We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Neuroendocrine: Feeling like you have a low temperature | Improves | -2.74 |
| Neurological: emotional overload | Improves | -2.74 |
| Neurological: Executive Decision Making (Difficulty making) | Improves | -2.42 |
| Neurological: fasciculations | Improves | -2.74 |
| Neurological: High degree of Empathy before onset | Improves | -2.74 |
| Neurological: Impairment of concentration | Improves | -2.42 |
| Neurological: Short-term memory issues | Improves | -2.74 |
| Neurological: Spatial instability and disorientation | Improves | -2.74 |
| Onset: less than 02 years since onset | Improves | -2.74 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Improves | -2.74 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Worsen | 2.42 |
| Allergic Rhinitis (Hay Fever) | Worsen | 2.41 |
| Allergies | Improves | -1.67 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 2.41 |
| Ankylosing spondylitis | Improves | -1.78 |
| Asthma | Worsen | 0 |
| Atherosclerosis | Worsen | 3.52 |
| Autism | Improves | -2.41 |
| Bipolar Disorder | Worsen | 2.41 |
| Brain Trauma | Worsen | 2.74 |
| Carcinoma | Worsen | 2.41 |
| Celiac Disease | Worsen | 2.42 |
| Chronic Kidney Disease | Worsen | 2.41 |
| Chronic Lyme | Worsen | 2.74 |
| Chronic Urticaria (Hives) | Worsen | 3.06 |
| Colorectal Cancer | Worsen | 3.45 |
| COVID-19 | Worsen | 3.24 |
| Crohn's Disease | Worsen | 4.39 |
| Depression | Worsen | 2.29 |
| Eczema | Worsen | 4 |
| Generalized anxiety disorder | Worsen | 3.45 |
| Graves' disease | Improves | -2.74 |
| Histamine Issues | Worsen | 2.65 |
| IgA nephropathy (IgAN) | Worsen | 2.74 |
| Inflammatory Bowel Disease | Worsen | 4.28 |
| Irritable Bowel Syndrome | Worsen | 4.11 |
| Liver Cirrhosis | Worsen | 3.91 |
| Mood Disorders | Worsen | 2.74 |
| neuropsychiatric disorders (PANDAS, PANS) | Worsen | 2.42 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Worsen | 4.17 |
| Obesity | Worsen | 3.24 |
| Osteoarthritis | Worsen | 2.41 |
| Osteoporosis | Worsen | 2.41 |
| Parkinson's Disease | Worsen | 3.54 |
| Psoriasis | Worsen | 2.42 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 3.24 |
| Schizophrenia | Improves | -2.74 |
| Sjögren syndrome | Worsen | 2.41 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Worsen | 3.07 |
| Stress / posttraumatic stress disorder | Worsen | 3.92 |
| Systemic Lupus Erythematosus | Worsen | 3.24 |
| Type 1 Diabetes | Worsen | 2.41 |
| Type 2 Diabetes | Worsen | 4.02 |
| Ulcerative colitis | Worsen | 4.03 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.