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Menopausal Symptoms: Dienestrol has been used to alleviate symptoms associated with menopause, including hot flashes, night sweats, vaginal dryness, and urogenital atrophy. As an estrogen medication, dienestrol helps restore hormonal balance in menopausal and postmenopausal women, thereby reducing the severity of these symptoms and improving quality of life.
Hormone Replacement Therapy (HRT): Dienestrol has been used as a component of hormone replacement therapy (HRT) regimens for menopausal and postmenopausal women who experience bothersome symptoms related to estrogen deficiency. HRT with dienestrol may also help prevent or alleviate certain long-term health consequences of estrogen deficiency, such as osteoporosis and cardiovascular disease.
Vaginal Atrophy: Dienestrol may be prescribed in the form of vaginal creams or suppositories for the treatment of vaginal atrophy (atrophic vaginitis) and dyspareunia (painful intercourse) associated with estrogen deficiency. Topical application of dienestrol helps restore the integrity and elasticity of the vaginal tissues and improve vaginal lubrication and comfort.
Osteoporosis Prevention: Estrogen replacement therapy, including dienestrol, has been shown to help prevent bone loss and reduce the risk of osteoporosis in menopausal and postmenopausal women. Estrogen plays a crucial role in maintaining bone density and strength, and HRT with dienestrol may help preserve bone health and reduce the risk of fractures.
Breast Cancer: While estrogen replacement therapy has been associated with a slightly increased risk of breast cancer, the specific impact of dienestrol on breast cancer risk remains unclear. Some studies have suggested a potential association between dienestrol use and breast cancer risk, while others have not found a significant relationship. Further research is needed to clarify this issue.
Cardiovascular Health: Estrogen replacement therapy, including dienestrol, has been hypothesized to have potential cardiovascular benefits, including improvements in lipid profiles and vascular function. However, the overall impact of estrogen therapy on cardiovascular health remains the subject of ongoing research and debate, and individual risk factors should be carefully considered when prescribing dienestrol or other estrogen medications.
Side Effects: Common side effects of dienestrol may include breast tenderness, fluid retention, headache, nausea, and breakthrough bleeding or spotting. More serious side effects, such as venous thromboembolism (blood clots), stroke, or endometrial hyperplasia, may occur rarely and require medical attention. The risk of side effects may vary depending on factors such as dosage, duration of treatment, and individual health status.
Rank | Probiotic | Impact |
---|---|---|
species | Bifidobacterium adolescentis | Reduces |
species | Escherichia coli | Reduces |
species | Lacticaseibacillus paracasei | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
Abdominal Aortic Aneurysm | 0.2 | 0.2 | |
Acne | 0.2 | -0.2 | |
ADHD | 5.2 | 0.6 | 7.67 |
Age-Related Macular Degeneration and Glaucoma | 1 | 0.5 | 1 |
Allergic Rhinitis (Hay Fever) | 2.7 | 0.7 | 2.86 |
Allergies | 4 | 2.1 | 0.9 |
Allergy to milk products | 1.5 | 1 | 0.5 |
Alopecia (Hair Loss) | 2 | 2 | |
Alzheimer's disease | 4.6 | 6.9 | -0.5 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | 3.7 | 0.5 | 6.4 |
Ankylosing spondylitis | 4.4 | 2.4 | 0.83 |
Anorexia Nervosa | 0.5 | 2.9 | -4.8 |
Antiphospholipid syndrome (APS) | 2.9 | 0.2 | 13.5 |
Asthma | 1 | 1 | 0 |
Atherosclerosis | 0.8 | 3 | -2.75 |
Atrial fibrillation | 4.1 | 2.6 | 0.58 |
Autism | 11.3 | 10.1 | 0.12 |
Barrett esophagus cancer | 0.5 | 0.5 | 0 |
benign prostatic hyperplasia | 0.2 | 0.2 | |
