We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Improves | -3.38 |
| Age: 50-60 | Worsen | 1.6 |
| Age: 60-70 | Improves | -1.46 |
| Asymptomatic: No Health Issues | Worsen | 2.26 |
| Autism: Official Diagnosis | Worsen | 3.34 |
| Autonomic Manifestations: cardiac arrhythmias | Improves | -3.94 |
| Autonomic Manifestations: irritable bowel syndrome | Improves | -2.99 |
| Autonomic Manifestations: light-headedness | Improves | -2.18 |
| Autonomic Manifestations: Orthostatic intolerance | Worsen | 3.04 |
| Autonomic Manifestations: palpitations | Improves | -2.32 |
| Autonomic Manifestations: urinary frequency dysfunction | Improves | -2.44 |
| Autonomic: Dizziness or fainting | Improves | -1.75 |
| Autonomic: Heart rate increase after standing | Improves | -2.08 |
| Autonomic: Inability to tolerate an upright position | Improves | -1.9 |
| Autonomic: Ocassional Tachycardia (Rapid heart beat) | Improves | -2.34 |
| Blood Type: A Positive | Worsen | 2.29 |
| Blood Type: O Positive | Improves | -1.04 |
| Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding | Improves | -1.67 |
| Comorbid-Mouth: Dry Mouth | Worsen | 3.08 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Improves | -2.31 |
| Comorbid: Constipation and Explosions (not diarrohea) | Improves | -3.49 |
| Comorbid: Fibromyalgia | Worsen | 1.71 |
| Comorbid: High Anxiety | Worsen | 2.68 |
| Comorbid: Histamine or Mast Cell issues | Worsen | 1.9 |
| Comorbid: Hypothyroidism | Improves | -3.57 |
| Comorbid: Inflammatory bowel disease | Worsen | 2.48 |
| Comorbid: Methylation issues (MTHFR) | Worsen | 2.72 |
| Comorbid: Multiple Chemical Sensitivity | Improves | -2.32 |
| Comorbid: Restless Leg | Worsen | 2.89 |
| Comorbid: Snoring (NOT Sleep Apnea | Improves | -3.47 |
| Condition: ME/CFS with IBS | Worsen | 2.8 |
| DePaul University Fatigue Questionnaire : Allergies | Worsen | 3.02 |
| DePaul University Fatigue Questionnaire : Anxiety/tension | Worsen | 3.55 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 2.91 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Worsen | 3.17 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 1.75 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 3.07 |
| DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) | Worsen | 3.24 |
| General: Fatigue | Improves | -2.87 |
| General: Headaches | Improves | -1.67 |
| General: Myalgia (pain) | Worsen | 2.02 |
| General: Sinus issues with headaches | Worsen | 2.46 |
| Immune Manifestations: Abdominal Pain | Worsen | 1.88 |
| Immune Manifestations: Alcohol Intolerant | Improves | -1.67 |
| Immune Manifestations: Bloating | Improves | -2.99 |
| Immune Manifestations: Constipation | Improves | -3.09 |
| Immune Manifestations: Diarrhea | Worsen | 2.14 |
| Immune Manifestations: general malaise | Improves | -3.6 |
| Immune Manifestations: Inflammation (General) | Worsen | 2.26 |
| Immune Manifestations: Inflammation of skin, eyes or joints | Improves | -1.9 |
| Immune Manifestations: Mucus in the stool | Improves | -3.2 |
| Immune Manifestations: new food sensitivities | Worsen | 3.03 |
| Immune: Viral infections with prolonged recovery periods | Worsen | 2.67 |
| Infection: Epstein-Barr virus | Worsen | 2.44 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 1.81 |
| Infection: Mycoplasma | Improves | -1.9 |
| Infection: Parasite - Other | Improves | -2.99 |
| Joint: Stiffness and swelling | Improves | -1.46 |
| Joint: Sudden and severe episodes of pain | Worsen | 2.72 |
