We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 60-70 | Improves | -2.56 |
| Blood Type: O Positive | Improves | -2.56 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Improves | -2.56 |
| Comorbid-Mouth: Dry Mouth | Improves | -2.8 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -2.56 |
| Comorbid: Constipation and Explosions (not diarrohea) | Improves | -2.56 |
| Comorbid: High Anxiety | Improves | -2.56 |
| Comorbid: Histamine or Mast Cell issues | Improves | -2.56 |
| Comorbid: Hypothyroidism | Improves | -2.56 |
| Comorbid: Multiple Chemical Sensitivity | Improves | -3.46 |
| Comorbid: Snoring (NOT Sleep Apnea | Improves | -2.56 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 2.51 |
| DePaul University Fatigue Questionnaire : Difficulty finding the right word | Improves | -1.93 |
| DePaul University Fatigue Questionnaire : Fatigue | Improves | -1.93 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Improves | -1.93 |
| General: Fatigue | Improves | -2.9 |
| General: Headaches | Improves | -2.56 |
| Immune Manifestations: Bloating | Improves | -2.56 |
| Immune Manifestations: Inflammation (General) | Improves | -3.24 |
| Joint: Stiffness and swelling | Improves | -2.56 |
| Joint: Tenderness | Improves | -2.97 |
| Neurocognitive: Can only focus on one thing at a time | Improves | -2.56 |
| Neurocognitive: Difficulty paying attention for a long period of time | Improves | -2.56 |
| Neurocognitive: Problems remembering things | Improves | -2.56 |
| Neurocognitive: Slowness of thought | Improves | -2.56 |
| Neurocognitive: Unable to focus vision and/or attention | Improves | -2.56 |
| Neuroendocrine Manifestations: Excessive adrenaline | Improves | -2.9 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Improves | -2.9 |
| Neuroendocrine Manifestations: Muscle weakness | Improves | -3.51 |
| Neuroendocrine Manifestations: subnormal body temperature | Improves | -2.56 |
| Neuroendocrine: Alcohol intolerance | Improves | -2.56 |
| Neuroendocrine: Lack of appetite | Improves | -2.88 |
| Neuroendocrine: Lost or gained weight without trying | Improves | -3.51 |
| Neurological-Audio: hypersensitivity to noise | Improves | -2.56 |
| Neurological-Audio: Tinnitus (ringing in ear) | Improves | -2.56 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -2.56 |
| Neurological-Sleep: Insomnia | Improves | -2.56 |
| Neurological-Vision: inability to focus eye/vision | Improves | -2.56 |
| Neurological-Vision: photophobia (Light Sensitivity) | Improves | -2.56 |
| Neurological: Confusion | Worsen | 2.97 |
| Neurological: Difficulty reading | Improves | -2.56 |
| Neurological: Dysautonomia | Worsen | 2.69 |
| Neurological: Executive Decision Making (Difficulty making) | Improves | -2.56 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Improves | -2.56 |
| Official Diagnosis: Autoimmune Disease | Improves | -2.97 |
| Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.56 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -2.56 |
| Onset: 2010-2020 | Improves | -2.56 |
| Sleep: Daytime drowsiness | Improves | -2.56 |
| Sleep: Problems staying asleep | Improves | -2.56 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Allergic Rhinitis (Hay Fever) | Improves | -2.9 |
| Allergies | Improves | -0.87 |
| Alzheimer's disease | Worsen | 5.02 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -2.56 |
| Ankylosing spondylitis | Improves | -1.82 |
| Asthma | Improves | -4.26 |
| Atherosclerosis | Worsen | 1.87 |
| Autism | Improves | -3.93 |
| Barrett esophagus cancer | Improves | -2.88 |
| Celiac Disease | Improves | -4.17 |
| Cerebral Palsy | Worsen | 0.06 |
| Chronic Fatigue Syndrome | Improves | -3.99 |
| Chronic Kidney Disease | Worsen | 2.59 |
| Chronic Urticaria (Hives) | Improves | -2.9 |
| Colorectal Cancer | Improves | -4.07 |
| Crohn's Disease | Improves | -2.9 |
| Depression | Improves | -3.55 |
| Eczema | Improves | -2.95 |
| Epilepsy | Improves | -1.85 |
| Fibromyalgia | Worsen | 3.56 |
| Functional constipation / chronic idiopathic constipation | Worsen | 2.59 |
| gallstone disease (gsd) | Improves | -2.9 |
| Graves' disease | Improves | -2.88 |
| High Blood Pressure | Improves | -1.16 |
| Hyperlipidemia (High Blood Fats) | Worsen | 3.51 |
| IgA nephropathy (IgAN) | Worsen | 2.9 |
| Inflammatory Bowel Disease | Worsen | 3.96 |
| Juvenile idiopathic arthritis | Improves | -2.69 |
| Liver Cirrhosis | Worsen | 3.27 |
| ME/CFS with IBS | Improves | -2.9 |
| ME/CFS without IBS | Improves | -3.99 |
| Metabolic Syndrome | Improves | -2.9 |
| Multiple Sclerosis | Worsen | 4.63 |
| Multiple system atrophy (MSA) | Improves | -0.13 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Worsen | 3.37 |
| Obesity | Improves | -4.48 |
| Osteoarthritis | Improves | -2.9 |
| Osteoporosis | Improves | -2.9 |
| Parkinson's Disease | Worsen | 5.41 |
| Psoriasis | Worsen | 4.09 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 3.78 |
| Rosacea | Worsen | 3.26 |
| Schizophrenia | Improves | -1.57 |
| Stress / posttraumatic stress disorder | Improves | -3.74 |
| Systemic Lupus Erythematosus | Improves | -3.91 |
| Type 1 Diabetes | Improves | -3.21 |
| Type 2 Diabetes | Worsen | 1.01 |
| Ulcerative colitis | Improves | -3.42 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.