Symptoms with End Product Relationships

The number of End Product found to have a P-value of 0.01 or less (z-score: +/-2.58) are shown. The higher the z-score

See Technical Note on Methodology

SymptomsRelationshipsSamples1Highest Z-score
Age: 0-10 24 31 6.06
Age: 10-20 1 21 3.1
Age: 20-30 5 77 2.98
Age: 30-40 7 150 3.18
Age: 40-50 9 108 5.78
Age: 50-60 11 81 5.12
Age: 60-70 21 173 4.89
Asymptomatic: Live in house with person with probable microbiome dysfunction 6 61 2.73
Asymptomatic: Minor Health Issues (a few symptoms only) 8 55 3.8
Asymptomatic: No Health Issues 21 203 5.64
Autism: High Functioning 18 18 6.86
Autism: More Avoidance of Eye Contact or Poor Eye Contact 7 8 4.87
Autism: More Behavioral Disturbances 6 8 4.42
Autism: More Decrease in Speaking 5 11 4.02
Autism: More deficits in Language Comprehension 22 10 8.4
Autism: More Intense Focus on One Topic 12 9 3.95
Autism: More Repeating Words or Phrases 3 6 2.76
Autism: More Sleep Disturbances 10 12 4
Autism: More Unusual Responses to an Unexpected Event 13 7 7.09
Autism: Official Diagnosis 11 116 5.11
Autism: Spectrum (not full) 3 11 5.66
Autonomic Manifestations: bladder dysfunction 2 11 2.66
Autonomic Manifestations: cardiac arrhythmias 16 42 3.63
Autonomic Manifestations: Chemical Smelling Urine (atypical) 5 13 -2.61
Autonomic Manifestations: Cortisol disorders or irregularity 5 60 3.85
Autonomic Manifestations: delayed postural hypotension 1 18 3.02
Autonomic Manifestations: exertional dyspnea 8 22 3.35
Autonomic Manifestations: extreme pallor 8 12 6.84
Autonomic Manifestations: irritable bowel syndrome 23 278 4.96
Autonomic Manifestations: light-headedness 5 88 3.25
Autonomic Manifestations: nausea 3 64 2.66
Autonomic Manifestations: Neurally mediated hypotension (NMH) 4 7 3.14
Autonomic Manifestations: Orthostatic intolerance 11 108 6.72
Autonomic Manifestations: palpitations 17 67 4.01
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS) 8 62 4.55
Autonomic Manifestations: urinary frequency dysfunction 8 70 3.55
Autonomic: Blurred or tunnel vision after standing 19 37 3.67
Autonomic: Dizziness or fainting 6 71 2.86
Autonomic: Graying or blacking out after standing 15 27 9.8
Autonomic: Heart rate increase after standing 7 83 2.82
Autonomic: Inability to tolerate an upright position 14 102 3.63
Autonomic: Irregular heartbeats 13 109 3.18
Autonomic: Nausea 12 51 3.49
Autonomic: Ocassional Tachycardia (Rapid heart beat) 6 64 3
Autonomic: Shortness of breath 3 72 3.73
Blood Type: A Negative 5 12 3.04
Blood Type: A Positive 3 60 3.82
Blood Type: B Positive 3 17 -2.63
Blood Type: FUT2 secretor 11 7 4.04
Blood Type: O Positive 18 203 6.65
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding 21 257 3.93
Comorbid-Mouth: Butterfly-shaped rash across cheeks and nose 18 8 8.82
Comorbid-Mouth: Dry Mouth 16 82 3.26
Comorbid-Mouth: Gingivits / Gum Disease 4 38 4.24
Comorbid-Mouth: Mouth Sores 11 49 5.35
Comorbid-Mouth: Periradicular periodontitis inflammatory / chronic lesion around roots of teeth 1 14 2.77
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome 26 196 4.73
Comorbid: Cancer 8 8 4.59
Comorbid: Carbohydrate intolerance 3 16 3.57
Comorbid: Chronic Halitosis 3 7 2.87
Comorbid: Constipation and Diarrohea (not explosions) 2 11 -3.09
Comorbid: Constipation and Explosions (not diarrohea) 19 150 5.21
Comorbid: Crohn's Disease 5 12 -2.74
