Anaplasmataceae Details: NCBI 942, gram-negative or unknown [family]

| Anaplasmataceae| Anaplasmataceae Philip 1957 (Approved Lists 1980) emend. Dumler et al. 2001| Ehrlichiaceae| Ehrlichiaceae Moshkovski 1945| Ehrlichieae| Ehrlichieae Philip 1957

1. Vector-Borne Diseases:

   • Anaplasmataceae bacteria are primarily transmitted through arthropod vectors such as ticks and fleas. Infection usually occurs when an infected arthropod bites a susceptible host, leading to the introduction of the bacteria into the host's bloodstream.

2. Human Diseases:

   • Anaplasmosis: Anaplasma species, such as Anaplasma phagocytophilum, can cause anaplasmosis in humans. Symptoms may include fever, headache, muscle aches, and other flu-like symptoms. Severe cases can lead to complications affecting the respiratory and central nervous systems.
   • Ehrlichiosis: Ehrlichia species, such as Ehrlichia chaffeensis and Ehrlichia ewingii, are responsible for ehrlichiosis in humans. Symptoms can range from mild to severe and may include fever, fatigue, muscle aches, and, in severe cases, complications affecting multiple organ systems.

3. Animal Diseases:

   • Anaplasmataceae bacteria can also infect a variety of domestic and wild animals, causing diseases such as anaplasmosis and ehrlichiosis in livestock and pets. The impact on animals varies, but it can lead to clinical signs such as fever, lethargy, anemia, and joint pain.

4. Geographical Distribution:

   • The distribution of diseases caused by Anaplasmataceae is often associated with the presence of competent arthropod vectors. Regions with a high prevalence of ticks or fleas that carry these bacteria are more likely to see cases of anaplasmosis and ehrlichiosis.

5. Diagnosis and Treatment:

   • Laboratory tests, including PCR assays and serological tests, are commonly used for the diagnosis of Anaplasmataceae infections. Treatment typically involves the use of antibiotics, such as doxycycline.

6. Prevention:

   • Preventive measures include avoiding tick and flea bites, using insect repellents, wearing protective clothing, and performing regular checks for ticks after outdoor activities. Controlling vector populations is also crucial for preventing the spread of these diseases.

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Other Sources for more information:

• Immune Epitope Database
• The NCBI taxonomy database
• UniProt
• Immune Epitope Taxonomy Database (IEDB)
• AI Engines For more Details: Perplexity  Kagi Labs  You 

More Information

Statistics

NCBI

Data Punk

End Products Produced

Lab Reporting

Different labs use different software to read the sample. See this post for more details.
One lab may say you have none, another may say you have a lot! - This may be solely due to the software they are using to estimate.
We deem lab specific values using values from the KM method for each specific lab to be the most reliable.

Desired Levels Suggestions for Anaplasmataceae

• Frequency - how often do samples show this bacteria
• UD - An alternative statistical algorithm (which factors in the frequency)
• Kaltoft-Moldrup Heuristic Using uploaded data
• Lab Low and High are calculated using the formula that most labs use: Mean - 2 Standard Deviation to Mean + 2 Standard Deviation

These are values that are computed from lab specific samples (Patent Pending)

Lab	Frequency	UD-Low	UD-High	KM Low	KM High	Lab Low	Lab High	Mean	Median	Standard Deviation	Box Plot Low	Box Plot High	KM Percentile Low	KM Percentile High
Other Labs	0.49			1	280	0	291	86.4	35	104.3	1	280	7.7 %ile	84.6 %ile
biomesight	26.82	0	20	10	190	0	266	58.6	30	105.8	10	110	0 %ile	96.6 %ile
thorne	82.76			1	33	0	24	8.4	5	8.2	1	21	0 %ile	100 %ile
thryve	1.99			1	52	0	40	19.8	18	10.3	11	25	0 %ile	100 %ile

External Reference Ranges for Anaplasmataceae

Anaplasmataceae (NCBI 942) per million

Source of Ranges	Low Boundary	High Boundary	Low Boundary %age	High Boundary %age
Thorne (20/80%ile)	2.28	7.95	0.0002	0.0008

Statistic by Lab Source for Anaplasmataceae

These desired values are reported from the lab reports

Lab	Frequency Seen	Average	Standard Deviation	Sample Count	Lab Samples
BiomeSight	28.923 %	0.006 %	0.009 %	857.0	2963
BiomeSightRdp	3.226 %	0.002 %	%	1.0	31
CerbaLab	66.667 %	0 %	0 %	2.0	3
CosmosId	3.125 %	0.011 %	%	1.0	32
custom	1.639 %	0.001 %	%	1.0	61
es-xenogene	13.793 %	0.019 %	0.01 %	4.0	29
Medivere	28.571 %	0.002 %	0.002 %	2.0	7
Thorne	60.577 %	0.001 %	0.001 %	63.0	104
Thryve	1.727 %	0.002 %	0.001 %	24.0	1390

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