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Sedation: Glutethimide exerts its primary effect as a central nervous system depressant, leading to sedation and drowsiness. It was historically used as a sleep aid due to its sedative properties.
Hypnotic Effects: Glutethimide has hypnotic effects, meaning it can induce sleep and promote relaxation. However, its use for this purpose has declined due to concerns about safety and the risk of dependence.
Muscle Relaxation: Glutethimide also possesses muscle relaxant properties, which can contribute to its sedative effects. It was sometimes prescribed for conditions involving muscle spasms or tension.
Anticonvulsant Properties: In addition to its sedative and muscle relaxant effects, glutethimide has been found to exhibit anticonvulsant properties. However, its use for this purpose is limited due to safety concerns and the availability of safer anticonvulsant medications.
Addiction and Dependence: Glutethimide has a high potential for addiction and dependence, especially when used for an extended period or in high doses. Chronic use of glutethimide can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.
Respiratory Depression: Like other sedative-hypnotic drugs, glutethimide can cause respiratory depression, particularly when taken in high doses or in combination with other central nervous system depressants such as alcohol or opioids. Severe respiratory depression can be life-threatening.
Overdose: Glutethimide overdose can result in severe central nervous system depression, coma, and death. Overdose requires immediate medical attention and supportive care, including airway management and administration of antidotes if available.
Drug Interactions: Glutethimide can interact with other medications, including other central nervous system depressants, leading to additive effects and increasing the risk of respiratory depression, sedation, and overdose.
Withdrawal Syndrome: Abrupt discontinuation of glutethimide after long-term use can result in withdrawal symptoms, including rebound insomnia, anxiety, agitation, tremors, and seizures. Withdrawal should be managed under medical supervision to minimize the risk of complications.
Regulatory Status: Due to its high potential for abuse, addiction, and overdose, glutethimide is a controlled substance in many countries. Its use is restricted, and it is not commonly prescribed in clinical practice.
Medical Uses: While glutethimide was historically used as a sleep aid and sedative, its use has largely been replaced by safer alternatives. It is rarely prescribed today and is not recommended for the treatment of any medical condition due to safety concerns and the availability of better treatment options.
| Rank | Probiotic | Impact |
|---|
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
| Taxonomy | Rank | Effect | Citations | Notation |
|---|---|---|---|---|
| unclassified Robinsoniella | no rank | Decreases | ⚗️ Source Study | |
| unclassified Fusobacterium | no rank | Decreases | ⚗️ Source Study | |
| unclassified Negativicoccus | no rank | Decreases | ⚗️ Source Study | |
| Eggerthellales | order | Decreases | ⚗️ Source Study | |
| Anaerofustis stercorihominis | species | Decreases | ⚗️ Source Study | |
| Asaccharospora irregularis | species | Decreases | ⚗️ Source Study | |
| Negativicoccus sp. S5-A15 | species | Decreases | ⚗️ Source Study | |
| Paraprevotella clara | species | Decreases | ⚗️ Source Study | |
| Slackia sp. NATTS | species | Decreases | ⚗️ Source Study | |
| Pseudoflavonifractor capillosus | species | Decreases | ⚗️ Source Study | |
| [Collinsella] massiliensis | species | Decreases | ⚗️ Source Study | |
| Parvibacter caecicola | species | Decreases | ⚗️ Source Study | |
| Coriobacterineae | suborder | Decreases | ⚗️ Source Study | |
| Chlamydiae/Verrucomicrobia group | superphylum | Decreases | ⚗️ Source Study |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Chronic Fatigue Syndrome | 0.1 | 0.1 | |
| Depression | 0.3 | 0.3 | |
| ME/CFS without IBS | 0.1 | 0.1 | |
| Mood Disorders | 0.3 | 0.3 |
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