🍽️ tranilast,(prescription)

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  1. Allergic Diseases:

    • Tranilast is indicated for the treatment of allergic conditions such as allergic rhinitis (hay fever), allergic conjunctivitis (eye allergies), and allergic asthma. It exerts its effects by inhibiting the release of inflammatory mediators such as histamine, leukotrienes, and prostaglandins from mast cells and other immune cells, thereby reducing allergic symptoms.
  2. Atopic Dermatitis (Eczema):

    • Tranilast may be used in the treatment of atopic dermatitis, a chronic inflammatory skin condition characterized by dry, itchy, and inflamed skin. It helps alleviate symptoms by suppressing inflammation and modulating the immune response in the skin.
  3. Keloids and Hypertrophic Scars:

    • Tranilast has been investigated for its potential role in the prevention and treatment of keloids and hypertrophic scars, which are abnormal types of scar tissue that result from excessive collagen formation during the wound healing process. Tranilast helps inhibit the proliferation of fibroblasts and the production of collagen, thereby reducing scar formation and promoting scar remodeling.
  4. Diabetic Complications:

    • Tranilast may be used in the management of diabetic complications such as diabetic nephropathy (kidney disease) and diabetic retinopathy (eye disease). It exerts protective effects on the kidneys and eyes by inhibiting the accumulation of extracellular matrix proteins, reducing inflammation, and preventing oxidative stress-induced damage.
  5. Interstitial Cystitis (Bladder Pain Syndrome):

    • Tranilast has been investigated as a potential treatment for interstitial cystitis, also known as bladder pain syndrome, a chronic bladder condition characterized by pelvic pain, urinary frequency, and urgency. Tranilast may help alleviate symptoms by reducing inflammation and modulating bladder function.
  6. Atherosclerosis and Cardiovascular Diseases:

    • Tranilast has been studied for its potential anti-atherosclerotic effects and its ability to prevent restenosis (re-narrowing of blood vessels) following angioplasty or stent placement. It may help inhibit the proliferation of smooth muscle cells in blood vessel walls and reduce inflammation, thereby preventing the progression of atherosclerosis and restenosis.
  7. Pulmonary Fibrosis:

    • Tranilast has shown promise in the treatment of pulmonary fibrosis, a progressive lung disease characterized by the formation of scar tissue in the lungs. It may help attenuate fibrosis by inhibiting the activation of fibroblasts and the deposition of collagen in the lung tissue.
  8. Side Effects:

    • Common side effects of tranilast may include gastrointestinal disturbances (such as nausea, diarrhea, and dyspepsia), dizziness, headache, and skin reactions. Rare but more serious side effects may include hepatotoxicity (liver damage) and hypersensitivity reactions. It's important to inform a healthcare provider of any adverse reactions experienced while taking tranilast.
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Data Contradictions β€” Limits of Certainity

