We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Age: 20-30 | Improves | -2.76 |
| Age: 30-40 | Improves | -1.79 |
| Asymptomatic: Live in house with person with probable microbiome dysfunction | Worsen | 3.47 |
| Asymptomatic: No Health Issues | Worsen | 2.95 |
| Autism: Official Diagnosis | Worsen | 2.44 |
| Autonomic Manifestations: Orthostatic intolerance | Improves | -1.79 |
| Blood Type: A Positive | Worsen | 2.42 |
| Blood Type: O Positive | Worsen | 2.42 |
| Comorbid-Mouth: Dry Mouth | Worsen | 2.37 |
| Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome | Worsen | 1.9 |
| Comorbid: Constipation and Explosions (not diarrohea) | Worsen | 2.44 |
| Comorbid: High Anxiety | Worsen | 1.9 |
| Comorbid: Hypothyroidism | Worsen | 1.9 |
| Comorbid: Inflammatory bowel disease | Worsen | 1.96 |
| Comorbid: Migraine | Worsen | 1.86 |
| Comorbid: Snoring (NOT Sleep Apnea | Worsen | 0.02 |
| DePaul University Fatigue Questionnaire : Fatigue | Worsen | 3 |
| DePaul University Fatigue Questionnaire : Forgetting what you are trying to say | Improves | -2.88 |
| DePaul University Fatigue Questionnaire : Impaired Memory & concentration | Worsen | 2.93 |
| DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired | Improves | -2.29 |
| General: Fatigue | Improves | -1.79 |
| General: Headaches | Improves | -1.62 |
| General: Heavy feeling in arms and legs | Improves | -2.88 |
| Immune Manifestations: Diarrhea | Improves | -1.93 |
| Immune Manifestations: Inflammation (General) | Improves | -3.24 |
| Immune Manifestations: Mucus in the stool | Worsen | 3.2 |
| Immune Manifestations: new food sensitivities | Improves | -1.9 |
| Immune Manifestations: tender lymph nodes | Worsen | 2.9 |
| Infection: Human Herpesvirus 6 (HHV6) | Worsen | 1.76 |
| Infection: Mycoplasma | Worsen | 1.9 |
| Infection: Parasite - Other | Improves | -2.15 |
| Joint: Stiffness and swelling | Improves | -1.7 |
| Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) | Worsen | 2.48 |
| Neuroendocrine Manifestations: Excessive adrenaline | Improves | -3.11 |
| Neuroendocrine Manifestations: intolerance of extremes of heat and cold | Worsen | 1.58 |
| Neuroendocrine Manifestations: sweating episodes | Improves | -2.96 |
| Neuroendocrine: Alcohol intolerance | Improves | -1.7 |
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
| Neuroendocrine: Lack of appetite | Improves | -2.88 |
| Neurological-Sleep: Insomnia | Worsen | 1.9 |
| Neurological-Sleep: Sleep Apnea | Worsen | 3.61 |
| Neurological-Sleep: Vivid Dreams/Nightmares | Worsen | 2.95 |
| Neurological: Cognitive/Sensory Overload | Improves | -1.64 |
| Neurological: Disorientation | Improves | -2.95 |
| Neurological: emotional overload | Worsen | 2.74 |
| Neurological: fasciculations | Worsen | 2.74 |
| Neurological: High degree of Empathy before onset | Worsen | 2.74 |
| Neurological: Joint hypermobility | Worsen | 3.2 |
| Neurological: Short-term memory issues | Worsen | 2.47 |
| Neurological: Slowed speech | Improves | -1.61 |
| Neurological: Spatial instability and disorientation | Improves | -1.52 |
| Neurological: Word-finding problems | Improves | -1.79 |
| Official Diagnosis: Allergic Rhinitis (Hay Fever) | Worsen | 2.44 |
| Official Diagnosis: Irritable Bowel Syndrome | Worsen | 1.9 |
| Official Diagnosis: Mast Cell Dysfunction | Improves | -1.69 |
| Onset: Gradual | Improves | -1.95 |
| Onset: less than 02 years since onset | Worsen | 2.74 |