Comorbid: Electromagnetic Sensitivity (EMF) 5 23 3.19
Comorbid: Fibromyalgia 13 68 3.01
Comorbid: High Anxiety 16 201 7.59
Comorbid: Histamine or Mast Cell issues 19 229 4.37
Comorbid: Hyperthyroidism 6 8 7.3
Comorbid: Hypothyroidism 17 200 5.64
Comorbid: Inflammatory bowel disease 10 132 4.18
Comorbid: Malodor 3 6 -2.6
Comorbid: Methylation issues (MTHFR) 5 57 2.96
Comorbid: Migraine 9 48 2.78
Comorbid: Mold Sensitivity / Exposure 17 75 3.67
Comorbid: Mood Swings 8 41 3.63
Comorbid: Multiple Chemical Sensitivity 28 85 5.77
Comorbid: Panic Attacks 7 19 2.63
Comorbid: Raynaud’s syndrome (Skin discoloration) 6 19 5.5
Comorbid: Reactive Hypoglicemia 1 7 -4.07
Comorbid: Restless Leg 3 48 4.68
Comorbid: Salicylate sensitive 20 9 11.64
Comorbid: Sleep Apnea Diagnosis 19 9 7.08
Comorbid: Small intestinal bacterial overgrowth (SIBO) 8 122 4.3
Comorbid: Snoring (NOT Sleep Apnea 20 154 7.59
Comorbid: Sugars cause sleep or cognitive issues 1 7 2.64
Comorbid: Ulcerative colitis 8 14 5.99
Condition: Acne 6 25 3.88
Condition: Asthma 21 11 5.95
Condition: Generalized anxiety disorder 2 9 2.73
Condition: ME/CFS with IBS 14 47 4.6
Condition: ME/CFS without IBS 19 22 3.94
Condition: Non-alcoholic Fatty Liver Disease 10 8 3.9
Condition: Non-Celiac Gluten Sensitivity 5 23 4.19
Condition: Osteoarthritis 4 7 4.4
Condition: Post-Traumatic Stress Disorder 20 12 4.23
Condition: Psoriasis 9 9 8.06
DePaul University Fatigue Questionnaire : Abdomen pain 1 34 -3.24
DePaul University Fatigue Questionnaire : Abnormal sensitivity to light 7 33 3.75
DePaul University Fatigue Questionnaire : Absent-mindedness 5 46 3.88
DePaul University Fatigue Questionnaire : Allergies 5 66 6.61
DePaul University Fatigue Questionnaire : Anxiety/tension 12 63 4.55
DePaul University Fatigue Questionnaire : Blurred Vision 4 23 3.5
DePaul University Fatigue Questionnaire : Chemical sensitivity 4 30 3.45
DePaul University Fatigue Questionnaire : Chilled or shivery 2 15 -3.63
DePaul University Fatigue Questionnaire : Concern with driving 2 19 -2.64
DePaul University Fatigue Questionnaire : Confusion/disorientation 2 19 3.3
DePaul University Fatigue Questionnaire : Depression 4 44 -2.6
DePaul University Fatigue Questionnaire : Difficulty comprehending Information 5 41 3.02
DePaul University Fatigue Questionnaire : Difficulty falling asleep 10 51 4.17
DePaul University Fatigue Questionnaire : Difficulty finding the right word 16 74 3.91
DePaul University Fatigue Questionnaire : Difficulty following things 2 34 3.39
DePaul University Fatigue Questionnaire : Difficulty reasoning things out 3 33 2.9
DePaul University Fatigue Questionnaire : Difficulty recalling information 4 52 2.95
DePaul University Fatigue Questionnaire : Difficulty retaining information 7 46 -2.69
DePaul University Fatigue Questionnaire : Difficulty staying asleep 4 55 3.75
DePaul University Fatigue Questionnaire : Dizziness 1 7 -2.65
DePaul University Fatigue Questionnaire : Does physical activity make you feel better 12 18 9.34
DePaul University Fatigue Questionnaire : Does physical activity make you feel no effect 6 6 7.54
DePaul University Fatigue Questionnaire : Does physical activity make you feel worse 10 59 2.99
DePaul University Fatigue Questionnaire : Easily irritated 6 51 4.56
DePaul University Fatigue Questionnaire : Eye pain 7 25 3.53
DePaul University Fatigue Questionnaire : Fatigue 10 214 7.13
