We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Age: 20-30 | Worsen | 3.28 |
Age: 60-70 | Worsen | 3.31 |
Autism: Official Diagnosis | Improves | -2.41 |
Autonomic Manifestations: cardiac arrhythmias | Improves | -2.75 |
Autonomic Manifestations: irritable bowel syndrome | Worsen | 2.39 |
Autonomic Manifestations: Orthostatic intolerance | Worsen | 1.79 |
Autonomic Manifestations: palpitations | Worsen | 3.59 |
Autonomic: Graying or blacking out after standing | Improves | -0.27 |
Autonomic: Heart rate increase after standing | Worsen | 3.21 |
Blood Type: A Positive | Improves | -2.42 |
Blood Type: O Positive | Improves | -0.3 |
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Worsen | 2.39 |
Comorbid-Mouth: Dry Mouth | Worsen | 3.05 |
Comorbid-Mouth: Mouth Sores | Worsen | 2.56 |
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 1.62 |
Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 3.67 |
Comorbid: High Anxiety | Worsen | 2.38 |
Comorbid: Histamine or Mast Cell issues | Worsen | 3 |
Comorbid: Hypothyroidism | Worsen | 2.39 |
Comorbid: Inflammatory bowel disease | Improves | -3.1 |
Comorbid: Methylation issues (MTHFR) | Improves | -3.48 |
Comorbid: Migraine | Improves | -3.16 |
Comorbid: Mold Sensitivity / Exposure | Worsen | 1.82 |
Comorbid: Multiple Chemical Sensitivity | Worsen | 3.55 |
Comorbid: Snoring (NOT Sleep Apnea | Worsen | 2.38 |
Condition: ME/CFS with IBS | Improves | -2.8 |
DePaul University Fatigue Questionnaire : Allergies | Improves | -3.95 |
DePaul University Fatigue Questionnaire : Anxiety/tension | Improves | -2.8 |
DePaul University Fatigue Questionnaire : Difficulty staying asleep | Improves | -3.59 |
DePaul University Fatigue Questionnaire : Fatigue | Improves | -4.43 |
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Improves | -3.61 |
DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -4.3 |
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Improves | -4.23 |
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Improves | -3.95 |
Gender: Female | Improves | -2.92 |
General: Fatigue | Worsen | 3.55 |
General: Headaches | Worsen | 2.7 |
Immune Manifestations: Abdominal Pain | Worsen | 2.48 |
Immune Manifestations: Alcohol Intolerant | Worsen | 2.7 |
Immune Manifestations: Bloating | Worsen | 2.39 |
Immune Manifestations: Constipation | Worsen | 3.32 |
Immune Manifestations: general malaise | Worsen | 3.32 |
Immune Manifestations: tender lymph nodes | Worsen | 3.95 |
Immune: Viral infections with prolonged recovery periods | Improves | -2.9 |
Infection: Epstein-Barr virus | Improves | -1.83 |
Infection: Human Herpesvirus 6 (HHV6) | Worsen | 1.75 |
Joint: Stiffness and swelling | Worsen | 2.73 |
Joint: Sudden and severe episodes of pain | Improves | -3.48 |
Neurocognitive: Absent-mindedness or forgetfulness | Worsen | 2.39 |
Neurocognitive: Brain Fog | Improves | -3.48 |
Neurocognitive: Can only focus on one thing at a time | Worsen | 2.39 |
Neurocognitive: Slowness of thought | Worsen | 3.08 |
Neurocognitive: Unable to focus vision and/or attention | Worsen | 2.56 |
Neuroendocrine Manifestations: Excessive adrenaline | Improves | -2.63 |
Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 3.43 |
Neuroendocrine Manifestations: Muscle weakness | Worsen | 3.95 |
Neuroendocrine Manifestations: subnormal body temperature | Worsen | 2.39 |
Neuroendocrine Manifestations: sweating episodes | Improves | -3.2 |
Neuroendocrine Manifestations: worsening of symptoms with stress. | Worsen | 3.45 |
Neuroendocrine: Alcohol intolerance | Worsen | 2.73 |
Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Worsen | 3.27 |
Neuroendocrine: Feeling like you have a low temperature | Worsen | 3.11 |
Neuroendocrine: Lack of appetite | Worsen | 2.87 |
Neuroendocrine: Lost or gained weight without trying | Worsen | 1.79 |
Neuroendocrine: Sweating hands | Worsen | 2.9 |
Neurological-Audio: hypersensitivity to noise | Worsen | 3.32 |
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Worsen | 3.13 |
Neurological-Sleep: Insomnia | Worsen | 2.39 |
Neurological-Vision: Blurred Vision | Worsen | 3.96 |
Neurological-Vision: inability to focus eye/vision | Worsen | 3.68 |
Neurological: Difficulty processing information (Understanding) | Worsen | 3.12 |
Neurological: Difficulty reading | Worsen | 2.39 |
Neurological: emotional overload | Worsen | 3.12 |
Neurological: Executive Decision Making (Difficulty making) | Worsen | 3.23 |