| Neurocognitive: Absent-mindedness or forgetfulness | Improves | -2.39 |
| Neurocognitive: Brain Fog | Worsen | 2.72 |
| Neurocognitive: Can only focus on one thing at a time | Improves | -2.39 |
| Neurocognitive: Difficulty expressing thoughts | Improves | -1.19 |
| Neurocognitive: Difficulty paying attention for a long period of time | Worsen | 1.88 |
| Neurocognitive: Slowness of thought | Improves | -2.39 |
| Neurocognitive: Unable to focus vision and/or attention | Improves | -1.49 |
| Neuroendocrine Manifestations: Air Hunger | Improves | -2.91 |
| Neuroendocrine Manifestations: cold extremities | Improves | -3.24 |
| Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Improves | -2.89 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 2.89 |
| Neuroendocrine Manifestations: subnormal body temperature | Improves | -2.66 |
| Neuroendocrine Manifestations: sweating episodes | Worsen | 3.16 |
| Neuroendocrine Manifestations: worsening of symptoms with stress. | Improves | -2.39 |
| Neuroendocrine: Alcohol intolerance | Improves | -1.46 |
| Neuroendocrine: Chills or shivers | Worsen | 2.71 |
| Neuroendocrine: Cold limbs (e.g. arms, legs hands) | Improves | -3.7 |
| Neuroendocrine: Feeling hot or cold for no reason | Worsen | 2.71 |
| Neuroendocrine: Feeling like you have a high temperature | Worsen | 3.61 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 0.37 |
| Neuroendocrine: Lack of appetite | Improves | -2.73 |
| Neuroendocrine: Lost or gained weight without trying | Worsen | 1.92 |
| Neuroendocrine: Sweating hands | Improves | -3.48 |
| Neurological-Audio: hypersensitivity to noise | Improves | -3.32 |
| Neurological-Audio: Tinnitus (ringing in ear) | Worsen | 2.32 |
| Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) | Improves | -3.03 |
| Neurological-Sleep: Insomnia | Improves | -2.81 |
| Neurological-Sleep: Night Sweats | Improves | -2.3 |
| Neurological-Vision: inability to focus eye/vision | Improves | -3.44 |
| Neurological-Vision: photophobia (Light Sensitivity) | Worsen | 1.88 |
| Neurological: Cognitive/Sensory Overload | Improves | -3.19 |
| Neurological: Difficulty processing information (Understanding) | Improves | -2.83 |
| Neurological: Difficulty reading | Improves | -3.4 |
| Neurological: emotional overload | Improves | -3.7 |
| Neurological: Executive Decision Making (Difficulty making) | Improves | -2.3 |
| Neurological: fasciculations | Improves | -3.45 |
| Neurological: High degree of Empathy before onset | Improves | -2.74 |
| Neurological: Impairment of concentration | Improves | -2.99 |
| Neurological: Joint hypermobility | Improves | -2.63 |
| Neurological: Short-term memory issues | Improves | -3.98 |
| Neurological: Spatial instability and disorientation | Improves | -2.74 |
| Neurological: Word-finding problems | Worsen | 3.04 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 2.76 |
| Official Diagnosis: Autoimmune Disease | Worsen | 2.81 |
| Official Diagnosis: Chronic Fatigue Syndrome | Improves | -2.76 |
| Official Diagnosis: Irritable Bowel Syndrome | Improves | -2.81 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -1.67 |
| Onset: 2010-2020 | Improves | -3.09 |
| Onset: Gradual | Improves | -3.53 |
| Onset: less than 02 years since onset | Improves | -2.74 |
| Other: Sensitivity to mold | Improves | -2.29 |
| Other: Sensitivity to vibrations | Improves | -1.89 |
| Pain: Aching of the eyes or behind the eyes | Improves | -2.91 |
| Pain: Chest pain | Worsen | 2.96 |
| Pain: Joint pain | Worsen | 1.51 |
