We take what shifts this modifier is known to make and the shifts reported for a symptom. There are many bacteria involved. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is based on associations discovered from annotated 16s microbiome samples. See this post for more information.
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Neuroendocrine: Feeling like you have a low temperature | Worsen | 2.74 |
| Neurological: emotional overload | Worsen | 2.74 |
| Neurological: fasciculations | Worsen | 2.74 |
| Neurological: High degree of Empathy before onset | Worsen | 2.74 |
| Neurological: Short-term memory issues | Worsen | 2.74 |
| Neurological: Spatial instability and disorientation | Worsen | 2.74 |
| Onset: less than 02 years since onset | Worsen | 2.74 |
| Post-exertional malaise: Worsening of symptoms after mild mental activity | Worsen | 2.74 |
We take what shifts this modifier is known to make and the shifts reported for a medical condition. There are many bacteria. We sum all of the shifts (some positive and some negative) to estimate a predictor. Some bacteria may have greater impact (that information is not available in 99% of studies) so the estimate can be wrong in edge cases.
This is according to the microbiome shifts reported in studies. Clinical studies may show different results
| Symptom | Impact | Predictor of Bacteria Shift |
|---|---|---|
| Allergic Rhinitis (Hay Fever) | Improves | -2.41 |
| Allergies | Worsen | 1.35 |
| Alzheimer's disease | Worsen | 3.18 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | Improves | -2.41 |
| Ankylosing spondylitis | Worsen | 2.5 |
| Asthma | Worsen | 0 |
| Atherosclerosis | Improves | -3.4 |
| Autism | Worsen | 2.41 |
| Bipolar Disorder | Improves | -2.41 |
| Brain Trauma | Improves | -2.74 |
| Carcinoma | Improves | -2.41 |
| Celiac Disease | Worsen | 0 |
| Cerebral Palsy | Worsen | 2.54 |
| Chronic Fatigue Syndrome | Worsen | 0 |
| Chronic Kidney Disease | Improves | -2.41 |
| Chronic Lyme | Improves | -2.74 |
| Chronic Urticaria (Hives) | Improves | -2.41 |
| Colorectal Cancer | Improves | -3.13 |
| COVID-19 | Improves | -2.8 |
| Crohn's Disease | Improves | -2.61 |
| Depression | Improves | -2.29 |
| Eczema | Improves | -3.76 |
| Epilepsy | Worsen | 2.54 |
| Generalized anxiety disorder | Improves | -1.97 |
| Graves' disease | Worsen | 2.74 |
| High Blood Pressure | Improves | -2.54 |
| Histamine Issues | Worsen | 2.28 |
| IgA nephropathy (IgAN) | Improves | -3.31 |
| Inflammatory Bowel Disease | Worsen | 1.76 |
| Irritable Bowel Syndrome | Improves | -3.4 |
| Liver Cirrhosis | Improves | -3.08 |
| ME/CFS with IBS | Worsen | 0 |
| ME/CFS without IBS | Worsen | 0 |
| Mood Disorders | Improves | -2.74 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | Improves | -4.17 |
| Obesity | Improves | -3.24 |
| Osteoarthritis | Improves | -2.41 |
| Osteoporosis | Improves | -2.41 |
| Parkinson's Disease | Improves | -3.14 |
| Psoriasis | Worsen | 2.54 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | Improves | -3.24 |
| Schizophrenia | Improves | -3.49 |
| Sjögren syndrome | Improves | -2.41 |
| Small Intestinal Bacterial Overgrowth (SIBO) | Worsen | 2.54 |
| Stress / posttraumatic stress disorder | Worsen | 2.16 |
| Systemic Lupus Erythematosus | Improves | -0.91 |
| Type 1 Diabetes | Improves | -2.41 |
| Type 2 Diabetes | Improves | -3.96 |
| Ulcerative colitis | Improves | -3.5 |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.