Symptoms with KEGG Module Relationships

The number of KEGG Module found to have a P-value of 0.01 or less (z-score: +/-2.58) are shown. The higher the z-score

See Technical Note on Methodology

SymptomsRelationshipsSamples1Highest Z-score
Age: 0-10 9 32 3.95
Age: 10-20 3 22 5.25
Age: 20-30 7 77 4.2
Age: 30-40 44 149 3.71
Age: 40-50 23 107 4.39
Age: 50-60 6 77 3.31
Age: 60-70 13 172 4.08
Asymptomatic: Live in house with person with probable microbiome dysfunction 18 66 -2.67
Asymptomatic: Minor Health Issues (a few symptoms only) 17 54 3.78
Asymptomatic: No Health Issues 16 202 2.98
Autism: High Functioning 76 18 7.95
Autism: More Avoidance of Eye Contact or Poor Eye Contact 5 8 2.99
Autism: More Behavioral Disturbances 53 9 9.32
Autism: More Decrease in Speaking 5 12 4.01
Autism: More deficits in Language Comprehension 48 10 8.08
Autism: More Flat or Monotonous Speech 1 6 2.63
Autism: More Inappropriate Social Interaction 56 6 10.4
Autism: More Intense Focus on One Topic 56 10 7.63
Autism: More Repeating Words or Phrases 48 7 6.29
Autism: More Repetitive Movements 56 6 10.41
Autism: More Sleep Disturbances 46 13 6.09
Autism: More Unusual Responses to an Unexpected Event 55 8 7.54
Autism: Official Diagnosis 7 117 4.72
Autism: Spectrum (not full) 22 11 9.43
Autonomic Manifestations: bladder dysfunction 2 23 4.41
Autonomic Manifestations: cardiac arrhythmias 7 42 3.16
Autonomic Manifestations: Chemical Smelling Urine (atypical) 12 12 7.11
Autonomic Manifestations: Cortisol disorders or irregularity 4 58 3.56
Autonomic Manifestations: delayed postural hypotension 1 6 4.2
Autonomic Manifestations: exertional dyspnea 14 23 4.13
Autonomic Manifestations: extreme pallor 36 13 -2.59
Autonomic Manifestations: irritable bowel syndrome 18 275 3.78
Autonomic Manifestations: light-headedness 12 89 7.29
Autonomic Manifestations: nausea 7 64 -2.66
Autonomic Manifestations: Orthostatic intolerance 12 106 4.7
Autonomic Manifestations: palpitations 17 67 3.56
Autonomic Manifestations: Postural orthostatic tachycardia syndrome (POTS) 30 62 2.97
Autonomic Manifestations: urinary frequency dysfunction 21 71 4.47
Autonomic: Blurred or tunnel vision after standing 17 38 4.21
Autonomic: Dizziness or fainting 10 72 2.82
Autonomic: Graying or blacking out after standing 31 27 7.07
Autonomic: Inability to tolerate an upright position 17 100 4.38
Autonomic: Irregular heartbeats 9 108 6.96
Autonomic: Nausea 12 52 5.25
Autonomic: Ocassional Tachycardia (Rapid heart beat) 5 64 3.27
Autonomic: Vasovagal syncope (easy fainting) 1 13 -2.69
Blood Type: A Negative 2 12 -2.64
Blood Type: A Positive 31 59 5.56
Blood Type: B Positive 4 16 2.8
Blood Type: FUT2 secretor 49 7 7.71
Blood Type: O Positive 25 202 6.25
Comorbid-Mouth: Bruxism - Jaw cleanching / Teeth grinding 8 250 4.14
Comorbid-Mouth: Butterfly-shaped rash across cheeks and nose 8 8 -2.61
Comorbid-Mouth: Dry Mouth 42 82 3.36
Comorbid-Mouth: Gingivits / Gum Disease 4 38 2.76
Comorbid-Mouth: Mouth Sores 9 50 4.14
Comorbid-Mouth: Periradicular periodontitis inflammatory / chronic lesion around roots of teeth 1 6 3.71
Comorbid-Mouth: TMJ / Dysfunction of the temporomandibular joint syndrome 17 195 4.38
Comorbid: Carbohydrate intolerance 3 14 -2.61
Comorbid: Chronic Halitosis 1 7 -2.91
