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Blood Glucose Control: Glimepiride helps lower blood sugar levels by increasing insulin secretion from the pancreas and improving insulin sensitivity in the body's cells. It is effective in managing hyperglycemia (high blood sugar) in patients with type 2 diabetes mellitus.
Insulin Secretagogue: As a sulfonylurea, glimepiride acts as an insulin secretagogue, promoting the release of insulin from the beta cells of the pancreas. This mechanism helps reduce blood glucose levels by increasing insulin availability.
Hypoglycemia: One of the common side effects of glimepiride is hypoglycemia, or low blood sugar levels. This can occur if the dose of glimepiride is too high relative to the individual's insulin needs or if meals are skipped or delayed.
Weight Gain: Some individuals may experience weight gain while taking glimepiride. This can be attributed to the medication's effect of increasing insulin levels, which can promote fat storage.
Gastrointestinal Effects: Glimepiride may cause gastrointestinal side effects such as nausea, vomiting, diarrhea, or abdominal discomfort in some patients. These effects are usually mild and transient.
Skin Reactions: Rarely, glimepiride may cause skin reactions such as rash or itching. If these symptoms occur, patients should consult their healthcare provider.
Liver Function: Glimepiride can affect liver function, although significant liver toxicity is rare. Liver function tests may be monitored periodically in patients taking glimepiride, especially those with pre-existing liver conditions.
Allergic Reactions: Some individuals may experience allergic reactions to glimepiride, although these are rare. Symptoms of an allergic reaction may include rash, itching, swelling, dizziness, or difficulty breathing. Immediate medical attention is necessary if an allergic reaction occurs.
Drug Interactions: Glimepiride may interact with other medications, including other antidiabetic drugs, leading to changes in blood sugar levels or an increased risk of hypoglycemia or other adverse effects. It's important for patients to inform their healthcare providers about all medications they are taking.
Cardiovascular Effects: While glimepiride itself does not directly affect the cardiovascular system, maintaining good blood sugar control with medications like glimepiride can reduce the risk of long-term cardiovascular complications associated with diabetes, such as heart disease and stroke.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Escherichia coli | Reduces |
| species | Parabacteroides distasonis | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| ADHD | 0.4 | 0.1 | 3 |
| Age-Related Macular Degeneration and Glaucoma | 0.4 | -0.4 | |
| Allergic Rhinitis (Hay Fever) | 0.7 | 0.7 | |
| Allergies | 0.3 | 0.1 | 2 |
| Allergy to milk products | 0.2 | 0.5 | -1.5 |
| Alopecia (Hair Loss) | 0.9 | 0.9 | |
| Alzheimer's disease | 0.8 | 0.4 | 1 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.3 | 0.1 | 2 |
| Ankylosing spondylitis | 1.2 | 0.2 | 5 |
| Anorexia Nervosa | 0.4 | 0.1 | 3 |
| Antiphospholipid syndrome (APS) | 0.2 | 0.2 | |
| Asthma | 0.1 | -0.1 | |
| Atrial fibrillation | 0.7 | 0.7 | 0 |
| Autism | 1 | 1.1 | -0.1 |
| Barrett esophagus cancer | 0.1 | -0.1 | |
| benign prostatic hyperplasia | 0 | 0 | |
| Biofilm | 0.2 | 0.2 | |
| Bipolar Disorder | 0.6 | 0.1 | 5 |
| Brain Trauma | 0.1 | -0.1 | |
| Carcinoma | 0.7 | 0.6 | 0.17 |
| Celiac Disease | 0.3 | 0.6 | -1 |
