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Hypertension (High Blood Pressure): Practolol was initially prescribed to manage hypertension by blocking the effects of adrenaline (epinephrine) on the heart and blood vessels. By reducing the workload on the heart and relaxing blood vessels, it helped lower blood pressure. However, due to the availability of safer and more effective alternatives, practolol is no longer commonly used for this indication.
Angina Pectoris: Angina pectoris is chest pain or discomfort caused by reduced blood flow to the heart muscle. Practolol was occasionally prescribed to relieve symptoms of angina by reducing the heart's workload and oxygen demand. However, its use for this purpose has diminished due to the availability of safer medications with fewer adverse effects.
Arrhythmias: Practolol was sometimes used to manage certain heart rhythm disorders (arrhythmias), including atrial fibrillation and supraventricular tachycardia. By blocking the effects of adrenaline on the heart's electrical conduction system, practolol helped stabilize heart rhythm. However, its use for this indication has declined due to safety concerns.
Adverse Effects: Practolol is associated with a range of adverse effects, some of which can be severe and irreversible. One of the most notable adverse effects is a unique oculomucocutaneous syndrome, characterized by inflammation and fibrosis of the eyes, mucous membranes, and skin. This syndrome can lead to permanent visual impairment and other serious complications.
Other Side Effects: In addition to the oculomucocutaneous syndrome, practolol may cause common beta-blocker side effects such as fatigue, dizziness, slow heart rate (bradycardia), low blood pressure (hypotension), bronchospasm (especially in patients with asthma or chronic obstructive pulmonary disease), depression, and impotence.
Withdrawal from the Market: Due to the severe adverse effects associated with practolol, including the oculomucocutaneous syndrome, it has been largely withdrawn from the market in many countries. Safer and more effective alternatives are available for the management of hypertension, angina, and arrhythmias.
| Rank | Probiotic | Impact |
|---|
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| ADHD | 0.1 | 0.1 | |
| Allergies | 0.1 | -0.1 | |
| Allergy to milk products | 0.1 | 0.1 | |
| Alzheimer's disease | 0.1 | 0.1 | 0 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.1 | -0.1 | |
| Ankylosing spondylitis | 0.1 | -0.1 | |
| Anorexia Nervosa | 0.1 | -0.1 | |
| Atherosclerosis | 0.1 | 0.1 | |
| Atrial fibrillation | 0.1 | 0.1 | |
| Autism | 0.1 | 0.1 | 0 |
| Bipolar Disorder | 0.1 | 0.1 | 0 |
| Carcinoma | 0.1 | 0.1 | 0 |
| Celiac Disease | 0.1 | -0.1 | |
| Cerebral Palsy | 0.1 | -0.1 | |
| Chronic Fatigue Syndrome | 0.3 | 0.3 | |
| Coagulation / Micro clot triggering bacteria | 0.1 | -0.1 | |
| Colorectal Cancer | 0.1 | 0.1 | |
| Coronary artery disease | 0.1 | 0.1 | |
| COVID-19 | 0.3 | 0.4 | -0.33 |
| Crohn's Disease | 0.1 | 0.1 | 0 |
| deep vein thrombosis | 0.1 | -0.1 | |
| Depression | 0.3 | 0.1 | 2 |
| Endometriosis | 0.1 | -0.1 | |
| Fibromyalgia | 0.2 | 0.2 | |
| Functional constipation / chronic idiopathic constipation | 0.1 | 0.1 | |
| gallstone disease (gsd) | 0.1 | 0.1 | |
| High Histamine/low DAO | 0.1 | -0.1 | |
| hypertension (High Blood Pressure | 0.1 | 0.1 | |
| Inflammatory Bowel Disease | 0.2 | 0.2 | 0 |
| Intracranial aneurysms | 0.1 | 0.1 | |
| Irritable Bowel Syndrome | 0.1 | 0.1 | |
| Liver Cirrhosis | 0.1 | 0.1 | 0 |
| Long COVID | 0.2 | 0.2 | 0 |
| Lung Cancer | 0.1 | -0.1 | |
| Mast Cell Issues / mastitis | 0.1 | -0.1 | |
| ME/CFS without IBS | 0.1 | 0.1 | |
| Metabolic Syndrome | 0.1 | 0.1 | 0 |
| Mood Disorders | 0.4 | 0.1 | 3 |
| Multiple Sclerosis | 0.1 | 0.1 | 0 |
| Multiple system atrophy (MSA) | 0.1 | -0.1 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.1 | -0.1 | |
| Obesity | 0.1 | 0.1 | 0 |
| obsessive-compulsive disorder | 0.1 | 0.1 | |
| Osteoarthritis | 0.2 | 0.1 | 1 |
| Osteoporosis | 0.1 | 0.1 | |
| Parkinson's Disease | 0.2 | 0.3 | -0.5 |
| Polycystic ovary syndrome | 0.1 | 0.1 | 0 |
| Psoriasis | 0.1 | 0.1 | |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 0.1 | 0.1 | |
| Rosacea | 0.1 | 0.1 | |
| Schizophrenia | 0.1 | 0.1 | 0 |
| scoliosis | 0.1 | -0.1 | |
| Sleep Apnea | 0.1 | 0.1 | |
| Slow gastric motility / Gastroparesis | 0.1 | 0.1 | |
| Systemic Lupus Erythematosus | 0.1 | -0.1 | |
| Tic Disorder | 0.1 | 0.1 | |
| Type 1 Diabetes | 0.1 | 0.1 | |
| Type 2 Diabetes | 0.1 | 0.1 | 0 |
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