Comorbid: Constipation and Diarrohea (not explosions) 5 22 -3.14
Comorbid: Constipation and Explosions (not diarrohea) 25 149 5.61
Comorbid: Crohn's Disease 18 12 6.37
Comorbid: Fibromyalgia 25 68 2.87
Comorbid: High Anxiety 21 199 7.19
Comorbid: Histamine or Mast Cell issues 10 227 3.76
Comorbid: Hyperthyroidism 3 8 3.47
Comorbid: Hypothyroidism 12 198 4.98
Comorbid: Inflammatory bowel disease 15 131 4.81
Comorbid: Malodor 7 6 3.77
Comorbid: Methylation issues (MTHFR) 35 58 3.35
Comorbid: Migraine 19 47 3.96
Comorbid: Mold Sensitivity / Exposure 20 75 -2.64
Comorbid: Mood Swings 53 39 4.63
Comorbid: Multiple Chemical Sensitivity 34 85 4.52
Comorbid: Panic Attacks 43 18 3.02
Comorbid: Raynaud’s syndrome (Skin discoloration) 8 19 5.85
Comorbid: Reactive Hypoglicemia 8 8 -2.59
Comorbid: Restless Leg 6 48 -2.66
Comorbid: Salicylate sensitive 53 9 -2.6
Comorbid: Sleep Apnea Diagnosis 42 9 3.43
Comorbid: Small intestinal bacterial overgrowth (SIBO) 36 120 4.65
Comorbid: Snoring (NOT Sleep Apnea 20 151 5.05
Comorbid: Sugars cause sleep or cognitive issues 2 9 -2.71
Comorbid: Ulcerative colitis 1 14 -2.8
Condition: Acne 32 25 4.38
Condition: Asthma 71 11 7.72
Condition: Generalized anxiety disorder 41 9 10.58
Condition: ME/CFS with IBS 13 46 8.37
Condition: ME/CFS without IBS 23 21 5.88
Condition: Non-alcoholic Fatty Liver Disease 33 8 3.82
Condition: Non-Celiac Gluten Sensitivity 15 23 4.28
Condition: Osteoarthritis 10 7 3.06
Condition: Post-Traumatic Stress Disorder 14 12 8.28
Condition: Psoriasis 9 9 4.1
DePaul University Fatigue Questionnaire : Abdomen pain 4 36 3.21
DePaul University Fatigue Questionnaire : Abnormal sensitivity to light 6 33 3.75
DePaul University Fatigue Questionnaire : Absent-mindedness 11 44 4.02
DePaul University Fatigue Questionnaire : Allergies 38 62 4.92
DePaul University Fatigue Questionnaire : Anxiety/tension 7 63 3.97
DePaul University Fatigue Questionnaire : Blurred Vision 10 21 3.49
DePaul University Fatigue Questionnaire : Chemical sensitivity 5 30 -2.66
DePaul University Fatigue Questionnaire : Concern with driving 14 19 4.04
DePaul University Fatigue Questionnaire : Depression 6 43 2.81
DePaul University Fatigue Questionnaire : Difficulty comprehending Information 11 40 4.72
DePaul University Fatigue Questionnaire : Difficulty falling asleep 32 49 3.58
DePaul University Fatigue Questionnaire : Difficulty finding the right word 15 71 4.51
DePaul University Fatigue Questionnaire : Difficulty following things 12 35 4.55
DePaul University Fatigue Questionnaire : Difficulty reasoning things out 6 30 4.49
DePaul University Fatigue Questionnaire : Difficulty recalling information 6 49 4.48
DePaul University Fatigue Questionnaire : Difficulty retaining information 4 43 3.76
DePaul University Fatigue Questionnaire : Difficulty staying asleep 17 52 4.09
DePaul University Fatigue Questionnaire : Dizziness 4 25 2.88
DePaul University Fatigue Questionnaire : Does physical activity make you feel better 2 17 -2.68
DePaul University Fatigue Questionnaire : Does physical activity make you feel no effect 2 6 -3.55
DePaul University Fatigue Questionnaire : Does physical activity make you feel worse 21 59 4.16
DePaul University Fatigue Questionnaire : Easily irritated 23 49 5.56
DePaul University Fatigue Questionnaire : Eye pain 1 23 -2.67
