vsl#3 (probiotics) ** full range

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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
Age: 60-70	Improves	-1.7
Autonomic Manifestations: cardiac arrhythmias	Improves	-3.5
Autonomic Manifestations: irritable bowel syndrome	Worsen	1.58
Autonomic Manifestations: Orthostatic intolerance	Improves	-1.5
Autonomic: Inability to tolerate an upright position	Improves	-1.5
Blood Type: A Positive	Worsen	1.86
Blood Type: O Positive	Worsen	1.86
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding	Worsen	2.84
Comorbid-Mouth: Mouth Sores	Improves	-2.48
Comorbid: Histamine or Mast Cell issues	Improves	-1.7
Comorbid: Inflammatory bowel disease	Worsen	1.86
Comorbid: Migraine	Worsen	1.86
DePaul University Fatigue Questionnaire : Allergies	Worsen	2.8
DePaul University Fatigue Questionnaire : Anxiety/tension	Worsen	2.8
DePaul University Fatigue Questionnaire : Fatigue	Worsen	3.09
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say	Worsen	2.8
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired	Worsen	1.86
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM)	Worsen	2.8
General: Fatigue	Worsen	1.58
General: Headaches	Improves	-1.62
Immune Manifestations: Abdominal Pain	Improves	-2.48
Immune Manifestations: Mucus in the stool	Improves	-1.5
Joint: Stiffness and swelling	Improves	-1.7
Neurocognitive: Slowness of thought	Improves	-2.48
Neuroendocrine Manifestations: Excessive adrenaline	Improves	-1.68
Neuroendocrine Manifestations: subnormal body temperature	Worsen	1.58
Neuroendocrine: Alcohol intolerance	Improves	-1.7
Neurological: Slowed speech	Improves	-1.61
Official Diagnosis: Mast Cell Dysfunction	Improves	-1.7
Post-exertional malaise: Mentally tired after the slightest effort	Worsen	2.88
Sleep: Problems staying asleep	Improves	-1.7

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
Acne	Improves	-3.47
ADHD	Worsen	3.56
Allergies	Improves	-3.55
Alzheimer's disease	Improves	-3.56
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Improves	-2.84
Ankylosing spondylitis	Worsen	4.19
Asthma	Worsen	2.88
Atherosclerosis	Worsen	4.47
Autism	Improves	-4.97
Barrett esophagus cancer	Improves	-2.62
Brain Trauma	Worsen	0.71
Carcinoma	Improves	-0.17
Celiac Disease	Improves	-2.9
Chronic Fatigue Syndrome	Improves	-4.53
Chronic Kidney Disease	Improves	-2.01
Chronic urticaria (Hives)	Worsen	2.83
Colorectal Cancer	Improves	-2.38
Coronary artery disease	Improves	-1.44
Crohn's Disease	Worsen	1.74
Depression	Worsen	3.91
Epilepsy	Improves	-2.78
Fibromyalgia	Improves	-3.58
gallstone disease (gsd)	Improves	-0.86
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	Improves	-3.56
Hashimoto's thyroiditis	Improves	-2.84
High Blood Pressure	Improves	-2.58
Histamine Issues	Worsen	2.1
Histamine Issues From Ubiome	Improves	-2.96
Hyperlipidemia (High Blood Fats)	Improves	-2.63
IgA nephropathy (IgAN)	Improves	-3.32
Inflammatory Bowel Disease	Worsen	4.12
Irritable Bowel Syndrome	Improves	-4.57
Liver Cirrhosis	Improves	-2.73
ME/CFS with IBS	Worsen	2.54
ME/CFS without IBS	Worsen	2.49
Mood Disorders	Improves	-2.84
Multiple Sclerosis	Worsen	3.87
Multiple system atrophy (MSA)	Improves	-1.3
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	Improves	-3.26
Obesity	Improves	-1.02
Osteoporosis	Worsen	2.72
Parkinson's Disease	Worsen	4.57
Psoriasis	Worsen	3.52
Rheumatoid arthritis	Improves	-4.68
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Worsen	3.47
Rosacea	Worsen	1.3
Schizophrenia	Worsen	3.83
Sjögren syndrome	Improves	-0.63
Small Intestinal Bacterial Overgrowth (SIBO)	Worsen	2.83
Stress / posttraumatic stress disorder	Worsen	2.72
Systemic Lupus Erythematosus	Improves	-3.23
Type 1 Diabetes	Improves	-3.44
Type 2 Diabetes	Worsen	2.68
Ulcerative colitis	Improves	-3.09

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.