| Pain: Myofascial pain | Improves | -2.4 |
| Pain: Pain or aching in muscles | Worsen | 2.71 |
| Pain: Sensitivity to pain | Worsen | 3.37 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Improves | -3.32 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 1.23 |
| Post-exertional malaise: Rapid cognitive fatigability, | Improves | -3.88 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Improves | -2.74 |
| Post-exertional malaise: Worsening of symptoms after mild physical activity | Improves | -1.68 |
| Sleep: Daytime drowsiness | Improves | -3.6 |
| Sleep: Problems staying asleep | Worsen | 2.38 |
| Sleep: Waking up early in the morning (e.g. 3 AM) | Worsen | 0.13 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Cerebral Palsy | Worsen | 3.99 |
| Acne | Improves | -2.95 |
| ADHD | Worsen | 4.18 |
| Allergies | Improves | -3.39 |
| Alzheimer's disease | Worsen | 0.19 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -2.78 |
| Ankylosing spondylitis | Improves | -2.86 |
| Asthma | Improves | -3.16 |
| Atherosclerosis | Worsen | 5.79 |
| Autism | Improves | -4.36 |
| Barrett esophagus cancer | Improves | -3.96 |
| Brain Trauma | Worsen | 4.3 |
| Carcinoma | Worsen | 4.08 |
| Celiac Disease | Worsen | 2.66 |
| Chronic Fatigue Syndrome | Improves | -4.33 |
| Chronic Kidney Disease | Worsen | 2.87 |
| Chronic urticaria (Hives) | Worsen | 3.59 |
| Colorectal Cancer | Worsen | 4.25 |
| Coronary artery disease | Improves | -2.91 |
| Crohn's Disease | Worsen | 3.14 |
| Depression | Worsen | 4.72 |
| Epilepsy | Improves | -3.37 |
| Fibromyalgia | Improves | -3.22 |
| Functional constipation / chronic idiopathic constipation | Worsen | 2.96 |
| gallstone disease (gsd) | Improves | -1.98 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Improves | -3.24 |
| Generalized anxiety disorder | Worsen | 2.65 |
| Gout | Worsen | 3.74 |
| Graves' disease | Worsen | 1.82 |
| Hashimoto's thyroiditis | Improves | -3.34 |
| High Blood Pressure | Improves | -3.58 |
| Histamine Issues | Worsen | 3.9 |
| Histamine Issues From Ubiome | Improves | -3.36 |
| hypercholesterolemia (High Cholesterol) | Improves | -3.52 |
| Hyperlipidemia (High Blood Fats) | Improves | -3.42 |
| hypertension (High Blood Pressure | Improves | -3.09 |
| IgA nephropathy (IgAN) | Improves | -2.14 |
| Inflammatory Bowel Disease | Worsen | 4.42 |
| Irritable Bowel Syndrome | Worsen | 3.27 |
| Liver Cirrhosis | Worsen | 6.16 |
| ME/CFS with IBS | Worsen | 3.65 |
| ME/CFS without IBS | Improves | -1.2 |
| Mood Disorders | Worsen | 2.74 |
| Multiple Sclerosis | Improves | -3.86 |
| Multiple system atrophy (MSA) | Worsen | 3.54 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -3.37 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Worsen | 1.27 |
| NonCeliac Gluten Sensitivity | Worsen | 1.98 |
| Obesity | Worsen | 5.15 |
| Osteoporosis | Improves | -2.18 |
| Parkinson's Disease | Worsen | 3.71 |
| Psoriasis | Worsen | 2.73 |
| Rheumatoid arthritis | Improves | -1.84 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 3.33 |
| Rosacea | Improves | -4.04 |
| Schizophrenia | Worsen | 2.82 |
| Sclerosis | Worsen | 3.4 |
| Sjögren syndrome | Worsen | 4.04 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Worsen | 3.4 |
| Stress / posttraumatic stress disorder | Worsen | 4.5 |
| Systemic Lupus Erythematosus | Improves | -3.37 |
| Type 1 Diabetes | Improves | -3.69 |
| Type 2 Diabetes | Worsen | 4.74 |
| Ulcerative colitis | Improves | -4.67 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.