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Hypertension (High Blood Pressure): Celiprolol is prescribed to lower blood pressure by blocking the effects of adrenaline on the heart and blood vessels. By reducing the heart rate and relaxing blood vessels, it helps to decrease the workload on the heart and improve blood flow, thereby lowering blood pressure.
Angina Pectoris: Celiprolol may be used in the treatment of angina pectoris, a condition characterized by chest pain or discomfort due to reduced blood flow to the heart muscles. By reducing heart rate and blood pressure, it can help alleviate symptoms of angina and improve exercise tolerance.
Arrhythmias: Celiprolol is sometimes used to manage certain types of cardiac arrhythmias (irregular heart rhythms), particularly supraventricular arrhythmias. By slowing down the heart rate and reducing the excitability of cardiac tissue, it can help stabilize the heart rhythm.
Heart Failure: Beta-blockers like celiprolol are also used as part of the treatment regimen for heart failure, especially in patients with systolic dysfunction. They help improve symptoms, reduce hospitalizations, and prolong survival by reducing the workload on the heart and improving cardiac function.
Migraine Prophylaxis: In some cases, celiprolol may be prescribed for the prevention of migraine headaches, particularly in individuals with concomitant hypertension or cardiac conditions. Its mechanism of action in migraine prophylaxis is not fully understood but may involve its effects on blood vessels and neurotransmitters.
Side Effects: Common side effects of celiprolol may include fatigue, dizziness, headache, nausea, diarrhea, cold hands and feet, and sexual dysfunction. These side effects are typically mild and transient but may require dose adjustments or discontinuation of therapy in some cases.
Bronchospastic Diseases: Celiprolol is generally avoided in individuals with bronchospastic diseases such as asthma or chronic obstructive pulmonary disease (COPD) due to its potential to induce bronchial constriction. However, it may be used with caution in patients with mild or well-controlled asthma under close medical supervision.
Diabetes: Beta-blockers like celiprolol can mask some of the symptoms of hypoglycemia (low blood sugar) in individuals with diabetes. They may also impair glucose tolerance and should be used cautiously in diabetic patients, with regular monitoring of blood sugar levels.
Withdrawal: Abrupt discontinuation of celiprolol therapy should be avoided, as it may lead to rebound hypertension, angina exacerbation, or cardiac arrhythmias. Doses should be tapered gradually under medical supervision when discontinuing treatment.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Akkermansia muciniphila | Reduces |
| species | Bifidobacterium adolescentis | Reduces |
| species | Bifidobacterium longum | Reduces |
| species | Escherichia coli | Reduces |
| subspecies | Bifidobacterium longum subsp. infantis | Reduces |
| subspecies | Bifidobacterium longum subsp. longum | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0.1 | 0.1 | |
| Acne | 0.2 | -0.2 | |
| ADHD | 2.4 | 0.3 | 7 |
| Age-Related Macular Degeneration and Glaucoma | 0.4 | 0.4 | |
| Allergic Rhinitis (Hay Fever) | 0.6 | 1.1 | -0.83 |
| Allergies | 2 | 1.8 | 0.11 |
| Allergy to milk products | 0.7 | 0.3 | 1.33 |
| Alopecia (Hair Loss) | 0.6 | 0.6 | |
| Alzheimer's disease | 1.3 | 2.8 | -1.15 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1.6 | 0.9 | 0.78 |
| Ankylosing spondylitis | 1.5 | 0.6 | 1.5 |
| Anorexia Nervosa | 1.1 | -1.1 | |
| Antiphospholipid syndrome (APS) | 0.2 | 0.1 | 1 |
| Asthma | 0.7 | 1.1 | -0.57 |
| Atherosclerosis | 0.7 | 0.9 | -0.29 |
| Atrial fibrillation | 1.6 | 0.7 | 1.29 |
| Autism | 4.7 | 4.1 | 0.15 |
| Barrett esophagus cancer | 0.3 | 0 | 0 |
| benign prostatic hyperplasia | 0.1 | 0.1 | |
| Biofilm | 0.4 | 0.4 | |
| Bipolar Disorder | 0.5 | 1.1 | -1.2 |
| Brain Trauma | 0.5 | 0.4 | 0.25 |
| Cancer (General) | 0.1 | 2.1 | -20 |
