Actinomyces Details: NCBI 1654, high G+C gram-positive [genus]

| "Actinocladothrix" Affanassieff and Schulz 1889| "Discomyces" Rivolta 1878| Actinocladothrix| Actinomyces| Actinomyces Harz 1877 (Approved Lists 1980) emend. Nouioui et al. 2018| Discomyces

1. Normal Flora:

   • Many Actinomyces species are part of the normal microbial flora in the oral cavity, gastrointestinal tract, and genital tract of humans. In these settings, they contribute to the balance of the microbiota and may have beneficial roles.

2. Pathogenic Potential:

   • While Actinomyces species are generally commensal, some can become opportunistic pathogens. Actinomyces species can cause infections, most notably actinomycosis. Actinomycosis is a chronic suppurative and granulomatous infection that can occur in various body sites, including the cervicofacial area, thorax, abdomen, and pelvis.

3. Actinomycosis:

   • Actinomycosis is characterized by the formation of abscesses, draining sinuses, and the presence of characteristic sulfur granules in the affected tissues. The condition often arises due to disruption of mucosal barriers, allowing Actinomyces to invade deeper tissues. Cervicofacial actinomycosis is one of the more common forms.

4. Dental Health:

   • Actinomyces species are commonly found in dental plaque and can be involved in dental caries and periodontal diseases. Maintaining good oral hygiene is important to prevent the overgrowth of potentially pathogenic bacteria.

5. Pelvic Inflammatory Disease (PID):

   • In the genital tract, Actinomyces species have been associated with pelvic inflammatory disease (PID), particularly in women with intrauterine devices (IUDs). This is considered a rare complication.

6. Endocarditis:

   • Actinomyces species have been implicated in infective endocarditis, particularly in individuals with pre-existing heart valve abnormalities.

7. Treatment:

   • Actinomycosis is typically treated with prolonged courses of antibiotics, often involving penicillin or other beta-lactam antibiotics. Surgical drainage and debridement may be necessary in severe cases.

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Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

More Information

Statistics

NCBI

Data Punk

End Products Produced

Lab Reporting

Different labs use different software to read the sample. See this post for more details.
One lab may say you have none, another may say you have a lot! - This may be solely due to the software they are using to estimate.
We deem lab specific values using values from the KM method for each specific lab to be the most reliable.

Desired Levels Suggestions for Actinomyces

• Frequency - how often do samples show this bacteria
• UD - An alternative statistical algorithm (which factors in the frequency)
• Kaltoft-Moldrup Heuristic Using uploaded data
• Lab Low and High are calculated using the formula that most labs use: Mean - 2 Standard Deviation to Mean + 2 Standard Deviation

These are values that are computed from lab specific samples (Patent Pending)

Lab	Frequency	UD-Low	UD-High	KM Low	KM High	Lab Low	Lab High	Mean	Median	Standard Deviation	Box Plot Low	Box Plot High	KM Percentile Low	KM Percentile High
Other Labs	2.87	0	0	13	7130	0	2706	492.4	100	1129.6	20	836	0 %ile	100 %ile
biomesight	68.02	0	70	10	150	0	1531	172.7	60	692.8	0	180	2.3 %ile	90.7 %ile
thorne	100			36	378	0	294	133.5	98	82	72	294	0 %ile	100 %ile
thryve	78.7	0	119	26	789	0	1261	183.4	78	550	0	227	11.6 %ile	96.6 %ile
ubiome	73.38	0	196	44	1769	0	5355	585.5	146	2433.6	0	490	8 %ile	95.9 %ile

External Reference Ranges for Actinomyces

Actinomyces (NCBI 1654) per million

Source of Ranges	Low Boundary	High Boundary	Low Boundary %age	High Boundary %age
Thorne (20/80%ile)	0	80.71	0	0.0081
Lab Teletest	0	500	0	0.05
Metagenomics	0	10000	0	1

