after the slightest effortImproves-5.22
Post-exertional malaise: Physically drained or sick after mild activityWorsen7.28
Post-exertional malaise: Post-exertional malaiseWorsen6.43
Post-exertional malaise: Rapid cognitive fatigability, Worsen8.16
Post-exertional malaise: Rapid muscular fatigability, Worsen6.43
Post-exertional malaise: Worsening of symptoms after mild mental activityWorsen7.5
Post-exertional malaise: Worsening of symptoms after mild physical activityWorsen6.6
Sleep: Daytime drowsinessWorsen6.62
Sleep: Need to nap dailyImproves-6.36
Sleep: Problems falling asleepWorsen8.14
Sleep: Problems staying asleepWorsen5.96
Sleep: Unrefreshed sleepWorsen7.52
Sleep: Waking up early in the morning (e.g. 3 AM)Improves-6.4

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

SymptomImpactPredictor of Bacteria Shift
Allergic Rhinitis (Hay Fever)Improves-3.24
Alzheimer's diseaseWorsen8.83
Amyotrophic lateral sclerosis (ALS) Motor NeuronWorsen7.76
Ankylosing spondylitisWorsen9.22
Autoimmune DiseaseImproves-3.29
Barrett esophagus cancerImproves-6.03
Brain TraumaImproves-6.89
Celiac DiseaseImproves-5.4
Chronic Fatigue SyndromeImproves-7.4
Chronic Kidney DiseaseImproves-7.56
Chronic urticaria (Hives)Improves-8.55
Colorectal CancerImproves-10.61
Crohn's DiseaseImproves-9.75
cystic fibrosisImproves-7.49
Functional constipation / chronic idiopathic constipationImproves-8.21
Gastro-esophageal reflux disease (Gerd) including Barrett's esophagusWorsen7.3
Generalized anxiety disorderImproves-8.69
Graves' diseaseWorsen6.97
Hashimoto's thyroiditisImproves-7.8
High Blood PressureWorsen8.63
Histamine IssuesImproves-8.9
Histamine Issues From UbiomeWorsen6.01
hypercholesterolemia (High Cholesterol)Improves-7.01
IgA nephropathy (IgAN)Worsen8.52
Inflammatory Bowel DiseaseImproves-9.07
Irritable Bowel SyndromeImproves-9.4
Juvenile idiopathic arthritisWorsen5.45
Liver CirrhosisImproves-9.14
ME/CFS with IBSImproves-8.5
ME/CFS without IBSImproves-9.27
Metabolic SyndromeWorsen7.16
Mood DisordersImproves-7.57
Multiple SclerosisImproves-8.86
neuropsychiatric disorders (PANDAS, PANS)Improves-8.02
Non-alcoholic Fatty Liver Disease (nafld) NonalcoholicImproves-6.8
Non-Celiac Gluten SensitivityWorsen1.35
Parkinson's DiseaseImproves-8.14
Rheumatoid arthritisWorsen8.15
rheumatoid arthritis (RA) and Spondyloarthritis (SpA)Improves-8.43
Sjögren syndromeImproves-8.4
Small Intestinal Bacterial Overgrowth (SIBO)Improves-9.08
Stress / post-traumatic stress disorderImproves-9.85
Systemic Lupus ErythematosusImproves-8.95
Type 1 DiabetesImproves-7.25
Type 2 DiabetesImproves-8.21
Ulcerative colitisWorsen8.38

Bacteria Impacted

Suggest a missed study:

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

📓 - direct citation | 👪 - Impacts Parent Taxa | 👶 - Impacts Child Taxa | 🧙 - Inferred
Taxonomy Rank Effect Citations
Bacilli class Decreases 📓 Source Study
Clostridia class Decreases 📓 Source Study
Erysipelotrichia class Decreases 📓 Source Study
Negativicutes class Decreases 📓 Source Study
Firmicutes phylum Decreases 📓 Source Study

Anonymous (Legacy User)