Bipolar Disorder | 1.5 | 1.2 | 0.25 |
Brain Trauma | 0.2 | 1 | -4 |
Carcinoma | 3.8 | 2.8 | 0.36 |
Celiac Disease | 2.9 | 3.3 | -0.14 |
Cerebral Palsy | 1.2 | 1.6 | -0.33 |
Chronic Fatigue Syndrome | 6.3 | 9.2 | -0.46 |
Chronic Kidney Disease | 3.4 | 2.3 | 0.48 |
Chronic Lyme | 1 | -1 | |
Chronic Obstructive Pulmonary Disease (COPD) | 2.9 | 1.4 | 1.07 |
Chronic Urticaria (Hives) | 1.7 | 2 | -0.18 |
Coagulation / Micro clot triggering bacteria | 1.7 | 1.5 | 0.13 |
Colorectal Cancer | 6.3 | 0.7 | 8 |
Constipation | 2.1 | 1 | 1.1 |
Coronary artery disease | 1.5 | 1 | 0.5 |
COVID-19 | 11.4 | 17.1 | -0.5 |
Crohn's Disease | 9.7 | 7.3 | 0.33 |
cystic fibrosis | 0.7 | 1.2 | -0.71 |
deep vein thrombosis | 0.7 | 1 | -0.43 |
Depression | 12.2 | 7.9 | 0.54 |
Dermatomyositis | 0.5 | 0.2 | 1.5 |
Eczema | 1.2 | 3.2 | -1.67 |
Endometriosis | 3.9 | 0.9 | 3.33 |
Eosinophilic Esophagitis | 0.5 | 0.5 | |
Epilepsy | 3.4 | 2.7 | 0.26 |
Fibromyalgia | 3.5 | 4.2 | -0.2 |
Functional constipation / chronic idiopathic constipation | 6.8 | 6.2 | 0.1 |
gallstone disease (gsd) | 2.3 | 1.2 | 0.92 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 2.5 | 1.5 | 0.67 |
Generalized anxiety disorder | 2.7 | 1.7 | 0.59 |
giant cell arteritis | 0.5 | -0.5 | |
Glioblastoma | 0.5 | -0.5 | |
Gout | 0.5 | -0.5 | |
Graves' disease | 1.2 | 1.5 | -0.25 |
Halitosis | 1 | 0.5 | 1 |
Hashimoto's thyroiditis | 3.2 | 0.9 | 2.56 |
Hidradenitis Suppurativa | 1.1 | 1.1 | |
Histamine Issues,Mast Cell Issue, DAO Insufficiency | 3.3 | 1.5 | 1.2 |
hypercholesterolemia (High Cholesterol) | 1 | 1 | |
hyperglycemia | 0.2 | 1.7 | -7.5 |
Hyperlipidemia (High Blood Fats) | 0.2 | 0.2 | |
hypersomnia | 0.7 | -0.7 | |
hypertension (High Blood Pressure | 2 | 4.6 | -1.3 |
Hypothyroidism | 1.4 | -1.4 | |
Hypoxia | 1 | 1 | |
IgA nephropathy (IgAN) | 6.4 | -6.4 | |
Inflammatory Bowel Disease | 5 | 8.6 | -0.72 |
Insomnia | 1.5 | 1.4 | 0.07 |
Intelligence | 2 | 1 | 1 |
Intracranial aneurysms | 1.6 | 1.6 | |
Irritable Bowel Syndrome | 4.5 | 5.1 | -0.13 |
Liver Cirrhosis | 5.6 | 3.4 | 0.65 |
Long COVID | 10.1 | 8.5 | 0.19 |
Low bone mineral density | 1.4 | -1.4 | |
Lung Cancer | 1.2 | 1.1 | 0.09 |
ME/CFS with IBS | 1.6 | 3.7 | -1.31 |
ME/CFS without IBS | 2.5 | 3.2 | -0.28 |
Menopause | 1.5 | 1.5 | |
Metabolic Syndrome | 9.2 | 8.9 | 0.03 |
Mood Disorders | 13.9 | 8.1 | 0.72 |
multiple chemical sensitivity [MCS] | 1.4 | 0.5 | 1.8 |
Multiple Sclerosis | 5.3 | 8.2 | -0.55 |
Multiple system atrophy (MSA) | 1 | 0.8 | 0.25 |
Neuropathy (all types) | 1 | 0.2 | 4 |
neuropsychiatric disorders (PANDAS, PANS) | 1 | 1 | |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 3.2 | 5.1 | -0.59 |
NonCeliac Gluten Sensitivity | 0.2 | -0.2 | |
Obesity | 9.7 | 5.2 | 0.87 |
obsessive-compulsive disorder | 8 | 6.2 | 0.29 |
Osteoarthritis | 2.7 | 0.1 | 26 |
Osteoporosis | 1.4 | 1 | 0.4 |
pancreatic cancer | 1 | 1 | |
Parkinson's Disease | 2.5 | 5.6 | -1.24 |
Polycystic ovary syndrome | 3.3 | 1.8 | 0.83 |
Postural orthostatic tachycardia syndrome | 0.5 | 0.7 | -0.4 |
Premenstrual dysphoric disorder | 0.7 | 0.5 | 0.4 |
primary biliary cholangitis | 0.5 | 1 | -1 |
Psoriasis | 4.2 | 4 | 0.05 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 7.6 | 4.7 | 0.62 |
Rosacea | 1.3 | 1 | 0.3 |
Schizophrenia | 5.9 | 2.3 | 1.57 |
scoliosis | 0.5 | 0.9 | -0.8 |
Sjögren syndrome | 3.2 | 4.2 | -0.31 |
Sleep Apnea | 1.8 | 2.1 | -0.17 |
Small Intestinal Bacterial Overgrowth (SIBO) | 1.4 | 1.4 | |
Stress / posttraumatic stress disorder | 3.7 | 2 | 0.85 |
Systemic Lupus Erythematosus | 6 | 2.1 | 1.86 |
Tic Disorder | 1.6 | 1.9 | -0.19 |
Tourette syndrome | 0.5 | -0.5 | |
Type 1 Diabetes | 5 | 3.3 | 0.52 |
Type 2 Diabetes | 9.7 | 9.2 | 0.05 |
Ulcerative colitis | 3.7 | 7.4 | -1 |
Unhealthy Ageing | 8.3 | 2.7 | 2.07 |
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