Statistic by Lab Source for Actinomyces

These desired values are reported from the lab reports

Lab	Frequency Seen	Average	Standard Deviation	Sample Count	Lab Samples
AmericanGut	20 %	0.015 %	0.018 %	3.0	15
BiomeSight	71.202 %	0.017 %	0.094 %	2109.0	2962
BiomeSightRdp	29.032 %	0.011 %	0.02 %	9.0	31
bugspeak	100 %	0.016 %	%	1.0	1
CerbaLab	66.667 %	0.011 %	0.005 %	2.0	3
CosmosId	87.5 %	0.078 %	0.161 %	28.0	32
custom	9.836 %	0.003 %	0.002 %	6.0	61
es-xenogene	17.241 %	0.019 %	0.012 %	5.0	29
Medivere	100 %	0.004 %	0.002 %	7.0	7
SequentiaBiotech	27.778 %	0.079 %	0.062 %	10.0	36
Thorne	86.139 %	0.007 %	0.007 %	87.0	101
Thryve	79.05 %	0.018 %	0.061 %	1098.0	1389
Tiny	50 %	0.008 %	%	1.0	2
uBiome	73.106 %	0.059 %	0.243 %	579.0	792

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Data Contradictions — Limits of Certainity

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General Substance	Specific Substance	Effect
Amino Acid and similar	maltitol	1 Studies recorded. The consensus is Increases👶, Click for details.
Antibiotics, Antivirals etc	azithromycin,(antibiotic)s[CFS]	1 Studies recorded. The consensus is Decreases👶, Click for details.
Antibiotics, Antivirals etc	metronidazole (antibiotic)s[CFS]	1 Studies recorded. The consensus is Increases👶, Click for details.
Diet Style	whole grain diet	2 Studies recorded. The consensus is Increases👶, Click for details.
Food (excluding seasonings)	alcoholic beverages	1 Studies recorded. The consensus is Decreases👶, Click for details.
Food (excluding seasonings)	low-sugar	1 Studies recorded. The consensus is Increases📓, Click for details.
Food (excluding seasonings)	oats	1 Studies recorded. The consensus is Increases👶, Click for details.
Herb or Spice	Sumac(Rhus coriaria)	1 Studies recorded. The consensus is Decreases👶, Click for details.
Prebiotics and similar	inulin (prebiotic)	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	bacillus subtilis,lactobacillus acidophilus (probiotics)	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	bifidobacterium animalis lactis (probiotics)	1 Studies recorded. The consensus is Decreases👶, Click for details.
Probiotics	lactobacillus gasseri (probiotics)	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	lactobacillus reuteri (probiotics)	1 Studies recorded. The consensus is Increases👶, Click for details.
Probiotics	lactobacillus rhamnosus (probiotics)	1 Studies recorded. The consensus is Decreases📓, Click for details.
Probiotics	Limosilactobacillus fermentum (probiotic)	1 Studies recorded. The consensus is Increases👶, Click for details.
Sugar and similar	saccharin	1 Studies recorded. The consensus is Decreases👶, Click for details.
Sugar and similar	sugar	1 Studies recorded. The consensus is Decreases👶, Click for details.
Vitamins, Minerals and similar	zinc	1 Studies recorded. The consensus is Decreases👶, Click for details.

Foods Containing the Actinomyces bacteria

Data comes from FoodMicrobionet. For the meaning of weight, see that site. The bacteria does not need to be alive to have an effect.

Cheese with dietary fibers Weight: 3.772 Betlehem cheese Weight: 1.003 Colonial cheese, cow milk Weight: 0.6589 Passito wine Weight: 0.22 Malaysian fermented fish sauce Weight: 0.156 Curd cheese, cow milk Weight: 0.145 Caipira cheese Weight: 0.1354 Piedmont hard cheese Weight: 0.1277 Reblochon Cheese (France) Weight: 0.1204 Kefir grain Weight: 0.1145 Soumaintrain Cheese(France) Weight: 0.0688 Serrano cheese, cow milk Weight: 0.06614 Tej, Ethiopia Weight: 0.06014 Beer Sour Flanders Red Ale Weight: 0.05061 Cheese Weight: 0.04121 Campo das Vertentes cheese Weight: 0.03102 Dehulled maize dough fermented 12h, Ghana Weight: 0.02934 Swiss-Dutch-type cheese Weight: 0.02789 Trentingrana Cheese (Italy) Weight: 0.02775 fermented Hakarl Weight: 0.02342 Teff dough fermented Weight: 0.0227 Dehulled maize dough, Ghana Weight: 0.02243 Ham fermented for 4 years Weight: 0.02173 DZ Liqvan cheese cheese farm D Weight: 0.01519 Sausage, Cyprus: Limassol Weight: 0.009786 Ogi from maize, Nigeria Weight: 0.008714 Ghee, Uganda Weight: 0.007271 Fermented finger millet Weight: 0.007212 Paipa cheese Weight: 0.006381 Chinese fish sauce Weight: 0.005688 yoghurt fermentation Weight: 0.002454

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