We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 0-10 | Improves | -2.88 |
| Autism: Official Diagnosis | Worsen | 1.9 |
| Autonomic Manifestations: Cortisol disorders or irregularity | Worsen | 3.05 |
| Autonomic: Heart rate increase after standing | Worsen | 3.05 |
| Autonomic: Inability to tolerate an upright position | Worsen | 1.9 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 1.9 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 1.9 |
| Comorbid: High Anxiety | Worsen | 1.9 |
| Comorbid: Hypothyroidism | Worsen | 1.9 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 1.9 |
| DePaul University Fatigue Questionnaire : Allergies | Improves | -2.9 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 3.2 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 3.2 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Worsen | 1.9 |
| Immune Manifestations: Abdominal Pain | Worsen | 1.9 |
| Immune Manifestations: medication sensitivities. | Worsen | 3.05 |
| Immune Manifestations: Mucus in the stool | Worsen | 3.2 |
| Immune Manifestations: new food sensitivities | Improves | -1.9 |
| Infection: Mycoplasma | Worsen | 1.9 |
| Infection: Parasite - Other | Worsen | 1.9 |
| Neuroendocrine Manifestations: Excessive adrenaline | Worsen | 3.64 |
| Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) | Worsen | 2.93 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
| Neurological-Sleep: Insomnia | Worsen | 1.9 |
| Neurological: emotional overload | Worsen | 2.74 |
| Neurological: fasciculations | Worsen | 2.74 |
| Neurological: High degree of Empathy before onset | Worsen | 2.74 |
| Neurological: Joint hypermobility | Worsen | 3.2 |
| Neurological: Short-term memory issues | Worsen | 2.74 |
| Neurological: Spatial instability and disorientation | Worsen | 2.74 |
| Official Diagnosis: Irritable Bowel Syndrome | Worsen | 1.9 |
| Onset: less than 02 years since onset | Worsen | 2.74 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 2.93 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 2.88 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Acne | Improves | -3.94 |
| ADHD | Worsen | 3.88 |
| Allergic Rhinitis (Hay Fever) | Worsen | 0.26 |
| Allergies | Worsen | 2.31 |
| Alzheimer's disease | Improves | -0.26 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.57 |
| Ankylosing spondylitis | Worsen | 4.45 |
| Asthma | Worsen | 3.96 |
| Atherosclerosis | Worsen | 3.87 |
| Autism | Improves | -4.68 |
| Brain Trauma | Improves | -2.74 |
| Carcinoma | Worsen | 0 |
| Celiac Disease | Improves | -4.49 |
| Cerebral Palsy | Worsen | 3.15 |
| Chronic Fatigue Syndrome | Improves | -3.63 |
| Chronic Lyme | Improves | -2.74 |
| Chronic Urticaria (Hives) | Worsen | 2.9 |
| Colorectal Cancer | Worsen | 2.73 |
| COVID-19 | Improves | -2.74 |
| Crohn's Disease | Improves | -3.26 |
| Depression | Improves | -2.56 |
| Eczema | Improves | -4.68 |
| Epilepsy | Improves | -3.39 |
| Fibromyalgia | Improves | -3.51 |
| Functional constipation / chronic idiopathic constipation | Worsen | 2.88 |
| gallstone disease (gsd) | Worsen | 2.95 |
| Generalized anxiety disorder | Improves | -2.54 |
| Graves' disease | Worsen | 2.74 |
| Hashimoto's thyroiditis | Worsen | 0.63 |
| High Blood Pressure | Worsen | 2.54 |
| Histamine Issues | Improves | -2.75 |
| Hyperlipidemia (High Blood Fats) | Worsen | 2.88 |
| IgA nephropathy (IgAN) | Improves | -3.63 |
| Inflammatory Bowel Disease | Improves | -4.47 |
| Irritable Bowel Syndrome | Improves | -4.11 |
| Liver Cirrhosis | Improves | -2.16 |
| ME/CFS with IBS | Improves | -1.85 |
| ME/CFS without IBS | Worsen | 1.85 |
| Mood Disorders | Improves | -2.74 |
| Multiple Sclerosis | Worsen | 2.79 |
| Multiple system atrophy (MSA) | Improves | -2.88 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -3.77 |
| NonCeliac Gluten Sensitivity | Improves | -2.88 |
| Obesity | Improves | -2.51 |
| Osteoarthritis | Worsen | 2.9 |
| Osteoporosis | Worsen | 2.9 |
| Parkinson's Disease | Worsen | 3.92 |
| Psoriasis | Worsen | 3.69 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -4.04 |
| Rosacea | Improves | -0.26 |
| Schizophrenia | Worsen | 3.08 |
| Sjögren syndrome | Improves | -4.24 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -2.54 |
| Stress / posttraumatic stress disorder | Improves | -3.74 |
| Systemic Lupus Erythematosus | Improves | -3.72 |
| Type 1 Diabetes | Improves | -2.9 |
| Type 2 Diabetes | Improves | -3.31 |
| Ulcerative colitis | Improves | -3.16 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.