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Skin Conditions: Clocortolone pivalate is commonly prescribed topically (in the form of creams, ointments, or lotions) for the treatment of various inflammatory skin conditions, including eczema (atopic dermatitis), psoriasis, allergic dermatitis, contact dermatitis, and seborrheic dermatitis. It helps to reduce inflammation, itching, redness, and swelling associated with these skin disorders by suppressing the immune response and inhibiting the release of inflammatory mediators.
Eczema: Clocortolone pivalate may be particularly effective in the management of eczema, a chronic inflammatory skin condition characterized by dry, itchy, and inflamed patches of skin. Topical application of clocortolone pivalate helps to relieve itching and inflammation, moisturize the skin, and improve skin barrier function, thereby reducing the frequency and severity of eczema flares and promoting symptom relief.
Psoriasis: Clocortolone pivalate may also be used topically in the treatment of psoriasis, a chronic autoimmune skin disorder characterized by red, scaly patches of skin. It helps to reduce inflammation and scaling associated with psoriatic lesions, alleviate itching and discomfort, and promote the clearance of psoriatic plaques. Clocortolone pivalate may be used alone or in combination with other topical or systemic medications for the management of psoriasis.
Contact Dermatitis: Clocortolone pivalate is effective in the treatment of contact dermatitis, a type of allergic skin reaction caused by exposure to allergens or irritants. It helps to alleviate inflammation, redness, and itching associated with contact dermatitis, promote healing of the affected skin, and prevent further irritation or allergic reactions.
Safety and Side Effects: Clocortolone pivalate is generally well-tolerated when used topically, and side effects are usually mild and transient. Common side effects may include skin irritation, burning, stinging, itching, dryness, or peeling at the site of application. Rare but more serious side effects may include skin thinning, skin discoloration, allergic contact dermatitis, and systemic absorption leading to adrenal suppression or Cushing's syndrome, particularly with prolonged use or application to large areas of skin.
Precautions: Clocortolone pivalate should be used with caution in certain populations, including children, pregnant or breastfeeding women, and individuals with a history of hypersensitivity reactions to corticosteroids. It should not be applied to open wounds, broken or infected skin, or areas of skin affected by viral infections such as herpes or chickenpox. Long-term use of clocortolone pivalate should be avoided, and treatment should be discontinued once symptoms have resolved to minimize the risk of side effects.
Rank | Probiotic | Impact |
---|---|---|
species | Lacticaseibacillus paracasei | Reduces |
species | Parabacteroides distasonis | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
Taxonomy | Rank | Effect | Citations | Notation |
---|---|---|---|---|
Lacticaseibacillus | genus | Decreases | 👪 Source Study | |
Roseburia | genus | Decreases | 👪 Source Study | |
Parabacteroides | genus | Decreases | 👪 Source Study | BMI, fat percent,blood pressure |
