We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 0-10 | Improves | -3.94 |
| Age: 20-30 | Improves | -2.65 |
| Age: 50-60 | Worsen | 2.68 |
| Age: 60-70 | Worsen | 2.33 |
| Asymptomatic: Minor Health Issues (a few symptoms only) | Worsen | 2.82 |
| Asymptomatic: No Health Issues | Improves | -3.17 |
| Autism: Official Diagnosis | Improves | -3 |
| Autonomic Manifestations: cardiac arrhythmias | Improves | -0.15 |
| Autonomic Manifestations: Cortisol disorders or irregularity | Worsen | 3.57 |
| Autonomic Manifestations: Orthostatic intolerance | Improves | -2.15 |
| Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS) | Worsen | 3.34 |
| Autonomic: Blurred or tunnel vision after standing | Improves | -2.83 |
| Autonomic: Heart rate increase after standing | Worsen | 3.05 |
| Autonomic: Inability to tolerate an upright position | Improves | -3.73 |
| Autonomic: Irregular heartbeats | Worsen | 2.95 |
| Autonomic: Shortness of breath | Improves | -1.14 |
| Blood Type: A Positive | Worsen | 2.1 |
| Blood Type: O Positive | Improves | -3.84 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Worsen | 2.91 |
| Comorbid-Mouth: Mouth Sores | Worsen | 2.73 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 3.78 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 3.18 |
| Comorbid: Fibromyalgia | Improves | -2.82 |
| Comorbid: High Anxiety | Worsen | 2.08 |
| Comorbid: Histamine or Mast Cell issues | Worsen | 1.93 |
| Comorbid: Hypothyroidism | Improves | -2.39 |
| Comorbid: Inflammatory bowel disease | Worsen | 1.99 |
| Comorbid: Methylation issues (MTHFR) | Worsen | 3.01 |
| Comorbid: Migraine | Improves | -1.53 |
| Comorbid: Multiple Chemical Sensitivity | Improves | -2.83 |
| Comorbid: Snoring (NOT Sleep Apnea | Improves | -2.09 |
| Condition: ME/CFS with IBS | Worsen | 3.56 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 3.63 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 4.15 |
| DePaul University Fatigue Questionnaire : Depression | Worsen | 2.95 |
| DePaul University Fatigue Questionnaire : Difficulty staying asleep | Worsen | 1.86 |
| DePaul University Fatigue Questionnaire : Fatigue | Improves | -3.99 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 3.73 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Improves | -3.51 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 1.54 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 3.49 |
| General: Headaches | Worsen | 1.62 |
| General: Myalgia (pain) | Worsen | 2.61 |
| General: Sinus issues with headaches | Worsen | 3.09 |
| Immune Manifestations: Abdominal Pain | Improves | -3.34 |
| Immune Manifestations: Alcohol Intolerant | Improves | -2.56 |
| Immune Manifestations: Constipation | Improves | -2.83 |
| Immune Manifestations: Inflammation (General) | Improves | -3.73 |
| Immune Manifestations: medication sensitivities. | Worsen | 3.05 |
| Immune Manifestations: Mucus in the stool | Improves | -3.34 |
| Immune Manifestations: new food sensitivities | Worsen | 2.51 |
| Immune: Recurrent Sore throat | Improves | -0.64 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 2.15 |
| Infection: Mycoplasma | Improves | -2.38 |
| Infection: Parasite - Other | Worsen | 3.81 |
| Joint: Redness | Improves | -2.82 |
| Joint: Stiffness and swelling | Worsen | 3.12 |
| Joint: Tenderness | Improves | -3.38 |
| Neurocognitive: Brain Fog | Worsen | 2.95 |
| Neurocognitive: Can only focus on one thing at a time | Improves | -2.83 |
| Neurocognitive: Difficulty paying attention for a long period of time | Improves | -2.83 |
| Neurocognitive: Problems remembering things | Improves | -2.83 |
| Neurocognitive: Unable to focus vision and/or attention | Worsen | 3.63 |
| Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Worsen | 2.48 |
| Neuroendocrine Manifestations: Excessive adrenaline | Worsen | 2.1 |
| Neuroendocrine Manifestations: loss of adaptability | Improves | -2.84 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Improves | -3.87 |
| Neuroendocrine Manifestations: Rapid muscular fatiguability | Worsen | 2.73 |
| Neuroendocrine Manifestations: subnormal body temperature | Improves | -2.83 |
| Neuroendocrine Manifestations: sweating episodes | Improves | -2.96 |
| Neuroendocrine: Alcohol intolerance | Worsen | 1.93 |
| Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Improves | -2.65 |
| Neuroendocrine: Feeling hot or cold for no reason | Worsen | 2.72 |
| Neurological-Audio: hypersensitivity to noise | Improves | -2.83 |
| Neurological-Audio: Tinnitus (ringing in ear) | Improves | -2.83 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Worsen | 2.79 |
| Neurological-Sleep: Insomnia | Improves | -2.51 |
