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Hypertension: Cyclopenthiazide is primarily used as an antihypertensive agent to lower blood pressure in individuals with hypertension. Thiazide diuretics like cyclopenthiazide work by increasing the excretion of sodium and water through the kidneys, leading to a reduction in blood volume and decreased vascular resistance. This helps to lower blood pressure and reduce the risk of cardiovascular complications associated with hypertension, such as heart attacks, strokes, and kidney disease.
Edema: Cyclopenthiazide may also be used in the management of edema (fluid retention) associated with various medical conditions, including congestive heart failure, liver cirrhosis, and kidney disorders (such as nephrotic syndrome). By promoting diuresis (increased urine production) and reducing fluid accumulation in the body tissues, cyclopenthiazide helps alleviate symptoms of edema such as swelling in the legs, ankles, and abdomen, and improves overall fluid balance.
Dosage and Administration: Cyclopenthiazide is typically administered orally in the form of tablets or capsules. The dosage and frequency of administration depend on factors such as the severity of hypertension or edema, the individual patient's response to treatment, and any underlying medical conditions. Cyclopenthiazide is usually taken once daily in the morning or as directed by the healthcare provider. It may be taken with or without food, but it is essential to take it consistently to achieve optimal therapeutic effects.
Side Effects: Common side effects of cyclopenthiazide may include increased urination, electrolyte imbalances (such as hypokalemia or hyponatremia), dehydration, dizziness, lightheadedness, weakness, muscle cramps, nausea, vomiting, diarrhea, and allergic reactions (such as rash or itching). Rare but serious side effects may include severe electrolyte disturbances, kidney dysfunction, pancreatitis, and blood disorders. Patients should be monitored regularly for side effects during cyclopenthiazide therapy, and treatment should be adjusted as needed based on individual response and tolerance.
Interactions: Cyclopenthiazide may interact with other medications, supplements, or substances, potentially affecting their efficacy or increasing the risk of side effects. It is essential to inform the healthcare provider about all other medications and supplements being taken, including prescription drugs, over-the-counter medications, vitamins, and herbal products, to avoid potential drug interactions.
Precautions: Cyclopenthiazide should be used with caution in patients with certain medical conditions, including kidney impairment, liver disease, diabetes mellitus, gout, electrolyte imbalances, and hypersensitivity to sulfonamide-derived medications. It may not be suitable for use in pregnant or breastfeeding women, and caution should be exercised in elderly patients due to the increased risk of adverse effects.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Akkermansia muciniphila | Reduces |
| species | Bifidobacterium adolescentis | Reduces |
| species | Bifidobacterium longum | Reduces |
| species | Escherichia coli | Reduces |
| species | Lacticaseibacillus paracasei | Reduces |
| subspecies | Bifidobacterium longum subsp. infantis | Reduces |
| subspecies | Bifidobacterium longum subsp. longum | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Acne | 0.3 | -0.3 | |
| ADHD | 2.8 | 0.1 | 27 |
| Age-Related Macular Degeneration and Glaucoma | 0.3 | 0.3 | |
| Allergic Rhinitis (Hay Fever) | 0.3 | 1.6 | -4.33 |
| Allergies | 2.6 | 2.2 | 0.18 |
| Allergy to milk products | 0.8 | 0.3 | 1.67 |
| Alopecia (Hair Loss) | 0.7 | 0.7 | |
| Alzheimer's disease | 2.3 | 2.7 | -0.17 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 2.3 | 1 | 1.3 |
| Ankylosing spondylitis | 1.4 | 0.9 | 0.56 |
| Anorexia Nervosa | 1.3 | -1.3 | |
| Antiphospholipid syndrome (APS) | 1.1 | 1.1 | |
| Asthma | 0.6 | 1.1 | -0.83 |
| Atherosclerosis | 1 | 0.8 | 0.25 |
| Atrial fibrillation | 2.1 | 0.6 | 2.5 |
