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Cardiovascular Health: Niacin has been shown to have beneficial effects on cardiovascular health. It helps increase levels of HDL (good) cholesterol while lowering levels of LDL (bad) cholesterol and triglycerides. Niacin also helps dilate blood vessels, improving blood flow and reducing the risk of atherosclerosis, heart attack, and stroke.
Lowering Cholesterol Levels: Niacin is often used as a treatment to lower cholesterol levels, particularly in individuals with high LDL cholesterol and low HDL cholesterol levels. Niacin supplements, when taken under medical supervision, can help improve the lipid profile and reduce the risk of cardiovascular disease.
Management of Diabetes: Niacin supplementation may help improve blood sugar control and insulin sensitivity in individuals with diabetes or metabolic syndrome. It helps regulate glucose metabolism and may reduce the risk of diabetic complications such as neuropathy and cardiovascular disease.
Skin Health: Niacin is important for maintaining healthy skin. It helps support the function of the skin barrier, promotes cell turnover, and reduces inflammation. Niacinamide, a form of niacin, is often used in skincare products for its moisturizing and anti-inflammatory properties and its ability to improve the appearance of fine lines, wrinkles, and hyperpigmentation.
Neurological Function: Niacin is involved in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine, which play key roles in mood regulation, cognition, and stress response. Adequate niacin levels are necessary for optimal brain function and mental well-being.
Treatment of Pellagra: Severe niacin deficiency can lead to a condition called pellagra, characterized by symptoms such as dermatitis, diarrhea, dementia, and death if left untreated. Niacin supplementation is the primary treatment for pellagra and can help alleviate symptoms and prevent complications.
Anti-inflammatory Effects: Niacinamide, a form of niacin, has anti-inflammatory properties and may help reduce inflammation in conditions such as acne, rosacea, and inflammatory skin disorders. Niacinamide supplementation or topical application may help improve symptoms and promote healing in these conditions.
Prevention of Migraines: Some research suggests that niacin supplementation may help prevent migraines and reduce the frequency and severity of migraine attacks. Niacin helps regulate blood flow to the brain and may have vasodilatory effects that help alleviate migraine symptoms.
Rank | Probiotic | Impact |
---|---|---|
species | Bacillus aeolius | Reduces |
species | Bacillus horti | Reduces |
species | Bacillus infernus | Reduces |
species | Bacillus pumilus | Reduces |
species | Bacillus thermotolerans | Reduces |
species | Bacillus thuringiensis | Reduces |
species group | Bacillus cereus group | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
Abdominal Aortic Aneurysm | 0.7 | 0.7 | |
Acne | 0.8 | 0.2 | 3 |
ADHD | 2.5 | 1.3 | 0.92 |
Age-Related Macular Degeneration and Glaucoma | 0.3 | 0.1 | 2 |
Allergic Rhinitis (Hay Fever) | 1.1 | 0.6 | 0.83 |
Allergies | 0.9 | 1.5 | -0.67 |
Allergy to milk products | 1.1 | 1.7 | -0.55 |
Alopecia (Hair Loss) | 0.3 | 0.3 | |
Alzheimer's disease | 2.8 | 1.6 | 0.75 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.7 | 1.3 | -0.86 |
Ankylosing spondylitis | 1.5 | 1.6 | -0.07 |
Anorexia Nervosa | 1.4 | 0.8 | 0.75 |
Asthma | 1.9 | 1.9 | |
Atherosclerosis | 0.7 | 0.5 | 0.4 |
Atrial fibrillation | 0.4 | 1.2 | -2 |
Autism | 3.5 | 3.8 | -0.09 |