Impacted of tranilast,(prescription) On Probiotics

Rank Probiotic Impact

Bacteria Impacted by tranilast,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Eggerthella genus Decreases 👪 Source Study
Streptococcus genus Decreases 👪 Source Study
Lachnospira genus Decreases 👪 Source Study
Agathobacter genus Decreases 👪 Source Study
Lacrimispora genus Decreases 👪 Source Study
Odoribacter genus Decreases 👪 Source Study
Fusobacterium genus Decreases 👪 Source Study Periodontal disease, Lemierre syndrome, skin ulcers
Clostridioides genus Decreases 👪 Source Study
Dorea genus Decreases 👪 Source Study
Roseburia genus Decreases 👪 Source Study
Thomasclavelia genus Decreases 👪 Source Study
Bacteroides genus Decreases 👪 Source Study
Ruminococcus genus Decreases 👪 Source Study
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
Eggerthellales order Decreases ⚗️ Source Study
Eggerthella lenta species Decreases 📓 Source Study
Streptococcus salivarius species Decreases 📓 Source Study Infectious bacteria
Lachnospira eligens species Decreases 📓 Source Study
Agathobacter rectalis species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Lacrimispora saccharolytica species Decreases 📓 Source Study
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Odoribacter splanchnicus species Decreases 📓 Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Fusobacterium nucleatum species Decreases 📓 Source Study Infectious bacteria
Clostridioides difficile species Decreases 📓 Source Study Colitis
Dorea formicigenerans species Decreases 📓 Source Study
Roseburia intestinalis species Decreases 📓 Source Study
Thomasclavelia ramosa species Decreases 📓 Source Study
Bacteroides xylanisolvens species Decreases 📓 Source Study
Ruminococcus bromii species Decreases 📓 Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study
Fusobacterium nucleatum subsp. nucleatum subspecies Decreases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of tranilast,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
ADHD 0.3 0.2 0.5
Age-Related Macular Degeneration and Glaucoma 0 0
Allergic Rhinitis (Hay Fever) 0 0
Allergies 0.4 0 0
Allergy to milk products 0 0
Alopecia (Hair Loss) 0 0
Alzheimer's disease 0.2 0.5 -1.5
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.4 0 0
Ankylosing spondylitis 0.2 0.2 0
Anorexia Nervosa 0.3 -0.3
Antiphospholipid syndrome (APS) 0.2 0.2
Asthma 0.5 0 0
Atherosclerosis 0.1 0.2 -1
Atrial fibrillation 0.5 0 0
Autism 1 0.9 0.11
Barrett esophagus cancer 0 0.2 0
Bipolar Disorder 0 0.3 0
Brain Trauma 0 0
Carcinoma 0.6 0.1 5
Celiac Disease 0.3 0.3 0
Cerebral Palsy 0.2 0.1 1
Chronic Fatigue Syndrome 1.1 0.5 1.2
Chronic Kidney Disease 0.3 0.4 -0.33
Chronic Lyme 0 0
Chronic Obstructive Pulmonary Disease (COPD) 0.6 0.2 2
Chronic Urticaria (Hives) 0.2 0.2
Coagulation / Micro clot triggering bacteria 0.2 0.2 0
Colorectal Cancer 0.7 0.1 6
Constipation 0.2 0 0
Coronary artery disease 0.1 0.1
COVID-19 1.2 1.8 -0.5
Crohn's Disease 0.5 0.8 -0.6
cystic fibrosis 0 0
deep vein thrombosis 0.2 -0.2
Depression 1.6 0.6 1.67
Dermatomyositis 0.2 0.2
Eczema 0.6 -0.6
Endometriosis 0.2 0.2 0
Eosinophilic Esophagitis 0 0
Epilepsy 0.3 0 0
Fibromyalgia 0.1 0 0
Functional constipation / chronic idiopathic constipation 0.2 0 0
gallstone disease (gsd) 0 0.1 0
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0 0.2 0
Generalized anxiety disorder 0 0 0
Glioblastoma 0.2 -0.2
Graves' disease 0 0 0
Halitosis 0.1 0.2 -1
Hashimoto's thyroiditis 0.1 0 0
Hidradenitis Suppurativa 0.2 0.2
Histamine Issues,Mast Cell Issue, DAO Insufficiency 0.3 0.1 2
hypercholesterolemia (High Cholesterol) 0.1 0.1
hyperglycemia 0 0
hypertension (High Blood Pressure 0.2 0.3 -0.5
Hypothyroidism 0.2 -0.2
Hypoxia 0 0
IgA nephropathy (IgAN) 0.3 -0.3
Inflammatory Bowel Disease 0.9 0.6 0.5
Insomnia 0.2 0.2 0
Intracranial aneurysms 0 0
Irritable Bowel Syndrome 0.1 0.2 -1
Liver Cirrhosis 0.4 0.3 0.33
Long COVID 0.9 0.8 0.13
Low bone mineral density 0.2 -0.2
Lung Cancer 0 0
ME/CFS with IBS 0.2 0.1 1
ME/CFS without IBS 1 0.1 9
Metabolic Syndrome 0.6 0.4 0.5
Mood Disorders 1.6 0.8 1
multiple chemical sensitivity [MCS] 0.6 0.6
Multiple Sclerosis 1.4 0.7 1
Multiple system atrophy (MSA) 0 0
Neuropathy (all types) 0.2 0.2
neuropsychiatric disorders (PANDAS, PANS) 0.1 0.1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.2 0.5 -1.5
Obesity 0.5 0.6 -0.2
obsessive-compulsive disorder 0.5 0.2 1.5
Osteoarthritis 0.3 0 0
Osteoporosis 0.3 0 0
pancreatic cancer 0.3 0.3
Parkinson's Disease 0.4 0.6 -0.5
Polycystic ovary syndrome 0 0.1 0
primary biliary cholangitis 0 0
Psoriasis 0.3 0 0
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.7 0.2 2.5
Rosacea 0 0 0
Schizophrenia 0.5 0 0
scoliosis 0.3 -0.3
Sjögren syndrome 0.3 0.2 0.5
Sleep Apnea 0.1 0.3 -2
Small Intestinal Bacterial Overgrowth (SIBO) 0.2 0.2
Stress / posttraumatic stress disorder 0.1 0.5 -4
Systemic Lupus Erythematosus 0.6 0.3 1
Tic Disorder 0.1 0 0
Tourette syndrome 0 0
Type 1 Diabetes 0 0.4 0
Type 2 Diabetes 0.6 0.3 1
Ulcerative colitis 0.2 0.1 1
Unhealthy Ageing 0.7 0.3 1.33

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