We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 0-10 | Worsen | 3.01 |
| Autism: Official Diagnosis | Worsen | 3.23 |
| Autonomic Manifestations: Cortisol disorders or irregularity | Improves | -1.7 |
| Blood Type: A Positive | Worsen | 1.76 |
| Blood Type: O Positive | Worsen | 3.23 |
| Comorbid-Mouth: Dry Mouth | Improves | -1.76 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 3.01 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 3.23 |
| Comorbid: High Anxiety | Worsen | 3.23 |
| Comorbid: Inflammatory bowel disease | Worsen | 1.64 |
| Comorbid: Methylation issues (MTHFR) | Worsen | 3.01 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 0.02 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 1.8 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 2.33 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 1.76 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 1.76 |
| Infection: Parasite - Other | Worsen | 3.01 |
| Joint: Tenderness | Worsen | 3.01 |
| Neurocognitive: Slowness of thought | Improves | -2.48 |
| Neurocognitive: Unable to focus vision and/or attention | Worsen | 3.01 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 1.58 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -1.64 |
| Neurological: Short-term memory issues | Improves | -1.56 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 3.23 |
| Official Diagnosis: Mast Cell Dysfunction | Worsen | 3.01 |
| Other: Sensitivity to mold | Improves | -1.76 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 3.01 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Worsen | 0 |
| ADHD | Improves | -2.72 |
| Allergies | Improves | -2.72 |
| Alzheimer's disease | Improves | -3.68 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 2.98 |
| Ankylosing spondylitis | Improves | -2.72 |
| Asthma | Improves | -3.01 |
| Atherosclerosis | Improves | -2.05 |
| Autism | Worsen | 2.99 |
| Bipolar Disorder | Improves | -3.01 |
| Brain Trauma | Improves | -3.54 |
| Celiac Disease | Improves | -1.7 |
| Cerebral Palsy | Improves | -3.01 |
| Chronic Fatigue Syndrome | Improves | -3.38 |
| Chronic Kidney Disease | Improves | -3.68 |
| Chronic Lyme | Improves | -3.01 |
| Chronic Urticaria (Hives) | Improves | -1.63 |
| Colorectal Cancer | Worsen | 1.62 |
| Coronary artery disease | Improves | -2.77 |
| COVID-19 | Improves | -1.95 |
| Crohn's Disease | Improves | -3.01 |
| Depression | Worsen | 0.79 |
| Epilepsy | Improves | -2.72 |
| Fibromyalgia | Worsen | 3.24 |
| Functional constipation / chronic idiopathic constipation | Improves | -4.26 |
| gallstone disease (gsd) | Improves | -3.01 |
| Hashimoto's thyroiditis | Worsen | 3.27 |
| High Blood Pressure | Improves | -3.17 |
| Histamine Issues From Ubiome | Improves | -2.72 |
| Hyperlipidemia (High Blood Fats) | Improves | -2.72 |
| IgA nephropathy (IgAN) | Improves | -2.72 |
| Inflammatory Bowel Disease | Improves | -3.91 |
| Insomnia | Improves | -3.01 |
| Irritable Bowel Syndrome | Improves | -4.09 |
| Liver Cirrhosis | Improves | -2.58 |
| ME/CFS with IBS | Worsen | 0 |
| ME/CFS without IBS | Worsen | 0 |
| Multiple Sclerosis | Improves | -3.68 |
| Multiple system atrophy (MSA) | Worsen | 2.72 |
| Obesity | Worsen | 3.49 |
| Osteoporosis | Worsen | 2.72 |
| Parkinson's Disease | Improves | -4.55 |
| Psoriasis | Improves | -1.82 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -4.29 |
| Rosacea | Improves | -3.54 |
| Schizophrenia | Worsen | 3.19 |
| Stress / posttraumatic stress disorder | Worsen | 2.72 |
| Systemic Lupus Erythematosus | Improves | -3.54 |
| Type 1 Diabetes | Improves | -4.14 |
| Type 2 Diabetes | Worsen | 3.26 |
| Ulcerative colitis | Worsen | 2.46 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.