benign prostatic hyperplasia | 0.3 | 0.3 | |
Bipolar Disorder | 2 | 1.8 | 0.11 |
Brain Trauma | 0.2 | 1.4 | -6 |
Breast Cancer | 0.2 | 0.2 | 0 |
Carcinoma | 1.5 | 0.8 | 0.88 |
Celiac Disease | 1.8 | 0.6 | 2 |
Cerebral Palsy | 1 | 0.5 | 1 |
Chronic Fatigue Syndrome | 0.7 | 1.1 | -0.57 |
Chronic Kidney Disease | 1.5 | 0.2 | 6.5 |
Chronic Obstructive Pulmonary Disease (COPD) | 0.8 | 0.2 | 3 |
Chronic Urticaria (Hives) | 0.2 | 0.7 | -2.5 |
Coagulation / Micro clot triggering bacteria | 1.3 | 1.3 | |
Colorectal Cancer | 0.9 | 0.7 | 0.29 |
Constipation | 0.2 | 1.3 | -5.5 |
Coronary artery disease | 0.7 | 1.1 | -0.57 |
COVID-19 | 2.5 | 2.2 | 0.14 |
Crohn's Disease | 3.6 | 2.3 | 0.57 |
cystic fibrosis | 0.5 | 0.5 | |
deep vein thrombosis | 0.5 | 0.5 | |
Depression | 3.9 | 3.8 | 0.03 |
Eczema | 0.3 | 0.2 | 0.5 |
Endometriosis | 1.3 | 0.6 | 1.17 |
Eosinophilic Esophagitis | 0.2 | 0.2 | |
Epilepsy | 1.1 | 2.1 | -0.91 |
erectile dysfunction | 0.3 | 0.3 | |
Fibromyalgia | 1.1 | 1.6 | -0.45 |
Functional constipation / chronic idiopathic constipation | 1.1 | 3 | -1.73 |
gallstone disease (gsd) | 0.6 | 0.7 | -0.17 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.5 | 0.5 | 0 |
Generalized anxiety disorder | 0.3 | -0.3 | |
giant cell arteritis | 0.3 | 0.3 | |
Glioblastoma | 0.7 | 0.5 | 0.4 |
Gout | 0.8 | 0.8 | |
Graves' disease | 1.6 | 1.6 | |
Halitosis | 0.5 | 0.2 | 1.5 |
Hashimoto's thyroiditis | 0.2 | 0.9 | -3.5 |
Hemorrhoidal disease, Hemorrhoids, Piles | 0.2 | 0.2 | 0 |
Hidradenitis Suppurativa | 0.5 | 0.5 | |
hypercholesterolemia (High Cholesterol) | 0.7 | 0.2 | 2.5 |
hyperglycemia | 0.6 | -0.6 | |
hypersomnia | 0.2 | 0.2 | 0 |
hypertension (High Blood Pressure | 2 | 1.3 | 0.54 |
Hypothyroidism | 0.9 | 0.5 | 0.8 |
Hypoxia | 0.1 | 0.7 | -6 |
IgA nephropathy (IgAN) | 0.4 | 1.3 | -2.25 |
Inflammatory Bowel Disease | 1.9 | 0.9 | 1.11 |
Insomnia | 1.7 | 0.5 | 2.4 |
Intelligence | 0.2 | 1.7 | -7.5 |
Intracranial aneurysms | 0.4 | 1.5 | -2.75 |
Irritable Bowel Syndrome | 1.2 | 2.5 | -1.08 |
Liver Cirrhosis | 1.9 | 1.6 | 0.19 |
Long COVID | 3.7 | 4.3 | -0.16 |
Low bone mineral density | 0.7 | 0.7 | |
Lung Cancer | 0.7 | 0.2 | 2.5 |
ME/CFS with IBS | 0.2 | 0.2 | |
ME/CFS without IBS | 0.5 | -0.5 | |
Metabolic Syndrome | 3.3 | 3.7 | -0.12 |
Mood Disorders | 4.4 | 4.9 | -0.11 |
Multiple Sclerosis | 2 | 2.1 | -0.05 |
Multiple system atrophy (MSA) | 0.4 | 0.2 | 1 |
Neuropathy (all types) | 0.4 | -0.4 | |
neuropsychiatric disorders (PANDAS, PANS) | 0.8 | 0.8 | |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 2.2 | 1.8 | 0.22 |
Obesity | 4 | 2.9 | 0.38 |
obsessive-compulsive disorder | 1.2 | 1.1 | 0.09 |
Osteoarthritis | 1 | 1 | |
Osteoporosis | 1.3 | 0.6 | 1.17 |
pancreatic cancer | 0.3 | -0.3 | |
Parkinson's Disease | 1.9 | 2.4 | -0.26 |
Polycystic ovary syndrome | 1.7 | 0.2 | 7.5 |
Premenstrual dysphoric disorder | 0.1 | -0.1 | |
primary biliary cholangitis | 0.9 | 0.9 | |
Psoriasis | 0.5 | 2 | -3 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2 | 2.5 | -0.25 |
Rosacea | 0.2 | 0.2 | 0 |
Schizophrenia | 1.9 | 2 | -0.05 |
scoliosis | 0.2 | 0.8 | -3 |
Sjögren syndrome | 1.9 | 0.9 | 1.11 |
Sleep Apnea | 0.8 | 0.8 | 0 |
Small Intestinal Bacterial Overgrowth (SIBO) | 0.5 | 0.3 | 0.67 |
Stress / posttraumatic stress disorder | 1.4 | 0.2 | 6 |
Systemic Lupus Erythematosus | 2.7 | 1.4 | 0.93 |
Tic Disorder | 0.5 | 2.1 | -3.2 |
Tourette syndrome | 0.5 | 0.5 | |
Type 1 Diabetes | 2 | 0.7 | 1.86 |
Type 2 Diabetes | 2.8 | 3.7 | -0.32 |
Ulcerative colitis | 2.5 | 3.1 | -0.24 |
Unhealthy Ageing | 0.5 | 0.5 | 0 |
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