| Autism | 3.9 | 5 | -0.28 |
| Barrett esophagus cancer | 0.3 | 0 | 0 |
| benign prostatic hyperplasia | 0 | 0 | |
| Bipolar Disorder | 0.8 | 1 | -0.25 |
| Brain Trauma | 0.5 | 0.4 | 0.25 |
| Carcinoma | 2.1 | 1.9 | 0.11 |
| Celiac Disease | 0.9 | 3.1 | -2.44 |
| Cerebral Palsy | 1 | 1.1 | -0.1 |
| Chronic Fatigue Syndrome | 2.9 | 2.6 | 0.12 |
| Chronic Kidney Disease | 0.4 | 0.4 | 0 |
| Chronic Lyme | 0.4 | -0.4 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 0.4 | 0.2 | 1 |
| Chronic Urticaria (Hives) | 0.4 | 0.9 | -1.25 |
| Coagulation / Micro clot triggering bacteria | 0.1 | 0.8 | -7 |
| Colorectal Cancer | 1.9 | 0.5 | 2.8 |
| Constipation | 0.5 | 0.3 | 0.67 |
| Coronary artery disease | 0.6 | 0.6 | 0 |
| COVID-19 | 7.2 | 8.4 | -0.17 |
| Crohn's Disease | 3.3 | 3.2 | 0.03 |
| cystic fibrosis | 0 | 0.7 | 0 |
| deep vein thrombosis | 0 | 0.6 | 0 |
| Depression | 5.1 | 3.7 | 0.38 |
| Dermatomyositis | 0 | 0.3 | 0 |
| Eczema | 0.4 | 0.8 | -1 |
| Endometriosis | 1.2 | 1.2 | 0 |
| Eosinophilic Esophagitis | 0.3 | -0.3 | |
| Epilepsy | 1.7 | 1.6 | 0.06 |
| Fibromyalgia | 1 | 0.6 | 0.67 |
| Functional constipation / chronic idiopathic constipation | 2.7 | 1.6 | 0.69 |
| gallstone disease (gsd) | 1.3 | 0.4 | 2.25 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.8 | 0.5 | 0.6 |
| Generalized anxiety disorder | 0.3 | 1.2 | -3 |
| giant cell arteritis | 0 | 0 | |
| Glioblastoma | 0 | 0 | |
| Graves' disease | 0.8 | 0.7 | 0.14 |
| Halitosis | 0.6 | 0 | 0 |
| Hashimoto's thyroiditis | 1.4 | 0.6 | 1.33 |
| Hidradenitis Suppurativa | 0 | 0.3 | 0 |
| Histamine Issues,Mast Cell Issue, DAO Insufficiency | 1.8 | 0.2 | 8 |
| hypercholesterolemia (High Cholesterol) | 0.2 | 0.5 | -1.5 |
| hyperglycemia | 0 | 1.6 | 0 |
| Hyperlipidemia (High Blood Fats) | 0.7 | 0.2 | 2.5 |
| hypersomnia | 0.2 | -0.2 | |
| hypertension (High Blood Pressure | 1.5 | 3.1 | -1.07 |
| Hypothyroidism | 0.7 | -0.7 | |
| Hypoxia | 0.5 | 0.5 | |
| IgA nephropathy (IgAN) | 2 | -2 | |
| Inflammatory Bowel Disease | 1.8 | 4.7 | -1.61 |
| Insomnia | 0.5 | 0.5 | 0 |
| Intelligence | 0 | 0 | |
| Intracranial aneurysms | 1 | 0.2 | 4 |
| Irritable Bowel Syndrome | 3.5 | 2.1 | 0.67 |
| Liver Cirrhosis | 2.5 | 2 | 0.25 |
| Long COVID | 4.5 | 6.5 | -0.44 |
| Low bone mineral density | 0.2 | -0.2 | |
| Lung Cancer | 0.5 | 1.5 | -2 |
| ME/CFS with IBS | 0.6 | 1.6 | -1.67 |
| ME/CFS without IBS | 0.5 | 1.3 | -1.6 |
| Menopause | 1.7 | 1.7 | |
| Metabolic Syndrome | 3.7 | 4.9 | -0.32 |
| Mood Disorders | 7 | 3.8 | 0.84 |
| multiple chemical sensitivity [MCS] | 0.7 | 0.2 | 2.5 |
| Multiple Sclerosis | 3.1 | 1.7 | 0.82 |
| Multiple system atrophy (MSA) | 1.1 | 1 | 0.1 |
| Neuropathy (all types) | 0.5 | 0 | 0 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.2 | 0.2 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.7 | 4 | -4.71 |
| NonCeliac Gluten Sensitivity | 0.3 | -0.3 | |
| Obesity | 4.2 | 2.8 | 0.5 |
| obsessive-compulsive disorder | 3.3 | 1.8 | 0.83 |
| Osteoarthritis | 0.7 | 0.5 | 0.4 |
| Osteoporosis | 1.3 | 1 | 0.3 |
| pancreatic cancer | 0.2 | 0.2 | |
| Parkinson's Disease | 1.4 | 1.8 | -0.29 |
| Polycystic ovary syndrome | 1 | 1.8 | -0.8 |
| Postural orthostatic tachycardia syndrome | 0 | 0.3 | 0 |
| Premenstrual dysphoric disorder | 0.7 | 0.7 | |
| primary biliary cholangitis | 0.2 | 0.2 | 0 |
| Psoriasis | 3 | 0.9 | 2.33 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2.7 | 2.1 | 0.29 |
| Rosacea | 0.8 | 0.1 | 7 |
| Schizophrenia | 4.3 | 1.2 | 2.58 |
| scoliosis | 0.8 | -0.8 | |
| Sjögren syndrome | 1.5 | 1.8 | -0.2 |
| Sleep Apnea | 1 | 0.7 | 0.43 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.1 | 0.6 | -5 |
| Stress / posttraumatic stress disorder | 1.2 | 1.6 | -0.33 |
| Systemic Lupus Erythematosus | 1.7 | 1.5 | 0.13 |
| Tic Disorder | 0.7 | 0.7 | 0 |
| Tourette syndrome | 0.2 | 0.3 | -0.5 |
| Type 1 Diabetes | 2.2 | 1 | 1.2 |
| Type 2 Diabetes | 3.7 | 4.1 | -0.11 |
| Ulcerative colitis | 1.2 | 2 | -0.67 |
| Unhealthy Ageing | 1.9 | 0.9 | 1.11 |
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