🍽️ chlorothiazide,(prescription)

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  1. Hypertension (High Blood Pressure): Chlorothiazide is indicated for the treatment of hypertension, either as monotherapy or in combination with other antihypertensive medications. It works by increasing the excretion of sodium and water through the kidneys, leading to decreased fluid volume and reduced blood pressure. Chlorothiazide helps lower both systolic and diastolic blood pressure, thereby reducing the risk of cardiovascular events such as heart attack, stroke, and heart failure.

  2. Edema: Chlorothiazide is also used to treat edema associated with various medical conditions, including congestive heart failure, liver cirrhosis, and renal dysfunction. By promoting diuresis (increased urine production), chlorothiazide helps reduce fluid accumulation in the body's tissues and alleviate symptoms of edema such as swelling in the legs, ankles, and abdomen. It may be used alone or in combination with other medications to manage fluid retention in individuals with underlying health conditions.

  3. Nephrogenic Diabetes Insipidus: Chlorothiazide may be prescribed to manage nephrogenic diabetes insipidus, a condition characterized by excessive urination and thirst due to impaired kidney function. By increasing urine production and reducing fluid volume in the body, chlorothiazide helps alleviate symptoms of polyuria (excessive urination) and polydipsia (excessive thirst) associated with nephrogenic diabetes insipidus. It may be used as adjunctive therapy along with dietary and lifestyle modifications.

  4. Hypercalciuria: Chlorothiazide may be beneficial in individuals with hypercalciuria (high urinary calcium levels), a condition characterized by the excessive excretion of calcium in the urine. By promoting diuresis and increasing urinary calcium excretion, chlorothiazide helps lower urinary calcium levels and reduce the risk of kidney stone formation. It may be used as part of a comprehensive treatment plan to manage hypercalciuria and prevent recurrent kidney stones.

  5. Osteoporosis: Some evidence suggests that thiazide diuretics like chlorothiazide may have beneficial effects on bone health and reduce the risk of osteoporosis-related fractures. Thiazides may increase renal calcium reabsorption and reduce urinary calcium excretion, leading to improved calcium balance and preservation of bone density. However, further research is needed to fully elucidate the impact of thiazide diuretics on bone metabolism and fracture risk reduction.

  6. Side Effects: Common side effects of chlorothiazide may include electrolyte imbalances (such as hypokalemia, hyponatremia, and hypomagnesemia), increased uric acid levels (hyperuricemia), dehydration, dizziness, lightheadedness, headache, muscle cramps, and gastrointestinal disturbances. These side effects are usually dose-dependent and may be mitigated by adequate monitoring of electrolyte levels and hydration status. Chlorothiazide may also increase blood glucose levels and worsen glucose tolerance, particularly in individuals with diabetes or prediabetes.

  7. Contraindications: Chlorothiazide is contraindicated in individuals with anuria (absence of urine production), severe renal impairment, electrolyte imbalances, or hypersensitivity to sulfonamide-derived medications. It should be used with caution in elderly patients, those with cardiovascular disease, electrolyte abnormalities, or impaired renal function, and pregnant or breastfeeding women. Chlorothiazide may interact with other medications, including lithium, digoxin, nonsteroidal anti-inflammatory drugs (NSAIDs), and certain antidiabetic agents, so it is important to inform the healthcare provider of all medications being taken.

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Impacted of chlorothiazide,(prescription) On Probiotics

Rank Probiotic Impact

Bacteria Impacted by chlorothiazide,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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Taxonomy Rank Effect Citations Notation
Bacteroides genus Decreases 👪 Source Study
Ruminococcus genus Decreases 👪 Source Study
Roseburia genus Decreases 👪 Source Study
unclassified Robinsoniella no rank Decreases ⚗️ Source Study
unclassified Fusobacterium no rank Decreases ⚗️ Source Study
unclassified Negativicoccus no rank Decreases ⚗️ Source Study
Eggerthellales order Decreases ⚗️ Source Study
Bacteroides xylanisolvens species Decreases 📓 Source Study
Anaerofustis stercorihominis species Decreases ⚗️ Source Study
Asaccharospora irregularis species Decreases ⚗️ Source Study
Negativicoccus sp. S5-A15 species Decreases ⚗️ Source Study
Paraprevotella clara species Decreases ⚗️ Source Study
Slackia sp. NATTS species Decreases ⚗️ Source Study
Pseudoflavonifractor capillosus species Decreases ⚗️ Source Study
[Collinsella] massiliensis species Decreases ⚗️ Source Study
Parvibacter caecicola species Decreases ⚗️ Source Study
Ruminococcus bromii species Decreases 📓 Source Study
Roseburia hominis species Decreases 📓 Source Study
Coriobacterineae suborder Decreases ⚗️ Source Study
Chlamydiae/Verrucomicrobia group superphylum Decreases ⚗️ Source Study