DePaul University Fatigue Questionnaire : Feel unsteady on feet 11 24 3.84
DePaul University Fatigue Questionnaire : Feeling like you have a temperature 1 18 -2.59
DePaul University Fatigue Questionnaire : Fever & Chills 3 13 2.6
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say 7 51 3.63
DePaul University Fatigue Questionnaire : Frequently get words or numbers in the wrong order 5 19 4.81
DePaul University Fatigue Questionnaire : Frequently loose train of thought 10 37 4.1
DePaul University Fatigue Questionnaire : Headaches 5 38 -2.59
DePaul University Fatigue Questionnaire : Hot or Cold spells 21 32 5.66
DePaul University Fatigue Questionnaire : Impaired Memory & concentration 13 170 6.83
DePaul University Fatigue Questionnaire : Mood swings 3 34 4.38
DePaul University Fatigue Questionnaire : Muscle Pain (i.e., sensations of pain or aching in your muscles. This does not include weakness or pain in other areas such as joints) 11 52 3.29
DePaul University Fatigue Questionnaire : Muscle weakness 10 49 3.08
DePaul University Fatigue Questionnaire : Need to have to focus on one thing at a time 6 45 3.71
DePaul University Fatigue Questionnaire : Need to nap during each day 13 37 3.02
DePaul University Fatigue Questionnaire : New trouble with math 8 15 8.29
DePaul University Fatigue Questionnaire : Night sweats 6 18 4.4
DePaul University Fatigue Questionnaire : Pain in Multiple Joints without Swelling or Redness 3 33 -2.96
DePaul University Fatigue Questionnaire : Poor Appetite 15 19 3.44
DePaul University Fatigue Questionnaire : Poor hand to eye coodination 4 8 3.82
DePaul University Fatigue Questionnaire : Post-exertional malaise, feeling worse after doing activities that require either physical or mental exertion 7 61 3.45
DePaul University Fatigue Questionnaire : Racing heart 3 22 3.05
DePaul University Fatigue Questionnaire : Rash 3 11 4.91
DePaul University Fatigue Questionnaire : Ringing in the Ears 7 44 4.84
DePaul University Fatigue Questionnaire : Sensitivity to Alcohol 3 42 3.03
DePaul University Fatigue Questionnaire : Shortness of breath 10 32 5.1
DePaul University Fatigue Questionnaire : Slow to react 9 25 3.31
DePaul University Fatigue Questionnaire : Slowness of thought 17 39 3.83
DePaul University Fatigue Questionnaire : Sore Throat 3 26 2.69
DePaul University Fatigue Questionnaire : Sweating hands 2 9 5.49
DePaul University Fatigue Questionnaire : Temperature lower than normal 8 32 2.77
DePaul University Fatigue Questionnaire : Tense muscles 8 27 4.36
DePaul University Fatigue Questionnaire : Tingling feeling 13 22 -2.64
DePaul University Fatigue Questionnaire : Trouble expressing thoughts 7 30 3.61
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired 14 196 6.46
DePaul University Fatigue Questionnaire : Upset stomach 4 34 3.86
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) 5 51 3.64
DePaul University Fatigue Questionnaire : Weight change 6 26 2.64
Gender: Female 15 226 4.59
Gender: Male 3 304 3.04
General: Depression 13 200 4.86
General: Fatigue 32 331 6.2
General: Headaches 21 234 5.13
General: Myalgia (pain) 25 155 4.14
General: Sinus issues with headaches 7 94 4.13
Immune Manifestations: Abdominal Pain 20 251 3.59
Immune Manifestations: Alcohol Intolerant 27 239 4.97
Immune Manifestations: Bloating 16 342 3.68