Neurological: fasciculations | Worsen | 3.71 |
Neurological: High degree of Empathy before onset | Worsen | 0 |
Neurological: Impairment of concentration | Worsen | 3.22 |
Neurological: Joint hypermobility | Improves | -1.83 |
Neurological: Myoclonic jerks or seizures | Worsen | 2.65 |
Neurological: Short-term memory issues | Worsen | 3.76 |
Neurological: Slowed speech | Worsen | 1.61 |
Neurological: Spatial instability and disorientation | Worsen | 0 |
Neurological: Word-finding problems | Worsen | 1.79 |
Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 2.38 |
Official Diagnosis: Chronic Fatigue Syndrome | Worsen | 1.53 |
Official Diagnosis: Irritable Bowel Syndrome | Worsen | 2.39 |
Official Diagnosis: Mast Cell Dysfunction | Worsen | 2.73 |
Onset: 2010-2020 | Worsen | 3.32 |
Onset: Gradual | Worsen | 3.75 |
Onset: less than 02 years since onset | Worsen | 0 |
Other: Sensitivity to mold | Worsen | 1.76 |
Other: Sensitivity to vibrations | Worsen | 1.53 |
Pain: Aching of the eyes or behind the eyes | Worsen | 2.63 |
Pain: Myofascial pain | Worsen | 1.53 |
Pain: Sensitivity to pain | Improves | -1.83 |
Post-exertional malaise: Mentally tired after the slightest effort | Improves | -1.13 |
Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 0 |
Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 0 |
Sleep: Daytime drowsiness | Worsen | 3.32 |
Sleep: Problems staying asleep | Worsen | 1.7 |
Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 2.73 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
Symptom | Impact | Predictor of Bacteria Shift |
---|---|---|
Cerebral Palsy | Worsen | 1.57 |
Acne | Worsen | 2.18 |
ADHD | Improves | -3.87 |
Allergic Rhinitis (Hay Fever) | Worsen | 2.22 |
Allergies | Worsen | 3.85 |
Alzheimer's disease | Improves | -3.87 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.55 |
Ankylosing spondylitis | Improves | -3.21 |
Asthma | Improves | -1.99 |
Atherosclerosis | Improves | -5.04 |
Autism | Improves | -4.24 |
Barrett esophagus cancer | Improves | -1.75 |
Brain Trauma | Improves | -2.13 |
Carcinoma | Worsen | 1.59 |
Celiac Disease | Worsen | 0.98 |
Chronic Fatigue Syndrome | Worsen | 3.33 |
Chronic Kidney Disease | Worsen | 2.97 |
Chronic urticaria (Hives) | Worsen | 2.15 |
Colorectal Cancer | Improves | -5.56 |
Coronary artery disease | Worsen | 3.16 |
Crohn's Disease | Improves | -4.47 |
cystic fibrosis | Improves | -2.21 |
Depression | Improves | -3.62 |
Epilepsy | Worsen | 2.82 |
Fibromyalgia | Worsen | 2.23 |
Functional constipation / chronic idiopathic constipation | Improves | -1.21 |
gallstone disease (gsd) | Improves | -3.07 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -4.26 |
Generalized anxiety disorder | Improves | -3.89 |
Gout | Worsen | 2.84 |
Graves' disease | Improves | -3.31 |
Hashimoto's thyroiditis | Worsen | 3.23 |
High Blood Pressure | Worsen | 3.66 |
Histamine Issues | Improves | -2.94 |
Histamine Issues From Ubiome | Worsen | 2.96 |
hypercholesterolemia (High Cholesterol) | Worsen | 1.03 |
Hyperlipidemia (High Blood Fats) | Worsen | 3.3 |
hypertension (High Blood Pressure | Improves | -3.68 |
IgA nephropathy (IgAN) | Worsen | 3.87 |
Inflammatory Bowel Disease | Improves | -1.79 |
Insomnia | Worsen | 2.76 |
Irritable Bowel Syndrome | Improves | -5.01 |
Liver Cirrhosis | Worsen | 3 |
ME/CFS with IBS | Worsen | 0.69 |
ME/CFS without IBS | Improves | -1.15 |
Metabolic Syndrome | Worsen | 2.47 |
Mood Disorders | Improves | -2.97 |
Multiple Sclerosis | Worsen | 3.78 |
Multiple system atrophy (MSA) | Improves | -3.49 |
neuropsychiatric disorders (PANDAS, PANS) | Improves | -2.82 |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -3.22 |
NonCeliac Gluten Sensitivity | Improves | -1.48 |
Obesity | Improves | -4.22 |
Osteoporosis | Improves | -4.39 |
Parkinson's Disease | Improves | -4.41 |
Psoriasis | Worsen | 1.6 |
Rheumatoid arthritis | Improves | -4.02 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -0.73 |
Rosacea | Worsen | 3.07 |
Schizophrenia | Improves | -2.56 |
Sclerosis | Improves | -3.22 |
Sjögren syndrome | Worsen | 3.84 |
Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -2.67 |
Stress / posttraumatic stress disorder | Improves | -4.55 |
Systemic Lupus Erythematosus | Worsen | 4.09 |
Type 1 Diabetes | Improves | -1.68 |
Type 2 Diabetes | Worsen | 3.74 |
Ulcerative colitis | Worsen | 4.17 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.