DePaul University Fatigue Questionnaire : Fatigue 51 212 5.98
DePaul University Fatigue Questionnaire : Feel unsteady on feet 3 22 3.22
DePaul University Fatigue Questionnaire : Fever & Chills 2 10 3.58
DePaul University Fatigue Questionnaire : Forgetting what you are trying to say 9 49 3.94
DePaul University Fatigue Questionnaire : Frequently get words or numbers in the wrong order 2 21 3.34
DePaul University Fatigue Questionnaire : Frequently loose train of thought 14 35 4.68
DePaul University Fatigue Questionnaire : Hot or Cold spells 3 31 4.2
DePaul University Fatigue Questionnaire : Impaired Memory & concentration 43 166 5.75
DePaul University Fatigue Questionnaire : Mood swings 15 34 4.15
DePaul University Fatigue Questionnaire : Muscle Pain (i.e., sensations of pain or aching in your muscles. This does not include weakness or pain in other areas such as joints) 43 51 4
DePaul University Fatigue Questionnaire : Muscle weakness 18 48 4.47
DePaul University Fatigue Questionnaire : Need to have to focus on one thing at a time 7 42 3.36
DePaul University Fatigue Questionnaire : Need to nap during each day 16 36 -2.65
DePaul University Fatigue Questionnaire : Night sweats 3 17 2.73
DePaul University Fatigue Questionnaire : Pain in Multiple Joints without Swelling or Redness 4 7 -2.91
DePaul University Fatigue Questionnaire : Poor Appetite 1 8 3.14
DePaul University Fatigue Questionnaire : Poor hand to eye coodination 17 8 7.28
DePaul University Fatigue Questionnaire : Post-exertional malaise, feeling worse after doing activities that require either physical or mental exertion 52 60 5.08
DePaul University Fatigue Questionnaire : Racing heart 2 11 3.07
DePaul University Fatigue Questionnaire : Rash 3 14 3.49
DePaul University Fatigue Questionnaire : Ringing in the Ears 12 43 4.32
DePaul University Fatigue Questionnaire : Sensitivity to Alcohol 3 40 2.98
DePaul University Fatigue Questionnaire : Shortness of breath 7 31 4.39
DePaul University Fatigue Questionnaire : Slow to react 1 25 2.63
DePaul University Fatigue Questionnaire : Slowness of thought 8 37 4.18
DePaul University Fatigue Questionnaire : Sore Throat 1 27 2.65
DePaul University Fatigue Questionnaire : Sweating hands 8 9 -2.68
DePaul University Fatigue Questionnaire : Temperature lower than normal 7 32 4.07
DePaul University Fatigue Questionnaire : Tense muscles 5 26 3.05
DePaul University Fatigue Questionnaire : Tingling feeling 12 22 -2.59
DePaul University Fatigue Questionnaire : Trouble expressing thoughts 1 30 3.5
DePaul University Fatigue Questionnaire : Unrefreshing Sleep, that is waking up feeling tired 50 193 5
DePaul University Fatigue Questionnaire : Upset stomach 6 33 2.74
DePaul University Fatigue Questionnaire : Walking up early in the morning (e.g. 3AM) 13 50 3.42
DePaul University Fatigue Questionnaire : Weight change 16 24 -2.59
Gender: Female 20 222 3.61
Gender: Male 4 310 3.09
General: Depression 25 200 4.17
General: Fatigue 26 330 3.95
General: Headaches 26 233 4.65
General: Heavy feeling in arms and legs 13 53 2.79
General: Myalgia (pain) 31 155 3.05
General: Sinus issues with headaches 9 83 -2.59
Immune Manifestations: Abdominal Pain 14 247 4.17
Immune Manifestations: Alcohol Intolerant 15 234 4.16
