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Diabetes Mellitus: Tolbutamide belongs to a class of medications known as sulfonylureas, which work by stimulating the pancreas to release insulin. Insulin is a hormone that helps regulate blood sugar levels by facilitating the uptake of glucose into cells for energy production. Tolbutamide helps lower blood sugar levels in individuals with type 2 diabetes by increasing insulin secretion from pancreatic beta cells. It is used as an adjunct to diet and exercise to control hyperglycemia (high blood sugar) in patients with diabetes who cannot adequately manage their condition with lifestyle modifications alone.
Blood Glucose Control: By promoting insulin release, tolbutamide helps improve glycemic control in individuals with type 2 diabetes. It helps reduce fasting blood glucose levels and postprandial (after-meal) glucose excursions, thereby lowering the risk of hyperglycemia-related complications such as diabetic neuropathy, retinopathy, nephropathy, and cardiovascular disease.
Dosage and Administration: Tolbutamide is typically administered orally in the form of tablets or capsules. The dosage may vary depending on the individual's response to treatment, medical history, renal function, and other factors. It is usually taken once or twice daily with meals to maximize efficacy and minimize the risk of hypoglycemia (low blood sugar). It is important to follow the prescribed dosage regimen and instructions provided by the healthcare provider.
Hypoglycemia: One of the potential side effects of tolbutamide therapy is hypoglycemia, characterized by abnormally low blood sugar levels. Hypoglycemia can occur if the dose of tolbutamide is too high relative to the individual's insulin requirements or if meals are skipped or delayed. Symptoms of hypoglycemia may include sweating, trembling, palpitations, confusion, dizziness, weakness, headache, blurred vision, and in severe cases, loss of consciousness or seizures. Patients should be educated about recognizing and managing hypoglycemia, including the importance of carrying a source of fast-acting glucose (such as glucose tablets or juice) to treat low blood sugar episodes promptly.
Adverse Reactions: In addition to hypoglycemia, tolbutamide may cause other side effects, including gastrointestinal disturbances (such as nausea, vomiting, diarrhea, or abdominal discomfort), allergic reactions (such as rash, itching, or hives), and hematologic abnormalities (such as leukopenia, thrombocytopenia, or hemolytic anemia). Rare but serious adverse effects may include hepatotoxicity (liver damage) and hypersensitivity reactions (such as Stevens-Johnson syndrome or toxic epidermal necrolysis). Patients should report any concerning symptoms to their healthcare provider promptly.
Drug Interactions: Tolbutamide may interact with other medications, including other antidiabetic agents (such as insulin, metformin, or thiazolidinediones), beta-blockers, salicylates, sulfa antibiotics, anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), and certain psychiatric medications. Concurrent use of tolbutamide with these medications may potentiate or diminish its effects on blood sugar control or increase the risk of hypoglycemia. Healthcare providers should be informed of all medications, supplements, and herbal products taken by the patient to prevent potential drug interactions.
Monitoring: Patients receiving tolbutamide therapy require regular monitoring of blood glucose levels to assess treatment efficacy and safety. Periodic assessment of renal function, liver function, hematologic parameters, and other relevant laboratory tests may also be warranted to detect potential adverse effects associated with long-term tolbutamide use.
Rank | Probiotic | Impact |
---|---|---|
species | Akkermansia muciniphila | Reduces |
species | Escherichia coli | Reduces |
species | Lacticaseibacillus paracasei | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
Abdominal Aortic Aneurysm | 0.2 | 0.2 | |
ADHD | 0.3 | 0.1 | 2 |
Age-Related Macular Degeneration and Glaucoma | 0.1 | 0.1 | |
Allergic Rhinitis (Hay Fever) | 0.4 | 0.4 | |
