We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Asymptomatic: No Health Issues | Improves | -1.6 |
| Autism: Official Diagnosis | Worsen | 1.9 |
| Autonomic Manifestations: Cortisol disorders or irregularity | Worsen | 3.05 |
| Autonomic: Heart rate increase after standing | Worsen | 3.05 |
| Comorbid-Mouth: Dry Mouth | Worsen | 2.74 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 1.9 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 1.9 |
| Comorbid: High Anxiety | Worsen | 1.9 |
| Comorbid: Hypothyroidism | Worsen | 1.9 |
| Comorbid: Mold Sensitivity / Exposure | Worsen | 3.05 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 3.2 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 2.93 |
| General: Myalgia (pain) | Worsen | 3.05 |
| Immune Manifestations: medication sensitivities. | Worsen | 3.05 |
| Immune Manifestations: Mucus in the stool | Worsen | 3.2 |
| Immune Manifestations: new food sensitivities | Improves | -1.9 |
| Immune Manifestations: tender lymph nodes | Improves | -2.9 |
| Infection: Mycoplasma | Worsen | 1.9 |
| Infection: Parasite - Other | Worsen | 1.9 |
| Neuroendocrine Manifestations: Excessive adrenaline | Worsen | 3.64 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
| Neurological-Sleep: Insomnia | Worsen | 1.9 |
| Neurological: Difficulty processing information (Understanding) | Worsen | 3.05 |
| Neurological: emotional overload | Worsen | 3.57 |
| Neurological: fasciculations | Worsen | 2.74 |
| Neurological: High degree of Empathy before onset | Worsen | 2.74 |
| Neurological: Impairment of concentration | Worsen | 3.05 |
| Neurological: Joint hypermobility | Worsen | 3.2 |
| Neurological: Short-term memory issues | Worsen | 3.57 |
| Neurological: Spatial instability and disorientation | Worsen | 2.74 |
| Official Diagnosis: Irritable Bowel Syndrome | Worsen | 1.9 |
| Onset: less than 02 years since onset | Worsen | 2.74 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 2.93 |
| Post-exertional malaise: General | Worsen | 2.74 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.48 |
| Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 3.57 |
| Post-exertional malaise: Post-exertional malaise | Worsen | 2.74 |
| Post-exertional malaise: Rapid cognitive fatigability, | Worsen | 3.57 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Cerebral Palsy | Worsen | 3.15 |
| Acne | Improves | -2.88 |
| ADHD | Worsen | 2.88 |
| Allergies | Improves | -1.28 |
| Alzheimer's disease | Improves | -3.56 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.51 |
| Ankylosing spondylitis | Worsen | 4.45 |
| Asthma | Worsen | 3.9 |
| Atherosclerosis | Worsen | 4.18 |
| Autism | Improves | -4.48 |
| Brain Trauma | Improves | -2.74 |
| Carcinoma | Worsen | 0 |
| Celiac Disease | Improves | -3.63 |
| Chronic Fatigue Syndrome | Improves | -3.63 |
| Chronic urticaria (Hives) | Worsen | 2.9 |
| Colorectal Cancer | Worsen | 2.73 |
| Crohn's Disease | Improves | -3.26 |
| Depression | Improves | -2.56 |
| Epilepsy | Improves | -3.39 |
| Fibromyalgia | Improves | -2.85 |
| gallstone disease (gsd) | Worsen | 2.95 |
| Generalized anxiety disorder | Improves | -2.54 |
| Graves' disease | Worsen | 2.74 |
| Hashimoto's thyroiditis | Worsen | 0.63 |
| High Blood Pressure | Worsen | 2.54 |
| Histamine Issues | Improves | -2.75 |
| Hyperlipidemia (High Blood Fats) | Worsen | 2.88 |
| IgA nephropathy (IgAN) | Improves | -3.63 |
| Inflammatory Bowel Disease | Improves | -4.07 |
| Irritable Bowel Syndrome | Improves | -4.11 |
| Liver Cirrhosis | Improves | -2.16 |
| ME/CFS with IBS | Improves | -1.85 |
| ME/CFS without IBS | Worsen | 1.85 |
| Mood Disorders | Improves | -2.74 |
| Multiple Sclerosis | Worsen | 2.95 |
| Multiple system atrophy (MSA) | Improves | -2.88 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Worsen | 0.26 |
| Obesity | Improves | -2.51 |
| Osteoporosis | Worsen | 2.9 |
| Parkinson's Disease | Worsen | 3.36 |
| Psoriasis | Worsen | 3.15 |
| Rheumatoid arthritis | Improves | -3.88 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 1.82 |
| Rosacea | Improves | -0.26 |
| Schizophrenia | Worsen | 2.73 |
| Sclerosis | Improves | -2.9 |
| Sjögren syndrome | Improves | -2.88 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -2.54 |
| Stress / posttraumatic stress disorder | Improves | -3.41 |
| Systemic Lupus Erythematosus | Worsen | 1.38 |
| Type 1 Diabetes | Improves | -3.05 |
| Type 2 Diabetes | Worsen | 0.97 |
| Ulcerative colitis | Improves | -2.2 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.