Impact of chlorothiazide,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
ADHD 0.1 0.1
Age-Related Macular Degeneration and Glaucoma 0 0
Allergic Rhinitis (Hay Fever) 0.1 0.1
Allergies 0.1 -0.1
Allergy to milk products 0.1 0.1
Alzheimer's disease 0.1 0.2 -1
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0 0
Ankylosing spondylitis 0.1 -0.1
Anorexia Nervosa 0.2 -0.2
Asthma 0.1 -0.1
Atherosclerosis 0 0 0
Atrial fibrillation 0.1 0.1 0
Autism 0.2 0.2 0
Bipolar Disorder 0.1 0.1 0
Brain Trauma 0.1 -0.1
Carcinoma 0.1 0.1 0
Celiac Disease 0.1 0.1 0
Cerebral Palsy 0.2 -0.2
Chronic Fatigue Syndrome 0.3 0.1 2
Chronic Kidney Disease 0.1 0 0
Chronic Lyme 0.1 -0.1
Chronic Obstructive Pulmonary Disease (COPD) 0 0
Coagulation / Micro clot triggering bacteria 0.1 -0.1
Colorectal Cancer 0.2 0.2
Constipation 0.1 0 0
Coronary artery disease 0 0
COVID-19 0.1 0.3 -2
Crohn's Disease 0.2 0.2 0
cystic fibrosis 0.1 -0.1
deep vein thrombosis 0.1 -0.1
Depression 0.5 0.2 1.5
Endometriosis 0.1 0 0
Epilepsy 0.1 0.1 0
Fibromyalgia 0 0.1 0
Functional constipation / chronic idiopathic constipation 0.1 0.1 0
gallstone disease (gsd) 0 0 0
Generalized anxiety disorder 0.1 -0.1
Graves' disease 0.1 0 0
Halitosis 0.1 0.1
Hashimoto's thyroiditis 0.1 0.1 0
Histamine Issues,Mast Cell Issue, DAO Insufficiency 0.1 0.1
hyperglycemia 0.1 -0.1
hypertension (High Blood Pressure 0.1 0.1 0
Hypoxia 0.1 0.1
Inflammatory Bowel Disease 0.1 0.3 -2
Insomnia 0.1 0.1 0
Intracranial aneurysms 0.1 0.1
Irritable Bowel Syndrome 0.2 0.1 1
Liver Cirrhosis 0.2 0.2 0
Long COVID 0.1 0.3 -2
Low bone mineral density 0 0
Lung Cancer 0 0
ME/CFS with IBS 0.1 -0.1
ME/CFS without IBS 0.1 0.1 0
Metabolic Syndrome 0.2 0.2 0
Mood Disorders 0.5 0.2 1.5
Multiple Sclerosis 0 0.2 0
Multiple system atrophy (MSA) 0 0 0
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.1 -0.1
Obesity 0.2 0.1 1
obsessive-compulsive disorder 0.2 0.1 1
Osteoarthritis 0.1 0 0
Osteoporosis 0.1 0.1 0
Parkinson's Disease 0.1 -0.1
Polycystic ovary syndrome 0.1 0.1 0
Psoriasis 0 0.1 0
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.2 0.1 1
Rosacea 0 0 0
Schizophrenia 0.1 0.1 0
scoliosis 0 0
Sjögren syndrome 0.1 -0.1
Sleep Apnea 0 0.1 0
Stress / posttraumatic stress disorder 0.1 0.1 0
Systemic Lupus Erythematosus 0.1 0.1 0
Tic Disorder 0 0
Tourette syndrome 0.1 -0.1
Type 1 Diabetes 0.1 0 0
Type 2 Diabetes 0.2 0.2 0
Ulcerative colitis 0.1 0.1 0
Unhealthy Ageing 0.1 0 0

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