We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 2.51 |
| DePaul University Fatigue Questionnaire : Difficulty finding the right word | Improves | -1.93 |
| DePaul University Fatigue Questionnaire : Fatigue | Improves | -1.93 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Improves | -1.93 |
| Immune Manifestations: Inflammation (General) | Improves | -3.24 |
| Joint: Tenderness | Improves | -2.97 |
| Neuroendocrine Manifestations: Excessive adrenaline | Improves | -2.9 |
| Neurological: Confusion | Worsen | 2.97 |
| Official Diagnosis: Autoimmune Disease | Improves | -2.97 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Allergic Rhinitis (Hay Fever) | Improves | -2.9 |
| Allergies | Improves | -0.87 |
| Alzheimer's disease | Worsen | 4.3 |
| Ankylosing spondylitis | Worsen | 3.63 |
| Asthma | Improves | -3.99 |
| Atherosclerosis | Worsen | 2.81 |
| Autism | Improves | -3.93 |
| Cerebral Palsy | Improves | -2.9 |
| Chronic Fatigue Syndrome | Improves | -3.99 |
| Chronic Urticaria (Hives) | Improves | -2.9 |
| Colorectal Cancer | Improves | -3.72 |
| Crohn's Disease | Improves | -2.9 |
| Depression | Improves | -2.9 |
| Eczema | Improves | -0.87 |
| Fibromyalgia | Worsen | 3.56 |
| gallstone disease (gsd) | Improves | -2.9 |
| High Blood Pressure | Improves | -1.16 |
| IgA nephropathy (IgAN) | Worsen | 2.9 |
| Inflammatory Bowel Disease | Worsen | 3.96 |
| Liver Cirrhosis | Worsen | 3.4 |
| ME/CFS with IBS | Improves | -2.9 |
| ME/CFS without IBS | Improves | -3.99 |
| Multiple Sclerosis | Worsen | 4.29 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -2.9 |
| Obesity | Improves | -2.89 |
| Osteoarthritis | Improves | -2.9 |
| Osteoporosis | Improves | -2.9 |
| Parkinson's Disease | Worsen | 1.66 |
| Psoriasis | Improves | -2.9 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 3.48 |
| Rosacea | Worsen | 2.51 |
| Schizophrenia | Worsen | 2.63 |
| Stress / posttraumatic stress disorder | Improves | -2.9 |
| Systemic Lupus Erythematosus | Improves | -3.11 |
| Type 1 Diabetes | Worsen | 2.9 |
| Type 2 Diabetes | Worsen | 3.97 |
| Ulcerative colitis | Worsen | 2.9 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.