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Antihistamine Effects: Pyrilamine maleate works by blocking the action of histamine, a substance in the body that is involved in allergic reactions. By inhibiting histamine receptors, pyrilamine maleate helps alleviate symptoms such as itching, sneezing, runny nose, watery eyes, and hives.
Allergic Rhinitis: Pyrilamine maleate is commonly used to relieve symptoms of allergic rhinitis, also known as hay fever. It helps reduce nasal congestion, sneezing, itching, and runny nose caused by allergens such as pollen, dust mites, pet dander, and mold.
Allergic Conjunctivitis: Pyrilamine maleate may also be used to alleviate symptoms of allergic conjunctivitis, including redness, itching, and watering of the eyes due to exposure to allergens.
Urticaria (Hives): Pyrilamine maleate can help relieve the itching and swelling associated with acute and chronic urticaria, commonly known as hives. It blocks histamine receptors in the skin, reducing the allergic response and alleviating symptoms.
Pruritus (Itching): Pyrilamine maleate is sometimes used to relieve generalized itching associated with various skin conditions, including eczema, dermatitis, and insect bites.
Motion Sickness: Pyrilamine maleate has mild sedative properties and may be used to prevent motion sickness and alleviate symptoms such as nausea and vomiting during travel.
Side Effects: Common side effects of pyrilamine maleate may include drowsiness, dizziness, dry mouth, blurred vision, constipation, and urinary retention. These side effects are typically mild and transient, but individuals should exercise caution when operating machinery or driving until they know how the medication affects them.
Central Nervous System Effects: Pyrilamine maleate can penetrate the blood-brain barrier, leading to central nervous system (CNS) effects such as sedation and drowsiness. This sedative effect may be enhanced when pyrilamine maleate is used concomitantly with other CNS depressants, such as alcohol or certain medications.
Drug Interactions: Pyrilamine maleate may interact with other medications, including central nervous system depressants, anticholinergic drugs, and certain antidepressants. These interactions can potentiate the sedative effects of pyrilamine maleate and increase the risk of adverse effects.
Special Populations: Pyrilamine maleate should be used with caution in elderly individuals, as they may be more susceptible to its sedative effects. It should also be used cautiously in children, as sedation and CNS effects may be more pronounced in this population.
Rank | Probiotic | Impact |
---|---|---|
species | Akkermansia muciniphila | Reduces |
species | Bifidobacterium adolescentis | Reduces |
species | Escherichia coli | Reduces |
species | Lacticaseibacillus paracasei | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
Abdominal Aortic Aneurysm | 0 | 0 | |
Acne | 0.2 | -0.2 | |
ADHD | 1.8 | 1.8 | |
Age-Related Macular Degeneration and Glaucoma | 0.5 | 0.5 | |
Allergic Rhinitis (Hay Fever) | 0.6 | 0.7 | -0.17 |
Allergies | 1.3 | 1.4 | -0.08 |
Allergy to milk products | 0.7 | 0.4 | 0.75 |
Alopecia (Hair Loss) | 0.3 | 0.3 | |
Alzheimer's disease | 1.8 | 2.4 | -0.33 |
Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1.9 | 1 | 0.9 |
Ankylosing spondylitis | 1.8 | 0.5 | 2.6 |
Anorexia Nervosa | 0.7 | -0.7 | |
Antiphospholipid syndrome (APS) | 0.8 | 0 | 0 |
Asthma | 0.3 | 1.3 | -3.33 |
Atherosclerosis | 0.4 | 0.7 | -0.75 |
Atrial fibrillation | 1.2 | 1 | 0.2 |
Autism | 4.1 | 4 | 0.02 |
Barrett esophagus cancer | 0.2 | 0.3 | -0.5 |
benign prostatic hyperplasia | 0.2 | 0.2 | |
Bipolar Disorder | 0.4 | 0.3 | 0.33 |
Brain Trauma | 0.3 | 0.4 | -0.33 |