| Other: Sensitivity to mold | Improves | -1.76 |
| Post-exertional malaise: Difficulty reading after mild physical or mental activity | Worsen | 2.93 |
| Post-exertional malaise: General | Worsen | 2.74 |
| Post-exertional malaise: Mentally tired after the slightest effort | Worsen | 3.48 |
| Post-exertional malaise: Physically drained or sick after mild activity | Worsen | 2.74 |
| Post-exertional malaise: Post-exertional malaise | Worsen | 2.74 |
| Post-exertional malaise: Rapid cognitive fatigability, | Improves | -1.73 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
| Sleep: Problems staying asleep | Improves | -1.7 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Cerebral Palsy | Improves | -2.15 |
| Acne | Improves | -2.56 |
| ADHD | Worsen | 3.02 |
| Allergies | Worsen | 2.12 |
| Alzheimer's disease | Worsen | 2.99 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Worsen | 3.53 |
| Ankylosing spondylitis | Worsen | 5.01 |
| Asthma | Worsen | 3.81 |
| Atherosclerosis | Worsen | 4.6 |
| Autism | Improves | -5.75 |
| Barrett esophagus cancer | Worsen | 3 |
| Brain Trauma | Improves | -3.85 |
| Carcinoma | Worsen | 1.74 |
| Celiac Disease | Improves | -3.16 |
| Chronic Fatigue Syndrome | Improves | -5.22 |
| Chronic Kidney Disease | Worsen | 2.4 |
| Chronic urticaria (Hives) | Improves | -3.75 |
| Colorectal Cancer | Improves | -3.63 |
| Coronary artery disease | Improves | -3.03 |
| Crohn's Disease | Worsen | 3.56 |
| Depression | Worsen | 2.88 |
| Epilepsy | Improves | -2.14 |
| Fibromyalgia | Worsen | 1.57 |
| Functional constipation / chronic idiopathic constipation | Worsen | 2.72 |
| gallstone disease (gsd) | Worsen | 3.86 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | Worsen | 4.02 |
| Generalized anxiety disorder | Worsen | 2.19 |
| Graves' disease | Worsen | 3.41 |
| Hashimoto's thyroiditis | Improves | -2.19 |
| High Blood Pressure | Improves | -3.59 |
| Histamine Issues | Improves | -2.18 |
| Histamine Issues From Ubiome | Improves | -2.96 |
| hypercholesterolemia (High Cholesterol) | Worsen | 2.76 |
| Hyperlipidemia (High Blood Fats) | Worsen | 3.55 |
| hypertension (High Blood Pressure | Worsen | 3.09 |
| IgA nephropathy (IgAN) | Improves | -4.34 |
| Inflammatory Bowel Disease | Worsen | 3.08 |
| Insomnia | Improves | -2.76 |
| Irritable Bowel Syndrome | Improves | -3.66 |
| Liver Cirrhosis | Worsen | 3.67 |
| ME/CFS with IBS | Improves | -3.58 |
| ME/CFS without IBS | Improves | -4.36 |
| Metabolic Syndrome | Worsen | 3.01 |
| Mood Disorders | Improves | -2.74 |
| Multiple Sclerosis | Worsen | 3.57 |
| Multiple system atrophy (MSA) | Improves | -3.04 |
| neuropsychiatric disorders (PANDAS, PANS) | Improves | -2.42 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -3.72 |
| Obesity | Worsen | 2.28 |
| Osteoporosis | Worsen | 2.01 |
| Parkinson's Disease | Improves | -2.91 |
| Psoriasis | Worsen | 2.92 |
| Rheumatoid arthritis | Worsen | 3.69 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Worsen | 4.34 |
| Rosacea | Worsen | 2.56 |
| Schizophrenia | Worsen | 4.39 |
| Sclerosis | Worsen | 3.5 |
| Sjögren syndrome | Improves | -3.81 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Improves | -1.89 |
| Stress / posttraumatic stress disorder | Improves | -3.07 |
| Systemic Lupus Erythematosus | Improves | -2.96 |
| Type 1 Diabetes | Improves | -2.88 |
| Type 2 Diabetes | Improves | -4.35 |
| Ulcerative colitis | Worsen | 3.36 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.