🍽️ isosorbide mononitrate,(prescription)

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  1. Headache: Headache is a common side effect of isosorbide mononitrate therapy, especially when initiating treatment or increasing the dosage. It is usually transient and may improve over time.

  2. Hypotension: Isosorbide mononitrate can cause low blood pressure, leading to symptoms such as dizziness, lightheadedness, and fainting, particularly when standing up quickly from a sitting or lying position.

  3. Tolerance: Prolonged use of isosorbide mononitrate may lead to the development of tolerance, necessitating dose adjustments or medication rotation to maintain its effectiveness in preventing angina.

  4. Reflex Tachycardia: Isosorbide mononitrate-induced vasodilation can trigger reflex tachycardia (rapid heart rate) as the body attempts to compensate for decreased blood pressure. This effect may be more pronounced in individuals with preexisting cardiovascular conditions.

  5. Interaction with Phosphodiesterase-5 Inhibitors: Concurrent use of isosorbide mononitrate with phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil) or riociguat can potentiate the hypotensive effects and increase the risk of adverse cardiovascular events.

  6. Nitrate Tolerance: Long-term use of nitrates, including isosorbide mononitrate, may lead to the development of nitrate tolerance, requiring intermittent drug-free periods or dose adjustments to maintain efficacy.

  7. Contraindications: Isosorbide mononitrate is contraindicated in individuals with severe hypotension, severe anemia, increased intracranial pressure, or those who have recently taken phosphodiesterase-5 inhibitors or riociguat due to the risk of severe hypotension and cardiovascular collapse.

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βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of isosorbide mononitrate,(prescription) On Probiotics

Rank Probiotic Impact
species Lacticaseibacillus paracasei Reduces

Bacteria Impacted by isosorbide mononitrate,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Ruminococcus genus Decreases 👪 Source Study
Lacrimispora genus Decreases 👪 Source Study
Parabacteroides genus Decreases 👪 Source Study BMI, fat percent,blood pressure
Lacticaseibacillus genus Decreases 👪 Source Study
Enterocloster genus Decreases 👪 Source Study
Streptococcus genus Decreases 👪 Source Study
Roseburia genus Decreases 👪 Source Study
Bilophila genus Decreases 👪 Source Study High Level Cause Brain Fog(Cognitive impairment)
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
Eggerthellales order Decreases ⚗️ Source Study
Ruminococcus bromii species Decreases 📓 Source Study
Lacrimispora saccharolytica species Decreases 📓 Source Study
Parabacteroides distasonis species Decreases 📓 Source Study
Lacticaseibacillus paracasei species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Enterocloster bolteae species Decreases 📓 Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Streptococcus parasanguinis species Decreases 📓 Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Roseburia hominis species Decreases 📓 Source Study
Bilophila wadsworthia species Decreases 📓 Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study
Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases 👶 Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of isosorbide mononitrate,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0 0
ADHD 0.7 0.7
Age-Related Macular Degeneration and Glaucoma 0 0.1 0
Allergic Rhinitis (Hay Fever) 0.1 0.1
Allergies 1 -1
Allergy to milk products 0.5 0.1 4
Alopecia (Hair Loss) 0.3 0.3
Alzheimer's disease 0.7 0.7 0
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.5 -0.5
Ankylosing spondylitis 0.4 0.5 -0.25
Anorexia Nervosa 0.1 0.5 -4
Antiphospholipid syndrome (APS) 0.1 0 0
Asthma 0 0
Atherosclerosis 0.5 0 0
Atrial fibrillation 0.7 0.2 2.5
Autism 0.9 0.8 0.13
Barrett esophagus cancer 0.1 -0.1
Bipolar Disorder 0.7 0.5 0.4
Brain Trauma 0 0
Cancer (General) 0.3 -0.3
Carcinoma 0.7 0.6 0.17
Celiac Disease 0.1 0.7 -6
Cerebral Palsy 0.1 0.5 -4
Chronic Fatigue Syndrome 2 0.4 4
Chronic Kidney Disease 0.1 0 0
Chronic Lyme 0 0
Chronic Obstructive Pulmonary Disease (COPD) 0.2 0 0
Chronic Urticaria (Hives) 0.1 0.1
Coagulation / Micro clot triggering bacteria 0.2 0.6 -2
Colorectal Cancer 0.7 0.7
Constipation 0 0
Coronary artery disease 0.5 0.5
COVID-19 0.7 1.6 -1.29
Crohn's Disease 0.7 0.7 0
cystic fibrosis 0 0
deep vein thrombosis 0.6 -0.6
Depression 1.5 1 0.5
Dermatomyositis 0.1 0.1
Eczema 0.1 -0.1
Endometriosis 0.2 0.5 -1.5
Epilepsy 0.1 0.1 0
Fibromyalgia 0.2 0.2
Functional constipation / chronic idiopathic constipation 0.6 0 0
gallstone disease (gsd) 0.6 0 0
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.1 -0.1
Glioblastoma 0.1 -0.1
Graves' disease 0.1 0 0
Halitosis 0.1 -0.1
Hashimoto's thyroiditis 0 0 0
Hidradenitis Suppurativa 0.1 0.1
Histamine Issues 0 0
hyperglycemia 0.1 -0.1
hypersomnia 0 0
hypertension (High Blood Pressure 0.7 0.2 2.5
Hypoxia 0.1 0.1
Inflammatory Bowel Disease 0.1 1.8 -17
Insomnia 0.1 0 0
Intracranial aneurysms 0.6 0.6
Irritable Bowel Syndrome 0.5 0.2 1.5
Liver Cirrhosis 0.8 0.6 0.33
Long COVID 0.4 1.7 -3.25
Low bone mineral density 0 0
Lung Cancer 0.5 -0.5
Mast Cell Issues / mastitis 0.1 0.5 -4
ME/CFS with IBS 0.2 0.2
ME/CFS without IBS 0.2 0.3 -0.5
Metabolic Syndrome 0.8 0.9 -0.13
Mood Disorders 2 1 1
multiple chemical sensitivity [MCS] 0.1 0.1
Multiple Sclerosis 0.9 1 -0.11
Multiple system atrophy (MSA) 0.2 0.5 -1.5
neuropathic pain 0.1 -0.1
Neuropathy (all types) 0.1 0.1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.1 0.5 -4
Obesity 0.9 0.9 0
obsessive-compulsive disorder 1.2 1.2
Osteoarthritis 0.1 0.5 -4
Osteoporosis 0.5 0.5
pancreatic cancer 0.1 0.1
Parkinson's Disease 0.2 0.6 -2
Polycystic ovary syndrome 0.6 1 -0.67
Premenstrual dysphoric disorder 0.1 -0.1
Psoriasis 0.6 0.5 0.2
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.8 0 0
Rosacea 0.5 0 0
Schizophrenia 0.7 0.5 0.4
scoliosis 0.5 -0.5
Sjögren syndrome 0.2 0.1 1
Sleep Apnea 0.5 0 0
Small Intestinal Bacterial Overgrowth (SIBO) 0.1 0.1
Stress / posttraumatic stress disorder 0.2 0 0
Systemic Lupus Erythematosus 0.2 0.5 -1.5
Tic Disorder 0.5 0.5
Type 1 Diabetes 0.5 0.1 4
Type 2 Diabetes 0.8 0.7 0.14
Ulcerative colitis 0.2 0.2 0
Unhealthy Ageing 0.3 0 0

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