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Cardiovascular Health: Genistein may have beneficial effects on cardiovascular health. It has been shown to help improve lipid profiles by reducing LDL cholesterol levels and increasing HDL cholesterol levels. Additionally, genistein may help improve endothelial function and reduce inflammation in blood vessels, which can lower the risk of cardiovascular diseases such as heart disease and stroke.
Bone Health: Genistein has been studied for its potential to help maintain bone density and reduce the risk of osteoporosis, particularly in postmenopausal women. It may help stimulate bone formation, inhibit bone resorption, and improve bone mineral density, potentially reducing the risk of fractures and improving overall bone health.
Cancer Prevention and Treatment: Genistein has been investigated for its potential cancer-preventive and anticancer properties. It may help inhibit the growth of cancer cells, induce apoptosis (programmed cell death), and prevent angiogenesis (the formation of new blood vessels that support tumor growth). Genistein has been studied in relation to various types of cancer, including breast, prostate, ovarian, and colon cancer.
Menopausal Symptoms: Genistein is considered a phytoestrogen, meaning it can exert estrogen-like effects in the body. It may help alleviate menopausal symptoms such as hot flashes, night sweats, and vaginal dryness by acting as a weak estrogen receptor agonist.
Anti-inflammatory Effects: Genistein possesses anti-inflammatory properties and may help reduce inflammation in the body. Chronic inflammation is linked to various health conditions, including cardiovascular disease, cancer, and neurodegenerative diseases. By reducing inflammation, genistein may help lower the risk of these chronic diseases.
Neuroprotective Effects: Some studies suggest that genistein may have neuroprotective effects and could potentially help prevent or slow down the progression of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It may help protect neurons from oxidative stress and neuroinflammation.
Metabolic Health: Genistein may have beneficial effects on metabolic health, including glucose and insulin metabolism. It may help improve insulin sensitivity, regulate blood sugar levels, and reduce the risk of type 2 diabetes and metabolic syndrome.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Lactococcus cremoris | Increases |
| species | Lactococcus lactis | Increases |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0.2 | 0.2 | |
| Acne | 2 | 1.2 | 0.67 |
| ADHD | 2.6 | 1.6 | 0.63 |
| Age-Related Macular Degeneration and Glaucoma | 0.8 | 0.6 | 0.33 |
| Allergic Rhinitis (Hay Fever) | 0.2 | 0.6 | -2 |
| Allergies | 0.8 | 2.6 | -2.25 |
| Allergy to milk products | 0.8 | 2.1 | -1.63 |
| Alopecia (Hair Loss) | 0.5 | 1.2 | -1.4 |
| Alzheimer's disease | 4.7 | 3 | 0.57 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1.2 | 4.5 | -2.75 |
| Ankylosing spondylitis | 1.6 | 2.6 | -0.63 |
| Anorexia Nervosa | 3.1 | 1.8 | 0.72 |
| Antiphospholipid syndrome (APS) | 0.2 | -0.2 | |
| Asthma | 1 | 1.1 | -0.1 |
| Atherosclerosis | 1.8 | 0.5 | 2.6 |
| Atrial fibrillation | 0.8 | 2.6 | -2.25 |
| Autism | 5.4 | 5.2 | 0.04 |
| Barrett esophagus cancer | 0.2 | 0.2 | |
| benign prostatic hyperplasia | 0.2 | 0.2 | |
| Bipolar Disorder | 2.2 | 2.6 | -0.18 |
| Brain Trauma | 1.1 | 0.3 | 2.67 |
| Breast Cancer | 0.2 | 0.2 | 0 |
| Carcinoma | 1.7 | 1.7 | 0 |
| Celiac Disease | 4.3 | 1.5 | 1.87 |
| Cerebral Palsy | 1.1 | 0.2 | 4.5 |
| Chronic Fatigue Syndrome | 1.9 | 2.7 | -0.42 |
| Chronic Kidney Disease | 2.2 | 1.3 | 0.69 |
| Chronic Lyme | 0.2 | 0.2 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 1.2 | 1.2 | 0 |