Immune Manifestations: Bloating 6 300 3.59
Immune Manifestations: Chronic Flatus / Flatulence / gas 7 30 4.4
Immune Manifestations: Constipation 10 277 4.87
Immune Manifestations: Diarrhea 13 120 -2.64
Immune Manifestations: general malaise 13 248 2.97
Immune Manifestations: Genitorinary / Nocturia - Urinary issues 7 33 3.28
Immune Manifestations: Hair loss 54 139 4.8
Immune Manifestations: High Altitude Intolerance 3 31 3.29
Immune Manifestations: hives 35 30 -2.6
Immune Manifestations: Inflammation (General) 39 179 4.01
Immune Manifestations: Inflammation of skin, eyes or joints 46 162 5.31
Immune Manifestations: medication sensitivities. 17 109 3.88
Immune Manifestations: Mucus in the stool 14 137 3.88
Immune Manifestations: new food sensitivities 32 113 5.12
Immune Manifestations: recurrent flu-like symptoms 4 85 2.78
Immune Manifestations: tender lymph nodes 14 81 -2.59
Immune Manifestations: Thick blood / Hypercoagulation 8 13 -3.72
Immune Manifestations: vomiting 3 6 -2.76
Immune: Chronic Sinusitis 6 42 -2.7
Immune: Flu-like symptoms 17 81 2.78
Immune: Sensitivity to smell/food/medication/chemicals 22 148 2.68
Immune: Tender / sore lymph nodes 7 86 3.53
Immune: Viral infections with prolonged recovery periods 29 64 -2.61
Infection: Coxsackie 19 24 3.87
Infection: Epstein-Barr virus 12 184 3.52
Infection: Human Herpesvirus 6 (HHV6) 13 120 3.99
Infection: Lyme 2 32 -2.63
Infection: Mycoplasma 3 97 2.83
Infection: Parasite - Other 10 65 5.03
Infection: Parasites - Giardia 2 7 -2.73
Infection: Parvovirus 25 9 3.74
Infection: Varicella Zoster Virus 6 8 -2.85
Joint: Redness 16 39 5.22
Joint: Stiffness and swelling 14 213 5.19
Joint: Sudden and severe episodes of pain 14 39 8.6
Joint: Tenderness 26 138 4.78
Neurocognitive: Absent-mindedness or forgetfulness 13 286 3.61
Neurocognitive: Brain Fog 9 319 3.19
Neurocognitive: Can only focus on one thing at a time 8 271 3.22
Neurocognitive: Difficulty expressing thoughts 5 117 4.1
Neurocognitive: Difficulty paying attention for a long period of time 8 293 4.45
Neurocognitive: Difficulty understanding things 6 116 -2.8
Neurocognitive: Feeling disoriented 5 82 2.6
Neurocognitive: Problems remembering things 9 291 3.82
Neurocognitive: Slowness of thought 19 273 4.94
Neurocognitive: Unable to focus vision and/or attention 11 237 3.84
Neuroendocrine Manifestations: abnormal appetite 12 59 3.4
Neuroendocrine Manifestations: Air Hunger 5 45 4.25
Neuroendocrine Manifestations: cold extremities 22 178 5.15
Neuroendocrine Manifestations: Dry Eye (Sicca or Sjogren Syndrome) 49 89 -2.61
Neuroendocrine Manifestations: Excessive adrenaline 9 47 7.75
Neuroendocrine Manifestations: intolerance of extremes of heat and cold 7 159 3.11
Neuroendocrine Manifestations: loss of adaptability 3 37 3.58
Neuroendocrine Manifestations: marked diurnal fluctuation 3 16 -2.99
Neuroendocrine Manifestations: marked weight change 4 89 3.32
Neuroendocrine Manifestations: Muscle weakness 21 149 2.96
Neuroendocrine Manifestations: Neuralgia 5 32 5.8
Neuroendocrine Manifestations: Painful menstrual periods 9 12 3.44
Neuroendocrine Manifestations: Paraesthesia (tingling burning of skin) 12 101 4.48
Neuroendocrine Manifestations: Poor gut motility 14 37 3.9
Neuroendocrine Manifestations: Rapid muscular fatiguability 20 112 2.64