Immune Manifestations: Chronic Flatus / Flatulence / gas 6 30 3.59
Immune Manifestations: Constipation 22 280 4.05
Immune Manifestations: Diarrhea 11 122 5.33
Immune Manifestations: general malaise 20 251 4.38
Immune Manifestations: Genitorinary / Nocturia - Urinary issues 8 32 3.18
Immune Manifestations: Hair loss 25 141 4.15
Immune Manifestations: High Altitude Intolerance 8 31 -2.76
Immune Manifestations: hives 8 30 2.74
Immune Manifestations: Inflammation (General) 5 182 4.01
Immune Manifestations: Inflammation of skin, eyes or joints 11 163 5.46
Immune Manifestations: medication sensitivities. 20 111 6.3
Immune Manifestations: Mucus in the stool 9 138 2.93
Immune Manifestations: new food sensitivities 18 112 3.92
Immune Manifestations: recurrent flu-like symptoms 4 86 3.75
Immune Manifestations: tender lymph nodes 12 80 3.26
Immune Manifestations: Thick blood / Hypercoagulation 3 35 -3.25
Immune: Chronic Sinusitis 14 42 4.94
Immune: Flu-like symptoms 11 81 3.48
Immune: Recurrent Sore throat 10 88 2.66
Immune: Sensitivity to smell/food/medication/chemicals 21 147 5.21
Immune: Tender / sore lymph nodes 3 85 3.2
Immune: Viral infections with prolonged recovery periods 12 63 3.01
Infection: Coxsackie 6 25 2.96
Infection: Epstein-Barr virus 10 184 5.8
Infection: Human Herpesvirus 6 (HHV6) 15 124 5.91
Infection: Lyme 5 38 2.67
Infection: Mycoplasma 13 97 4.83
Infection: Parasite - Other 4 66 -2.59
Infection: Parasites - Giardia 1 7 2.65
Infection: Parvovirus 10 10 5.25
Infection: Varicella Zoster Virus 8 9 4.65
Joint: Redness 6 40 3.69
Joint: Stiffness and swelling 19 214 5.33
Joint: Sudden and severe episodes of pain 5 38 2.75
Joint: Tenderness 19 138 4.17
Maternal Haplotype: H1+H3 17 6 5.69
Neurocognitive: Absent-mindedness or forgetfulness 30 289 4.95
Neurocognitive: Brain Fog 14 378 3.48
Neurocognitive: Can only focus on one thing at a time 18 275 4.01
Neurocognitive: Difficulty expressing thoughts 2 150 3.65
Neurocognitive: Difficulty paying attention for a long period of time 27 297 4.22
Neurocognitive: Difficulty understanding things 6 118 -2.68
Neurocognitive: Feeling disoriented 7 85 3.26
Neurocognitive: Problems remembering things 25 295 3.95
Neurocognitive: Slowness of thought 27 276 5.66
Neurocognitive: Unable to focus vision and/or attention 16 239 4.57
Neuroendocrine Manifestations: abnormal appetite 16 59 4.58
Neuroendocrine Manifestations: Air Hunger 8 52 3.55
Neuroendocrine Manifestations: cold extremities 10 178 -2.58
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) 11 89 2.91
Neuroendocrine Manifestations: Excessive adrenaline 9 47 4.35
Neuroendocrine Manifestations: intolerance of extremes of heat and cold 24 159 4.25
Neuroendocrine Manifestations: Laboured breathing 3 16 3.79
Neuroendocrine Manifestations: loss of adaptability 2 41 3.06
Neuroendocrine Manifestations: marked diurnal fluctuation 16 16 3.81
Neuroendocrine Manifestations: marked weight change 1 89 3.17
Neuroendocrine Manifestations: Muscle weakness 33 150 3.38
Neuroendocrine Manifestations: Neuralgia 8 32 -2.77
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) 12 100 3.6
Neuroendocrine Manifestations: Poor gut motility 6 39 -3.05
Neuroendocrine Manifestations: Rapid muscular fatiguability 16 114 3.35
Neuroendocrine Manifestations: recurrent feelings of feverishness 4 50 2.61
Neuroendocrine Manifestations: subnormal body temperature 25 211 5.32
