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Citizen Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.

Symptom	Impact	Predictor of Bacteria Shift
Age: 20-30	Improves	-3.31
Age: 60-70	Worsen	2.56
Asymptomatic: Minor Health Issues (a few symptoms only)	Worsen	1.85
Asymptomatic: No Health Issues	Worsen	2.73
Autism: Official Diagnosis	Improves	-1.8
Autonomic: Inability to tolerate an upright position	Improves	-3.17
Blood Type: O Positive	Improves	-3.16
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding	Improves	-1.8
Comorbid-Mouth: Mouth Sores	Worsen	2.56
Comorbid: Constipation and Explosions (not diarrohea)	Worsen	2.07
Comorbid: High Anxiety	Improves	-1.8
Comorbid: Histamine or Mast Cell issues	Improves	-1.8
Comorbid: Inflammatory bowel disease	Improves	-3.17
Comorbid: Snoring (NOT Sleep Apnea	Improves	-1.8
Condition: ME/CFS with IBS	Worsen	2.8
DePaul University Fatigue Questionnaire : Allergies	Improves	-2.19
DePaul University Fatigue Questionnaire : Anxiety/tension	Improves	-1.12
DePaul University Fatigue Questionnaire : Difficulty staying asleep	Improves	-2.83
DePaul University Fatigue Questionnaire : Fatigue	Improves	-2.64
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say	Worsen	2.8
DePaul University Fatigue Questionnaire : Impaired Memory & concentration	Improves	-3.51
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired	Improves	-3.16
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM)	Improves	-1.12
General: Myalgia (pain)	Worsen	2.73
General: Sinus issues with headaches	Improves	-1.8
Immune Manifestations: Abdominal Pain	Worsen	2.48
Immune Manifestations: Inflammation (General)	Improves	-3.98
Immune Manifestations: Mucus in the stool	Improves	-2.92
Immune Manifestations: tender lymph nodes	Worsen	2.9
Joint: Sudden and severe episodes of pain	Worsen	1.85
Joint: Tenderness	Improves	-3.22
Neurocognitive: Difficulty expressing thoughts	Improves	-1.04
Neurocognitive: Slowness of thought	Worsen	2.48
Neurocognitive: Unable to focus vision and/or attention	Worsen	2.56
Neuroendocrine Manifestations: Excessive adrenaline	Improves	-2.9
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin)	Improves	-3.17
Neuroendocrine Manifestations: subnormal body temperature	Worsen	2.7
Neuroendocrine: Cold limbs (e.g. arms, legs hands)	Improves	-2.65
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep)	Worsen	2.56
Neurological-Vision: Blurred Vision	Worsen	2.73
Neurological-Vision: inability to focus eye/vision	Worsen	2.07
Neurological: emotional overload	Improves	-2.44
Neurological: Joint hypermobility	Improves	-1.8
Official Diagnosis: Allergic Rhinitis (Hay Fever)	Improves	-3.16
Official Diagnosis: Chronic Fatigue Syndrome	Improves	-2.65
Official Diagnosis: Irritable Bowel Syndrome	Improves	-2.92
Official Diagnosis: Mast Cell Dysfunction	Improves	-1.8
Onset: Gradual	Improves	-2.65
Other: Sensitivity to vibrations	Improves	-2.65
Pain: Myofascial pain	Improves	-2.65
Pain: Sensitivity to pain	Improves	-1.8
Post-exertional malaise: Mentally tired after the slightest effort	Worsen	1.61
Post-exertional malaise: Rapid cognitive fatigability,	Worsen	2.73

Published Science Infered Impact

We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.

This is according to the microbiome shifts reported in studies. Clinical studies may show different results

Symptom	Impact	Predictor of Bacteria Shift
Cerebral Palsy	Improves	-0.26
Acne	Improves	-3.47
ADHD	Worsen	3.95
Allergies	Improves	-1.93
Alzheimer's disease	Worsen	4.35
Amyotrophic lateral sclerosis (ALS) Motor Neuron	Improves	-2.26
Ankylosing spondylitis	Worsen	4.43
Asthma	Improves	-0.26
Atherosclerosis	Worsen	4.24
Autism	Improves	-5.03
Barrett esophagus cancer	Improves	-3.54
Brain Trauma	Worsen	1.36
Carcinoma	Worsen	0
Celiac Disease	Improves	-1.48
Chronic Fatigue Syndrome	Improves	-5.01
Chronic Kidney Disease	Improves	-2.07
Chronic urticaria (Hives)	Improves	-0.79
Colorectal Cancer	Improves	-5.29
COVID-19	Improves	-2.79
Crohn's Disease	Worsen	3.13
Depression	Worsen	1.41
Epilepsy	Improves	-3.47
Fibromyalgia	Improves	-2.7
Functional constipation / chronic idiopathic constipation	Improves	-3.49
gallstone disease (gsd)	Improves	-2.15
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	Improves	-2.72
Generalized anxiety disorder	Improves	-2.48
Hashimoto's thyroiditis	Improves	-3.65
High Blood Pressure	Improves	-1.33
Histamine Issues	Worsen	1.84
Histamine Issues From Ubiome	Improves	-2.72
Hyperlipidemia (High Blood Fats)	Improves	-2.63
hypertension (High Blood Pressure	Worsen	1.79
IgA nephropathy (IgAN)	Improves	-2.7
Inflammatory Bowel Disease	Worsen	4.75
Irritable Bowel Syndrome	Improves	-4.42
Liver Cirrhosis	Worsen	2.03
ME/CFS with IBS	Improves	-3.56
ME/CFS without IBS	Improves	-4.26
Multiple Sclerosis	Worsen	3.64
Multiple system atrophy (MSA)	Improves	-1.3
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	Improves	-3.27
Obesity	Worsen	3.98
Osteoporosis	Worsen	3.16
Parkinson's Disease	Worsen	4.88
Psoriasis	Improves	-3.48
Rheumatoid arthritis	Worsen	2.68
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	Worsen	3.47
Rosacea	Worsen	2.7
Schizophrenia	Worsen	4.15
Sclerosis	Worsen	1.98
Sjögren syndrome	Improves	-2.88
Small Intestinal Bacterial Overgrowth (SIBO)	Improves	-3.48
Stress / posttraumatic stress disorder	Improves	-3.49
Systemic Lupus Erythematosus	Improves	-4.2
Type 1 Diabetes	Improves	-3.27
Type 2 Diabetes	Worsen	4.01
Ulcerative colitis	Worsen	1.9

Bacteria Impacted

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.