Neuroendocrine Manifestations: recurrent feelings of feverishness 5 48 3.74
Neuroendocrine Manifestations: subnormal body temperature 19 211 7.42
Neuroendocrine Manifestations: sweating episodes 2 63 6.02
Neuroendocrine Manifestations: worsening of symptoms with stress. 13 298 3.11
Neuroendocrine: Alcohol intolerance 14 206 3.86
Neuroendocrine: Chills or shivers 11 38 -2.67
Neuroendocrine: Cold limbs (e.g. arms, legs hands) 12 111 2.95
Neuroendocrine: Feeling hot or cold for no reason 13 104 3.08
Neuroendocrine: Feeling like you have a high temperature 10 57 3.71
Neuroendocrine: Feeling like you have a low temperature 6 49 -2.63
Neuroendocrine: Lack of appetite 13 40 3.03
Neuroendocrine: Lost or gained weight without trying 20 76 -2.69
Neuroendocrine: Sweating hands 22 33 3.61
Neuroendocrine: Temperature fluctuations throughout the day 4 50 3.32
Neurological-Audio: hypersensitivity to noise 9 252 3.88
Neurological-Audio: Tinnitus (ringing in ear) 5 210 4.56
Neurological-Sleep: Chaotic diurnal sleep rhythms (Erratic Sleep) 17 192 6.71
Neurological-Sleep: Inability for deep (delta) sleep 3 99 2.81
Neurological-Sleep: Insomnia 9 241 4.37
Neurological-Sleep: Prolonged Sleep 3 22 4.33
Neurological-Sleep: Sleep Apnea 30 56 3.96
Neurological-Sleep: Sleep Reversal 2 15 2.68
Neurological-Sleep: Vivid Dreams/Nightmares 3 8 2.97
Neurological-Vision: Acquired or exertional dyslexia 28 10 8.16
Neurological-Vision: Blurred Vision 25 100 4.08
Neurological-Vision: Impaired Depth Perceptions 8 21 3.93
Neurological-Vision: inability to focus eye/vision 28 192 5.68
Neurological-Vision: photophobia (Light Sensitivity) 9 223 4.5
Neurological: Ataxia (lack of volunatary muscle control) 13 18 -2.63
Neurological: Cognitive/Sensory Overload 14 134 3.05
Neurological: Confusion 10 66 3.93
Neurological: Difficulty processing information (Understanding) 28 127 3.61
Neurological: Difficulty reading 24 218 5.44
Neurological: Disorientation 1 47 3
Neurological: Dysautonomia 7 83 3.85
Neurological: emotional overload 33 135 3.83
Neurological: Executive Decision Making (Difficulty making) 17 230 6.32
Neurological: fasciculations 20 56 4.06
Neurological: High degree of Empathy before onset 6 55 3.91
Neurological: Impairment of concentration 31 262 4.44
Neurological: Joint hypermobility 9 137 4.11
Neurological: Myoclonic jerks or seizures 33 33 2.94
Neurological: Neuropathy 7 20 2.82
Neurological: Seasonal Affective Disorder (SAD) 19 102 4.32
Neurological: Short-term memory issues 38 143 8.81
Neurological: Slowed speech 8 82 4.55
Neurological: Spatial instability and disorientation 4 42 -3.08
Neurological: Word-finding problems 9 191 3.28
Official Diagnosis: Allergic Rhinitis (Hay Fever) 13 178 4.51
Official Diagnosis: Attention deficit hyperactivity disorder (ADHD) 4 31 2.79
Official Diagnosis: Autoimmune Disease 27 130 5.04
Official Diagnosis: Celiac Disease 6 19 2.92
Official Diagnosis: Chronic Fatigue Syndrome (CFS/ME) 8 11 -2.59
Official Diagnosis: Crohn's Disease 17 16 4.87
Official Diagnosis: Depression 9 51 3.5
Official Diagnosis: Dermatitis (all types) 12 7 -2.58
Official Diagnosis: Diabetes Type 1 70 6 18.83
Official Diagnosis: Fibromyalgia 6 11 -3.67
Official Diagnosis: High Blood Pressure (Hypertension) 3 14 3.55