Neuroendocrine Manifestations: sweating episodes 12 147 3.01
Neuroendocrine Manifestations: worsening of symptoms with stress. 28 298 5.1
Neuroendocrine: Alcohol intolerance 27 211 4.77
Neuroendocrine: Chills or shivers 6 38 -2.6
Neuroendocrine: Cold limbs (e.g. arms, legs hands) 12 111 3.55
Neuroendocrine: Feeling hot or cold for no reason 22 105 3.32
Neuroendocrine: Feeling like you have a high temperature 7 58 2.76
Neuroendocrine: Feeling like you have a low temperature 2 47 4.43
Neuroendocrine: Lack of appetite 22 39 3.82
Neuroendocrine: Lost or gained weight without trying 15 76 3.55
Neuroendocrine: Sweating hands 10 33 3.32
Neuroendocrine: Temperature fluctuations throughout the day 1 24 2.87
Neurological-Audio: hypersensitivity to noise 18 258 5.35
Neurological-Audio: Tinnitus (ringing in ear) 20 267 4.25
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) 23 196 5.24
Neurological-Sleep: Inability for deep (delta) sleep 10 101 4.32
Neurological-Sleep: Insomnia 17 247 5.74
Neurological-Sleep: Night Sweats 4 110 2.81
Neurological-Sleep: Prolonged Sleep 1 8 -4.02
Neurological-Sleep: Sleep Apnea 19 55 5.7
Neurological-Sleep: Sleep Reversal 9 15 3.6
Neurological-Sleep: Vivid Dreams/Nightmares 5 71 3.82
Neurological-Vision: Acquired or exertional dyslexia 14 11 4.02
Neurological-Vision: Blurred Vision 14 101 4.12
Neurological-Vision: Impaired Depth Perceptions 3 22 7.5
Neurological-Vision: inability to focus eye/vision 24 194 5.72
Neurological-Vision: photophobia (Light Sensitivity) 25 223 5.56
Neurological: Ataxia (lack of volunatary muscle control) 1 6 -3.79
Neurological: Cognitive/Sensory Overload 14 134 6.03
Neurological: Confusion 6 68 3.17
Neurological: Difficulty processing information (Understanding) 19 129 4.4
Neurological: Difficulty reading 18 220 7.59
Neurological: Disorientation 5 49 5.41
Neurological: Dysautonomia 5 85 3.88
Neurological: emotional overload 18 135 4.39
Neurological: Executive Decision Making (Difficulty making) 28 233 8.36
Neurological: fasciculations 7 56 4.9
Neurological: High degree of Empathy before onset 8 55 3.32
Neurological: Impairment of concentration 37 263 6.87
Neurological: Joint hypermobility 15 138 4.31
Neurological: Myoclonic jerks or seizures 4 32 2.95
Neurological: Neuropathy 8 44 3.04
Neurological: Seasonal Affective Disorder (SAD) 8 103 4.93
Neurological: Short-term memory issues 31 144 5.81
Neurological: Slowed speech 10 83 4.22
Neurological: Spatial instability and disorientation 4 41 3.86
Neurological: Word-finding problems 11 192 3.93
Official Diagnosis: Allergic Rhinitis (Hay Fever) 12 182 4.68
Official Diagnosis: Attention deficit hyperactivity disorder (ADHD) 2 31 3.19
Official Diagnosis: Autoimmune Disease 10 131 3.97
Official Diagnosis: Celiac Disease 9 19 3.5
Official Diagnosis: Chronic Fatigue Syndrome (CFS/ME) 7 145 3.26
Official Diagnosis: Crohn's Disease 6 16 -2.7
Official Diagnosis: Depression 8 51 3.63
Official Diagnosis: Dermatitis (all types) 11 7 3.21
Official Diagnosis: Diabetes Type 1 39 6 92032516.28
Official Diagnosis: Fibromyalgia 4 43 -2.77
Official Diagnosis: Gastroesophageal reflux disease (GERD) 5 22 -2.62
Official Diagnosis: Hypercholesterolemia (High Cholesterol) 8 9 4.84
Official Diagnosis: Inflammatory Bowel Disease (IBD) 5 19 -2.82
Official Diagnosis: Irritable Bowel Syndrome 18 258 4.31