Carcinoma | 1.3 | 0.8 | 0.63 |
Celiac Disease | 1.3 | 1.2 | 0.08 |
Cerebral Palsy | 0.9 | 0.5 | 0.8 |
Chronic Fatigue Syndrome | 1.7 | 2 | -0.18 |
Chronic Kidney Disease | 1.1 | 0.5 | 1.2 |
Chronic Lyme | 0.4 | -0.4 | |
Chronic Obstructive Pulmonary Disease (COPD) | 1.5 | 0.3 | 4 |
Chronic Urticaria (Hives) | 1 | 1.1 | -0.1 |
Coagulation / Micro clot triggering bacteria | 0.9 | 0.5 | 0.8 |
Colorectal Cancer | 2.8 | 0.4 | 6 |
Constipation | 0.7 | 0.3 | 1.33 |
Coronary artery disease | 0.2 | 0.1 | 1 |
COVID-19 | 4.4 | 6.6 | -0.5 |
Crohn's Disease | 3.1 | 1.9 | 0.63 |
cystic fibrosis | 0.6 | 0.7 | -0.17 |
deep vein thrombosis | 0.6 | 0.5 | 0.2 |
Depression | 3.9 | 2.7 | 0.44 |
Dermatomyositis | 0.3 | 0.2 | 0.5 |
Eczema | 0.4 | 1.6 | -3 |
Endometriosis | 1.6 | 0.2 | 7 |
Eosinophilic Esophagitis | 0.1 | 0.1 | 0 |
Epilepsy | 1.6 | 1.4 | 0.14 |
Fibromyalgia | 0.8 | 1 | -0.25 |
Functional constipation / chronic idiopathic constipation | 2 | 2.5 | -0.25 |
gallstone disease (gsd) | 0.7 | 0.6 | 0.17 |
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.7 | 0.3 | 1.33 |
Generalized anxiety disorder | 0.9 | 0.5 | 0.8 |
giant cell arteritis | 0.1 | -0.1 | |
Glioblastoma | 0.3 | -0.3 | |
Graves' disease | 0.5 | 0.6 | -0.2 |
Halitosis | 0.4 | 0.3 | 0.33 |
Hashimoto's thyroiditis | 1.8 | 0.5 | 2.6 |
Hidradenitis Suppurativa | 0.4 | 0.1 | 3 |
Histamine Issues,Mast Cell Issue, DAO Insufficiency | 1.6 | 0.3 | 4.33 |
hypercholesterolemia (High Cholesterol) | 0.1 | 0.6 | -5 |
hyperglycemia | 0.2 | 1.4 | -6 |
Hyperlipidemia (High Blood Fats) | 0.6 | 0.1 | 5 |
hypersomnia | 0.1 | -0.1 | |
hypertension (High Blood Pressure | 1.2 | 2.2 | -0.83 |
Hypothyroidism | 0.3 | -0.3 | |
Hypoxia | 0.5 | 0.5 | |
IgA nephropathy (IgAN) | 1.5 | -1.5 | |
Inflammatory Bowel Disease | 2.7 | 2.5 | 0.08 |
Insomnia | 0.5 | 0.5 | 0 |
Intelligence | 0.3 | 0.3 | 0 |
Intracranial aneurysms | 0.2 | 0.1 | 1 |
Irritable Bowel Syndrome | 2.9 | 2.3 | 0.26 |
Liver Cirrhosis | 2.1 | 1.7 | 0.24 |
Long COVID | 3.1 | 2.3 | 0.35 |
Low bone mineral density | 0.3 | -0.3 | |
Lung Cancer | 0.9 | 0.9 | 0 |
ME/CFS with IBS | 0.3 | 1 | -2.33 |
ME/CFS without IBS | 0.6 | 1.1 | -0.83 |
Menopause | 0.8 | 0.8 | |
Metabolic Syndrome | 3.6 | 4.1 | -0.14 |
Mood Disorders | 5 | 2.7 | 0.85 |
multiple chemical sensitivity [MCS] | 1.5 | 0 | 0 |
Multiple Sclerosis | 2.9 | 1.6 | 0.81 |
Multiple system atrophy (MSA) | 1.6 | 0.3 | 4.33 |
Neuropathy (all types) | 0.6 | 0.2 | 2 |
neuropsychiatric disorders (PANDAS, PANS) | 0.5 | 0.5 | |
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 1.2 | 1.9 | -0.58 |
NonCeliac Gluten Sensitivity | 0.2 | -0.2 | |
Obesity | 4.5 | 2.8 | 0.61 |
obsessive-compulsive disorder | 2.4 | 2.4 | 0 |
Osteoarthritis | 1 | 1 | |
Osteoporosis | 0.6 | 0.8 | -0.33 |
pancreatic cancer | 0.3 | 0.3 | |
Parkinson's Disease | 1.9 | 1.3 | 0.46 |
Polycystic ovary syndrome | 0.8 | 0.9 | -0.13 |
Postural orthostatic tachycardia syndrome | 0.1 | 0.2 | -1 |
Premenstrual dysphoric disorder | 0.3 | 0.3 | |
primary biliary cholangitis | 0.2 | 0.3 | -0.5 |
Psoriasis | 2.2 | 1.3 | 0.69 |
rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2.7 | 1.5 | 0.8 |
Rosacea | 0.8 | 0.3 | 1.67 |
Schizophrenia | 2.3 | 0.6 | 2.83 |
scoliosis | 0.1 | -0.1 | |
Sjögren syndrome | 1.1 | 1.5 | -0.36 |
Sleep Apnea | 0.4 | 0.5 | -0.25 |
Small Intestinal Bacterial Overgrowth (SIBO) | 0.8 | 0.8 | |
Stress / posttraumatic stress disorder | 1.8 | 1.3 | 0.38 |
Systemic Lupus Erythematosus | 1.3 | 0.6 | 1.17 |
Tic Disorder | 0.4 | 0.8 | -1 |
Tourette syndrome | 0.3 | 0.2 | 0.5 |
Type 1 Diabetes | 1.4 | 1.4 | 0 |
Type 2 Diabetes | 3.8 | 3.6 | 0.06 |
Ulcerative colitis | 1.7 | 2.9 | -0.71 |
Unhealthy Ageing | 2.2 | 1 | 1.2 |
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