Allergies | 0.8 | 0.7 | 0.14 |
Allergy to milk products | 0.5 | 0.2 | 1.5 |
Alzheimer's disease | 1.6 | 1.5 | 0.07 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1 | 0.5 | 1 |
Ankylosing spondylitis | 1.1 | 0.4 | 1.75 |
Anorexia Nervosa | 0.3 | -0.3 | |
Antiphospholipid syndrome (APS) | 1 | 0.2 | 4 |
Asthma | 0.1 | 0.5 | -4 |
Atherosclerosis | 0.2 | 0.4 | -1 |
Atrial fibrillation | 0.5 | 1 | -1 |
Autism | 2.1 | 2.6 | -0.24 |
Barrett esophagus cancer | 0.2 | 0.2 | 0 |
benign prostatic hyperplasia | 0.2 | 0.2 | |
Bipolar Disorder | 0.5 | 0.2 | 1.5 |
Brain Trauma | 0.2 | -0.2 | |
Carcinoma | 0.7 | 0.1 | 6 |
Celiac Disease | 0.9 | 0.4 | 1.25 |
Cerebral Palsy | 0.3 | 0.2 | 0.5 |
Chronic Fatigue Syndrome | 0.7 | 1 | -0.43 |
Chronic Kidney Disease | 0.4 | 0.3 | 0.33 |
Chronic Lyme | 0.2 | -0.2 | |
Chronic Obstructive Pulmonary Disease (COPD) | 1 | 0.2 | 4 |
Chronic Urticaria (Hives) | 0.7 | 1.1 | -0.57 |
Coagulation / Micro clot triggering bacteria | 0.6 | 0.3 | 1 |
Colorectal Cancer | 1.8 | 0 | 0 |
Constipation | 0.6 | 0.1 | 5 |
Coronary artery disease | 0.1 | 0.1 | 0 |
COVID-19 | 1.4 | 2.4 | -0.71 |
Crohn's Disease | 2.3 | 1.2 | 0.92 |
cystic fibrosis | 0.5 | 0.2 | 1.5 |
deep vein thrombosis | 0.5 | 0.3 | 0.67 |
Depression | 2.8 | 1.6 | 0.75 |
Dermatomyositis | 0.2 | 0.2 | |
Eczema | 0.2 | 0.7 | -2.5 |
Endometriosis | 0.9 | 0.9 | |
Eosinophilic Esophagitis | 0.2 | 0.2 | |
Epilepsy | 1.2 | 0.3 | 3 |
Fibromyalgia | 0.2 | 1 | -4 |
Functional constipation / chronic idiopathic constipation | 1.7 | 1.7 | 0 |
gallstone disease (gsd) | 0.2 | 0.3 | -0.5 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 1 | 0.2 | 4 |
Generalized anxiety disorder | 0.7 | 0.3 | 1.33 |
giant cell arteritis | 0.1 | -0.1 | |
Glioblastoma | 0.2 | -0.2 | |
Gout | 0.1 | -0.1 | |
Graves' disease | 0.1 | 0.1 | 0 |
Halitosis | 0.3 | 0.2 | 0.5 |
Hashimoto's thyroiditis | 0.3 | 0.4 | -0.33 |
Hidradenitis Suppurativa | 0.6 | 0.6 | |
Histamine Issues,Mast Cell Issue, DAO Insufficiency | 0.7 | 0.1 | 6 |
hypercholesterolemia (High Cholesterol) | 0.1 | 0.1 | 0 |
hyperglycemia | 0.2 | 0.3 | -0.5 |
Hyperlipidemia (High Blood Fats) | 0.1 | 0.1 | |
hypersomnia | 0.2 | -0.2 | |
hypertension (High Blood Pressure | 0.5 | 1.3 | -1.6 |
Hypothyroidism | 0.1 | -0.1 | |
Hypoxia | 0.2 | 0.2 | |
IgA nephropathy (IgAN) | 0.9 | -0.9 | |
Inflammatory Bowel Disease | 1.4 | 1.9 | -0.36 |
Insomnia | 0.3 | 0.2 | 0.5 |
Intelligence | 0.2 | 0.5 | -1.5 |
Intracranial aneurysms | 0.1 | 0.1 | |
Irritable Bowel Syndrome | 1.4 | 0.7 | 1 |
Liver Cirrhosis | 1.2 | 0.9 | 0.33 |
Long COVID | 1.9 | 1.1 | 0.73 |
Low bone mineral density | 0.2 | -0.2 | |
Lung Cancer | 0.4 | 0.1 | 3 |
ME/CFS with IBS | 0.2 | 0.4 | -1 |
ME/CFS without IBS | 0.4 | 0.1 | 3 |
Metabolic Syndrome | 2.4 | 2 | 0.2 |
Mood Disorders | 3.5 | 1.6 | 1.19 |
multiple chemical sensitivity [MCS] | 0.3 | 0.3 | |
Multiple Sclerosis | 1.5 | 1.6 | -0.07 |
Multiple system atrophy (MSA) | 0.9 | 0.9 | |
Neuropathy (all types) | 0.2 | 0.2 | 0 |
neuropsychiatric disorders (PANDAS, PANS) | 0.3 | 0.3 | |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.9 | 0.5 | 0.8 |
Obesity | 1.4 | 0.9 | 0.56 |
obsessive-compulsive disorder | 1.6 | 1 | 0.6 |
Osteoarthritis | 0.6 | 0.6 | |
Osteoporosis | 0.3 | 0.3 | 0 |
pancreatic cancer | 0.2 | 0.2 | |
Parkinson's Disease | 1.1 | 1.5 | -0.36 |
Polycystic ovary syndrome | 0.7 | 0.2 | 2.5 |
Postural orthostatic tachycardia syndrome | 0.1 | 0.1 | 0 |
Psoriasis | 1.1 | 1 | 0.1 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 1.9 | 1.1 | 0.73 |
Rosacea | 0.2 | -0.2 | |
Schizophrenia | 0.8 | 0.3 | 1.67 |
scoliosis | 0.1 | 0.2 | -1 |
Sjögren syndrome | 0.8 | 0.2 | 3 |
Sleep Apnea | 0.3 | 0.4 | -0.33 |
Small Intestinal Bacterial Overgrowth (SIBO) | 0.7 | 0.7 | |
Stress / posttraumatic stress disorder | 0.9 | 0.5 | 0.8 |
Systemic Lupus Erythematosus | 1.6 | 0.1 | 15 |
Tic Disorder | 0.3 | 0.5 | -0.67 |
Tourette syndrome | 0.1 | 0.1 | 0 |
Type 1 Diabetes | 1.4 | 0.6 | 1.33 |
Type 2 Diabetes | 2.6 | 2.4 | 0.08 |
Ulcerative colitis | 1 | 1.7 | -0.7 |
Unhealthy Ageing | 2.1 | 0.4 | 4.25 |
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