| Carcinoma | 1.6 | 1.3 | 0.23 |
| Celiac Disease | 0.8 | 2.2 | -1.75 |
| Cerebral Palsy | 1.1 | 0.8 | 0.38 |
| Chronic Fatigue Syndrome | 3.5 | 2.5 | 0.4 |
| Chronic Kidney Disease | 0.9 | 0.8 | 0.13 |
| Chronic Lyme | 0.4 | -0.4 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 0.5 | 0.4 | 0.25 |
| Chronic Urticaria (Hives) | 0.8 | 0.7 | 0.14 |
| Coagulation / Micro clot triggering bacteria | 0.2 | 0.6 | -2 |
| Colorectal Cancer | 1.1 | 0.5 | 1.2 |
| Constipation | 0.3 | 0.4 | -0.33 |
| Coronary artery disease | 0.7 | 0.7 | 0 |
| COVID-19 | 5.4 | 6 | -0.11 |
| Crohn's Disease | 3.4 | 2.2 | 0.55 |
| cystic fibrosis | 0.2 | 0.6 | -2 |
| deep vein thrombosis | 0.2 | 0.5 | -1.5 |
| Depression | 4.4 | 4.3 | 0.02 |
| Dermatomyositis | 0 | 0.2 | 0 |
| Eczema | 0.5 | 0.5 | 0 |
| Endometriosis | 1.1 | 0.7 | 0.57 |
| Eosinophilic Esophagitis | 0.3 | -0.3 | |
| Epilepsy | 1.2 | 1.3 | -0.08 |
| Fibromyalgia | 0.8 | 1.5 | -0.88 |
| Functional constipation / chronic idiopathic constipation | 2 | 2.1 | -0.05 |
| gallstone disease (gsd) | 1.2 | 0.4 | 2 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.4 | 0.4 | 0 |
| Generalized anxiety disorder | 0.5 | 1.2 | -1.4 |
| giant cell arteritis | 0.2 | -0.2 | |
| Glioblastoma | 0 | 0 | |
| Gout | 0.2 | -0.2 | |
| Graves' disease | 0.7 | 0.8 | -0.14 |
| Halitosis | 0.5 | 0 | 0 |
| Hashimoto's thyroiditis | 1.5 | 0.5 | 2 |
| Hidradenitis Suppurativa | 0.1 | 0.3 | -2 |
| High Histamine/low DAO | 1 | 0.4 | 1.5 |
| hypercholesterolemia (High Cholesterol) | 0.3 | 0.5 | -0.67 |
| hyperglycemia | 0.2 | 1.3 | -5.5 |
| Hyperlipidemia (High Blood Fats) | 0.7 | 0.3 | 1.33 |
| hypersomnia | 0.2 | -0.2 | |
| hypertension (High Blood Pressure | 1.2 | 2.7 | -1.25 |
| Hypothyroidism | 0.7 | -0.7 | |
| Hypoxia | 0.4 | 0.4 | |
| IgA nephropathy (IgAN) | 1.6 | -1.6 | |
| Inflammatory Bowel Disease | 1.2 | 3.9 | -2.25 |
| Insomnia | 0.4 | 0.4 | 0 |
| Intelligence | 0.7 | 0.2 | 2.5 |
| Intracranial aneurysms | 0.6 | 0.3 | 1 |
| Irritable Bowel Syndrome | 2.6 | 2.2 | 0.18 |
| Liver Cirrhosis | 2.4 | 2.1 | 0.14 |
| Long COVID | 3.1 | 4.2 | -0.35 |
| Low bone mineral density | 0.4 | -0.4 | |
| Lung Cancer | 0.6 | 1.1 | -0.83 |
| Mast Cell Issues / mastitis | 0.1 | 0.6 | -5 |
| ME/CFS with IBS | 0.4 | 1.4 | -2.5 |
| ME/CFS without IBS | 0.9 | 0.8 | 0.13 |
| Menopause | 1.3 | 1.3 | |
| Metabolic Syndrome | 3.9 | 4.3 | -0.1 |
| Mood Disorders | 6.8 | 4.4 | 0.55 |
| multiple chemical sensitivity [MCS] | 0.6 | 0.2 | 2 |
| Multiple Sclerosis | 2.6 | 1.7 | 0.53 |
| Multiple system atrophy (MSA) | 1.3 | 0.6 | 1.17 |
| neuropathic pain | 1 | -1 | |
| Neuropathy (all types) | 0.5 | 0.1 | 4 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.2 | 0.2 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 1.1 | 2.9 | -1.64 |
| NonCeliac Gluten Sensitivity | 1.3 | 0.4 | 2.25 |
| Obesity | 4.9 | 2.2 | 1.23 |
| obsessive-compulsive disorder | 2.5 | 2.2 | 0.14 |
| Osteoarthritis | 0.7 | 0.2 | 2.5 |
| Osteoporosis | 1.1 | 0.8 | 0.38 |
| pancreatic cancer | 0.2 | 0.2 | |
| Parkinson's Disease | 3.4 | 2 | 0.7 |
| Polycystic ovary syndrome | 0.9 | 1.5 | -0.67 |
| Postural orthostatic tachycardia syndrome | 0.2 | 0.4 | -1 |
| Premenstrual dysphoric disorder | 0.7 | 0.7 | |
| primary biliary cholangitis | 0.2 | 0.6 | -2 |
| Psoriasis | 2.5 | 1.2 | 1.08 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 3.1 | 1.9 | 0.63 |
| Rosacea | 0.8 | 0.4 | 1 |
| Schizophrenia | 4.5 | 1.2 | 2.75 |
| scoliosis | 0.2 | 0.4 | -1 |
| Sjögren syndrome | 1.5 | 1.5 | 0 |
| Sleep Apnea | 0.8 | 0.8 | 0 |
| Slow gastric motility / Gastroparesis | 0.8 | 0.2 | 3 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.2 | 0.4 | -1 |
| Stress / posttraumatic stress disorder | 1.3 | 1.8 | -0.38 |
| Systemic Lupus Erythematosus | 1.4 | 1 | 0.4 |
| Tic Disorder | 0.4 | 0.8 | -1 |
| Tourette syndrome | 0.3 | 0.2 | 0.5 |
| Type 1 Diabetes | 1.7 | 1 | 0.7 |
| Type 2 Diabetes | 3.7 | 3 | 0.23 |
| Ulcerative colitis | 1.2 | 2.9 | -1.42 |
| Unhealthy Ageing | 1.7 | 1 | 0.7 |
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