| Chronic Urticaria (Hives) | 1.2 | 0.5 | 1.4 |
| Coagulation / Micro clot triggering bacteria | 3.4 | 0.2 | 16 |
| Colorectal Cancer | 0.8 | 2.2 | -1.75 |
| Constipation | 0.6 | 1 | -0.67 |
| Coronary artery disease | 2.2 | 1.3 | 0.69 |
| COVID-19 | 5.6 | 4.2 | 0.33 |
| Crohn's Disease | 6.7 | 4.8 | 0.4 |
| cystic fibrosis | 0.4 | 0.4 | |
| deep vein thrombosis | 2.8 | 2.8 | |
| Depression | 5.5 | 5.7 | -0.04 |
| Dermatomyositis | 1.9 | -1.9 | |
| Eczema | 0.6 | 1 | -0.67 |
| Endometriosis | 1.2 | 1.3 | -0.08 |
| Eosinophilic Esophagitis | 0.3 | 1.5 | -4 |
| Epilepsy | 2.4 | 3.1 | -0.29 |
| erectile dysfunction | 0.8 | -0.8 | |
| Fibromyalgia | 1.6 | 1.9 | -0.19 |
| Functional constipation / chronic idiopathic constipation | 1.5 | 4.4 | -1.93 |
| gallstone disease (gsd) | 0.8 | 1.3 | -0.63 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.7 | 0.6 | 0.17 |
| Generalized anxiety disorder | 0.2 | 0.4 | -1 |
| Glioblastoma | 1.2 | 0.4 | 2 |
| Gout | 1.7 | 0.8 | 1.13 |
| Graves' disease | 1.9 | 1.7 | 0.12 |
| Halitosis | 0.6 | 0.7 | -0.17 |
| Hashimoto's thyroiditis | 0.4 | 1.8 | -3.5 |
| Heart Failure | 0.2 | 0.2 | |
| Hemorrhoidal disease, Hemorrhoids, Piles | 0.2 | -0.2 | |
| Hidradenitis Suppurativa | 0.2 | 0.7 | -2.5 |
| Histamine Issues,Mast Cell Issue, DAO Insufficiency | 0.8 | 0.6 | 0.33 |
| hypercholesterolemia (High Cholesterol) | 0.2 | 0.3 | -0.5 |
| hyperglycemia | 0.2 | 0.8 | -3 |
| Hyperlipidemia (High Blood Fats) | 0.8 | 0.2 | 3 |
| hypersomnia | 0.8 | 0.2 | 3 |
| hypertension (High Blood Pressure | 4.4 | 1.4 | 2.14 |
| Hypothyroidism | 2.1 | 0.2 | 9.5 |
| IgA nephropathy (IgAN) | 0.7 | 1.6 | -1.29 |
| Inflammatory Bowel Disease | 4.5 | 1.8 | 1.5 |
| Insomnia | 0.6 | 1.1 | -0.83 |
| Intelligence | 0.2 | 1.2 | -5 |
| Intracranial aneurysms | 0.6 | 1.5 | -1.5 |
| Irritable Bowel Syndrome | 2.3 | 3 | -0.3 |
| Juvenile idiopathic arthritis | 1.1 | -1.1 | |
| Liver Cirrhosis | 2.3 | 3.3 | -0.43 |
| Long COVID | 7.1 | 8.3 | -0.17 |
| Low bone mineral density | 1.8 | 1 | 0.8 |
| Lung Cancer | 1.5 | 0.4 | 2.75 |
| ME/CFS with IBS | 0.2 | 0.2 | 0 |
| ME/CFS without IBS | 0.2 | 0.6 | -2 |
| Metabolic Syndrome | 5.8 | 5.6 | 0.04 |
| Mood Disorders | 5.9 | 8.1 | -0.37 |
| multiple chemical sensitivity [MCS] | 0.2 | 0.2 | 0 |
| Multiple Sclerosis | 3.7 | 2 | 0.85 |
| Multiple system atrophy (MSA) | 0.4 | 0.4 | |
| myasthenia gravis | 0.2 | -0.2 | |
| Neuropathy (all types) | 1.3 | 2.1 | -0.62 |
| neuropsychiatric disorders (PANDAS, PANS) | 1.4 | 1.1 | 0.27 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 3.3 | 1.6 | 1.06 |
| Obesity | 5.5 | 3.8 | 0.45 |
| obsessive-compulsive disorder | 3.3 | 1.3 | 1.54 |
| Osteoarthritis | 0.7 | 1.3 | -0.86 |
| Osteoporosis | 1.4 | 1.8 | -0.29 |
| pancreatic cancer | 0.2 | -0.2 | |
| Parkinson's Disease | 4.8 | 2.8 | 0.71 |
| Polycystic ovary syndrome | 0.4 | 1.4 | -2.5 |
| Postural orthostatic tachycardia syndrome | 0.2 | 0.2 | 0 |
| Premenstrual dysphoric disorder | 1 | 0.4 | 1.5 |
| primary biliary cholangitis | 0.8 | -0.8 | |
| Psoriasis | 2.2 | 0.9 | 1.44 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 3.3 | 4.5 | -0.36 |
| Rosacea | 0.2 | 1.5 | -6.5 |
| Schizophrenia | 1.4 | 4.9 | -2.5 |
| scoliosis | 0.5 | 1 | -1 |
| sensorineural hearing loss | 0.6 | 0.6 | |
| Sjögren syndrome | 2.8 | 0.8 | 2.5 |
| Sleep Apnea | 1.7 | 0.9 | 0.89 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.7 | -0.7 | |
| Stress / posttraumatic stress disorder | 2.1 | 1.1 | 0.91 |
| Systemic Lupus Erythematosus | 4 | 2.4 | 0.67 |
| Tic Disorder | 0.2 | 0.5 | -1.5 |
| Type 1 Diabetes | 2.9 | 1.6 | 0.81 |
| Type 2 Diabetes | 4.4 | 5.6 | -0.27 |
| Ulcerative colitis | 4.2 | 4.1 | 0.02 |
| Unhealthy Ageing | 1.1 | 0.4 | 1.75 |
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