vsl#3 (probiotics) ** full range

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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
Age: 0-10	Improves	-3.56
Age: 60-70	Improves	-1.7
Autonomic Manifestations: cardiac arrhythmias	Improves	-3.5
Autonomic Manifestations: irritable bowel syndrome	Worsen	1.58
Autonomic Manifestations: Orthostatic intolerance	Improves	-1.5
Autonomic: Inability to tolerate an upright position	Improves	-1.5
Blood Type: A Positive	Worsen	1.86
Blood Type: O Positive	Worsen	1.86
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding	Worsen	2.84
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome	Improves	-1.62
Comorbid: Histamine or Mast Cell issues	Improves	-1.7
Comorbid: Migraine	Worsen	1.86
Condition: ME/CFS with IBS	Worsen	2.8
DePaul University Fatigue Questionnaire : Abdomen pain	Worsen	2.8
DePaul University Fatigue Questionnaire : Allergies	Worsen	2.8
DePaul University Fatigue Questionnaire : Anxiety/tension	Worsen	2.8
DePaul University Fatigue Questionnaire : Depression	Worsen	2.8
DePaul University Fatigue Questionnaire : Difficulty falling asleep	Worsen	2.85
DePaul University Fatigue Questionnaire : Difficulty finding the right word	Worsen	3.49
DePaul University Fatigue Questionnaire : Fatigue	Worsen	3.09
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say	Worsen	2.8
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired	Worsen	1.86
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM)	Worsen	2.55
General: Headaches	Improves	-1.62
Immune Manifestations: Alcohol Intolerant	Improves	-1.62
Immune Manifestations: Diarrhea	Worsen	2.84
Immune Manifestations: Mucus in the stool	Improves	-1.5
Joint: Stiffness and swelling	Improves	-1.7
Neurocognitive: Can only focus on one thing at a time	Improves	-1.7
Neurocognitive: Slowness of thought	Improves	-2.48
Neuroendocrine Manifestations: Excessive adrenaline	Improves	-1.68
Neuroendocrine Manifestations: subnormal body temperature	Worsen	1.58
Neuroendocrine: Alcohol intolerance	Improves	-1.7
Neurological-Audio: Tinnitus (ringing in ear)	Improves	-1.7
Neurological: Slowed speech	Improves	-1.61
Official Diagnosis: Attention deficit hyperactivity disorder (ADHD)	Worsen	2.84
Official Diagnosis: Mast Cell Dysfunction	Improves	-1.7
Post-exertional malaise: Mentally tired after the slightest effort	Worsen	3.56
Sleep: Problems staying asleep	Improves	-1.7
Sleep: Waking up early in the morning (e.g. 3 AM)	Improves	-1.7

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
Acne	Improves	-3.94
ADHD	Worsen	4.27
Allergic Rhinitis (Hay Fever)	Improves	-2.9
Allergies	Improves	-4.47
Alzheimer's disease	Worsen	3.21
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Worsen	3.21
Ankylosing spondylitis	Worsen	4.22
Asthma	Improves	-2.82
Atherosclerosis	Worsen	4.47
Autism	Improves	-5.05
Barrett esophagus cancer	Improves	-2.62
Bipolar Disorder	Worsen	1.9
Brain Trauma	Improves	-2.65
Carcinoma	Improves	-0.17
Celiac Disease	Improves	-4.22
Cerebral Palsy	Worsen	3.52
Chronic Fatigue Syndrome	Improves	-4.53
Chronic Kidney Disease	Improves	-2.01
Chronic Urticaria (Hives)	Worsen	2.83
Colorectal Cancer	Improves	-2.38
Coronary artery disease	Improves	-1.44
COVID-19	Worsen	2.83
Crohn's Disease	Worsen	1.74
Depression	Worsen	3.91
Eczema	Improves	-4.59
Epilepsy	Improves	-2.78
Fibromyalgia	Improves	-4.28
Functional constipation / chronic idiopathic constipation	Worsen	3.39
gallstone disease (gsd)	Improves	-0.86
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	Improves	-3.56
Hashimoto's thyroiditis	Improves	-2.84
High Blood Pressure	Improves	-2.58
Histamine Issues	Worsen	2.1
Histamine Issues From Ubiome	Improves	-2.96
Hyperlipidemia (High Blood Fats)	Improves	-2.63
IgA nephropathy (IgAN)	Improves	-3.32
Inflammatory Bowel Disease	Worsen	4.12
Irritable Bowel Syndrome	Improves	-4.57
Liver Cirrhosis	Improves	-2.73
ME/CFS with IBS	Worsen	2.54
ME/CFS without IBS	Worsen	2.49
Mood Disorders	Improves	-2.84
Multiple Sclerosis	Worsen	4.27
Multiple system atrophy (MSA)	Improves	-1.3
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	Worsen	3.71
NonCeliac Gluten Sensitivity	Improves	-2.88
Obesity	Improves	-2.06
Osteoarthritis	Worsen	2.83
Osteoporosis	Worsen	2.72
Parkinson's Disease	Worsen	5.28
Psoriasis	Worsen	4.58
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Improves	-4.3
Rosacea	Worsen	1.3
Schizophrenia	Worsen	3.36
Sjögren syndrome	Improves	-2.82
Small Intestinal Bacterial Overgrowth (SIBO)	Worsen	2.83
Stress / posttraumatic stress disorder	Worsen	2.72
Systemic Lupus Erythematosus	Improves	-2.73
Type 1 Diabetes	Improves	-4.09
Type 2 Diabetes	Worsen	3.64
Ulcerative colitis	Worsen	3.33

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.