| Cerebral Palsy | 0.1 | 0.1 | 0 |
| Chronic Fatigue Syndrome | 0.4 | 1.3 | -2.25 |
| Chronic Kidney Disease | 0.7 | 0.1 | 6 |
| Chronic Lyme | 0.1 | -0.1 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 0.3 | 0.1 | 2 |
| Chronic Urticaria (Hives) | 0.2 | 0.3 | -0.5 |
| Coagulation / Micro clot triggering bacteria | 0.7 | 0.1 | 6 |
| Colorectal Cancer | 1.2 | 1.2 | |
| Constipation | 0.2 | 0.2 | |
| Coronary artery disease | 0.1 | 0.1 | 0 |
| COVID-19 | 0.8 | 0.6 | 0.33 |
| Crohn's Disease | 1.1 | 0.9 | 0.22 |
| cystic fibrosis | 0.1 | 0.1 | 0 |
| deep vein thrombosis | 0.1 | 0.1 | 0 |
| Depression | 1.8 | 0.9 | 1 |
| Dermatomyositis | 0.1 | 0.1 | |
| Eczema | 0.2 | 0.6 | -2 |
| Endometriosis | 0.9 | 0.9 | |
| Epilepsy | 0.5 | 0.6 | -0.2 |
| Fibromyalgia | 0.4 | 0.4 | 0 |
| Functional constipation / chronic idiopathic constipation | 0.9 | 0.5 | 0.8 |
| gallstone disease (gsd) | 0.5 | 0.5 | |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.2 | 0.1 | 1 |
| Generalized anxiety disorder | 0.3 | 0.2 | 0.5 |
| Glioblastoma | 0.1 | -0.1 | |
| Gout | 0.1 | -0.1 | |
| Graves' disease | 0.6 | 0.6 | |
| Halitosis | 0.1 | 0.1 | 0 |
| Hashimoto's thyroiditis | 0.1 | 0.1 | 0 |
| Hidradenitis Suppurativa | 0.1 | 0.1 | |
| High Histamine/low DAO | 0.1 | 0.1 | |
| hyperglycemia | 0 | 0.6 | 0 |
| hypertension (High Blood Pressure | 0.7 | 0.5 | 0.4 |
| Hypothyroidism | 0.1 | -0.1 | |
| Hypoxia | 0.6 | 0.6 | |
| IgA nephropathy (IgAN) | 0.2 | -0.2 | |
| Inflammatory Bowel Disease | 0.9 | 1.4 | -0.56 |
| Insomnia | 0.2 | 0.1 | 1 |
| Intelligence | 0.1 | 0.1 | 0 |
| Intracranial aneurysms | 0.6 | 0.6 | |
| Irritable Bowel Syndrome | 0.3 | 0.6 | -1 |
| Liver Cirrhosis | 0.8 | 0.3 | 1.67 |
| Long COVID | 1 | 0.6 | 0.67 |
| Low bone mineral density | 0.1 | -0.1 | |
| Lung Cancer | 0 | 0 | |
| Mast Cell Issues / mastitis | 0.2 | 0.1 | 1 |
| ME/CFS with IBS | 0.1 | 0.3 | -2 |
| ME/CFS without IBS | 0.2 | 1 | -4 |
| Metabolic Syndrome | 1.2 | 1 | 0.2 |
| Mood Disorders | 1.9 | 0.9 | 1.11 |
| multiple chemical sensitivity [MCS] | 0.3 | 0.3 | |
| Multiple Sclerosis | 0.8 | 1.9 | -1.37 |
| neuropathic pain | 0.1 | -0.1 | |
| Neuropathy (all types) | 0.1 | 0 | 0 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.1 | 0.1 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.2 | 0.2 | 0 |
| NonCeliac Gluten Sensitivity | 0.1 | -0.1 | |
| Obesity | 0.9 | 0.9 | 0 |
| obsessive-compulsive disorder | 1 | 0.4 | 1.5 |
| Osteoarthritis | 0.4 | 0.4 | |
| Osteoporosis | 0.2 | 0.1 | 1 |
| pancreatic cancer | 0.1 | 0.1 | |
| Parkinson's Disease | 1.3 | 0.6 | 1.17 |
| Polycystic ovary syndrome | 0.6 | 0.6 | |
| Postural orthostatic tachycardia syndrome | 0.1 | -0.1 | |
| Premenstrual dysphoric disorder | 0.4 | -0.4 | |
| Psoriasis | 0.4 | 1.6 | -3 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 1 | 0.4 | 1.5 |
| Schizophrenia | 0.6 | 0.1 | 5 |
| scoliosis | 0.1 | 0.1 | |
| Sjögren syndrome | 0.7 | 0.6 | 0.17 |
| Sleep Apnea | 0.1 | 0.2 | -1 |
| Slow gastric motility / Gastroparesis | 0.2 | 0.2 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.2 | 0.2 | |
| Stress / posttraumatic stress disorder | 0.7 | 0.2 | 2.5 |
| Systemic Lupus Erythematosus | 1.1 | 1.1 | |
| Tic Disorder | 0.1 | -0.1 | |
| Tourette syndrome | 0.1 | -0.1 | |
| Type 1 Diabetes | 0.5 | 0.1 | 4 |
| Type 2 Diabetes | 1.2 | 1.1 | 0.09 |
| Ulcerative colitis | 0.4 | 0.7 | -0.75 |
| Unhealthy Ageing | 0.7 | 0.1 | 6 |
| Vitiligo | 0.3 | 0.6 | -1 |
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