Official Diagnosis: Mast Cell Dysfunction 20 169 6.57
Official Diagnosis: Metabolic Syndrome 3 15 -2.83
Official Diagnosis: Mood Disorders 20 32 5.14
Official Diagnosis: Osteoporosis 13 14 -2.59
Official Diagnosis: Rheumatoid arthritis 19 14 6.85
Official Diagnosis: Type 2 Diabetes 8 6 5.2
Official Diagnosis: Ulcerative colitis 4 19 3.44
Onset: 1970-1980 14 7 8.53
Onset: 1980-1990 4 22 4.66
Onset: 1990-2000 3 24 3.86
Onset: 2000-2010 5 83 3.04
Onset: 2010-2020 18 233 5.53
Onset: Gradual 11 120 3.77
Onset: less than 02 years since onset 1 24 3.3
Onset: less than 04 years since onset 2 44 2.83
Onset: less than 08 years since onset 7 36 2.89
Onset: less than 16 years since onset 7 36 2.98
Onset: less than 32 years since onset 8 30 3.01
Onset: over 31 years since onset 6 19 4.32
Onset: Sudden 5 27 3.17
Other: Deep cracks in heels (heel fissures) 10 12 3.42
Other: Sensitivity to mold 16 83 3.73
Other: Sensitivity to vibrations 10 36 2.9
Pain: Aching of the eyes or behind the eyes 3 66 -2.69
Pain: Chest pain 4 37 3.1
Pain: Eye pain 5 42 -2.63
Pain: Joint pain 13 124 2.96
Pain: Myofascial pain 7 68 2.99
Pain: Pain or aching in muscles 14 115 3.84
Pain: Sensitivity to pain 14 142 3.71
Physical: African 13 6 8.06
Physical: Amalgam fillings 11 13 5.93
Physical: Appendix removed 7 8 5.49
Physical: Breastfed 5 20 4.33
Physical: Eastern European 1 12 -2.62
Physical: Good Air Quality 5 6 8.42
Physical: Keto Diet 9 7 8.8
Physical: Long term (chronic) stress 14 34 5.15
Physical: Medium Air Quality 11 6 8.6
Physical: Northern European 16 52 5.26
Physical: Organic Diet 11 22 4.87
Physical: Pets 6 29 4
Physical: Southern European 10 6 7.19
Physical: Steps Per Day < 2000 8 20 4.86
Physical: Steps Per Day 2000-4000 10 14 6.03
Physical: Steps Per Day 4000-8000 3 16 3.69
Physical: Tonsils removed 2 12 -2.62
Physical: Work-Sitting 14 41 6.59
Post-exertional malaise: Difficulty reading after mild physical or mental activity 12 127 3.71
Post-exertional malaise: General 9 122 3.27
Post-exertional malaise: Inappropriate loss of physical and mental stamina, 24 161 3.83
Post-exertional malaise: Mentally tired after the slightest effort 9 99 4.19
Post-exertional malaise: Muscle fatigue after mild physical activity 2 162 -2.6
Post-exertional malaise: Next-day soreness after everyday activities 1 114 2.92
Post-exertional malaise: Physically drained or sick after mild activity 15 133 3.34
Post-exertional malaise: Physically tired after minimum exercise 5 178 -2.58
Post-exertional malaise: Post-exertional malaise 13 165 3.01
Post-exertional malaise: Rapid cognitive fatigability, 9 125 3.71
Post-exertional malaise: Rapid muscular fatigability, 19 111 3.26
Post-exertional malaise: Worsening of symptoms after mild mental activity 11 92 3.36
Post-exertional malaise: Worsening of symptoms after mild physical activity 5 168 3.79
Sleep: Daytime drowsiness 13 251 3.54
Sleep: Need to nap daily 2 80 3.31
Sleep: Problems falling asleep 2 109 2.9
Sleep: Problems staying asleep 21 258 4.58
Sleep: Sleeping all day and staying awake all night 12 27 3.86
Sleep: Unrefreshed sleep 26 304 5.46
Sleep: Waking up early in the morning (e.g. 3 AM) 20 261 5.35
1 This is the effective sample count based on clustering.
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This is an Academic site. It generates theoretical models of what may benefit a specific microbiome results.