Thomasclavelia | genus | Decreases | 👪 Source Study | |
Lacticaseibacillus paracasei | species | Decreases | 📓 Source Study | |
Roseburia intestinalis | species | Decreases | 📓 Source Study | |
Parabacteroides distasonis | species | Decreases | 📓 Source Study | |
Thomasclavelia ramosa | species | Decreases | 📓 Source Study | |
Lacticaseibacillus paracasei subsp. paracasei | subspecies | Decreases | 👶 Source Study | |
Lacticaseibacillus paracasei subsp. tolerans | subspecies | Decreases | 👶 Source Study |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
ADHD | 0.4 | 0.4 | |
Age-Related Macular Degeneration and Glaucoma | 0.3 | 0.1 | 2 |
Allergic Rhinitis (Hay Fever) | 0.1 | 0.1 | |
Allergy to milk products | 0.1 | -0.1 | |
Alopecia (Hair Loss) | 0.2 | 0.2 | |
Alzheimer's disease | 0.1 | 0.3 | -2 |
Ankylosing spondylitis | 0.2 | 0.2 | |
Anorexia Nervosa | 0.1 | 0.3 | -2 |
Antiphospholipid syndrome (APS) | 0.5 | 0.5 | |
Asthma | 0.3 | -0.3 | |
Atherosclerosis | 0.8 | -0.8 | |
Atrial fibrillation | 0.1 | 0.1 | 0 |
Autism | 0.4 | 0.4 | 0 |
Bipolar Disorder | 0.1 | 0.3 | -2 |
Brain Trauma | 0.3 | -0.3 | |
Cancer (General) | 0.7 | -0.7 | |
Carcinoma | 0.1 | 0.1 | 0 |
Celiac Disease | 0.1 | -0.1 | |
Cerebral Palsy | 0.3 | -0.3 | |
Chronic Fatigue Syndrome | 0.3 | 0.2 | 0.5 |
Chronic Kidney Disease | 0.1 | 0.3 | -2 |
Chronic Lyme | 0.3 | -0.3 | |
Chronic Obstructive Pulmonary Disease (COPD) | 0.3 | -0.3 | |
Coagulation / Micro clot triggering bacteria | 0.1 | 0.3 | -2 |
Colorectal Cancer | 0.4 | 0.4 | |
Constipation | 0.3 | -0.3 | |
COVID-19 | 0.2 | 0.8 | -3 |
Crohn's Disease | 0.4 | 0.4 | 0 |
cystic fibrosis | 0.3 | -0.3 | |
deep vein thrombosis | 0.3 | -0.3 | |
Depression | 1.3 | 1 | 0.3 |
Endometriosis | 0.1 | 0.1 | |
Epilepsy | 0.1 | -0.1 | |
Fibromyalgia | 0.4 | 0.4 | |
Functional constipation / chronic idiopathic constipation | 0.6 | 0.3 | 1 |
gallstone disease (gsd) | 0.1 | 0.3 | -2 |
Graves' disease | 0.1 | 0.3 | -2 |
Hashimoto's thyroiditis | 0.3 | 0.3 | |
High Histamine/low DAO | 0.3 | 0.3 | |
hyperglycemia | 0.1 | -0.1 | |
hypertension (High Blood Pressure | 0.1 | 0.3 | -2 |
Hypoxia | 0.1 | 0.1 | |
Inflammatory Bowel Disease | 0 | 1 | 0 |
Insomnia | 0.3 | -0.3 | |
Intracranial aneurysms | 0.1 | 0.1 | |
Irritable Bowel Syndrome | 0.3 | 0.4 | -0.33 |
Liver Cirrhosis | 0.4 | 0.3 | 0.33 |
Long COVID | 0.2 | 0.4 | -1 |
Low bone mineral density | 0.3 | -0.3 | |
ME/CFS without IBS | 0.2 | -0.2 | |
Metabolic Syndrome | 0.4 | 0.4 | 0 |
Mood Disorders | 1.3 | 1 | 0.3 |
Multiple Sclerosis | 0.1 | 0.6 | -5 |
Obesity | 0.4 | 0.8 | -1 |
obsessive-compulsive disorder | 0.1 | 0.1 | |
Osteoarthritis | 0 | 0 | |
Parkinson's Disease | 0.1 | 0.8 | -7 |
Polycystic ovary syndrome | 0.1 | 0.3 | -2 |
Premenstrual dysphoric disorder | 0.1 | -0.1 | |
Psoriasis | 0.6 | -0.6 | |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 0.4 | 0.3 | 0.33 |
Rosacea | 0.3 | -0.3 | |
Schizophrenia | 0.1 | 0.3 | -2 |
Sjögren syndrome | 0.1 | 0.1 | 0 |
Sleep Apnea | 0.3 | -0.3 | |
Stress / posttraumatic stress disorder | 0.4 | 0.3 | 0.33 |
Systemic Lupus Erythematosus | 0.1 | 0.3 | -2 |
Type 1 Diabetes | 0.3 | -0.3 | |
Type 2 Diabetes | 0.4 | 0.4 | 0 |
Ulcerative colitis | 0.3 | 0.4 | -0.33 |
Unhealthy Ageing | 0.3 | -0.3 | |
Vitiligo | 0.1 | -0.1 |
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