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Digestive Health: Both Bacillus subtilis and Lactobacillus acidophilus are known to support digestive health by promoting a healthy balance of gut bacteria, aiding in the breakdown and absorption of nutrients, and supporting regular bowel movements. They can help alleviate symptoms of gastrointestinal disorders such as diarrhea, constipation, and irritable bowel syndrome (IBS).
Immune Support: Bacillus subtilis and Lactobacillus acidophilus have immune-modulating properties that can enhance the body's natural defense mechanisms. They stimulate the production of antibodies, activate immune cells, and promote the integrity of the gut mucosal barrier, which plays a crucial role in immune function. Regular consumption of these probiotics may help reduce the risk of infections and support overall immune health.
Anti-inflammatory Effects: Both probiotics have been shown to have anti-inflammatory effects by modulating the activity of immune cells and reducing the production of inflammatory cytokines. This can help alleviate inflammation associated with chronic conditions such as inflammatory bowel disease (IBD), arthritis, and allergies.
Vaginal Health: Lactobacillus acidophilus is a predominant species in the vaginal microbiota and plays a crucial role in maintaining a healthy vaginal environment. It helps prevent the overgrowth of harmful bacteria and yeast, thus reducing the risk of vaginal infections such as bacterial vaginosis and yeast infections. The combination of Bacillus subtilis and Lactobacillus acidophilus may support vaginal health by promoting a balanced vaginal microbiome.
Cholesterol Management: Some studies suggest that certain strains of Lactobacillus acidophilus may help lower LDL (bad) cholesterol levels by inhibiting the absorption of dietary cholesterol in the intestines and promoting its excretion. Bacillus subtilis may also contribute to cholesterol reduction through its effects on bile acid metabolism. As a result, the combination of these probiotics may have a beneficial impact on cholesterol levels and cardiovascular health.
Antimicrobial Activity: Both Bacillus subtilis and Lactobacillus acidophilus produce antimicrobial compounds such as bacteriocins and organic acids that inhibit the growth of pathogenic bacteria and fungi in the gut. This antimicrobial activity helps maintain a healthy microbial balance and prevent the colonization of harmful microorganisms, thereby reducing the risk of gastrointestinal infections.
Allergy Management: Probiotics like Lactobacillus acidophilus have been studied for their potential role in managing allergies and allergic conditions such as eczema and allergic rhinitis. They modulate the immune response and promote immune tolerance, which may help reduce the severity of allergic reactions and improve symptoms in susceptible individuals.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Clostridium butyricum | Increases |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Allergic Rhinitis (Hay Fever) | 0.6 | 0.3 | 1 |
| Allergies | 0.3 | 0.3 | |
| Allergy to milk products | 0.3 | -0.3 | |
| Alzheimer's disease | 0.3 | 0.3 | |
| Ankylosing spondylitis | 0.6 | -0.6 | |
| Anorexia Nervosa | 0.3 | 0.6 | -1 |
| Antiphospholipid syndrome (APS) | 0.2 | -0.2 | |
| Asthma | 0.3 | -0.3 | |
| Atherosclerosis | 0.3 | 0.3 | |
| Autism | 0.3 | 0.9 | -2 |
| Barrett esophagus cancer | 1.2 | 1.2 | |
| Celiac Disease | 0.6 | 0.3 | 1 |
| Cerebral Palsy | 0.3 | -0.3 | |
| Chronic Fatigue Syndrome | 0.6 | 0.9 | -0.5 |
| Chronic Urticaria (Hives) | 0.3 | -0.3 | |
| COVID-19 | 0.6 | 1.1 | -0.83 |
| Crohn's Disease | 0.9 | -0.9 | |
| Depression | 0.9 | 0.9 | 0 |
| Eczema | 0.3 | 0.3 | |
| Eosinophilic Esophagitis | 0.6 | 0.6 | |
| Epilepsy | 0.6 | -0.6 | |
| Fibromyalgia | 0.3 | 0.3 | 0 |
| Functional constipation / chronic idiopathic constipation | 0.3 | 0.3 | 0 |
| gallstone disease (gsd) | 0.3 | -0.3 | |
| Generalized anxiety disorder | 0.3 | 0.3 | |
| giant cell arteritis | 0.3 | 0.3 | |
| Graves' disease | 0.9 | 0.9 | |
| Halitosis | 0.6 | -0.6 | |
| hypercholesterolemia (High Cholesterol) | 0.3 | -0.3 | |
| IgA nephropathy (IgAN) | 0.3 | 0.3 | |
| Inflammatory Bowel Disease | 0.9 | 0.8 | 0.13 |
| Intelligence | 0.3 | -0.3 | |
| Irritable Bowel Syndrome | 0.3 | -0.3 | |
| Liver Cirrhosis | 0.9 | 0.9 | 0 |
| Long COVID | 1.4 | -1.4 | |
| ME/CFS with IBS | 0.3 | -0.3 | |
| ME/CFS without IBS | 0.3 | -0.3 | |
| Metabolic Syndrome | 0.9 | 0.3 | 2 |
| Mood Disorders | 0.9 | 1.2 | -0.33 |
| multiple chemical sensitivity [MCS] | 0.6 | -0.6 | |
| Multiple Sclerosis | 0.3 | 0.3 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.3 | 0.3 | 0 |
| Obesity | 0.2 | 0.3 | -0.5 |
| obsessive-compulsive disorder | 0.6 | 0.6 | |
| Osteoarthritis | 0.3 | -0.3 | |
| Osteoporosis | 0.9 | -0.9 | |
| Parkinson's Disease | 0.2 | -0.2 | |
| Polycystic ovary syndrome | 0.3 | 0.3 | 0 |
| Postural orthostatic tachycardia syndrome | 0.3 | -0.3 | |
| Psoriasis | 0.3 | -0.3 | |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 0.3 | 0.8 | -1.67 |
| Rosacea | 0.3 | 0.3 | |
| Schizophrenia | 0.3 | 1.2 | -3 |
| Stress / posttraumatic stress disorder | 0.3 | -0.3 | |
| Systemic Lupus Erythematosus | 0.2 | -0.2 | |
| Type 1 Diabetes | 0.3 | 0.3 | |
| Type 2 Diabetes | 0.9 | 0.9 | |
| Ulcerative colitis | 0.9 | 0.9 | 0 |
| Unhealthy Ageing | 0.6 | -0.6 |
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