AI Engines For more Details: Perplexity Kagi Labs You
Antimicrobial Properties: Squalamine has demonstrated broad-spectrum antimicrobial activity against bacteria, viruses, fungi, and parasites. It has shown efficacy against various pathogens, including antibiotic-resistant bacteria like MRSA (Methicillin-resistant Staphylococcus aureus) and VRSA (Vancomycin-resistant Staphylococcus aureus).
Antiviral Activity: Research suggests that squalamine may have antiviral properties and could be effective against enveloped viruses such as herpes simplex virus (HSV), human immunodeficiency virus (HIV), and hepatitis C virus (HCV). It may inhibit viral entry into host cells and disrupt viral replication.
Anti-inflammatory Effects: Squalamine has been investigated for its potential anti-inflammatory properties. It may help reduce inflammation by modulating the immune response and inhibiting the production of pro-inflammatory molecules.
Anti-angiogenic Activity: Angiogenesis is the process of new blood vessel formation, which is essential for tumor growth and metastasis. Squalamine has been shown to inhibit angiogenesis by targeting vascular endothelial growth factor (VEGF) and other angiogenic factors, potentially offering therapeutic benefits in cancer treatment.
Cardioprotective Effects: Some studies suggest that squalamine may have cardioprotective properties by improving cardiac function, reducing inflammation, and inhibiting the formation of blood clots. It may also help maintain healthy cholesterol levels and prevent atherosclerosis.
Neuroprotective Potential: Preliminary research indicates that squalamine may have neuroprotective effects and could be beneficial in the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It may help protect neurons from damage and improve cognitive function.
Wound Healing: Squalamine has been investigated for its potential role in promoting wound healing. It may accelerate the healing process by enhancing tissue repair, reducing inflammation, and preventing infection.
Ocular Health: Squalamine eye drops have been studied for the treatment of various eye conditions, including age-related macular degeneration (AMD), diabetic retinopathy, and corneal neovascularization. Squalamine may help inhibit abnormal blood vessel growth in the eyes and protect against vision loss.
Safety Considerations: While squalamine has shown promising health benefits in preclinical studies, more research is needed to fully understand its safety profile and potential side effects in humans. Additionally, sustainable sources of squalamine that do not rely on shark harvesting are being explored to address ethical and environmental concerns.
| Rank | Probiotic | Impact |
|---|---|---|
| order | Rhodospirillales | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Allergies | 0.5 | 0.5 | |
| Anorexia Nervosa | 0.5 | 0.5 | |
| Carcinoma | 0.5 | 0.5 | 0 |
| Celiac Disease | 0.5 | -0.5 | |
| Crohn's Disease | 0.7 | 0.5 | 0.4 |
| Functional constipation / chronic idiopathic constipation | 0.5 | 0.5 | |
| Hidradenitis Suppurativa | 0.1 | 0.1 | |
| hypercholesterolemia (High Cholesterol) | 0.2 | 0.2 | |
| Inflammatory Bowel Disease | 0.5 | -0.5 | |
| Irritable Bowel Syndrome | 0.5 | 0.5 | 0 |
| Liver Cirrhosis | 0.5 | 0.5 | |
| Metabolic Syndrome | 0.7 | 0.7 | 0 |
| Mood Disorders | 0.5 | 0.5 | |
| Multiple Sclerosis | 1.5 | 1.5 | |
| Obesity | 0.7 | 1 | -0.43 |
| obsessive-compulsive disorder | 0.5 | -0.5 | |
| Parkinson's Disease | 0.5 | 0.5 | |
| Psoriasis | 0.5 | 0.5 | |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 0.5 | 0.5 | |
| Schizophrenia | 0.5 | 0.5 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1 | 1 | |
| Stress / posttraumatic stress disorder | 0.5 | 0.5 | |
| Type 2 Diabetes | 0.7 | 0.7 | 0 |
| Ulcerative colitis | 0.5 | 0.5 | 0 |
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