Official Diagnosis: Hypercholesterolemia (High Cholesterol) 19 8 3.32
Official Diagnosis: Inflammatory Bowel Disease (IBD) 6 19 3.08
Official Diagnosis: Irritable Bowel Syndrome 7 257 4.28
Official Diagnosis: Mast Cell Dysfunction 27 168 5.88
Official Diagnosis: Metabolic Syndrome 8 14 -2.59
Official Diagnosis: Mood Disorders 55 33 4.4
Official Diagnosis: Osteoporosis 25 14 -2.65
Official Diagnosis: Rheumatoid arthritis 36 14 6.78
Official Diagnosis: Ulcerative colitis 1 19 -2.89
Onset: 1970-1980 9 7 6.28
Onset: 1980-1990 1 22 -2.86
Onset: 1990-2000 12 25 3.53
Onset: 2000-2010 5 82 2.98
Onset: 2010-2020 16 232 5.18
Onset: Gradual 16 121 4.41
Onset: less than 02 years since onset 12 27 4.09
Onset: less than 08 years since onset 7 36 -2.76
Onset: less than 16 years since onset 7 43 2.99
Onset: less than 32 years since onset 41 30 4.32
Onset: over 31 years since onset 9 19 4.63
Onset: Sudden 9 24 2.8
Other: Deep cracks in heels (heel fissures) 17 12 5.82
Other: Sensitivity to mold 16 84 2.7
Other: Sensitivity to vibrations 13 37 2.63
Pain: Aching of the eyes or behind the eyes 3 64 2.98
Pain: Chest pain 2 11 3.62
Pain: Eye pain 11 41 2.91
Pain: Joint pain 16 125 3.78
Pain: Myofascial pain 18 69 3.55
Pain: Pain or aching in muscles 28 115 4.29
Pain: Sensitivity to pain 8 142 5.39
Physical: African 1 6 3.04
Physical: Amalgam fillings 32 13 6.61
Physical: Appendix removed 5 8 4.97
Physical: Breastfed 10 20 4.37
Physical: Good Air Quality 11 6 3.42
Physical: Keto Diet 21 7 4.46
Physical: Long term (chronic) stress 17 33 5.17
Physical: Northern European 23 51 2.98
Physical: Organic Diet 13 22 3.71
Physical: Pets 15 28 4.53
Physical: Southern European 5 6 5.86
Physical: Steps Per Day < 2000 9 19 3.94
Physical: Steps Per Day 2000-4000 27 14 3.69
Physical: Steps Per Day 4000-8000 12 16 4.7
Physical: Tonsils removed 23 12 2.7
Physical: Work-Sitting 19 41 5.53
Post-exertional malaise: Difficulty reading after mild physical or mental activity 14 126 3.28
Post-exertional malaise: General 15 120 3.6
Post-exertional malaise: Inappropriate loss of physical and mental stamina, 21 160 2.86
Post-exertional malaise: Mentally tired after the slightest effort 2 98 -2.9
Post-exertional malaise: Muscle fatigue after mild physical activity 10 164 3.43
Post-exertional malaise: Next-day soreness after everyday activities 3 6 3.35
Post-exertional malaise: Physically drained or sick after mild activity 14 133 3.65
Post-exertional malaise: Physically tired after minimum exercise 6 177 3.54
Post-exertional malaise: Post-exertional malaise 8 166 2.89
Post-exertional malaise: Rapid cognitive fatigability, 20 124 3.52
Post-exertional malaise: Rapid muscular fatigability, 22 110 3.43
Post-exertional malaise: Worsening of symptoms after mild mental activity 13 91 4.48
Post-exertional malaise: Worsening of symptoms after mild physical activity 3 140 3.08
Sleep: Daytime drowsiness 11 248 4.53
Sleep: Need to nap daily 4 26 -2.6
Sleep: Problems falling asleep 8 127 3.8
Sleep: Problems staying asleep 10 252 3.79
Sleep: Sleeping all day and staying awake all night 11 26 2.74
Sleep: Unrefreshed sleep 22 299 4.09
Sleep: Waking up early in the morning (e.g. 3 AM) 10 259 4.46
1 This is the effective sample count based on clustering.
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