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Hypercholesterolemia (High Cholesterol): Statins are most commonly prescribed to reduce elevated levels of low-density lipoprotein (LDL) cholesterol, often referred to as "bad" cholesterol. By lowering LDL cholesterol levels, statins help reduce the risk of cardiovascular diseases such as heart attack and stroke.
Atherosclerosis: Atherosclerosis is the buildup of plaque in the arteries, which can lead to narrowing and hardening of the arteries, increasing the risk of heart disease and stroke. Statins help slow down the progression of atherosclerosis by lowering LDL cholesterol levels and reducing inflammation in the arteries.
Coronary Artery Disease (CAD): CAD occurs when the arteries that supply blood to the heart become narrowed or blocked due to atherosclerosis. Statins are used as part of the treatment plan for CAD to lower cholesterol levels and reduce the risk of heart-related events such as heart attack and angina (chest pain).
Stroke Prevention: Statins have been shown to reduce the risk of stroke, particularly ischemic stroke, which occurs when a blood clot blocks a blood vessel in the brain. By lowering LDL cholesterol levels and stabilizing plaques in the arteries, statins help prevent the formation of blood clots that can lead to stroke.
Peripheral Arterial Disease (PAD): PAD occurs when plaque buildup narrows the arteries in the legs and other parts of the body, reducing blood flow to the extremities. Statins are used to manage PAD by lowering cholesterol levels and improving blood flow to the affected areas, thereby reducing symptoms such as leg pain and cramping.
Diabetes: Statins may benefit individuals with diabetes by not only lowering LDL cholesterol levels but also by reducing inflammation and improving endothelial function, which is important for maintaining healthy blood vessels. People with diabetes are at a higher risk of cardiovascular complications, and statins can help reduce this risk.
Heart Failure: Some studies suggest that statins may have benefits for individuals with heart failure by reducing inflammation, improving endothelial function, and lowering the risk of cardiovascular events. However, the use of statins in heart failure management remains an area of ongoing research and debate.
Other Conditions: Statins have also been studied for their potential benefits in other medical conditions, such as Alzheimer's disease, multiple sclerosis, and certain types of cancer. However, more research is needed to fully understand the role of statins in these conditions.
| Rank | Probiotic | Impact |
|---|
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Allergies | 0.5 | 0.5 | |
| Anorexia Nervosa | 0.5 | 0.5 | |
| Antiphospholipid syndrome (APS) | 0.6 | 0.6 | |
| Autism | 0.6 | -0.6 | |
| Bipolar Disorder | 0.6 | -0.6 | |
| Carcinoma | 0.5 | 0.5 | 0 |
| Celiac Disease | 0.6 | 0.5 | 0.2 |
| Crohn's Disease | 0.7 | 0.5 | 0.4 |
| Depression | 0.6 | -0.6 | |
| Functional constipation / chronic idiopathic constipation | 1.1 | 0.6 | 0.83 |
| Histamine Issues,Mast Cell Issue, DAO Insufficiency | 0.6 | 0.6 | |
| hypercholesterolemia (High Cholesterol) | 0.2 | 0.2 | |
| hypertension (High Blood Pressure | 0.6 | 0.6 | |
| Hypoxia | 0.6 | -0.6 | |
| IgA nephropathy (IgAN) | 0.2 | 0.2 | |
| Inflammatory Bowel Disease | 0.5 | -0.5 | |
| Irritable Bowel Syndrome | 1.1 | 0.5 | 1.2 |
| Liver Cirrhosis | 1.1 | 1.1 | |
| Long COVID | 0.6 | 0.6 | |
| Metabolic Syndrome | 1.6 | 1.3 | 0.23 |
| Mood Disorders | 0.5 | 0.6 | -0.2 |
| Multiple Sclerosis | 2.3 | 0.6 | 2.83 |
| Neuropathy (all types) | 0.6 | 0.6 | |
| Obesity | 1 | 1 | 0 |
| obsessive-compulsive disorder | 0.5 | -0.5 | |
| Parkinson's Disease | 0.5 | 0.6 | -0.2 |
| Psoriasis | 0.5 | 0.5 | |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 0.5 | 0.6 | -0.2 |
| Schizophrenia | 0.5 | 0.5 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1 | 1 | |
| Stress / posttraumatic stress disorder | 0.5 | 0.5 | |
| Type 2 Diabetes | 1 | 1.3 | -0.3 |
| Ulcerative colitis | 1.1 | 0.7 | 0.57 |
| Unhealthy Ageing | 0.6 | 0.6 |
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