| Neurological-Sleep: Night Sweats | Worsen | 2.73 |
| Neurological-Sleep: Sleep Apnea | Worsen | 3.4 |
| Neurological-Vision: Blurred Vision | Improves | -1.86 |
| Neurological-Vision: inability to focus eye/vision | Worsen | 0.9 |
| Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 2.78 |
| Neurological: Cognitive/Sensory Overload | Worsen | 2.73 |
| Neurological: Confusion | Worsen | 2.97 |
| Neurological: Difficulty processing information (Understanding) | Worsen | 3.05 |
| Neurological: Difficulty reading | Worsen | 2.91 |
| Neurological: emotional overload | Worsen | 2.73 |
| Neurological: fasciculations | Improves | -1.1 |
| Neurological: Impairment of concentration | Worsen | 2.58 |
| Neurological: Joint hypermobility | Improves | -4.54 |
| Neurological: Seasonal Affective Disorder (SAD) | Worsen | 1.36 |
| Neurological: Short-term memory issues | Worsen | 3.38 |
| Neurological: Slowed speech | Worsen | 2.88 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 3.08 |
| Official Diagnosis: Autoimmune Disease | Improves | -2.81 |
| Official Diagnosis: Chronic Fatigue Syndrome | Improves | -2.65 |
| Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.51 |
| Official Diagnosis: Mast Cell Dysfunction | Worsen | 3.75 |
| Onset: 2010-2020 | Improves | -2.83 |
| Other: Sensitivity to vibrations | Improves | -2.65 |
| Pain: Aching of the eyes or behind the eyes | Worsen | 2.73 |
| Pain: Joint pain | Worsen | 1.56 |
| Pain: Myofascial pain | Worsen | 0.74 |
| Pain: Sensitivity to pain | Improves | -2.33 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 2.79 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.24 |
| Sleep: Problems staying asleep | Worsen | 1.7 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 1.7 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -4.83 |
| ADHD | Worsen | 2.88 |
| Allergic Rhinitis (Hay Fever) | Improves | -3.26 |
| Allergies | Improves | -3.86 |
| Alzheimer's disease | Worsen | 4.54 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -3.85 |
| Ankylosing spondylitis | Worsen | 5.09 |
| Asthma | Improves | -4.41 |
| Atherosclerosis | Worsen | 5.19 |
| Autism | Improves | -4.87 |
| Barrett esophagus cancer | Improves | -2.83 |
| Bipolar Disorder | Worsen | 2.55 |
| Brain Trauma | Improves | -2.85 |
| Carcinoma | Worsen | 0 |
| Celiac Disease | Improves | -4.82 |
| Cerebral Palsy | Improves | -3.9 |
| Chronic Fatigue Syndrome | Improves | -4.61 |
| Chronic Kidney Disease | Improves | -4.04 |
| Chronic Lyme | Improves | -3.01 |
| Chronic Urticaria (Hives) | Worsen | 2.5 |
| Colorectal Cancer | Improves | -5.78 |
| Coronary artery disease | Worsen | 0.21 |
| COVID-19 | Worsen | 2.93 |
| Crohn's Disease | Improves | -4.88 |
| cystic fibrosis | Worsen | 2.99 |
| Depression | Worsen | 3.08 |
| Epilepsy | Improves | -4.41 |
| Fibromyalgia | Worsen | 3.25 |
| Functional constipation / chronic idiopathic constipation | Worsen | 3 |
| gallstone disease (gsd) | Improves | -3.98 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -3.95 |
| Generalized anxiety disorder | Improves | -3.98 |
| Hashimoto's thyroiditis | Improves | -3.46 |
| High Blood Pressure | Improves | -1.44 |
| Histamine Issues | Improves | -2.92 |
| Histamine Issues From Ubiome | Improves | -2.42 |
| hypercholesterolemia (High Cholesterol) | Improves | -2.31 |
| Hyperlipidemia (High Blood Fats) | Worsen | 2.12 |
| hypertension (High Blood Pressure | Worsen | 3.71 |
| IgA nephropathy (IgAN) | Worsen | 4.3 |
| Inflammatory Bowel Disease | Improves | -4.65 |
| Insomnia | Worsen | 2.92 |
| Irritable Bowel Syndrome | Improves | -3.76 |
| Juvenile idiopathic arthritis | Worsen | 2.99 |
| Liver Cirrhosis | Worsen | 4.35 |
| ME/CFS with IBS | Improves | -3.15 |
| ME/CFS without IBS | Improves | -3.97 |
| Metabolic Syndrome | Improves | -3.31 |
| Multiple Sclerosis | Worsen | 5.18 |
| Multiple system atrophy (MSA) | Worsen | 2.99 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -4.99 |
| NonCeliac Gluten Sensitivity | Improves | -2.88 |
| Obesity | Improves | -2.42 |
| Osteoarthritis | Improves | -2.9 |
| Osteoporosis | Improves | -1.38 |
| Parkinson's Disease | Worsen | 2.22 |
| Psoriasis | Worsen | 3.14 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 3.67 |
| Rosacea | Worsen | 4.23 |
| Schizophrenia | Worsen | 4.67 |
| Sjögren syndrome | Improves | -4.22 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -2.54 |
| Stress / posttraumatic stress disorder | Improves | -4.6 |
| Systemic Lupus Erythematosus | Improves | -5.3 |
| Type 1 Diabetes | Improves | -3.07 |
| Type 2 Diabetes | Worsen | 3.15 |
| Ulcerative colitis | Worsen | 3.04 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.